Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline
Identifieur interne : 000D54 ( Pmc/Checkpoint ); précédent : 000D53; suivant : 000D55Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline
Auteurs : Aysegul Arman [Turquie] ; Duriye Deniz Demirseren [Turquie] ; Tamer Takmaz [Turquie]Source :
- International Journal of Ophthalmology [ 2222-3959 ] ; 2015.
Abstract
To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.
One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.
Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (
Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.
Url:
DOI: 10.3980/j.issn.2222-3959.2015.03.19
PubMed: 26086005
PubMed Central: 4458660
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4458660Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline</title><author><name sortKey="Arman, Aysegul" sort="Arman, Aysegul" uniqKey="Arman A" first="Aysegul" last="Arman">Aysegul Arman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author><author><name sortKey="Demirseren, Duriye Deniz" sort="Demirseren, Duriye Deniz" uniqKey="Demirseren D" first="Duriye Deniz" last="Demirseren">Duriye Deniz Demirseren</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author><author><name sortKey="Takmaz, Tamer" sort="Takmaz, Tamer" uniqKey="Takmaz T" first="Tamer" last="Takmaz">Tamer Takmaz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26086005</idno><idno type="pmc">4458660</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458660</idno><idno type="RBID">PMC:4458660</idno><idno type="doi">10.3980/j.issn.2222-3959.2015.03.19</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000278</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000278</idno><idno type="wicri:Area/Pmc/Curation">000278</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000278</idno><idno type="wicri:Area/Pmc/Checkpoint">000D54</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline</title><author><name sortKey="Arman, Aysegul" sort="Arman, Aysegul" uniqKey="Arman A" first="Aysegul" last="Arman">Aysegul Arman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author><author><name sortKey="Demirseren, Duriye Deniz" sort="Demirseren, Duriye Deniz" uniqKey="Demirseren D" first="Duriye Deniz" last="Demirseren">Duriye Deniz Demirseren</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author><author><name sortKey="Takmaz, Tamer" sort="Takmaz, Tamer" uniqKey="Takmaz T" first="Tamer" last="Takmaz">Tamer Takmaz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800</wicri:regionArea><wicri:noRegion>Ankara 06800</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Ophthalmology</title><idno type="ISSN">2222-3959</idno><idno type="eISSN">2227-4898</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>AIM</title><p>To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.</p></sec><sec><title>METHODS</title><p>One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.</p></sec><sec><title>RESULTS</title><p>Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (<italic>P</italic><0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs (<italic>P</italic>=0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group (<italic>P</italic><0.05).</p></sec><sec><title>CONCLUSION</title><p>Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Ophthalmol</journal-id><journal-id journal-id-type="publisher-id">IJO</journal-id><journal-title-group><journal-title>International Journal of Ophthalmology</journal-title></journal-title-group><issn pub-type="ppub">2222-3959</issn><issn pub-type="epub">2227-4898</issn><publisher><publisher-name>International Journal of Ophthalmology Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26086005</article-id><article-id pub-id-type="pmc">4458660</article-id><article-id pub-id-type="publisher-id">ijo-08-03-544</article-id><article-id pub-id-type="doi">10.3980/j.issn.2222-3959.2015.03.19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject></subj-group></article-categories><title-group><article-title>Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arman</surname><given-names>Aysegul</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Demirseren</surname><given-names>Duriye Deniz</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Takmaz</surname><given-names>Tamer</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Ophthalmology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Dermatology Clinic, Ankara Ataturk Training and Research Hospital, Ankara 06800, Turkey</addr-line></aff><author-notes><corresp><bold>Correspondence to:</bold> Duriye Deniz Demirseren. Dermatology Clinic, Ataturk Training and Research Hospital, Ankara 06800, Turkey. <email>ddemirseren@yahoo.com</email></corresp></author-notes><pub-date pub-type="epub"><day>18</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>8</volume><issue>3</issue><fpage>544</fpage><lpage>549</lpage><history><date date-type="received"><day>18</day><month>2</month><year>2014</year></date><date date-type="accepted"><day>9</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>International Journal of Ophthalmology Press</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec><title>AIM</title><p>To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.</p></sec><sec><title>METHODS</title><p>One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.</p></sec><sec><title>RESULTS</title><p>Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes (<italic>P</italic><0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs (<italic>P</italic>=0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group (<italic>P</italic><0.05).</p></sec><sec><title>CONCLUSION</title><p>Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage.</p></sec></abstract><kwd-group><kwd>cyclosporine A</kwd><kwd>doxycycline</kwd><kwd>rosacea</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Arman, Aysegul" sort="Arman, Aysegul" uniqKey="Arman A" first="Aysegul" last="Arman">Aysegul Arman</name></noRegion><name sortKey="Demirseren, Duriye Deniz" sort="Demirseren, Duriye Deniz" uniqKey="Demirseren D" first="Duriye Deniz" last="Demirseren">Duriye Deniz Demirseren</name><name sortKey="Takmaz, Tamer" sort="Takmaz, Tamer" uniqKey="Takmaz T" first="Tamer" last="Takmaz">Tamer Takmaz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D54 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000D54 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4458660
|texte= Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:26086005" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |