Thyroid dermopathy—a diagnostic clue of hidden hyperthyroidism
Identifieur interne : 000D64 ( Pmc/Checkpoint ); précédent : 000D63; suivant : 000D65Thyroid dermopathy—a diagnostic clue of hidden hyperthyroidism
Auteurs : Tapan Kumar Dhali ; Monica ChaharSource :
- Dermato-endocrinology [ 1938-1972 ] ; 2015.
Abstract
Thyroid dermopathy is an uncommon manifestation of autoimmune thyroid disease. About 0.5%–4.3% of patients with history of thyrotoxicosis and 15% of patients with severe Graves’ ophthalmopathy have this cutaneous manifestation. However thyroid dermopathy is almost always associated with ophthalmopathy (96%) and sign and symptoms of hyperth-yroidism. The diagnosis of thyroid dermopathy is based on clinical sign and symptoms, serological thyroid hormone abnormalities supported by skin pathology. Isolated dermopathy is an uncommon manifestation of hyperthyroidism. A 35-year-old male presented with 7 months history of asymptomatic, multiple skin colored nodulo-tumorous growth over anterior aspect of both leg and one erythematous plaque with mild central atrophy on left leg. On examination most of the nodulo-tumorous growth (1 cm × 1 cm to 4 cm × 4 cm) and plaque (3 cm × 4 cm) showed ‘peau d’ orange’ appearance and were firm in consistency, indurated, non-tender with no rise of local temperature. Complete systemic and ophthalmological examination revealed no abnormalities. Abnormal thyroid function test and cutaneous deposition of mucin on histopathology suggested the diagnosis.The case is reported for its uncommon manifestation. Clinical sign should be documented and analysis of skin histopathology should be carried out in patients with suspected thyroid dermopathy.
Url:
DOI: 10.4161/19381980.2014.981078
PubMed: 26413185
PubMed Central: 4580047
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thyroid dermopathy—a diagnostic clue of hidden hyperthyroidism</title><author><name sortKey="Dhali, Tapan Kumar" sort="Dhali, Tapan Kumar" uniqKey="Dhali T" first="Tapan Kumar" last="Dhali">Tapan Kumar Dhali</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Chahar, Monica" sort="Chahar, Monica" uniqKey="Chahar M" first="Monica" last="Chahar">Monica Chahar</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26413185</idno><idno type="pmc">4580047</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580047</idno><idno type="RBID">PMC:4580047</idno><idno type="doi">10.4161/19381980.2014.981078</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000510</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000510</idno><idno type="wicri:Area/Pmc/Curation">000510</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000510</idno><idno type="wicri:Area/Pmc/Checkpoint">000D64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Thyroid dermopathy—a diagnostic clue of hidden hyperthyroidism</title><author><name sortKey="Dhali, Tapan Kumar" sort="Dhali, Tapan Kumar" uniqKey="Dhali T" first="Tapan Kumar" last="Dhali">Tapan Kumar Dhali</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Chahar, Monica" sort="Chahar, Monica" uniqKey="Chahar M" first="Monica" last="Chahar">Monica Chahar</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Dermato-endocrinology</title><idno type="ISSN">1938-1972</idno><idno type="eISSN">1938-1980</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Thyroid dermopathy is an uncommon manifestation of autoimmune thyroid disease. About 0.5%–4.3% of patients with history of thyrotoxicosis and 15% of patients with severe Graves’ ophthalmopathy have this cutaneous manifestation. However thyroid dermopathy is almost always associated with ophthalmopathy (96%) and sign and symptoms of hyperth-yroidism. The diagnosis of thyroid dermopathy is based on clinical sign and symptoms, serological thyroid hormone abnormalities supported by skin pathology. Isolated dermopathy is an uncommon manifestation of hyperthyroidism. A 35-year-old male presented with 7 months history of asymptomatic, multiple skin colored nodulo-tumorous growth over anterior aspect of both leg and one erythematous plaque with mild central atrophy on left leg. On examination most of the nodulo-tumorous growth (1 cm × 1 cm to 4 cm × 4 cm) and plaque (3 cm × 4 cm) showed ‘peau d’ orange’ appearance and were firm in consistency, indurated, non-tender with no rise of local temperature. Complete systemic and ophthalmological examination revealed no abnormalities. Abnormal thyroid function test and cutaneous deposition of mucin on histopathology suggested the diagnosis.The case is reported for its uncommon manifestation. Clinical sign should be documented and analysis of skin histopathology should be carried out in patients with suspected thyroid dermopathy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cannavo, Sp" uniqKey="Cannavo S">SP Cannavo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fatourechi, V" uniqKey="Fatourechi V">V Fatourechi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kriss, Jp" uniqKey="Kriss J">JP Kriss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omohundro, C" uniqKey="Omohundro C">C Omohundro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Km" uniqKey="Schwartz K">KM Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beierwaltes, Wh" uniqKey="Beierwaltes W">WH Beierwaltes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davies, T" uniqKey="Davies T">T Davies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagayama, Y" uniqKey="Nagayama Y">Y Nagayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schermer, Dr" uniqKey="Schermer D">DR Schermer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matzinger, P" uniqKey="Matzinger P">P Matzinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitter, Dg" uniqKey="Gitter D">DG Gitter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kato, N" uniqKey="Kato N">N Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gitter, Dg" uniqKey="Gitter D">DG Gitter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegler, M" uniqKey="Siegler M">M Siegler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rapoport, B" uniqKey="Rapoport B">B Rapoport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishii, M" uniqKey="Ishii M">M Ishii</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heymann, W" uniqKey="Heymann W">W Heymann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonelli, A" uniqKey="Antonelli A">A Antonelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandona, P" uniqKey="Dandona P">P Dandona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuzuya, N" uniqKey="Kuzuya N">N Kuzuya</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dermatoendocrinol</journal-id><journal-id journal-id-type="iso-abbrev">Dermatoendocrinol</journal-id><journal-id journal-id-type="pmc">KDER</journal-id><journal-title-group><journal-title>Dermato-endocrinology</journal-title></journal-title-group><issn pub-type="ppub">1938-1972</issn><issn pub-type="epub">1938-1980</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26413185</article-id><article-id pub-id-type="pmc">4580047</article-id><article-id pub-id-type="publisher-id">981078</article-id><article-id pub-id-type="doi">10.4161/19381980.2014.981078</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Thyroid dermopathy—a diagnostic clue of hidden hyperthyroidism</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dhali</surname><given-names>Tapan Kumar</given-names></name><xref ref-type="aff" rid="af0001"></xref></contrib><contrib contrib-type="author"><name><surname>Chahar</surname><given-names>Monica</given-names></name><xref ref-type="aff" rid="af0001"></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><aff id="af0001"><institution>Department of Dermatology; Employees' State Insurance Post Graduate Institute of Medical Science and Research</institution>; New Delhi,<country>India</country></aff></contrib-group><author-notes><corresp id="an0001"><label>*</label>Correspondence to: Monica Chahar; Email: <email xlink:href="Chahar.monica@yahoo.com">Chahar.monica@yahoo.com</email></corresp></author-notes><pub-date pub-type="collection"><season>Jan-Dec</season><year>2014</year></pub-date><pub-date pub-type="epub"><day>26</day><month>1</month><year>2015</year></pub-date><volume>6</volume><issue>1</issue><elocation-id seq="2">e981078</elocation-id><history><date date-type="received"><day>30</day><month>6</month><year>2014</year></date><date date-type="rev-recd"><day>14</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>21</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC</copyright-statement><copyright-statement content-type="description">© Tapan Kumar Dhali and Monica Chahar</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. </license-p></license></permissions><self-uri content-type="pdf" xlink:href="kder-06-01-981078.pdf"></self-uri><abstract><p>Thyroid dermopathy is an uncommon manifestation of autoimmune thyroid disease. About 0.5%–4.3% of patients with history of thyrotoxicosis and 15% of patients with severe Graves’ ophthalmopathy have this cutaneous manifestation. However thyroid dermopathy is almost always associated with ophthalmopathy (96%) and sign and symptoms of hyperth-yroidism. The diagnosis of thyroid dermopathy is based on clinical sign and symptoms, serological thyroid hormone abnormalities supported by skin pathology. Isolated dermopathy is an uncommon manifestation of hyperthyroidism. A 35-year-old male presented with 7 months history of asymptomatic, multiple skin colored nodulo-tumorous growth over anterior aspect of both leg and one erythematous plaque with mild central atrophy on left leg. On examination most of the nodulo-tumorous growth (1 cm × 1 cm to 4 cm × 4 cm) and plaque (3 cm × 4 cm) showed ‘peau d’ orange’ appearance and were firm in consistency, indurated, non-tender with no rise of local temperature. Complete systemic and ophthalmological examination revealed no abnormalities. Abnormal thyroid function test and cutaneous deposition of mucin on histopathology suggested the diagnosis.The case is reported for its uncommon manifestation. Clinical sign should be documented and analysis of skin histopathology should be carried out in patients with suspected thyroid dermopathy.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>Graves’ disease</kwd><kwd>hyperthyroidism</kwd><kwd>mucin</kwd><kwd>pretibial myxedema</kwd><kwd>thyroid dermopathy</kwd></kwd-group><counts><fig-count count="6"></fig-count><table-count count="0"></table-count><ref-count count="20"></ref-count><page-count count="5"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chahar, Monica" sort="Chahar, Monica" uniqKey="Chahar M" first="Monica" last="Chahar">Monica Chahar</name><name sortKey="Dhali, Tapan Kumar" sort="Dhali, Tapan Kumar" uniqKey="Dhali T" first="Tapan Kumar" last="Dhali">Tapan Kumar Dhali</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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