Mechanisms of lymphatic metastasis
Identifieur interne : 001A08 ( Pmc/Checkpoint ); précédent : 001A07; suivant : 001A09Mechanisms of lymphatic metastasis
Auteurs : Sinem Karaman ; Michael DetmarSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Abstract
Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.
Url:
DOI: 10.1172/JCI71606
PubMed: 24590277
PubMed Central: 3938272
Affiliations:
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PMC:3938272Le document en format XML
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<series><title level="j">The Journal of Clinical Investigation</title>
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<front><div type="abstract" xml:lang="en"><p>Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.</p>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id>
<journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Review Series</subject>
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<title-group><article-title>Mechanisms of lymphatic metastasis</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Karaman</surname>
<given-names>Sinem</given-names>
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<contrib contrib-type="author"><name><surname>Detmar</surname>
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<aff id="JCI71606">Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.</aff>
<author-notes><corresp>Address correspondence to: Michael Detmar, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Vladimir-Prelog-Weg 3, HCI H303, CH-8093 Zurich, Switzerland. Phone: 41.44.633.7361; Fax: 41.44.633.1364; E-mail:
<email>michael.detmar@pharma.ethz.ch</email>
.
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<pub-date pub-type="epub"><day>3</day>
<month>3</month>
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<pub-date pub-type="ppub"><day>3</day>
<month>3</month>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>1</month>
<year>2015</year>
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<pmc-comment> PMC Release delay is 9 months and
29 days and was based on the . </pmc-comment>
<volume>124</volume>
<issue>3</issue>
<fpage>922</fpage>
<lpage>928</lpage>
<permissions><copyright-statement>Copyright © 2014, American Society for Clinical Investigation</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><p>Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.</p>
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