Intimal sarcoma of the abdominal aorta and common iliac arteries presenting as epithelioid angiosarcoma of the skin: a case report
Identifieur interne : 001161 ( Pmc/Checkpoint ); précédent : 001160; suivant : 001162Intimal sarcoma of the abdominal aorta and common iliac arteries presenting as epithelioid angiosarcoma of the skin: a case report
Auteurs : Shogo Tajima [Japon] ; Katsuyuki Hoshina [Japon] ; Tets Oushik [Japon] ; Kunihiro Shigematsu [Japon] ; Masashi Fukayama [Japon]Source :
- International Journal of Clinical and Experimental Pathology [ 1936-2625 ] ; 2015.
Abstract
Intimal sarcoma (IS) is the most common type of sarcoma of the aorta. IS tumor emboli can involve various organs, including the skin. However, a limited number of IS cases with an initial presentation of skin metastasis has been reported. Cutaneous metastasis as a form of epithelioid angiosarcoma (EAS) has not been well described. Herein, we present a 61-year-old Japanese man with an initial presentation of EAS of the skin, followed by multiple metastases to the skin as a form of EAS prior to detection of IS of the infrarenal aorta and common iliac arteries. In our case, the IS was CD31 and cytokeratin positive but did not express CD34 and factor VIII-related antigen. The EASs in our case exhibited diffuse CD31 expression, and focal factor VIII-related antigen and cytokeratin expression were observed throughout the tumor, including the neoplastic vascular structure; CD34 expression was not identifiable. IS metastasis to the skin has been documented as a form of angiosarcoma. However, IS metastasis has not been well described as a form of EAS. Our case could prove a morphological change from IS to EAS. Given the rarity of primary cutaneous EAS, it is recommended that primary sites other than the skin should be thoroughly investigated when EAS of the skin is encountered.
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PubMed: 26191309
PubMed Central: 4503180
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uniqKey="Hoshina K" first="Katsuyuki" last="Hoshina">Katsuyuki Hoshina</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Oushik, Tets" sort="Oushik, Tets" uniqKey="Oushik T" first="Tets" last="Oushik">Tets Oushik</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Pathology, Graduate School of Medicine, The University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Shigematsu, Kunihiro" sort="Shigematsu, Kunihiro" uniqKey="Shigematsu K" first="Kunihiro" last="Shigematsu">Kunihiro Shigematsu</name><affiliation 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IS tumor emboli can involve various organs, including the skin. However, a limited number of IS cases with an initial presentation of skin metastasis has been reported. Cutaneous metastasis as a form of epithelioid angiosarcoma (EAS) has not been well described. Herein, we present a 61-year-old Japanese man with an initial presentation of EAS of the skin, followed by multiple metastases to the skin as a form of EAS prior to detection of IS of the infrarenal aorta and common iliac arteries. In our case, the IS was CD31 and cytokeratin positive but did not express CD34 and factor VIII-related antigen. The EASs in our case exhibited diffuse CD31 expression, and focal factor VIII-related antigen and cytokeratin expression were observed throughout the tumor, including the neoplastic vascular structure; CD34 expression was not identifiable. IS metastasis to the skin has been documented as a form of angiosarcoma. However, IS metastasis has not been well described as a form of EAS. Our case could prove a morphological change from IS to EAS. Given the rarity of primary cutaneous EAS, it is recommended that primary sites other than the skin should be thoroughly investigated when EAS of the skin is encountered.</p></div></front></TEI><pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Int J Clin Exp Pathol</journal-id><journal-id journal-id-type="publisher-id">ijcep</journal-id><journal-title-group><journal-title>International Journal of Clinical and Experimental Pathology</journal-title></journal-title-group><issn pub-type="epub">1936-2625</issn><publisher><publisher-name>e-Century Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26191309</article-id><article-id pub-id-type="pmc">4503180</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Intimal sarcoma of the abdominal aorta and common iliac arteries presenting as epithelioid angiosarcoma of the skin: a case report</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tajima</surname><given-names>Shogo</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Hoshina</surname><given-names>Katsuyuki</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Oushik</surname><given-names>Tets</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shigematsu</surname><given-names>Kunihiro</given-names></name><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fukayama</surname><given-names>Masashi</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><aff id="au1"><label>1</label><institution>Department of Pathology, Graduate School of Medicine, The University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></aff><aff id="au2"><label>2</label><institution>Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo</institution><addr-line>Tokyo, Japan</addr-line></aff></contrib-group><author-notes><corresp><bold>Address correspondence to:</bold> Dr. Shogo Tajima, Department of Pathology, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Tel: +81-3-5841-3341; Fax: +81-3-3815-8379; E-mail: <email>stajima-tky@umin.ac.jp</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>01</day><month>5</month><year>2015</year></pub-date><volume>8</volume><issue>5</issue><fpage>5856</fpage><lpage>5862</lpage><history><date date-type="received"><day>01</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>IJCEP Copyright © 2015</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>Intimal sarcoma (IS) is the most common type of sarcoma of the aorta. IS tumor emboli can involve various organs, including the skin. However, a limited number of IS cases with an initial presentation of skin metastasis has been reported. Cutaneous metastasis as a form of epithelioid angiosarcoma (EAS) has not been well described. Herein, we present a 61-year-old Japanese man with an initial presentation of EAS of the skin, followed by multiple metastases to the skin as a form of EAS prior to detection of IS of the infrarenal aorta and common iliac arteries. In our case, the IS was CD31 and cytokeratin positive but did not express CD34 and factor VIII-related antigen. The EASs in our case exhibited diffuse CD31 expression, and focal factor VIII-related antigen and cytokeratin expression were observed throughout the tumor, including the neoplastic vascular structure; CD34 expression was not identifiable. IS metastasis to the skin has been documented as a form of angiosarcoma. However, IS metastasis has not been well described as a form of EAS. Our case could prove a morphological change from IS to EAS. Given the rarity of primary cutaneous EAS, it is recommended that primary sites other than the skin should be thoroughly investigated when EAS of the skin is encountered.</p></abstract><kwd-group><kwd>Intimal sarcoma</kwd><kwd>aorta</kwd><kwd>common iliac artery</kwd><kwd>metastasis</kwd><kwd>skin</kwd><kwd>epithelioid angiosarcoma</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Tajima, Shogo" sort="Tajima, Shogo" uniqKey="Tajima S" first="Shogo" last="Tajima">Shogo Tajima</name></noRegion><name sortKey="Fukayama, Masashi" sort="Fukayama, Masashi" uniqKey="Fukayama M" first="Masashi" last="Fukayama">Masashi Fukayama</name><name sortKey="Hoshina, Katsuyuki" sort="Hoshina, Katsuyuki" uniqKey="Hoshina K" first="Katsuyuki" last="Hoshina">Katsuyuki Hoshina</name><name sortKey="Oushik, Tets" sort="Oushik, Tets" uniqKey="Oushik T" first="Tets" last="Oushik">Tets Oushik</name><name sortKey="Shigematsu, Kunihiro" sort="Shigematsu, Kunihiro" uniqKey="Shigematsu K" first="Kunihiro" last="Shigematsu">Kunihiro Shigematsu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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