Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood
Identifieur interne : 001339 ( Pmc/Checkpoint ); précédent : 001338; suivant : 001340Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood
Auteurs : Tamara Svobodova [République tchèque] ; Ester Mejstrikova [République tchèque] ; Ulrich Salzer [Allemagne] ; Martina Sukova [République tchèque] ; Petr Hubacek [République tchèque] ; Radoslav Matej [République tchèque] ; Martina Vasakova [République tchèque] ; Ludmila Hornofova [République tchèque] ; Marcela Dvorakova [République tchèque] ; Eva Fronkova [République tchèque] ; Felix Votava [République tchèque] ; Tomas Freiberger [République tchèque] ; Petr Pohunek [République tchèque] ; Jan Stary [République tchèque] ; Ales Janda [Allemagne]Source :
- BMC Pulmonary Medicine [ 1471-2466 ] ; 2015.
Abstract
GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. Patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease.
We present a case of a 17-year-old previously healthy Caucasian male who was admitted to the hospital with fever, malaise, headache, cough and dyspnea. A chest X-ray revealed bilateral interstitial infiltrates and pneumonia was diagnosed. Despite prompt clinical improvement under antibiotic therapy, interstitial changes remained stable. A high resolution computer tomography showed severe diffuse parenchymal lung disease, while the patient’s pulmonary function tests were normal and he was asymptomatic. Lung tissue biopsy revealed chronic reparative and resorptive reaction with organizing vasculitis. At the time of the initial presentation to the hospital, serological signs of acute infection with Epstein-Barr virus (EBV) were present; EBV viremia with atypical serological response persisted during two-year follow up. No other infectious agents were found. Marked monocytopenia combined with B-cell lymphopenia led to a suspicion of GATA-2 deficiency. Diagnosis was confirmed by detection of the previously published heterozygous mutation in
We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic cell- and B-lymphopenia, irrespective of severity of the clinical phenotype. Genetic counseling and screening for
Url:
DOI: 10.1186/s12890-015-0006-2
PubMed: 25879889
PubMed Central: 4340788
Affiliations:
- Allemagne, République tchèque
- Bade-Wurtemberg, Bohême centrale, District de Fribourg-en-Brisgau, Moravie
- Brno, Fribourg-en-Brisgau, Prague
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PMC:4340788Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood</title>
<author><name sortKey="Svobodova, Tamara" sort="Svobodova, Tamara" uniqKey="Svobodova T" first="Tamara" last="Svobodova">Tamara Svobodova</name>
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<author><name sortKey="Mejstrikova, Ester" sort="Mejstrikova, Ester" uniqKey="Mejstrikova E" first="Ester" last="Mejstrikova">Ester Mejstrikova</name>
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<wicri:regionArea>Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
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<author><name sortKey="Salzer, Ulrich" sort="Salzer, Ulrich" uniqKey="Salzer U" first="Ulrich" last="Salzer">Ulrich Salzer</name>
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<author><name sortKey="Sukova, Martina" sort="Sukova, Martina" uniqKey="Sukova M" first="Martina" last="Sukova">Martina Sukova</name>
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<wicri:regionArea>Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
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<author><name sortKey="Matej, Radoslav" sort="Matej, Radoslav" uniqKey="Matej R" first="Radoslav" last="Matej">Radoslav Matej</name>
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<author><name sortKey="Vasakova, Martina" sort="Vasakova, Martina" uniqKey="Vasakova M" first="Martina" last="Vasakova">Martina Vasakova</name>
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<wicri:regionArea>Department of Respiratory Medicine, Thomayer’s University Hospital, Prague</wicri:regionArea>
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<author><name sortKey="Hornofova, Ludmila" sort="Hornofova, Ludmila" uniqKey="Hornofova L" first="Ludmila" last="Hornofova">Ludmila Hornofova</name>
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<wicri:regionArea>Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
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<author><name sortKey="Dvorakova, Marcela" sort="Dvorakova, Marcela" uniqKey="Dvorakova M" first="Marcela" last="Dvorakova">Marcela Dvorakova</name>
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<wicri:regionArea>Department of Radiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
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<author><name sortKey="Fronkova, Eva" sort="Fronkova, Eva" uniqKey="Fronkova E" first="Eva" last="Fronkova">Eva Fronkova</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
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<author><name sortKey="Votava, Felix" sort="Votava, Felix" uniqKey="Votava F" first="Felix" last="Votava">Felix Votava</name>
<affiliation wicri:level="3"><nlm:aff id="Aff9">Department of Pediatrics, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Pediatrics, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovske Vinohrady, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
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<author><name sortKey="Freiberger, Tomas" sort="Freiberger, Tomas" uniqKey="Freiberger T" first="Tomas" last="Freiberger">Tomas Freiberger</name>
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<placeName><settlement type="city">Brno</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Clinical Immunology and Allergology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Clinical Immunology and Allergology, Medical Faculty, Masaryk University Brno, Brno</wicri:regionArea>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pohunek, Petr" sort="Pohunek, Petr" uniqKey="Pohunek P" first="Petr" last="Pohunek">Petr Pohunek</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague</wicri:regionArea>
<placeName><settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Janda, Ales" sort="Janda, Ales" uniqKey="Janda A" first="Ales" last="Janda">Ales Janda</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg, Freiburg im Breisgau, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg, Freiburg im Breisgau</wicri:regionArea>
<wicri:noRegion>Freiburg im Breisgau</wicri:noRegion>
<wicri:noRegion>Freiburg im Breisgau</wicri:noRegion>
<wicri:noRegion>Freiburg im Breisgau</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff12">Department of Pediatric Infectious Diseases and Rheumatology, Center of Pediatrics and Adolescent Medicine, University Medical Center and University of Freiburg, Mathildenstrasse 1, 79106 Freiburg im Breisgau, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatric Infectious Diseases and Rheumatology, Center of Pediatrics and Adolescent Medicine, University Medical Center and University of Freiburg, Mathildenstrasse 1, 79106 Freiburg im Breisgau</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Pulmonary Medicine</title>
<idno type="eISSN">1471-2466</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. Patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease.</p>
</sec>
<sec><title>Case presentation</title>
<p>We present a case of a 17-year-old previously healthy Caucasian male who was admitted to the hospital with fever, malaise, headache, cough and dyspnea. A chest X-ray revealed bilateral interstitial infiltrates and pneumonia was diagnosed. Despite prompt clinical improvement under antibiotic therapy, interstitial changes remained stable. A high resolution computer tomography showed severe diffuse parenchymal lung disease, while the patient’s pulmonary function tests were normal and he was asymptomatic. Lung tissue biopsy revealed chronic reparative and resorptive reaction with organizing vasculitis. At the time of the initial presentation to the hospital, serological signs of acute infection with Epstein-Barr virus (EBV) were present; EBV viremia with atypical serological response persisted during two-year follow up. No other infectious agents were found. Marked monocytopenia combined with B-cell lymphopenia led to a suspicion of GATA-2 deficiency. Diagnosis was confirmed by detection of the previously published heterozygous mutation in <italic>GATA2</italic>
(c.1081 C > T, p.R361C). The patient’s brother and father were both carriers of the same genetic defect. The brother had no clinically relevant ailments despite leukocyte changes similar to the index patient. The father suffered from spondylarthritis, and apart from B-cell lymphopenia, no other changes within the leukocyte pool were seen.</p>
</sec>
<sec><title>Conclusion</title>
<p>We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic cell- and B-lymphopenia, irrespective of severity of the clinical phenotype. Genetic counseling and screening for <italic>GATA2</italic>
mutations within the patient’s family should be provided as the phenotype is highly variable and carriers without apparent immunodeficiency are still in danger of developing myeloid malignancy. A prompt recognition of this rare condition helps to direct clinical treatment strategies and follow-up procedures.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Pulm Med</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Pulm Med</journal-id>
<journal-title-group><journal-title>BMC Pulmonary Medicine</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-2466</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25879889</article-id>
<article-id pub-id-type="pmc">4340788</article-id>
<article-id pub-id-type="publisher-id">6</article-id>
<article-id pub-id-type="doi">10.1186/s12890-015-0006-2</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Svobodova</surname>
<given-names>Tamara</given-names>
</name>
<address><email>tamara.svobodova@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mejstrikova</surname>
<given-names>Ester</given-names>
</name>
<address><email>ester.mejstrikova@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Salzer</surname>
<given-names>Ulrich</given-names>
</name>
<address><email>ulrich.salzer@uniklinik-freiburg.de</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sukova</surname>
<given-names>Martina</given-names>
</name>
<address><email>martina.sukova@fnmotol.cz</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hubacek</surname>
<given-names>Petr</given-names>
</name>
<address><email>petr.hubacek@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Matej</surname>
<given-names>Radoslav</given-names>
</name>
<address><email>radoslav.matej@ftn.cz</email>
</address>
<xref ref-type="aff" rid="Aff5"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vasakova</surname>
<given-names>Martina</given-names>
</name>
<address><email>martina.vasakova@ftn.cz</email>
</address>
<xref ref-type="aff" rid="Aff6"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hornofova</surname>
<given-names>Ludmila</given-names>
</name>
<address><email>hornofova@centrum.cz</email>
</address>
<xref ref-type="aff" rid="Aff7"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dvorakova</surname>
<given-names>Marcela</given-names>
</name>
<address><email>marcela.dvorakova@fnmotol.cz</email>
</address>
<xref ref-type="aff" rid="Aff8"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fronkova</surname>
<given-names>Eva</given-names>
</name>
<address><email>eva.fronkova@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Votava</surname>
<given-names>Felix</given-names>
</name>
<address><email>felix.votava@fnkv.cz</email>
</address>
<xref ref-type="aff" rid="Aff9"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Freiberger</surname>
<given-names>Tomas</given-names>
</name>
<address><email>tomas.freiberger@cktch.cz</email>
</address>
<xref ref-type="aff" rid="Aff10"></xref>
<xref ref-type="aff" rid="Aff11"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pohunek</surname>
<given-names>Petr</given-names>
</name>
<address><email>petr.pohunek@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stary</surname>
<given-names>Jan</given-names>
</name>
<address><email>jan.stary@lfmotol.cuni.cz</email>
</address>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Janda</surname>
<given-names>Ales</given-names>
</name>
<address><email>ales.janda@uniklinik-freiburg.de</email>
</address>
<xref ref-type="aff" rid="Aff3"></xref>
<xref ref-type="aff" rid="Aff12"></xref>
</contrib>
<aff id="Aff1"><label></label>
Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="Aff2"><label></label>
Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="Aff3"><label></label>
Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg, Freiburg im Breisgau, Germany</aff>
<aff id="Aff4"><label></label>
Department of Medical Microbiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="Aff5"><label></label>
Department of Pathology and Molecular Medicine, Thomayer’s University Hospital, Prague, Czech Republic</aff>
<aff id="Aff6"><label></label>
Department of Respiratory Medicine, Thomayer’s University Hospital, Prague, Czech Republic</aff>
<aff id="Aff7"><label></label>
Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="Aff8"><label></label>
Department of Radiology, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic</aff>
<aff id="Aff9"><label></label>
Department of Pediatrics, 3rd Faculty of Medicine, Charles University in Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic</aff>
<aff id="Aff10"><label></label>
Molecular Genetics Lab, Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic</aff>
<aff id="Aff11"><label></label>
Department of Clinical Immunology and Allergology, Medical Faculty, Masaryk University Brno, Brno, Czech Republic</aff>
<aff id="Aff12"><label></label>
Department of Pediatric Infectious Diseases and Rheumatology, Center of Pediatrics and Adolescent Medicine, University Medical Center and University of Freiburg, Mathildenstrasse 1, 79106 Freiburg im Breisgau, Germany</aff>
</contrib-group>
<pub-date pub-type="epub"><day>10</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>2</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>15</volume>
<elocation-id>8</elocation-id>
<history><date date-type="received"><day>6</day>
<month>6</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>27</day>
<month>1</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© Svobodova et al.; licensee BioMed Central. 2015</copyright-statement>
<license license-type="open-access"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. Patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease.</p>
</sec>
<sec><title>Case presentation</title>
<p>We present a case of a 17-year-old previously healthy Caucasian male who was admitted to the hospital with fever, malaise, headache, cough and dyspnea. A chest X-ray revealed bilateral interstitial infiltrates and pneumonia was diagnosed. Despite prompt clinical improvement under antibiotic therapy, interstitial changes remained stable. A high resolution computer tomography showed severe diffuse parenchymal lung disease, while the patient’s pulmonary function tests were normal and he was asymptomatic. Lung tissue biopsy revealed chronic reparative and resorptive reaction with organizing vasculitis. At the time of the initial presentation to the hospital, serological signs of acute infection with Epstein-Barr virus (EBV) were present; EBV viremia with atypical serological response persisted during two-year follow up. No other infectious agents were found. Marked monocytopenia combined with B-cell lymphopenia led to a suspicion of GATA-2 deficiency. Diagnosis was confirmed by detection of the previously published heterozygous mutation in <italic>GATA2</italic>
(c.1081 C > T, p.R361C). The patient’s brother and father were both carriers of the same genetic defect. The brother had no clinically relevant ailments despite leukocyte changes similar to the index patient. The father suffered from spondylarthritis, and apart from B-cell lymphopenia, no other changes within the leukocyte pool were seen.</p>
</sec>
<sec><title>Conclusion</title>
<p>We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic cell- and B-lymphopenia, irrespective of severity of the clinical phenotype. Genetic counseling and screening for <italic>GATA2</italic>
mutations within the patient’s family should be provided as the phenotype is highly variable and carriers without apparent immunodeficiency are still in danger of developing myeloid malignancy. A prompt recognition of this rare condition helps to direct clinical treatment strategies and follow-up procedures.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Primary immunodeficiency</kwd>
<kwd>GATA-2 deficiency</kwd>
<kwd>Diffuse parenchymal lung disease</kwd>
<kwd>EBV Viremia</kwd>
<kwd>Childhood</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>République tchèque</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bohême centrale</li>
<li>District de Fribourg-en-Brisgau</li>
<li>Moravie</li>
</region>
<settlement><li>Brno</li>
<li>Fribourg-en-Brisgau</li>
<li>Prague</li>
</settlement>
</list>
<tree><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Svobodova, Tamara" sort="Svobodova, Tamara" uniqKey="Svobodova T" first="Tamara" last="Svobodova">Tamara Svobodova</name>
</region>
<name sortKey="Dvorakova, Marcela" sort="Dvorakova, Marcela" uniqKey="Dvorakova M" first="Marcela" last="Dvorakova">Marcela Dvorakova</name>
<name sortKey="Freiberger, Tomas" sort="Freiberger, Tomas" uniqKey="Freiberger T" first="Tomas" last="Freiberger">Tomas Freiberger</name>
<name sortKey="Freiberger, Tomas" sort="Freiberger, Tomas" uniqKey="Freiberger T" first="Tomas" last="Freiberger">Tomas Freiberger</name>
<name sortKey="Fronkova, Eva" sort="Fronkova, Eva" uniqKey="Fronkova E" first="Eva" last="Fronkova">Eva Fronkova</name>
<name sortKey="Hornofova, Ludmila" sort="Hornofova, Ludmila" uniqKey="Hornofova L" first="Ludmila" last="Hornofova">Ludmila Hornofova</name>
<name sortKey="Hubacek, Petr" sort="Hubacek, Petr" uniqKey="Hubacek P" first="Petr" last="Hubacek">Petr Hubacek</name>
<name sortKey="Hubacek, Petr" sort="Hubacek, Petr" uniqKey="Hubacek P" first="Petr" last="Hubacek">Petr Hubacek</name>
<name sortKey="Matej, Radoslav" sort="Matej, Radoslav" uniqKey="Matej R" first="Radoslav" last="Matej">Radoslav Matej</name>
<name sortKey="Mejstrikova, Ester" sort="Mejstrikova, Ester" uniqKey="Mejstrikova E" first="Ester" last="Mejstrikova">Ester Mejstrikova</name>
<name sortKey="Pohunek, Petr" sort="Pohunek, Petr" uniqKey="Pohunek P" first="Petr" last="Pohunek">Petr Pohunek</name>
<name sortKey="Stary, Jan" sort="Stary, Jan" uniqKey="Stary J" first="Jan" last="Stary">Jan Stary</name>
<name sortKey="Sukova, Martina" sort="Sukova, Martina" uniqKey="Sukova M" first="Martina" last="Sukova">Martina Sukova</name>
<name sortKey="Vasakova, Martina" sort="Vasakova, Martina" uniqKey="Vasakova M" first="Martina" last="Vasakova">Martina Vasakova</name>
<name sortKey="Votava, Felix" sort="Votava, Felix" uniqKey="Votava F" first="Felix" last="Votava">Felix Votava</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Salzer, Ulrich" sort="Salzer, Ulrich" uniqKey="Salzer U" first="Ulrich" last="Salzer">Ulrich Salzer</name>
</noRegion>
<name sortKey="Janda, Ales" sort="Janda, Ales" uniqKey="Janda A" first="Ales" last="Janda">Ales Janda</name>
<name sortKey="Janda, Ales" sort="Janda, Ales" uniqKey="Janda A" first="Ales" last="Janda">Ales Janda</name>
</country>
</tree>
</affiliations>
</record>
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