Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets
Identifieur interne : 001894 ( Pmc/Checkpoint ); précédent : 001893; suivant : 001895Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets
Auteurs : Yanfang Pan [États-Unis, République populaire de Chine] ; Tadayuki Yago [États-Unis] ; Jianxin Fu [États-Unis, République populaire de Chine] ; Brett Herzog [États-Unis] ; J. Michael Mcdaniel [États-Unis] ; Padmaja Mehta-D Ouza [États-Unis] ; Xiaofeng Cai [États-Unis] ; Changgeng Ruan [République populaire de Chine] ; Rodger P. Mcever [États-Unis] ; Christopher West [États-Unis] ; Kesheng Dai [République populaire de Chine] ; Hong Chen [États-Unis] ; Lijun Xia [États-Unis, République populaire de Chine]Source :
- Blood [ 0006-4971 ] ; 2014.
Abstract
Sialylated Sialylated core 1
Url:
DOI: 10.1182/blood-2014-04-572107
PubMed: 25336627
PubMed Central: 4256915
Affiliations:
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Michael" last="Mcdaniel">J. Michael Mcdaniel</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Mehta D Ouza, Padmaja" sort="Mehta D Ouza, Padmaja" uniqKey="Mehta D Ouza P" first="Padmaja" last="Mehta-D Ouza">Padmaja Mehta-D Ouza</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Cai, Xiaofeng" sort="Cai, Xiaofeng" uniqKey="Cai X" first="Xiaofeng" last="Cai">Xiaofeng Cai</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Ruan, Changgeng" sort="Ruan, Changgeng" uniqKey="Ruan C" first="Changgeng" last="Ruan">Changgeng Ruan</name><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Mcever, Rodger P" sort="Mcever, Rodger P" uniqKey="Mcever R" first="Rodger P." last="Mcever">Rodger P. Mcever</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="West, Christopher" sort="West, Christopher" uniqKey="West C" first="Christopher" last="West">Christopher West</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Dai, Kesheng" sort="Dai, Kesheng" uniqKey="Dai K" first="Kesheng" last="Dai">Kesheng Dai</name><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25336627</idno><idno type="pmc">4256915</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256915</idno><idno type="RBID">PMC:4256915</idno><idno type="doi">10.1182/blood-2014-04-572107</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002C84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C84</idno><idno type="wicri:Area/Pmc/Curation">002C83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C83</idno><idno type="wicri:Area/Pmc/Checkpoint">001894</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001894</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Podoplanin requires sialylated <italic>O</italic>-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets</title><author><name sortKey="Pan, Yanfang" sort="Pan, Yanfang" uniqKey="Pan Y" first="Yanfang" last="Pan">Yanfang Pan</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang</wicri:regionArea><wicri:noRegion>Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Yago, Tadayuki" sort="Yago, Tadayuki" uniqKey="Yago T" first="Tadayuki" last="Yago">Tadayuki Yago</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Herzog, Brett" sort="Herzog, Brett" uniqKey="Herzog B" first="Brett" last="Herzog">Brett Herzog</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Mcdaniel, J Michael" sort="Mcdaniel, J Michael" uniqKey="Mcdaniel J" first="J. Michael" last="Mcdaniel">J. Michael Mcdaniel</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Mehta D Ouza, Padmaja" sort="Mehta D Ouza, Padmaja" uniqKey="Mehta D Ouza P" first="Padmaja" last="Mehta-D Ouza">Padmaja Mehta-D Ouza</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Cai, Xiaofeng" sort="Cai, Xiaofeng" uniqKey="Cai X" first="Xiaofeng" last="Cai">Xiaofeng Cai</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Ruan, Changgeng" sort="Ruan, Changgeng" uniqKey="Ruan C" first="Changgeng" last="Ruan">Changgeng Ruan</name><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Mcever, Rodger P" sort="Mcever, Rodger P" uniqKey="Mcever R" first="Rodger P." last="Mcever">Rodger P. Mcever</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="West, Christopher" sort="West, Christopher" uniqKey="West C" first="Christopher" last="West">Christopher West</name><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Dai, Kesheng" sort="Dai, Kesheng" uniqKey="Dai K" first="Kesheng" last="Dai">Kesheng Dai</name><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation wicri:level="2"><nlm:aff id="aff1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oklahoma</region></placeName><wicri:cityArea>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City</wicri:cityArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Sialylated <italic>O</italic>-glycans protects PDPN from proteolytic degradation.</p></list-item><list-item><p>Sialylated core 1 <italic>O</italic>-glycans of PDPN on lymphatic endothelial cells (LECs) are required for interacting with platelets.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25336627</article-id><article-id pub-id-type="pmc">4256915</article-id><article-id pub-id-type="publisher-id">2014/572107</article-id><article-id pub-id-type="doi">10.1182/blood-2014-04-572107</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>35</subject><subject>38</subject></subj-group><subj-group subj-group-type="heading"><subject>Vascular Biology</subject></subj-group></article-categories><title-group><article-title>Podoplanin requires sialylated <italic>O</italic>-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pan</surname><given-names>Yanfang</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Yago</surname><given-names>Tadayuki</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fu</surname><given-names>Jianxin</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Herzog</surname><given-names>Brett</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>McDaniel</surname><given-names>J. Michael</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mehta-D’Souza</surname><given-names>Padmaja</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Xiaofeng</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ruan</surname><given-names>Changgeng</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>McEver</surname><given-names>Rodger P.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>West</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dai</surname><given-names>Kesheng</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Xia</surname><given-names>Lijun</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><aff id="aff1"><label>1</label>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK;</aff><aff id="aff2"><label>2</label>Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;</aff><aff id="aff3"><label>3</label>Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China;</aff><aff id="aff4"><label>4</label>Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China</aff></contrib-group><pub-date pub-type="ppub"><day>4</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epreprint"><day>21</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>4</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>124</volume><issue>24</issue><fpage>3656</fpage><lpage>3665</lpage><history><date date-type="received"><day>24</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>02</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 by The American Society of Hematology</copyright-statement><copyright-year>2014</copyright-year></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="3656.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Sialylated <italic>O</italic>-glycans protects PDPN from proteolytic degradation.</p></list-item><list-item><p>Sialylated core 1 <italic>O</italic>-glycans of PDPN on lymphatic endothelial cells (LECs) are required for interacting with platelets.</p></list-item></list></p></abstract><abstract><p><italic>O</italic>-glycosylation of podoplanin (PDPN) on lymphatic endothelial cells is critical for the separation of blood and lymphatic systems by interacting with platelet C-type lectin-like receptor 2 during development. However, how <italic>O</italic>-glycosylation controls endothelial PDPN function and expression remains unclear. In this study, we report that core 1 <italic>O</italic>-glycan–deficient or desialylated PDPN was highly susceptible to proteolytic degradation by various proteases, including metalloproteinases (MMP)-2/9. We found that the lymph contained activated MMP-2/9 and incubation of the lymph reduced surface levels of PDPN on core 1 <italic>O</italic>-glycan–deficient endothelial cells, but not on wild-type ECs. The lymph from mice with sepsis induced by cecal ligation and puncture, which contained bacteria-derived sialidase, reduced PDPN levels on wild-type ECs. The MMP inhibitor, GM6001, rescued these reductions. Additionally, GM6001 treatment rescued the reduction of PDPN level on lymphatic endothelial cells in mice lacking endothelial core 1 <italic>O</italic>-glycan or cecal ligation and puncture-treated mice. Furthermore, core 1 <italic>O</italic>-glycan–deficient or desialylated PDPN impaired platelet interaction under physiological flow. These data indicate that sialylated <italic>O</italic>-glycans of PDPN are essential for platelet adhesion and prevent PDPN from proteolytic degradation primarily mediated by MMPs in the lymph.</p></abstract><funding-group><award-group><funding-source id="CS100">National Institutes of Health</funding-source></award-group></funding-group><counts><page-count count="10"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Oklahoma</li></region></list><tree><country name="États-Unis"><region name="Oklahoma"><name sortKey="Pan, Yanfang" sort="Pan, Yanfang" uniqKey="Pan Y" first="Yanfang" last="Pan">Yanfang Pan</name></region><name sortKey="Cai, Xiaofeng" sort="Cai, Xiaofeng" uniqKey="Cai X" first="Xiaofeng" last="Cai">Xiaofeng Cai</name><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><name sortKey="Herzog, Brett" sort="Herzog, Brett" uniqKey="Herzog B" first="Brett" last="Herzog">Brett Herzog</name><name sortKey="Herzog, Brett" sort="Herzog, Brett" uniqKey="Herzog B" first="Brett" last="Herzog">Brett Herzog</name><name sortKey="Mcdaniel, J Michael" sort="Mcdaniel, J Michael" uniqKey="Mcdaniel J" first="J. Michael" last="Mcdaniel">J. Michael Mcdaniel</name><name sortKey="Mcever, Rodger P" sort="Mcever, Rodger P" uniqKey="Mcever R" first="Rodger P." last="Mcever">Rodger P. Mcever</name><name sortKey="Mcever, Rodger P" sort="Mcever, Rodger P" uniqKey="Mcever R" first="Rodger P." last="Mcever">Rodger P. Mcever</name><name sortKey="Mehta D Ouza, Padmaja" sort="Mehta D Ouza, Padmaja" uniqKey="Mehta D Ouza P" first="Padmaja" last="Mehta-D Ouza">Padmaja Mehta-D Ouza</name><name sortKey="Pan, Yanfang" sort="Pan, Yanfang" uniqKey="Pan Y" first="Yanfang" last="Pan">Yanfang Pan</name><name sortKey="West, Christopher" sort="West, Christopher" uniqKey="West C" first="Christopher" last="West">Christopher West</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><name sortKey="Yago, Tadayuki" sort="Yago, Tadayuki" uniqKey="Yago T" first="Tadayuki" last="Yago">Tadayuki Yago</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Pan, Yanfang" sort="Pan, Yanfang" uniqKey="Pan Y" first="Yanfang" last="Pan">Yanfang Pan</name></noRegion><name sortKey="Dai, Kesheng" sort="Dai, Kesheng" uniqKey="Dai K" first="Kesheng" last="Dai">Kesheng Dai</name><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><name sortKey="Ruan, Changgeng" sort="Ruan, Changgeng" uniqKey="Ruan C" first="Changgeng" last="Ruan">Changgeng Ruan</name><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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