The non-canonical role of vascular endothelial growth factor-C axis in cancer progression
Identifieur interne : 000D79 ( Pmc/Checkpoint ); précédent : 000D78; suivant : 000D80The non-canonical role of vascular endothelial growth factor-C axis in cancer progression
Auteurs : Chu-An Wang [Taïwan] ; Shaw-Jenq Tsai [Taïwan]Source :
- Experimental Biology and Medicine [ 1535-3702 ] ; 2015.
Abstract
It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.
Url:
DOI: 10.1177/1535370215583802
PubMed: 25888649
PubMed Central: 4935218
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Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Biol Med (Maywood)</journal-id><journal-id journal-id-type="iso-abbrev">Exp. Biol. Med. (Maywood)</journal-id><journal-id journal-id-type="publisher-id">EBM</journal-id><journal-id journal-id-type="hwp">spebm</journal-id><journal-title-group><journal-title>Experimental Biology and Medicine</journal-title></journal-title-group><issn pub-type="ppub">1535-3702</issn><issn pub-type="epub">1535-3699</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage UK: London, England</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25888649</article-id><article-id pub-id-type="pmc">4935218</article-id><article-id pub-id-type="doi">10.1177/1535370215583802</article-id><article-id pub-id-type="publisher-id">10.1177_1535370215583802</article-id><article-categories><subj-group subj-group-type="heading"><subject>Minireviews</subject></subj-group></article-categories><title-group><article-title>The non-canonical role of vascular endothelial growth factor-C axis in cancer progression</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Chu-An</given-names></name><xref ref-type="aff" rid="aff1-1535370215583802">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Tsai</surname><given-names>Shaw-Jenq</given-names></name><xref ref-type="aff" rid="aff1-1535370215583802">1</xref><xref ref-type="aff" rid="aff2-1535370215583802">2</xref><xref ref-type="corresp" rid="corresp1-1535370215583802"></xref></contrib></contrib-group><aff id="aff1-1535370215583802"><label>1</label>Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan</aff><aff id="aff2-1535370215583802"><label>2</label>Department of Physiology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan</aff><author-notes><corresp id="corresp1-1535370215583802">Shaw-Jenq Tsai. Email: <email>seantsai@mail.ncku.edu.tw</email></corresp></author-notes><pub-date pub-type="epub-ppub"><month>6</month><year>2015</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><volume>240</volume><issue>6</issue><issue-title>Minireview Annual Issue</issue-title><fpage>718</fpage><lpage>724</lpage><permissions><copyright-statement>© 2015 by the Society for Experimental Biology and Medicine</copyright-statement><copyright-year>2015</copyright-year><copyright-holder content-type="society">The Society for Experimental Biology and Medicine</copyright-holder></permissions><abstract><p>It has been shown in many clinical studies that the level of vascular endothelial growth factor-C (VEGF-C) positively correlates with lymph node metastasis. Nevertheless, beyond the canonical role of VEGF-C in stimulating lymphangiogenesis and thus promoting lymph node/distant metastasis, emerging evidence indicates that expression of VEGF-C contributes to various aspects of carcinogenicity via autocrine regulation. The newly identified functions of VEGF-C include but are not limited to proliferation, migration, invasion, and chemo-resistance. Besides tumor cell autocrine regulation, VEGF-C can also modulate the immune system such that tumor cells more easily escape immune surveillance. Therefore, understanding the functional roles and regulatory mechanisms related to the VEGF-C axis may lead to alternative strategies for cancer treatment. This mini-review will focus on summarizing recent discoveries regarding the unconventional functions of VEGF-C in cancer progression.</p></abstract><kwd-group><kwd>Vascular endothelial growth factor-C</kwd><kwd>autocrine</kwd><kwd>cancer stem cells</kwd><kwd>drug resistance</kwd><kwd>lymphangiogenesis</kwd><kwd>immunomodulation</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Wang, Chu An" sort="Wang, Chu An" uniqKey="Wang C" first="Chu-An" last="Wang">Chu-An Wang</name></noRegion><name sortKey="Tsai, Shaw Jenq" sort="Tsai, Shaw Jenq" uniqKey="Tsai S" first="Shaw-Jenq" last="Tsai">Shaw-Jenq Tsai</name><name sortKey="Tsai, Shaw Jenq" sort="Tsai, Shaw Jenq" uniqKey="Tsai S" first="Shaw-Jenq" last="Tsai">Shaw-Jenq Tsai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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