The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo
Identifieur interne : 000D71 ( Pmc/Checkpoint ); précédent : 000D70; suivant : 000D72The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo
Auteurs : Marie Amitani [Japon] ; Haruka Amitani [Japon] ; Robert A. Sloan [Japon] ; Hajime Suzuki [Japon] ; Nanami Sameshima [Japon] ; Akihiro Asakawa [Japon] ; Yasuhito Nerome [Japon] ; Tetsuhiro Owaki [Japon] ; Akio Inui [Japon] ; Etsuo Hoshino [Japon]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2015.
Abstract
Complementary and alternative medicine (CAM) including Japanese Kampo is known to have anticancer potential. An increasing number of cancer survivors are using CAM for disease prevention, immune system enhancement, and symptom control. Although there have been abundant previous clinical reports regarding CAM, scientific investigations aimed at acquiring quantifiable results in clinical trials, as well as basic research regarding CAM, have only recently been undertaken. Recent studies suggest that CAM enhancement of immune function is related to cytokines. This review provides a translational aspect of CAM, particularly Hozai in Kampo from both scientific and clinical points of view for further development of CAM for cancer treatment.
Url:
DOI: 10.3389/fphar.2015.00150
PubMed: 26300773
PubMed Central: 4527580
Affiliations:
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Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Amitani, Haruka" sort="Amitani, Haruka" uniqKey="Amitani H" first="Haruka" last="Amitani">Haruka Amitani</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Sloan, Robert A" sort="Sloan, Robert A" uniqKey="Sloan R" first="Robert A." last="Sloan">Robert A. Sloan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Hajime" sort="Suzuki, Hajime" uniqKey="Suzuki H" first="Hajime" last="Suzuki">Hajime Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Sameshima, Nanami" sort="Sameshima, Nanami" uniqKey="Sameshima N" first="Nanami" last="Sameshima">Nanami Sameshima</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Asakawa, Akihiro" sort="Asakawa, Akihiro" uniqKey="Asakawa A" first="Akihiro" last="Asakawa">Akihiro Asakawa</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Nerome, Yasuhito" sort="Nerome, Yasuhito" uniqKey="Nerome Y" first="Yasuhito" last="Nerome">Yasuhito Nerome</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Owaki, Tetsuhiro" sort="Owaki, Tetsuhiro" uniqKey="Owaki T" first="Tetsuhiro" last="Owaki">Tetsuhiro Owaki</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Inui, Akio" sort="Inui, Akio" uniqKey="Inui A" first="Akio" last="Inui">Akio Inui</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Hoshino, Etsuo" sort="Hoshino, Etsuo" uniqKey="Hoshino E" first="Etsuo" last="Hoshino">Etsuo Hoshino</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Kampo Support, Cancer Institute Hospital</institution><country>Tokyo, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26300773</idno><idno type="pmc">4527580</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527580</idno><idno type="RBID">PMC:4527580</idno><idno type="doi">10.3389/fphar.2015.00150</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000517</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000517</idno><idno type="wicri:Area/Pmc/Curation">000517</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000517</idno><idno type="wicri:Area/Pmc/Checkpoint">000D71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo</title><author><name sortKey="Amitani, Marie" sort="Amitani, Marie" uniqKey="Amitani M" first="Marie" last="Amitani">Marie Amitani</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Amitani, Haruka" sort="Amitani, Haruka" uniqKey="Amitani H" first="Haruka" last="Amitani">Haruka Amitani</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Sloan, Robert A" sort="Sloan, Robert A" uniqKey="Sloan R" first="Robert A." last="Sloan">Robert A. Sloan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Suzuki, Hajime" sort="Suzuki, Hajime" uniqKey="Suzuki H" first="Hajime" last="Suzuki">Hajime Suzuki</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Sameshima, Nanami" sort="Sameshima, Nanami" uniqKey="Sameshima N" first="Nanami" last="Sameshima">Nanami Sameshima</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Asakawa, Akihiro" sort="Asakawa, Akihiro" uniqKey="Asakawa A" first="Akihiro" last="Asakawa">Akihiro Asakawa</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Nerome, Yasuhito" sort="Nerome, Yasuhito" uniqKey="Nerome Y" first="Yasuhito" last="Nerome">Yasuhito Nerome</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Owaki, Tetsuhiro" sort="Owaki, Tetsuhiro" uniqKey="Owaki T" first="Tetsuhiro" last="Owaki">Tetsuhiro Owaki</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Inui, Akio" sort="Inui, Akio" uniqKey="Inui A" first="Akio" last="Inui">Akio Inui</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author><author><name sortKey="Hoshino, Etsuo" sort="Hoshino, Etsuo" uniqKey="Hoshino E" first="Etsuo" last="Hoshino">Etsuo Hoshino</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Kampo Support, Cancer Institute Hospital</institution><country>Tokyo, Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>L.A. Koehler, PT, PhD, CLT-LANA, Program in Physical Therapy, Physical Medicine and Rehabilitation Department and Masonic Cancer Center, University of Minnesota Medical School, Mayo Mail Code 388, 420 Delaware St SE, Minneapolis</wicri:regionArea><wicri:noRegion>Minneapolis</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Complementary and alternative medicine (CAM) including Japanese Kampo is known to have anticancer potential. An increasing number of cancer survivors are using CAM for disease prevention, immune system enhancement, and symptom control. Although there have been abundant previous clinical reports regarding CAM, scientific investigations aimed at acquiring quantifiable results in clinical trials, as well as basic research regarding CAM, have only recently been undertaken. Recent studies suggest that CAM enhancement of immune function is related to cytokines. This review provides a translational aspect of CAM, particularly Hozai in Kampo from both scientific and clinical points of view for further development of CAM for cancer treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adachi, K" uniqKey="Adachi K">K. Adachi</name></author><author><name sortKey="Nanba, H" uniqKey="Nanba H">H. Nanba</name></author><author><name sortKey="Otsuka, M" uniqKey="Otsuka M">M. Otsuka</name></author><author><name sortKey="Kuroda, H" uniqKey="Kuroda H">H. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Pharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Front Pharmacol</journal-id><journal-id journal-id-type="publisher-id">Front. Pharmacol.</journal-id><journal-title-group><journal-title>Frontiers in Pharmacology</journal-title></journal-title-group><issn pub-type="epub">1663-9812</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26300773</article-id><article-id pub-id-type="pmc">4527580</article-id><article-id pub-id-type="doi">10.3389/fphar.2015.00150</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pharmacology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>The translational aspect of complementary and alternative medicine for cancer with particular emphasis on Kampo</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Amitani</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/64341"></uri></contrib><contrib contrib-type="author"><name><surname>Amitani</surname><given-names>Haruka</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/86558"></uri></contrib><contrib contrib-type="author"><name><surname>Sloan</surname><given-names>Robert A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/232640"></uri></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Hajime</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/256611"></uri></contrib><contrib contrib-type="author"><name><surname>Sameshima</surname><given-names>Nanami</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/256558"></uri></contrib><contrib contrib-type="author"><name><surname>Asakawa</surname><given-names>Akihiro</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/86553"></uri></contrib><contrib contrib-type="author"><name><surname>Nerome</surname><given-names>Yasuhito</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/256543"></uri></contrib><contrib contrib-type="author"><name><surname>Owaki</surname><given-names>Tetsuhiro</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/256546"></uri></contrib><contrib contrib-type="author"><name><surname>Inui</surname><given-names>Akio</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/63127"></uri></contrib><contrib contrib-type="author"><name><surname>Hoshino</surname><given-names>Etsuo</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/258075"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences</institution><country>Kagoshima, Japan</country></aff><aff id="aff3"><sup>3</sup><institution>Division of Kampo Support, Cancer Institute Hospital</institution><country>Tokyo, Japan</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: <italic>Ruiwen Zhang, Texas Tech University Health Sciences Center, USA</italic></p></fn><fn fn-type="edited-by"><p>Reviewed by: <italic>Xiao-Feng Zhu, Sun Yat-sen University, China; Jiang-Jiang Qin, Texas Tech University Health Sciences Center, USA</italic></p></fn><corresp id="fn001">*Correspondence: <italic>Haruka Amitani, Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan, <email xlink:type="simple">amitani@m3.kufm.kagoshima-u.ac.jp</email></italic></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology</p></fn></author-notes><pub-date pub-type="epub"><day>06</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>6</volume><elocation-id>150</elocation-id><history><date date-type="received"><day>10</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>09</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Amitani, Amitani, Sloan, Suzuki, Sameshima, Asakawa, Nerome, Owaki, Inui and Hoshino.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Amitani, Amitani, Sloan, Suzuki, Sameshima, Asakawa, Nerome, Owaki, Inui and Hoshino</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Complementary and alternative medicine (CAM) including Japanese Kampo is known to have anticancer potential. An increasing number of cancer survivors are using CAM for disease prevention, immune system enhancement, and symptom control. Although there have been abundant previous clinical reports regarding CAM, scientific investigations aimed at acquiring quantifiable results in clinical trials, as well as basic research regarding CAM, have only recently been undertaken. Recent studies suggest that CAM enhancement of immune function is related to cytokines. This review provides a translational aspect of CAM, particularly Hozai in Kampo from both scientific and clinical points of view for further development of CAM for cancer treatment.</p></abstract><kwd-group><kwd>complementary and alternative medicine (CAM)</kwd><kwd>Kampo</kwd><kwd>Hozai</kwd><kwd>cancer</kwd><kwd>Hochu-ekki-to</kwd><kwd>Juzen-taiho-to</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="153"></ref-count><page-count count="13"></page-count><word-count count="0"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Amitani, Marie" sort="Amitani, Marie" uniqKey="Amitani M" first="Marie" last="Amitani">Marie Amitani</name></noRegion><name sortKey="Amitani, Haruka" sort="Amitani, Haruka" uniqKey="Amitani H" first="Haruka" last="Amitani">Haruka Amitani</name><name sortKey="Amitani, Marie" sort="Amitani, Marie" uniqKey="Amitani M" first="Marie" last="Amitani">Marie Amitani</name><name sortKey="Asakawa, Akihiro" sort="Asakawa, Akihiro" uniqKey="Asakawa A" first="Akihiro" last="Asakawa">Akihiro Asakawa</name><name sortKey="Hoshino, Etsuo" sort="Hoshino, Etsuo" uniqKey="Hoshino E" first="Etsuo" last="Hoshino">Etsuo Hoshino</name><name sortKey="Inui, Akio" sort="Inui, Akio" uniqKey="Inui A" first="Akio" last="Inui">Akio Inui</name><name sortKey="Nerome, Yasuhito" sort="Nerome, Yasuhito" uniqKey="Nerome Y" first="Yasuhito" last="Nerome">Yasuhito Nerome</name><name sortKey="Owaki, Tetsuhiro" sort="Owaki, Tetsuhiro" uniqKey="Owaki T" first="Tetsuhiro" last="Owaki">Tetsuhiro Owaki</name><name sortKey="Sameshima, Nanami" sort="Sameshima, Nanami" uniqKey="Sameshima N" first="Nanami" last="Sameshima">Nanami Sameshima</name><name sortKey="Sloan, Robert A" sort="Sloan, Robert A" uniqKey="Sloan R" first="Robert A." last="Sloan">Robert A. Sloan</name><name sortKey="Suzuki, Hajime" sort="Suzuki, Hajime" uniqKey="Suzuki H" first="Hajime" last="Suzuki">Hajime Suzuki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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