Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis
Identifieur interne : 000B06 ( Pmc/Checkpoint ); précédent : 000B05; suivant : 000B07Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis
Auteurs : Carmen B. Lupia Ez [Espagne] ; María T. Villaescusa [Espagne] ; Agostinho Carvalho [Portugal] ; Jan Springer [Allemagne] ; Michaela Lackner [Autriche] ; José M. Sánchez-Maldonado [Espagne] ; Luz M. Canet [Espagne] ; Cristina Cunha [Portugal] ; Juana Segura-Catena [Espagne] ; Laura Alcazar-Fuoli [Espagne] ; Carlos Solano [Espagne] ; Luana Fianchi [Italie] ; Livio Pagano [Italie] ; Leonardo Potenza [Italie] ; José M. Aguado [Espagne] ; Mario Luppi [Italie] ; Manuel Cuenca-Estrella [Espagne] ; Cornelia Lass-Flörl [Autriche] ; Hermann Einsele [Allemagne] ; Lourdes Vázquez [Espagne] ; Rafael Ríos-Tamayo [Espagne] ; Jurgen Loeffler [Allemagne] ; Manuel Jurado [Espagne] ; Juan Sainz [Espagne]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2016.
Abstract
Invasive Aspergillosis (IA) is an opportunistic infection caused by
Url:
DOI: 10.3389/fmicb.2016.01243
PubMed: 27570521
PubMed Central: 4982195
Affiliations:
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PMC:4982195Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis</title>
<author><name sortKey="Lupia Ez, Carmen B" sort="Lupia Ez, Carmen B" uniqKey="Lupia Ez C" first="Carmen B." last="Lupia Ez">Carmen B. Lupia Ez</name>
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</author>
<author><name sortKey="Carvalho, Agostinho" sort="Carvalho, Agostinho" uniqKey="Carvalho A" first="Agostinho" last="Carvalho">Agostinho Carvalho</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho</institution>
<country>Braga, Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>ICVS/3B's - PT Government Associate Laboratory</institution>
<country>Braga, Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Springer, Jan" sort="Springer, Jan" uniqKey="Springer J" first="Jan" last="Springer">Jan Springer</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Universitätsklinikum Würzburg, Medizinische Klinik II</institution>
<country>Würzburg, Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lackner, Michaela" sort="Lackner, Michaela" uniqKey="Lackner M" first="Michaela" last="Lackner">Michaela Lackner</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Hygiene and Medical Microbiology, Medical University of Innsbruck</institution>
<country>Innsbruck, Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez Maldonado, Jose M" sort="Sanchez Maldonado, Jose M" uniqKey="Sanchez Maldonado J" first="José M." last="Sánchez-Maldonado">José M. Sánchez-Maldonado</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Canet, Luz M" sort="Canet, Luz M" uniqKey="Canet L" first="Luz M." last="Canet">Luz M. Canet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cunha, Cristina" sort="Cunha, Cristina" uniqKey="Cunha C" first="Cristina" last="Cunha">Cristina Cunha</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho</institution>
<country>Braga, Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>ICVS/3B's - PT Government Associate Laboratory</institution>
<country>Braga, Portugal</country>
</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Segura Catena, Juana" sort="Segura Catena, Juana" uniqKey="Segura Catena J" first="Juana" last="Segura-Catena">Juana Segura-Catena</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hematology Department, Virgen de las Nieves University Hospital</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alcazar Fuoli, Laura" sort="Alcazar Fuoli, Laura" uniqKey="Alcazar Fuoli L" first="Laura" last="Alcazar-Fuoli">Laura Alcazar-Fuoli</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III</institution>
<country>Madrid, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Solano, Carlos" sort="Solano, Carlos" uniqKey="Solano C" first="Carlos" last="Solano">Carlos Solano</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Hematology Department, Clinic University Hospital of Valencia</institution>
<country>Valencia, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fianchi, Luana" sort="Fianchi, Luana" uniqKey="Fianchi L" first="Luana" last="Fianchi">Luana Fianchi</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Istituto di Ematologia, Università Cattolica del S. Cuore</institution>
<country>Rome, Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pagano, Livio" sort="Pagano, Livio" uniqKey="Pagano L" first="Livio" last="Pagano">Livio Pagano</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Istituto di Ematologia, Università Cattolica del S. Cuore</institution>
<country>Rome, Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Potenza, Leonardo" sort="Potenza, Leonardo" uniqKey="Potenza L" first="Leonardo" last="Potenza">Leonardo Potenza</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia</institution>
<country>AOU Policlinico, Modena, Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aguado, Jose M" sort="Aguado, Jose M" uniqKey="Aguado J" first="José M." last="Aguado">José M. Aguado</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Unit of Infectious Diseases, University Hospital 12 de Octubre, Research Institute of Hospital 12 de Octubre (i+12)</institution>
<country>Madrid, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Luppi, Mario" sort="Luppi, Mario" uniqKey="Luppi M" first="Mario" last="Luppi">Mario Luppi</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia</institution>
<country>AOU Policlinico, Modena, Italy</country>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cuenca Estrella, Manuel" sort="Cuenca Estrella, Manuel" uniqKey="Cuenca Estrella M" first="Manuel" last="Cuenca-Estrella">Manuel Cuenca-Estrella</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III</institution>
<country>Madrid, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lass Florl, Cornelia" sort="Lass Florl, Cornelia" uniqKey="Lass Florl C" first="Cornelia" last="Lass-Flörl">Cornelia Lass-Flörl</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Division of Hygiene and Medical Microbiology, Medical University of Innsbruck</institution>
<country>Innsbruck, Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Universitätsklinikum Würzburg, Medizinische Klinik II</institution>
<country>Würzburg, Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vazquez, Lourdes" sort="Vazquez, Lourdes" uniqKey="Vazquez L" first="Lourdes" last="Vázquez">Lourdes Vázquez</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Hematology Department, University Hospital of Salamanca</institution>
<country>Salamanca, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rios Tamayo, Rafael" sort="Rios Tamayo, Rafael" uniqKey="Rios Tamayo R" first="Rafael" last="Ríos-Tamayo">Rafael Ríos-Tamayo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hematology Department, Virgen de las Nieves University Hospital</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loeffler, Jurgen" sort="Loeffler, Jurgen" uniqKey="Loeffler J" first="Jurgen" last="Loeffler">Jurgen Loeffler</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Universitätsklinikum Würzburg, Medizinische Klinik II</institution>
<country>Würzburg, Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jurado, Manuel" sort="Jurado, Manuel" uniqKey="Jurado M" first="Manuel" last="Jurado">Manuel Jurado</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hematology Department, Virgen de las Nieves University Hospital</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sainz, Juan" sort="Sainz, Juan" uniqKey="Sainz J" first="Juan" last="Sainz">Juan Sainz</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Hematology Department, Virgen de las Nieves University Hospital</institution>
<country>Granada, Spain</country>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Gwinnett Sports Rehabilitation, Gwinnett Medical Center, 500 Medical Center Blvd, Suite 130, Lawrenceville</wicri:regionArea>
<wicri:noRegion>Lawrenceville</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Microbiology</title>
<idno type="eISSN">1664-302X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Invasive Aspergillosis (IA) is an opportunistic infection caused by <italic>Aspergillus</italic>
, a ubiquitously present airborne pathogenic mold. A growing number of studies suggest a major host genetic component in disease susceptibility. Here, we evaluated whether 14 single-nucleotide polymorphisms within <italic>NF</italic>
κ<italic>B1, NF</italic>
κ<italic>B2, RelA, RelB, Rel</italic>
, and <italic>IRF4</italic>
genes influence the risk of IA in a population of 834 high-risk patients (157 IA and 677 non-IA) recruited through a collaborative effort involving the aspBIOmics consortium and four European clinical institutions. No significant overall associations between selected SNPs and the risk of IA were found in this large cohort. Although a hematopoietic stem cell transplantation (HSCT)-stratified analysis revealed that carriers of the <italic>IRF4</italic>
<sub>rs12203592T/T</sub>
genotype had a six-fold increased risk of developing the infection when compared with those carrying the C allele (OR<sub>REC</sub>
= 6.24, 95%CI 1.25–31.2, <italic>P</italic>
= 0.026), the association of this variant with IA risk did not reach significance at experiment-wide significant threshold. In addition, we found an association of the IRF4<sub>AAT<underline>C</underline>
</sub>
and IRF4<sub>GGT<underline>C</underline>
</sub>
haplotypes (not including the <italic>IRF4</italic>
<sub>rs12203592T</sub>
risk allele) with a decreased risk of IA but the magnitude of the association was similar to the one observed in the single-SNP analysis, which indicated that the haplotypic effect on IA risk was likely due to the <italic>IRF4</italic>
<sub>rs12203592</sub>
SNP. Finally, no evidence of significant interactions among the genetic markers tested and the risk of IA was found. These results suggest that the SNPs on the studied genes do not have a clinically relevant impact on the risk of developing IA.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abe, K" uniqKey="Abe K">K. Abe</name>
</author>
<author><name sortKey="Yarovinsky, F O" uniqKey="Yarovinsky F">F. O. Yarovinsky</name>
</author>
<author><name sortKey="Murakami, T" uniqKey="Murakami T">T. Murakami</name>
</author>
<author><name sortKey="Shakhov, A N" uniqKey="Shakhov A">A. N. Shakhov</name>
</author>
<author><name sortKey="Tumanov, A V" uniqKey="Tumanov A">A. V. Tumanov</name>
</author>
<author><name sortKey="Ito, D" uniqKey="Ito D">D. Ito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aguado, J M" uniqKey="Aguado J">J. M. Aguado</name>
</author>
<author><name sortKey="Vazquez, L" uniqKey="Vazquez L">L. Vázquez</name>
</author>
<author><name sortKey="Fernandez Ruiz, M" uniqKey="Fernandez Ruiz M">M. Fernandez-Ruiz</name>
</author>
<author><name sortKey="Villaescusa, T" uniqKey="Villaescusa T">T. Villaescusa</name>
</author>
<author><name sortKey="Ruiz Camps, I" uniqKey="Ruiz Camps I">I. Ruiz-Camps</name>
</author>
<author><name sortKey="Barba, P" uniqKey="Barba P">P. Barba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name>
</author>
<author><name sortKey="Takeda, K" uniqKey="Takeda K">K. Takeda</name>
</author>
<author><name sortKey="Kaisho, T" uniqKey="Kaisho T">T. Kaisho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ali, F R" uniqKey="Ali F">F. R. Ali</name>
</author>
<author><name sortKey="Barton, A" uniqKey="Barton A">A. Barton</name>
</author>
<author><name sortKey="Smith, R L" uniqKey="Smith R">R. L. Smith</name>
</author>
<author><name sortKey="Bowes, J" uniqKey="Bowes J">J. Bowes</name>
</author>
<author><name sortKey="Flynn, E" uniqKey="Flynn E">E. Flynn</name>
</author>
<author><name sortKey="Mangino, M" uniqKey="Mangino M">M. Mangino</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baja A, S" uniqKey="Baja A S">S. Bajaña</name>
</author>
<author><name sortKey="Turner, S" uniqKey="Turner S">S. Turner</name>
</author>
<author><name sortKey="Paul, J" uniqKey="Paul J">J. Paul</name>
</author>
<author><name sortKey="Ainsua Enrich, E" uniqKey="Ainsua Enrich E">E. Ainsua-Enrich</name>
</author>
<author><name sortKey="Kovats, S" uniqKey="Kovats S">S. Kovats</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beinke, S" uniqKey="Beinke S">S. Beinke</name>
</author>
<author><name sortKey="Ley, S C" uniqKey="Ley S">S. C. Ley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bellocchio, S" uniqKey="Bellocchio S">S. Bellocchio</name>
</author>
<author><name sortKey="Moretti, S" uniqKey="Moretti S">S. Moretti</name>
</author>
<author><name sortKey="Perruccio, K" uniqKey="Perruccio K">K. Perruccio</name>
</author>
<author><name sortKey="Fallarino, F" uniqKey="Fallarino F">F. Fallarino</name>
</author>
<author><name sortKey="Bozza, S" uniqKey="Bozza S">S. Bozza</name>
</author>
<author><name sortKey="Montagnoli, C" uniqKey="Montagnoli C">C. Montagnoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bochud, P Y" uniqKey="Bochud P">P. Y. Bochud</name>
</author>
<author><name sortKey="Chien, J W" uniqKey="Chien J">J. W. Chien</name>
</author>
<author><name sortKey="Marr, K A" uniqKey="Marr K">K. A. Marr</name>
</author>
<author><name sortKey="Leisenring, W M" uniqKey="Leisenring W">W. M. Leisenring</name>
</author>
<author><name sortKey="Upton, A" uniqKey="Upton A">A. Upton</name>
</author>
<author><name sortKey="Janer, M" uniqKey="Janer M">M. Janer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boddicker, R L" uniqKey="Boddicker R">R. L. Boddicker</name>
</author>
<author><name sortKey="Kip, N S" uniqKey="Kip N">N. S. Kip</name>
</author>
<author><name sortKey="Xing, X" uniqKey="Xing X">X. Xing</name>
</author>
<author><name sortKey="Zeng, Y" uniqKey="Zeng Y">Y. Zeng</name>
</author>
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<author><name sortKey="Lecompte, T D" uniqKey="Lecompte T">T. D. Lecompte</name>
</author>
<author><name sortKey="Bibert, S" uniqKey="Bibert S">S. Bibert</name>
</author>
<author><name sortKey="Manuel, O" uniqKey="Manuel O">O. Manuel</name>
</author>
<author><name sortKey="Rueger, S" uniqKey="Rueger S">S. Rüeger</name>
</author>
<author><name sortKey="Berger, C" uniqKey="Berger C">C. Berger</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id>
<journal-title-group><journal-title>Frontiers in Microbiology</journal-title>
</journal-title-group>
<issn pub-type="epub">1664-302X</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27570521</article-id>
<article-id pub-id-type="pmc">4982195</article-id>
<article-id pub-id-type="doi">10.3389/fmicb.2016.01243</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lupiañez</surname>
<given-names>Carmen B.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/342298/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Villaescusa</surname>
<given-names>María T.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carvalho</surname>
<given-names>Agostinho</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/44807/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Springer</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/314786/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Lackner</surname>
<given-names>Michaela</given-names>
</name>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sánchez-Maldonado</surname>
<given-names>José M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Canet</surname>
<given-names>Luz M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cunha</surname>
<given-names>Cristina</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Segura-Catena</surname>
<given-names>Juana</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alcazar-Fuoli</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/59225/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Solano</surname>
<given-names>Carlos</given-names>
</name>
<xref ref-type="aff" rid="aff10"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fianchi</surname>
<given-names>Luana</given-names>
</name>
<xref ref-type="aff" rid="aff11"><sup>11</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pagano</surname>
<given-names>Livio</given-names>
</name>
<xref ref-type="aff" rid="aff11"><sup>11</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/356507/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Potenza</surname>
<given-names>Leonardo</given-names>
</name>
<xref ref-type="aff" rid="aff12"><sup>12</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aguado</surname>
<given-names>José M.</given-names>
</name>
<xref ref-type="aff" rid="aff13"><sup>13</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Luppi</surname>
<given-names>Mario</given-names>
</name>
<xref ref-type="aff" rid="aff12"><sup>12</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cuenca-Estrella</surname>
<given-names>Manuel</given-names>
</name>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lass-Flörl</surname>
<given-names>Cornelia</given-names>
</name>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Einsele</surname>
<given-names>Hermann</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vázquez</surname>
<given-names>Lourdes</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><collab>PCRAGA Study Group</collab>
<xref ref-type="aff" rid="aff14"><sup>14</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ríos-Tamayo</surname>
<given-names>Rafael</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loeffler</surname>
<given-names>Jurgen</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jurado</surname>
<given-names>Manuel</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sainz</surname>
<given-names>Juan</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/218114/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Genomic Oncology Area, GENYO, Center for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada</institution>
<country>Granada, Spain</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Hematology Department, Virgen de las Nieves University Hospital</institution>
<country>Granada, Spain</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Hematology Department, University Hospital of Salamanca</institution>
<country>Salamanca, Spain</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Hematology Department, Jiménez Díaz Foundation</institution>
<country>Madrid, Spain</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho</institution>
<country>Braga, Portugal</country>
</aff>
<aff id="aff6"><sup>6</sup>
<institution>ICVS/3B's - PT Government Associate Laboratory</institution>
<country>Braga, Portugal</country>
</aff>
<aff id="aff7"><sup>7</sup>
<institution>Universitätsklinikum Würzburg, Medizinische Klinik II</institution>
<country>Würzburg, Germany</country>
</aff>
<aff id="aff8"><sup>8</sup>
<institution>Division of Hygiene and Medical Microbiology, Medical University of Innsbruck</institution>
<country>Innsbruck, Austria</country>
</aff>
<aff id="aff9"><sup>9</sup>
<institution>Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III</institution>
<country>Madrid, Spain</country>
</aff>
<aff id="aff10"><sup>10</sup>
<institution>Hematology Department, Clinic University Hospital of Valencia</institution>
<country>Valencia, Spain</country>
</aff>
<aff id="aff11"><sup>11</sup>
<institution>Istituto di Ematologia, Università Cattolica del S. Cuore</institution>
<country>Rome, Italy</country>
</aff>
<aff id="aff12"><sup>12</sup>
<institution>Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia</institution>
<country>AOU Policlinico, Modena, Italy</country>
</aff>
<aff id="aff13"><sup>13</sup>
<institution>Unit of Infectious Diseases, University Hospital 12 de Octubre, Research Institute of Hospital 12 de Octubre (i+12)</institution>
<country>Madrid, Spain</country>
</aff>
<aff id="aff14"><sup>14</sup>
<institution>PCRAGA Study Group</institution>
<country>Salamanca, Spain</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Frederic Lamoth, Centre Hospitalier Universitaire Vaudois, Switzerland</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: William J. Steinbach, Duke University, USA; Pierre-Yves Bochud, Centre Hospitalier Universitaire Vaudois, Switzerland</p>
</fn>
<corresp id="fn001">*Correspondence: Juan Sainz <email xlink:type="simple">juan.sainz@genyo.es</email>
</corresp>
<fn fn-type="other" id="fn002"><p>This article was submitted to Fungi and Their Interactions, a section of the journal Frontiers in Microbiology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>12</day>
<month>8</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>7</volume>
<elocation-id>1243</elocation-id>
<history><date date-type="received"><day>14</day>
<month>4</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>26</day>
<month>7</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2016 Lupiañez, Villaescusa, Carvalho, Springer, Lackner, Sánchez-Maldonado, Canet, Cunha, Segura-Catena, Alcazar-Fuoli, Solano, Fianchi, Pagano, Potenza, Aguado, Luppi, Cuenca-Estrella, Lass-Flörl, Einsele, Vázquez, PCRAGA Study Group, Ríos-Tamayo, Loeffler, Jurado and Sainz.</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Lupiañez, Villaescusa, Carvalho, Springer, Lackner, Sánchez-Maldonado, Canet, Cunha, Segura-Catena, Alcazar-Fuoli, Solano, Fianchi, Pagano, Potenza, Aguado, Luppi, Cuenca-Estrella, Lass-Flörl, Einsele, Vázquez, PCRAGA Study Group, Ríos-Tamayo, Loeffler, Jurado and Sainz</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Invasive Aspergillosis (IA) is an opportunistic infection caused by <italic>Aspergillus</italic>
, a ubiquitously present airborne pathogenic mold. A growing number of studies suggest a major host genetic component in disease susceptibility. Here, we evaluated whether 14 single-nucleotide polymorphisms within <italic>NF</italic>
κ<italic>B1, NF</italic>
κ<italic>B2, RelA, RelB, Rel</italic>
, and <italic>IRF4</italic>
genes influence the risk of IA in a population of 834 high-risk patients (157 IA and 677 non-IA) recruited through a collaborative effort involving the aspBIOmics consortium and four European clinical institutions. No significant overall associations between selected SNPs and the risk of IA were found in this large cohort. Although a hematopoietic stem cell transplantation (HSCT)-stratified analysis revealed that carriers of the <italic>IRF4</italic>
<sub>rs12203592T/T</sub>
genotype had a six-fold increased risk of developing the infection when compared with those carrying the C allele (OR<sub>REC</sub>
= 6.24, 95%CI 1.25–31.2, <italic>P</italic>
= 0.026), the association of this variant with IA risk did not reach significance at experiment-wide significant threshold. In addition, we found an association of the IRF4<sub>AAT<underline>C</underline>
</sub>
and IRF4<sub>GGT<underline>C</underline>
</sub>
haplotypes (not including the <italic>IRF4</italic>
<sub>rs12203592T</sub>
risk allele) with a decreased risk of IA but the magnitude of the association was similar to the one observed in the single-SNP analysis, which indicated that the haplotypic effect on IA risk was likely due to the <italic>IRF4</italic>
<sub>rs12203592</sub>
SNP. Finally, no evidence of significant interactions among the genetic markers tested and the risk of IA was found. These results suggest that the SNPs on the studied genes do not have a clinically relevant impact on the risk of developing IA.</p>
</abstract>
<kwd-group><kwd>Invasive Aspergillosis</kwd>
<kwd>genetic polymorphisms</kwd>
<kwd>susceptibility</kwd>
<kwd>NFκB-related genes</kwd>
<kwd>interaction</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">Instituto de Salud Carlos III<named-content content-type="fundref-id">10.13039/501100004587</named-content>
</funding-source>
<award-id rid="cn001">PI12/02688</award-id>
</award-group>
<award-group><funding-source id="cn002">Ministerio de Ciencia e Innovación<named-content content-type="fundref-id">10.13039/501100004837</named-content>
</funding-source>
<award-id rid="cn002">PIM2010EPA-00756</award-id>
</award-group>
<award-group><funding-source id="cn003">Deutsche Forschungsgemeinschaft<named-content content-type="fundref-id">10.13039/501100001659</named-content>
</funding-source>
<award-id rid="cn003">the Collaborative Research Center / Transregio 124 FungiNet</award-id>
</award-group>
<award-group><funding-source id="cn004">Austrian Science Fund<named-content content-type="fundref-id">10.13039/501100002428</named-content>
</funding-source>
<award-id rid="cn004">FWF I-656-B09</award-id>
</award-group>
<award-group><funding-source id="cn005">Fundação para a Ciência e a Tecnologia<named-content content-type="fundref-id">10.13039/501100001871</named-content>
</funding-source>
<award-id rid="cn005">PEst-C/SAU/LA0026/2013</award-id>
<award-id rid="cn005">IF/00735/2014</award-id>
<award-id rid="cn005">SFRH/BPD/96176/2013</award-id>
</award-group>
</funding-group>
<counts><fig-count count="1"></fig-count>
<table-count count="6"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="95"></ref-count>
<page-count count="11"></page-count>
<word-count count="8961"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Autriche</li>
<li>Espagne</li>
<li>Italie</li>
<li>Portugal</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Lupia Ez, Carmen B" sort="Lupia Ez, Carmen B" uniqKey="Lupia Ez C" first="Carmen B." last="Lupia Ez">Carmen B. Lupia Ez</name>
</noRegion>
<name sortKey="Aguado, Jose M" sort="Aguado, Jose M" uniqKey="Aguado J" first="José M." last="Aguado">José M. Aguado</name>
<name sortKey="Alcazar Fuoli, Laura" sort="Alcazar Fuoli, Laura" uniqKey="Alcazar Fuoli L" first="Laura" last="Alcazar-Fuoli">Laura Alcazar-Fuoli</name>
<name sortKey="Canet, Luz M" sort="Canet, Luz M" uniqKey="Canet L" first="Luz M." last="Canet">Luz M. Canet</name>
<name sortKey="Cuenca Estrella, Manuel" sort="Cuenca Estrella, Manuel" uniqKey="Cuenca Estrella M" first="Manuel" last="Cuenca-Estrella">Manuel Cuenca-Estrella</name>
<name sortKey="Jurado, Manuel" sort="Jurado, Manuel" uniqKey="Jurado M" first="Manuel" last="Jurado">Manuel Jurado</name>
<name sortKey="Jurado, Manuel" sort="Jurado, Manuel" uniqKey="Jurado M" first="Manuel" last="Jurado">Manuel Jurado</name>
<name sortKey="Lupia Ez, Carmen B" sort="Lupia Ez, Carmen B" uniqKey="Lupia Ez C" first="Carmen B." last="Lupia Ez">Carmen B. Lupia Ez</name>
<name sortKey="Rios Tamayo, Rafael" sort="Rios Tamayo, Rafael" uniqKey="Rios Tamayo R" first="Rafael" last="Ríos-Tamayo">Rafael Ríos-Tamayo</name>
<name sortKey="Rios Tamayo, Rafael" sort="Rios Tamayo, Rafael" uniqKey="Rios Tamayo R" first="Rafael" last="Ríos-Tamayo">Rafael Ríos-Tamayo</name>
<name sortKey="Sainz, Juan" sort="Sainz, Juan" uniqKey="Sainz J" first="Juan" last="Sainz">Juan Sainz</name>
<name sortKey="Sainz, Juan" sort="Sainz, Juan" uniqKey="Sainz J" first="Juan" last="Sainz">Juan Sainz</name>
<name sortKey="Sanchez Maldonado, Jose M" sort="Sanchez Maldonado, Jose M" uniqKey="Sanchez Maldonado J" first="José M." last="Sánchez-Maldonado">José M. Sánchez-Maldonado</name>
<name sortKey="Segura Catena, Juana" sort="Segura Catena, Juana" uniqKey="Segura Catena J" first="Juana" last="Segura-Catena">Juana Segura-Catena</name>
<name sortKey="Segura Catena, Juana" sort="Segura Catena, Juana" uniqKey="Segura Catena J" first="Juana" last="Segura-Catena">Juana Segura-Catena</name>
<name sortKey="Solano, Carlos" sort="Solano, Carlos" uniqKey="Solano C" first="Carlos" last="Solano">Carlos Solano</name>
<name sortKey="Vazquez, Lourdes" sort="Vazquez, Lourdes" uniqKey="Vazquez L" first="Lourdes" last="Vázquez">Lourdes Vázquez</name>
<name sortKey="Villaescusa, Maria T" sort="Villaescusa, Maria T" uniqKey="Villaescusa M" first="María T." last="Villaescusa">María T. Villaescusa</name>
<name sortKey="Villaescusa, Maria T" sort="Villaescusa, Maria T" uniqKey="Villaescusa M" first="María T." last="Villaescusa">María T. Villaescusa</name>
</country>
<country name="Portugal"><noRegion><name sortKey="Carvalho, Agostinho" sort="Carvalho, Agostinho" uniqKey="Carvalho A" first="Agostinho" last="Carvalho">Agostinho Carvalho</name>
</noRegion>
<name sortKey="Carvalho, Agostinho" sort="Carvalho, Agostinho" uniqKey="Carvalho A" first="Agostinho" last="Carvalho">Agostinho Carvalho</name>
<name sortKey="Cunha, Cristina" sort="Cunha, Cristina" uniqKey="Cunha C" first="Cristina" last="Cunha">Cristina Cunha</name>
<name sortKey="Cunha, Cristina" sort="Cunha, Cristina" uniqKey="Cunha C" first="Cristina" last="Cunha">Cristina Cunha</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Springer, Jan" sort="Springer, Jan" uniqKey="Springer J" first="Jan" last="Springer">Jan Springer</name>
</noRegion>
<name sortKey="Einsele, Hermann" sort="Einsele, Hermann" uniqKey="Einsele H" first="Hermann" last="Einsele">Hermann Einsele</name>
<name sortKey="Loeffler, Jurgen" sort="Loeffler, Jurgen" uniqKey="Loeffler J" first="Jurgen" last="Loeffler">Jurgen Loeffler</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Lackner, Michaela" sort="Lackner, Michaela" uniqKey="Lackner M" first="Michaela" last="Lackner">Michaela Lackner</name>
</noRegion>
<name sortKey="Lass Florl, Cornelia" sort="Lass Florl, Cornelia" uniqKey="Lass Florl C" first="Cornelia" last="Lass-Flörl">Cornelia Lass-Flörl</name>
</country>
<country name="Italie"><noRegion><name sortKey="Fianchi, Luana" sort="Fianchi, Luana" uniqKey="Fianchi L" first="Luana" last="Fianchi">Luana Fianchi</name>
</noRegion>
<name sortKey="Luppi, Mario" sort="Luppi, Mario" uniqKey="Luppi M" first="Mario" last="Luppi">Mario Luppi</name>
<name sortKey="Pagano, Livio" sort="Pagano, Livio" uniqKey="Pagano L" first="Livio" last="Pagano">Livio Pagano</name>
<name sortKey="Potenza, Leonardo" sort="Potenza, Leonardo" uniqKey="Potenza L" first="Leonardo" last="Potenza">Leonardo Potenza</name>
</country>
</tree>
</affiliations>
</record>
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