Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline
Identifieur interne : 000D54 ( Pmc/Checkpoint ); précédent : 000D53; suivant : 000D55Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline
Auteurs : Aysegul Arman [Turquie] ; Duriye Deniz Demirseren [Turquie] ; Tamer Takmaz [Turquie]Source :
- International Journal of Ophthalmology [ 2222-3959 ] ; 2015.
Abstract
To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.
One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.
Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (
Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.
Url:
DOI: 10.3980/j.issn.2222-3959.2015.03.19
PubMed: 26086005
PubMed Central: 4458660
Affiliations:
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<author><name sortKey="Demirseren, Duriye Deniz" sort="Demirseren, Duriye Deniz" uniqKey="Demirseren D" first="Duriye Deniz" last="Demirseren">Duriye Deniz Demirseren</name>
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<author><name sortKey="Demirseren, Duriye Deniz" sort="Demirseren, Duriye Deniz" uniqKey="Demirseren D" first="Duriye Deniz" last="Demirseren">Duriye Deniz Demirseren</name>
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<series><title level="j">International Journal of Ophthalmology</title>
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<front><div type="abstract" xml:lang="en"><sec><title>AIM</title>
<p>To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.</p>
</sec>
<sec><title>METHODS</title>
<p>One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.</p>
</sec>
<sec><title>RESULTS</title>
<p>Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (<italic>P</italic>
<0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs (<italic>P</italic>
=0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group (<italic>P</italic>
<0.05).</p>
</sec>
<sec><title>CONCLUSION</title>
<p>Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Ophthalmol</journal-id>
<journal-id journal-id-type="publisher-id">IJO</journal-id>
<journal-title-group><journal-title>International Journal of Ophthalmology</journal-title>
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<issn pub-type="ppub">2222-3959</issn>
<issn pub-type="epub">2227-4898</issn>
<publisher><publisher-name>International Journal of Ophthalmology Press</publisher-name>
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<article-id pub-id-type="publisher-id">ijo-08-03-544</article-id>
<article-id pub-id-type="doi">10.3980/j.issn.2222-3959.2015.03.19</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject>
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</article-categories>
<title-group><article-title>Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Arman</surname>
<given-names>Aysegul</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
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<contrib contrib-type="author"><name><surname>Demirseren</surname>
<given-names>Duriye Deniz</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Takmaz</surname>
<given-names>Tamer</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
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<aff id="aff1"><label>1</label>
<addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line>
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<aff id="aff2"><label>2</label>
<addr-line>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line>
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<author-notes><corresp><bold>Correspondence to:</bold>
Duriye Deniz Demirseren. Dermatology Clinic, Ataturk Training and Research Hospital, Ankara 06800, Turkey. <email>ddemirseren@yahoo.com</email>
</corresp>
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<pub-date pub-type="epub"><day>18</day>
<month>6</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>8</volume>
<issue>3</issue>
<fpage>544</fpage>
<lpage>549</lpage>
<history><date date-type="received"><day>18</day>
<month>2</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>9</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>International Journal of Ophthalmology Press</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><sec><title>AIM</title>
<p>To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.</p>
</sec>
<sec><title>METHODS</title>
<p>One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.</p>
</sec>
<sec><title>RESULTS</title>
<p>Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (<italic>P</italic>
<0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs (<italic>P</italic>
=0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group (<italic>P</italic>
<0.05).</p>
</sec>
<sec><title>CONCLUSION</title>
<p>Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.</p>
</sec>
</abstract>
<kwd-group><kwd>cyclosporine A</kwd>
<kwd>doxycycline</kwd>
<kwd>rosacea</kwd>
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<name sortKey="Takmaz, Tamer" sort="Takmaz, Tamer" uniqKey="Takmaz T" first="Tamer" last="Takmaz">Tamer Takmaz</name>
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