Association between Body Mass Index and Physical Function among Endometrial Cancer Survivors
Identifieur interne : 000B77 ( Pmc/Checkpoint ); précédent : 000B76; suivant : 000B78Association between Body Mass Index and Physical Function among Endometrial Cancer Survivors
Auteurs : Xiaochen Zhang [États-Unis] ; Justin C. Brown [États-Unis] ; Kathryn H. Schmitz [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
We sought to quantify the relationship between body mass index (BMI) and physical function among endometrial cancer survivors. Understanding this relationship would help healthcare providers target efforts to refer obese endometrial cancer survivors to weight loss and exercise interventions.
We conducted a survey of 213 endometrial cancer survivors who received cancer care at an academic l health system between 2006 and 2010. Physical function subscale was quantified using physical functional component score from the SF-12 questionnaire. We compared physical function of endometrial cancer survivors to population-based age-standardized normative values.
Among the 213 patients, 16% were normal weight (BMI ≤25 kg/m2), and 52% were obese (≥30 kg/m2). Higher BMI categories were associated with lower physical function (
Among endometrial cancer survivors, higher BMI is associated with lower physical function. Younger endometrial cancer survivors report lower physical function compared to age-standardized normative values. Healthcare providers should be aware that younger, obese endometrial cancer survivors may particularly benefit from interventions such as exercise and weight loss to increase or preserve physical function.
Url:
DOI: 10.1371/journal.pone.0160954
PubMed: 27529546
PubMed Central: 4986945
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between Body Mass Index and Physical Function among Endometrial Cancer Survivors</title><author><name sortKey="Zhang, Xiaochen" sort="Zhang, Xiaochen" uniqKey="Zhang X" first="Xiaochen" last="Zhang">Xiaochen Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Public Health Science, Penn State College of Medicine, Hershey, PA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Science, Penn State College of Medicine, Hershey, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Justin C" sort="Brown, Justin C" uniqKey="Brown J" first="Justin C." last="Brown">Justin C. Brown</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Public Health Science, Penn State College of Medicine, Hershey, PA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Science, Penn State College of Medicine, Hershey, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27529546</idno><idno type="pmc">4986945</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986945</idno><idno type="RBID">PMC:4986945</idno><idno type="doi">10.1371/journal.pone.0160954</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">004404</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004404</idno><idno type="wicri:Area/Pmc/Curation">004403</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004403</idno><idno type="wicri:Area/Pmc/Checkpoint">000B77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between Body Mass Index and Physical Function among Endometrial Cancer Survivors</title><author><name sortKey="Zhang, Xiaochen" sort="Zhang, Xiaochen" uniqKey="Zhang X" first="Xiaochen" last="Zhang">Xiaochen Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Public Health Science, Penn State College of Medicine, Hershey, PA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Science, Penn State College of Medicine, Hershey, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Justin C" sort="Brown, Justin C" uniqKey="Brown J" first="Justin C." last="Brown">Justin C. Brown</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Public Health Science, Penn State College of Medicine, Hershey, PA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Science, Penn State College of Medicine, Hershey, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title><p>We sought to quantify the relationship between body mass index (BMI) and physical function among endometrial cancer survivors. Understanding this relationship would help healthcare providers target efforts to refer obese endometrial cancer survivors to weight loss and exercise interventions.</p></sec><sec id="sec002"><title>Methods</title><p>We conducted a survey of 213 endometrial cancer survivors who received cancer care at an academic l health system between 2006 and 2010. Physical function subscale was quantified using physical functional component score from the SF-12 questionnaire. We compared physical function of endometrial cancer survivors to population-based age-standardized normative values.</p></sec><sec id="sec003"><title>Results</title><p>Among the 213 patients, 16% were normal weight (BMI ≤25 kg/m<sup>2</sup>), and 52% were obese (≥30 kg/m<sup>2</sup>). Higher BMI categories were associated with lower physical function (<italic>P</italic><sub>trend</sub> = 0.003), as a continuous variable each 5kg/m<sup>2</sup> higher BMI, physical function score was lower by 0.15 points (β = -0.15; <italic>P</italic> = 0.045). Compared to population-based age-standardized normative values, patients <75yrs reported lower physical function, whereas patients ≥75yrs reported better physical function. BMI was the only covariate associated with differences in physical function between survivors and age-standardized normative values (<italic>P</italic> = 0.039).</p></sec><sec id="sec004"><title>Conclusions</title><p>Among endometrial cancer survivors, higher BMI is associated with lower physical function. Younger endometrial cancer survivors report lower physical function compared to age-standardized normative values. Healthcare providers should be aware that younger, obese endometrial cancer survivors may particularly benefit from interventions such as exercise and weight loss to increase or preserve physical function.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Jc" uniqKey="Brown J">JC Brown</name></author><author><name sortKey="Schmitz, Kh" uniqKey="Schmitz K">KH Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Painter, P" uniqKey="Painter P">P Painter</name></author><author><name sortKey="Stewart, Al" uniqKey="Stewart A">AL Stewart</name></author><author><name sortKey="Carey, S" uniqKey="Carey S">S Carey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cesari, M" uniqKey="Cesari M">M Cesari</name></author><author><name sortKey="Onder, G" uniqKey="Onder G">G Onder</name></author><author><name 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sortKey="Courneya, Ks" uniqKey="Courneya K">KS Courneya</name></author><author><name sortKey="Fairey, As" uniqKey="Fairey A">AS Fairey</name></author><author><name sortKey="Mackey, Jr" uniqKey="Mackey J">JR Mackey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Oh, M" uniqKey="Oh M">M Oh</name></author><author><name sortKey="Park, H" uniqKey="Park H">H Park</name></author><author><name sortKey="Chae, J" uniqKey="Chae J">J Chae</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Gruenigen, Ve" uniqKey="Von Gruenigen V">VE von Gruenigen</name></author><author><name sortKey="Courneya, Ks" uniqKey="Courneya K">KS Courneya</name></author><author><name sortKey="Gibbons, He" uniqKey="Gibbons H">HE Gibbons</name></author><author><name sortKey="Kavanagh, Mb" uniqKey="Kavanagh M">MB Kavanagh</name></author><author><name sortKey="Waggoner, Se" uniqKey="Waggoner S">SE Waggoner</name></author><author><name sortKey="Lerner, E" uniqKey="Lerner E">E Lerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Gruenigen, V" uniqKey="Von Gruenigen V">V von Gruenigen</name></author><author><name sortKey="Frasure, H" uniqKey="Frasure H">H Frasure</name></author><author><name sortKey="Kavanagh, Mb" uniqKey="Kavanagh M">MB Kavanagh</name></author><author><name sortKey="Janata, J" uniqKey="Janata J">J Janata</name></author><author><name sortKey="Waggoner, S" uniqKey="Waggoner S">S Waggoner</name></author><author><name sortKey="Rose, P" uniqKey="Rose P">P Rose</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27529546</article-id><article-id pub-id-type="pmc">4986945</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0160954</article-id><article-id pub-id-type="publisher-id">PONE-D-16-17092</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject><subj-group><subject>Cancers and Neoplasms</subject><subj-group><subject>Gynecological Tumors</subject><subj-group><subject>Uterine Cancer</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Physiological Parameters</subject><subj-group><subject>Body Weight</subject><subj-group><subject>Body Mass Index</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Physiological Parameters</subject><subj-group><subject>Body Weight</subject><subj-group><subject>Body Mass Index</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Physiological Parameters</subject><subj-group><subject>Body Weight</subject><subj-group><subject>Obesity</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Physiology</subject><subj-group><subject>Physiological Parameters</subject><subj-group><subject>Body Weight</subject><subj-group><subject>Obesity</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Diagnostic Medicine</subject><subj-group><subject>Cancer Detection and Diagnosis</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject><subj-group><subject>Cancer Detection and Diagnosis</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject><subj-group><subject>Cancer Treatment</subject><subj-group><subject>Surgical Oncology</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Clinical Medicine</subject><subj-group><subject>Clinical Oncology</subject><subj-group><subject>Surgical Oncology</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject><subj-group><subject>Clinical Oncology</subject><subj-group><subject>Surgical Oncology</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Surgical and Invasive Medical Procedures</subject></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Oncology</subject><subj-group><subject>Cancer Treatment</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Health Care</subject><subj-group><subject>Quality of Life</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Association between Body Mass Index and Physical Function among Endometrial Cancer Survivors</article-title><alt-title alt-title-type="running-head">BMI and Physical Function in Endometrial Cancer</alt-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-3086-1285</contrib-id><name><surname>Zhang</surname><given-names>Xiaochen</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Justin C.</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schmitz</surname><given-names>Kathryn H.</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Public Health Science, Penn State College of Medicine, Hershey, PA, United States of America</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Lucia</surname><given-names>Alejandro</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Universidad Europea de Madrid, SPAIN</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceived and designed the experiments:</bold> XZ JCB KHS.</p></list-item><list-item><p><bold>Performed the experiments:</bold> XZ JCB.</p></list-item><list-item><p><bold>Analyzed the data:</bold> XZ.</p></list-item><list-item><p><bold>Contributed reagents/materials/analysis tools:</bold> XZ JCB.</p></list-item><list-item><p><bold>Wrote the paper:</bold> XZ JCB KHS.</p></list-item></list></p></fn><corresp id="cor001">* E-mail: <email>kschmitz@phs.psu.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>16</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>8</issue><elocation-id>e0160954</elocation-id><history><date date-type="received"><day>27</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>27</day><month>7</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Zhang et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Zhang et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0160954.pdf"></self-uri><abstract><sec id="sec001"><title>Objectives</title><p>We sought to quantify the relationship between body mass index (BMI) and physical function among endometrial cancer survivors. Understanding this relationship would help healthcare providers target efforts to refer obese endometrial cancer survivors to weight loss and exercise interventions.</p></sec><sec id="sec002"><title>Methods</title><p>We conducted a survey of 213 endometrial cancer survivors who received cancer care at an academic l health system between 2006 and 2010. Physical function subscale was quantified using physical functional component score from the SF-12 questionnaire. We compared physical function of endometrial cancer survivors to population-based age-standardized normative values.</p></sec><sec id="sec003"><title>Results</title><p>Among the 213 patients, 16% were normal weight (BMI ≤25 kg/m<sup>2</sup>), and 52% were obese (≥30 kg/m<sup>2</sup>). Higher BMI categories were associated with lower physical function (<italic>P</italic><sub>trend</sub> = 0.003), as a continuous variable each 5kg/m<sup>2</sup> higher BMI, physical function score was lower by 0.15 points (β = -0.15; <italic>P</italic> = 0.045). Compared to population-based age-standardized normative values, patients <75yrs reported lower physical function, whereas patients ≥75yrs reported better physical function. BMI was the only covariate associated with differences in physical function between survivors and age-standardized normative values (<italic>P</italic> = 0.039).</p></sec><sec id="sec004"><title>Conclusions</title><p>Among endometrial cancer survivors, higher BMI is associated with lower physical function. Younger endometrial cancer survivors report lower physical function compared to age-standardized normative values. Healthcare providers should be aware that younger, obese endometrial cancer survivors may particularly benefit from interventions such as exercise and weight loss to increase or preserve physical function.</p></sec></abstract><funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/100000002</institution-id><institution>National Institutes of Health</institution></institution-wrap></funding-source><award-id>1U54CA155850-01</award-id><principal-award-recipient><name><surname>Schmitz</surname><given-names>Kathryn H.</given-names></name></principal-award-recipient></award-group><funding-statement>This work was supported by NIH NCI 1U54CA155850-01.</funding-statement></funding-group><counts><fig-count count="1"></fig-count><table-count count="4"></table-count><page-count count="12"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Xiaochen" sort="Zhang, Xiaochen" uniqKey="Zhang X" first="Xiaochen" last="Zhang">Xiaochen Zhang</name></noRegion><name sortKey="Brown, Justin C" sort="Brown, Justin C" uniqKey="Brown J" first="Justin C." last="Brown">Justin C. Brown</name><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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