An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma
Identifieur interne : 001518 ( Pmc/Checkpoint ); précédent : 001517; suivant : 001519An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma
Auteurs : Ömer Bay R [Turquie] ; Demet Y Lmazer [Turquie] ; Reyhan Ersoy [Turquie] ; Yasemin Akca [Turquie] ; Güleser Saylam [Turquie] ; Ünsal Han [Turquie] ; Ali Özdek [Turquie] ; Bekir Çak R [Turquie] ; Mehmet Hakan Korkmaz [Turquie]Source :
- International Journal of Surgery Case Reports [ 2210-2612 ] ; 2015.
Abstract
Thyroid angiosarcoma is a quite rare and aggressive malignancy with poor prognosis. A patient is presented who died postoperatively due to recurrent hematomas. Extracapsular invasion and distant metastasis are strong negative prognostic factors. Treatment is difficult due to local aggression, destruction and high recurrence. In differential diagnosis for anaplastic carcinoma, angiosarcoma should be kept in mind.
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DOI: 10.1016/j.ijscr.2015.12.028
PubMed: 26741273
PubMed Central: 4756211
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma</title><author><name sortKey="Bay R, Omer" sort="Bay R, Omer" uniqKey="Bay R O" first="Ömer" last="Bay R">Ömer Bay R</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Y Lmazer, Demet" sort="Y Lmazer, Demet" uniqKey="Y Lmazer D" first="Demet" last="Y Lmazer">Demet Y Lmazer</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ersoy, Reyhan" sort="Ersoy, Reyhan" uniqKey="Ersoy R" first="Reyhan" last="Ersoy">Reyhan Ersoy</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Atatürk Research and Training Hospital, Department of Endocrinology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Atatürk Research and Training Hospital, Department of Endocrinology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Akca, Yasemin" sort="Akca, Yasemin" uniqKey="Akca Y" first="Yasemin" last="Akca">Yasemin Akca</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Saylam, Guleser" sort="Saylam, Guleser" uniqKey="Saylam G" first="Güleser" last="Saylam">Güleser Saylam</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Han, Unsal" sort="Han, Unsal" uniqKey="Han U" first="Ünsal" last="Han">Ünsal Han</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ozdek, Ali" sort="Ozdek, Ali" uniqKey="Ozdek A" first="Ali" last="Özdek">Ali Özdek</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Cak R, Bekir" sort="Cak R, Bekir" uniqKey="Cak R B" first="Bekir" last="Çak R">Bekir Çak R</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Atatürk Research and Training Hospital, Department of Endocrinology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Atatürk Research and Training Hospital, Department of Endocrinology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Korkmaz, Mehmet Hakan" sort="Korkmaz, Mehmet Hakan" uniqKey="Korkmaz M" first="Mehmet Hakan" last="Korkmaz">Mehmet Hakan Korkmaz</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Yıldırım Beyazıt University, Medical Faculty, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Yıldırım Beyazıt University, Medical Faculty, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26741273</idno><idno type="pmc">4756211</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756211</idno><idno type="RBID">PMC:4756211</idno><idno type="doi">10.1016/j.ijscr.2015.12.028</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002272</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002272</idno><idno type="wicri:Area/Pmc/Curation">002271</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002271</idno><idno type="wicri:Area/Pmc/Checkpoint">001518</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001518</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma</title><author><name sortKey="Bay R, Omer" sort="Bay R, Omer" uniqKey="Bay R O" first="Ömer" last="Bay R">Ömer Bay R</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Y Lmazer, Demet" sort="Y Lmazer, Demet" uniqKey="Y Lmazer D" first="Demet" last="Y Lmazer">Demet Y Lmazer</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ersoy, Reyhan" sort="Ersoy, Reyhan" uniqKey="Ersoy R" first="Reyhan" last="Ersoy">Reyhan Ersoy</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Atatürk Research and Training Hospital, Department of Endocrinology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Atatürk Research and Training Hospital, Department of Endocrinology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Akca, Yasemin" sort="Akca, Yasemin" uniqKey="Akca Y" first="Yasemin" last="Akca">Yasemin Akca</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Saylam, Guleser" sort="Saylam, Guleser" uniqKey="Saylam G" first="Güleser" last="Saylam">Güleser Saylam</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Han, Unsal" sort="Han, Unsal" uniqKey="Han U" first="Ünsal" last="Han">Ünsal Han</name><affiliation wicri:level="1"><nlm:aff id="aff0010">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Ozdek, Ali" sort="Ozdek, Ali" uniqKey="Ozdek A" first="Ali" last="Özdek">Ali Özdek</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Cak R, Bekir" sort="Cak R, Bekir" uniqKey="Cak R B" first="Bekir" last="Çak R">Bekir Çak R</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Atatürk Research and Training Hospital, Department of Endocrinology, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Atatürk Research and Training Hospital, Department of Endocrinology, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Korkmaz, Mehmet Hakan" sort="Korkmaz, Mehmet Hakan" uniqKey="Korkmaz M" first="Mehmet Hakan" last="Korkmaz">Mehmet Hakan Korkmaz</name><affiliation wicri:level="1"><nlm:aff id="aff0020">Yıldırım Beyazıt University, Medical Faculty, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Yıldırım Beyazıt University, Medical Faculty, Department of Otolaryngology and Head & Neck Surgery, Ankara</wicri:regionArea><wicri:noRegion>Ankara</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Surgery Case Reports</title><idno type="eISSN">2210-2612</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple"><list-item id="lsti0005"><label>•</label><p>Thyroid angiosarcoma is a quite rare and aggressive malignancy with poor prognosis.</p></list-item><list-item id="lsti0010"><label>•</label><p>A patient is presented who died postoperatively due to recurrent hematomas.</p></list-item><list-item id="lsti0015"><label>•</label><p>Extracapsular invasion and distant metastasis are strong negative prognostic factors.</p></list-item><list-item id="lsti0020"><label>•</label><p>Treatment is difficult due to local aggression, destruction and high recurrence.</p></list-item><list-item id="lsti0025"><label>•</label><p>In differential diagnosis for anaplastic carcinoma, angiosarcoma should be kept in mind.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ain, K B" uniqKey="Ain K">K.B. Ain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petronella, P" uniqKey="Petronella P">P. Petronella</name></author><author><name sortKey="Scorzelli, M" uniqKey="Scorzelli M">M. Scorzelli</name></author><author><name sortKey="Luise, R" uniqKey="Luise R">R. Luise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gouveia, P" uniqKey="Gouveia P">P. Gouveia</name></author><author><name sortKey="Silva, C" uniqKey="Silva C">C. Silva</name></author><author><name sortKey="Magalhaes, F" uniqKey="Magalhaes F">F. Magalhães</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalitova, P" uniqKey="Kalitova P">P. Kalitova</name></author><author><name sortKey="Plzak, J" uniqKey="Plzak J">J. Plzak</name></author><author><name sortKey="Kodet, R" uniqKey="Kodet R">R. Kodet</name></author><author><name sortKey="Astl, J" uniqKey="Astl J">J. 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Arturi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fulciniti, F" uniqKey="Fulciniti F">F. Fulciniti</name></author><author><name sortKey="Di Mattia, D" uniqKey="Di Mattia D">D. Di Mattia</name></author><author><name sortKey="Patrizia, B" uniqKey="Patrizia B">B. Patrizia</name></author><author><name sortKey="Mastro, A A" uniqKey="Mastro A">A.A. Mastro</name></author><author><name sortKey="De Chiara, A" uniqKey="De Chiara A">A. De Chiara</name></author><author><name sortKey="Botti, G" uniqKey="Botti G">G. Botti</name></author><author><name sortKey="Petrillo, A" uniqKey="Petrillo A">A. Petrillo</name></author><author><name sortKey="Apize, G" uniqKey="Apize G">G. Apize</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Surg Case Rep</journal-id><journal-id journal-id-type="iso-abbrev">Int J Surg Case Rep</journal-id><journal-title-group><journal-title>International Journal of Surgery Case Reports</journal-title></journal-title-group><issn pub-type="epub">2210-2612</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26741273</article-id><article-id pub-id-type="pmc">4756211</article-id><article-id pub-id-type="publisher-id">S2210-2612(15)00543-X</article-id><article-id pub-id-type="doi">10.1016/j.ijscr.2015.12.028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bayır</surname><given-names>Ömer</given-names></name><email>bayiromer@hotmail.com</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author"><name><surname>Yılmazer</surname><given-names>Demet</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Ersoy</surname><given-names>Reyhan</given-names></name><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Akca</surname><given-names>Yasemin</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Saylam</surname><given-names>Güleser</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Ünsal</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Özdek</surname><given-names>Ali</given-names></name><xref rid="aff0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Çakır</surname><given-names>Bekir</given-names></name><xref rid="aff0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Korkmaz</surname><given-names>Mehmet Hakan</given-names></name><xref rid="aff0020" ref-type="aff">d</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</aff><aff id="aff0010"><label>b</label>Ministry of Health, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Pathology, Ankara, Turkey</aff><aff id="aff0015"><label>c</label>Atatürk Research and Training Hospital, Department of Endocrinology, Ankara, Turkey</aff><aff id="aff0020"><label>d</label>Yıldırım Beyazıt University, Medical Faculty, Department of Otolaryngology and Head & Neck Surgery, Ankara, Turkey</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: İrfan Baştuğ Cd. S.B. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Kulak Burun Boğaz Kliniği, Dışkapı, Altındağ, Ankara,Turkey. Fax: +90 312 318 66 90. <email>bayiromer@hotmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>23</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2015</year></pub-date><volume>19</volume><fpage>92</fpage><lpage>96</lpage><history><date date-type="received"><day>27</day><month>9</month><year>2015</year></date><date date-type="rev-recd"><day>16</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>17</day><month>12</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Authors</copyright-statement><copyright-year>2015</copyright-year><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</license-p></license></permissions><abstract abstract-type="author-highlights"><title>Highlights</title><p><list list-type="simple"><list-item id="lsti0005"><label>•</label><p>Thyroid angiosarcoma is a quite rare and aggressive malignancy with poor prognosis.</p></list-item><list-item id="lsti0010"><label>•</label><p>A patient is presented who died postoperatively due to recurrent hematomas.</p></list-item><list-item id="lsti0015"><label>•</label><p>Extracapsular invasion and distant metastasis are strong negative prognostic factors.</p></list-item><list-item id="lsti0020"><label>•</label><p>Treatment is difficult due to local aggression, destruction and high recurrence.</p></list-item><list-item id="lsti0025"><label>•</label><p>In differential diagnosis for anaplastic carcinoma, angiosarcoma should be kept in mind.</p></list-item></list></p></abstract><abstract><sec><title>Introduction</title><p>Thyroid angiosarcoma is a rather rare malignancy featuring a poor prognosis, and which may interfere with other aggressive thyroid tumors; it is usually seen in the Alpine region.</p></sec><sec><title>Case presentation</title><p>A 74-year-old male was referred to our center with complaints of progressive neck swelling and dyspnea. He had multiple nodules featuring cystic degeneration and calcifications in the thyroid gland, together with multiple lymphadenopathies of the neck region. Fine-needle aspiration cytology (FNAC) confirmed the presence of anaplastic carcinoma. A total thyroidectomy was performed. During the postoperative period, multiple drainage were performed for recurrent hematomas, but hematoma development could not be prevented. On postoperative day 7, the patient died due to multiple-system failure. Histopathological investigation of the thyroidectomy specimen indicated that the lesion was an angiosarcoma.</p></sec><sec><title>Discussion</title><p>The cytological diagnosis of thyroid angiosarcoma is quite difficult. Extracapsular invasion and distant organ metastasis during surgery are known as strong and negative prognostic factors for thyroid angiosarcoma. Treatment is quite difficult, since this tumor is locally aggressive, destructive, and features a high recurrence rate. In this case, since extracapsular invasion, as well as lymph node and lung metastasis were present at the time of surgery; the expected survival time was quite short.</p></sec><sec><title>Conclusion</title><p>This case shows that during differential diagnosis, patients initially diagnosed with anaplastic carcinoma via FNAC may actually present with angiosarcoma. It may be helpful to review the treatment modalities for this cancer type, which has a rather poor prognosis and features severe bleeding, as well as local and distant metastasis.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Thyroid gland</kwd><kwd>Primary angiosarcoma</kwd><kwd>Head and neck malignancy</kwd><kwd>Surgery</kwd><kwd>Hematoma</kwd></kwd-group></article-meta></front><floats-group><fig id="fig0005"><label>Fig. 1</label><caption><p>Preoperative neck CT images of the patient. The trachea is seen to be deviated to the left. Red arrow: thyroid gland featuring calcifications and extending into the retrosternal area, which cannot be clearly differentiated from the surrounding tissues. Yellow arrow: lymphadenopathies.</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig0010"><label>Fig. 2</label><caption><p>The image of the total thyroidectomy specimen of the patient.</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="fig0015"><label>Fig. 3</label><caption><p>The venography image of the patient performed after the development of the third hematoma. The right IJV is observed to be obliterated in inferior parts (r: right; white arrow: the obliterated area of the IJV).</p></caption><graphic xlink:href="gr3"></graphic></fig><fig id="fig0020"><label>Fig. 4</label><caption><p>Histopathological and immunohistochemical images of the patient: (a) vascular tumoral structures between thyroid follicles (H&E c40). (b) Vascular tumoral structures in the muscle tissues around the thyroid gland (H&E ×40). (c) CD31 positivity (×40). (d) CD34 positivity (×40).</p></caption><graphic xlink:href="gr4"></graphic></fig><fig id="fig0025"><label>Fig. 5</label><caption><p>Immunohistochemical images of the patient. (a) Vimentin positivity (×40). (b) Ki67 positivity (×40). (c) Thyroglobulin negativity (×40). (d) TTF-1 negativity (×40).</p></caption><graphic xlink:href="gr5"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Bay R, Omer" sort="Bay R, Omer" uniqKey="Bay R O" first="Ömer" last="Bay R">Ömer Bay R</name></noRegion><name sortKey="Akca, Yasemin" sort="Akca, Yasemin" uniqKey="Akca Y" first="Yasemin" last="Akca">Yasemin Akca</name><name sortKey="Cak R, Bekir" sort="Cak R, Bekir" uniqKey="Cak R B" first="Bekir" last="Çak R">Bekir Çak R</name><name sortKey="Ersoy, Reyhan" sort="Ersoy, Reyhan" uniqKey="Ersoy R" first="Reyhan" last="Ersoy">Reyhan Ersoy</name><name sortKey="Han, Unsal" sort="Han, Unsal" uniqKey="Han U" first="Ünsal" last="Han">Ünsal Han</name><name sortKey="Korkmaz, Mehmet Hakan" sort="Korkmaz, Mehmet Hakan" uniqKey="Korkmaz M" first="Mehmet Hakan" last="Korkmaz">Mehmet Hakan Korkmaz</name><name sortKey="Ozdek, Ali" sort="Ozdek, Ali" uniqKey="Ozdek A" first="Ali" last="Özdek">Ali Özdek</name><name sortKey="Saylam, Guleser" sort="Saylam, Guleser" uniqKey="Saylam G" first="Güleser" last="Saylam">Güleser Saylam</name><name sortKey="Y Lmazer, Demet" sort="Y Lmazer, Demet" uniqKey="Y Lmazer D" first="Demet" last="Y Lmazer">Demet Y Lmazer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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