The lymph node microenvironment and its role in the progression of metastatic cancer
Identifieur interne : 000D82 ( Pmc/Checkpoint ); précédent : 000D81; suivant : 000D83The lymph node microenvironment and its role in the progression of metastatic cancer
Auteurs : Ethel R. Pereira ; Dennis Jones ; Keehoon Jung ; Timothy P. PaderaSource :
- Seminars in cell & developmental biology [ 1084-9521 ] ; 2015.
Abstract
Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.
Url:
DOI: 10.1016/j.semcdb.2015.01.008
PubMed: 25620792
PubMed Central: 4397158
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P2">Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.</p>
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<title-group><article-title>The lymph node microenvironment and its role in the progression of metastatic cancer</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Pereira</surname>
<given-names>Ethel R.</given-names>
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<contrib contrib-type="author"><name><surname>Jones</surname>
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<contrib contrib-type="author"><name><surname>Jung</surname>
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<contrib contrib-type="author"><name><surname>Padera</surname>
<given-names>Timothy P.</given-names>
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<aff id="A1">E.L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA</aff>
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<author-notes><corresp id="FN1">To whom correspondence should be addressed: Timothy P. Padera, PhD, Edwin L Steele Laboratory for Tumor Biology, 55 Fruit Street, Cox Building, Boston, MA 02114, <email>tpadera@steele.mgh.harvard.edu</email>
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<pub-date pub-type="pmc-release"><day>01</day>
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<volume>38</volume>
<fpage>98</fpage>
<lpage>105</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.semcdb.2015.01.008</pmc-comment>
<permissions><copyright-statement>© 2015 Published by Elsevier Ltd.</copyright-statement>
<copyright-year>2015</copyright-year>
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<abstract><p id="P2">Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.</p>
</abstract>
<kwd-group><kwd>Lymph node</kwd>
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