Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
Identifieur interne : 000988 ( Pmc/Checkpoint ); précédent : 000987; suivant : 000989Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
Auteurs : Alessandro Guidotti [États-Unis] ; Dennis R. Grayson [États-Unis] ; Hector J. Caruncho [Canada]Source :
- Frontiers in Cellular Neuroscience [ 1662-5102 ] ; 2016.
Abstract
REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix (ECM), RELN binds to VLDL, APOE2, and α3β2 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal neurons. Reduced levels of RELN expression in the adult brain induce cognitive impairment and dendritic spine density deficits. RELN supplementation recovers these deficits suggesting a trophic action for RELN in synaptic plasticity. We and others have shown that altered RELN expression in schizophrenia (SZ) and bipolar (BP) disorder patients is difficult to reconcile with classical Mendelian genetic disorders and it is instead plausible to associate these disorders with altered epigenetic homeostasis. Support for the contribution of altered epigenetic mechanisms in the down-regulation of RELN expression in corticolimbic structures of psychotic patients includes the concomitant increase of DNA-methyltransferases and the increased levels of the methyl donor S-adenosylmethionine (SAM). It is hypothesized that these conditions lead to RELN promoter hypermethylation and a reduction in RELN protein amounts in psychotic patients. The decreased synthesis and release of RELN from GABAergic corticolimbic neurons could serve as a model to elucidate the epigenetic pathophysiological mechanisms acting at pyramidal neuron dendrites that regulate synaptic plasticity and cognition in psychotic and non-psychotic subjects.
Url:
DOI: 10.3389/fncel.2016.00089
PubMed: 27092053
PubMed Central: 4820443
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:4820443Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders</title><author><name sortKey="Guidotti, Alessandro" sort="Guidotti, Alessandro" uniqKey="Guidotti A" first="Alessandro" last="Guidotti">Alessandro Guidotti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago</institution><country>Chicago, IL, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author><author><name sortKey="Grayson, Dennis R" sort="Grayson, Dennis R" uniqKey="Grayson D" first="Dennis R." last="Grayson">Dennis R. Grayson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago</institution><country>Chicago, IL, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author><author><name sortKey="Caruncho, Hector J" sort="Caruncho, Hector J" uniqKey="Caruncho H" first="Hector J." last="Caruncho">Hector J. Caruncho</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>College of Pharmacy and Nutrition, University of Saskatchewan</institution><country>Saskatoon, SK, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27092053</idno><idno type="pmc">4820443</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820443</idno><idno type="RBID">PMC:4820443</idno><idno type="doi">10.3389/fncel.2016.00089</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000882</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000882</idno><idno type="wicri:Area/Pmc/Curation">000882</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000882</idno><idno type="wicri:Area/Pmc/Checkpoint">000988</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000988</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders</title><author><name sortKey="Guidotti, Alessandro" sort="Guidotti, Alessandro" uniqKey="Guidotti A" first="Alessandro" last="Guidotti">Alessandro Guidotti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago</institution><country>Chicago, IL, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author><author><name sortKey="Grayson, Dennis R" sort="Grayson, Dennis R" uniqKey="Grayson D" first="Dennis R." last="Grayson">Dennis R. Grayson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago</institution><country>Chicago, IL, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author><author><name sortKey="Caruncho, Hector J" sort="Caruncho, Hector J" uniqKey="Caruncho H" first="Hector J." last="Caruncho">Hector J. Caruncho</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>College of Pharmacy and Nutrition, University of Saskatchewan</institution><country>Saskatoon, SK, Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Spinal Surgery,The First Hospital of Jilin University, No.71,Xinmin Avenue, Chaoyang District, Changchun, Jilin Province 130021</wicri:regionArea><wicri:noRegion>Jilin Province 130021</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Cellular Neuroscience</title><idno type="eISSN">1662-5102</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix (ECM), RELN binds to VLDL, APOE2, and α3β2 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal neurons. Reduced levels of RELN expression in the adult brain induce cognitive impairment and dendritic spine density deficits. RELN supplementation recovers these deficits suggesting a trophic action for RELN in synaptic plasticity. We and others have shown that altered RELN expression in schizophrenia (SZ) and bipolar (BP) disorder patients is difficult to reconcile with classical Mendelian genetic disorders and it is instead plausible to associate these disorders with altered epigenetic homeostasis. Support for the contribution of altered epigenetic mechanisms in the down-regulation of RELN expression in corticolimbic structures of psychotic patients includes the concomitant increase of DNA-methyltransferases and the increased levels of the methyl donor S-adenosylmethionine (SAM). It is hypothesized that these conditions lead to RELN promoter hypermethylation and a reduction in RELN protein amounts in psychotic patients. The decreased synthesis and release of RELN from GABAergic corticolimbic neurons could serve as a model to elucidate the epigenetic pathophysiological mechanisms acting at pyramidal neuron dendrites that regulate synaptic plasticity and cognition in psychotic and non-psychotic subjects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abdolmaleky, H M" uniqKey="Abdolmaleky H">H. M. Abdolmaleky</name></author><author><name sortKey="Cheng, K H" uniqKey="Cheng K">K. H. Cheng</name></author><author><name sortKey="Russo, A" uniqKey="Russo A">A. Russo</name></author><author><name sortKey="Smith, C L" uniqKey="Smith C">C. L. Smith</name></author><author><name sortKey="Faraone, S V" uniqKey="Faraone S">S. V. Faraone</name></author><author><name sortKey="Wilcox, M" uniqKey="Wilcox M">M. Wilcox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aberg, K A" uniqKey="Aberg K">K. A. Aberg</name></author><author><name sortKey="Mcclay, J L" uniqKey="Mcclay J">J. L. McClay</name></author><author><name sortKey="Nerella, S" uniqKey="Nerella S">S. Nerella</name></author><author><name sortKey="Clark, S" uniqKey="Clark S">S. Clark</name></author><author><name sortKey="Kumar, G" uniqKey="Kumar G">G. Kumar</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alcantara, S" uniqKey="Alcantara S">S. Alcántara</name></author><author><name sortKey="Ruiz, M" uniqKey="Ruiz M">M. Ruiz</name></author><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author><author><name sortKey="Ezan, F" uniqKey="Ezan F">F. Ezan</name></author><author><name sortKey="De Lecea, L" uniqKey="De Lecea L">L. de Lecea</name></author><author><name sortKey="Curran, T" uniqKey="Curran T">T. Curran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ammassari Teule, M" uniqKey="Ammassari Teule M">M. Ammassari-Teule</name></author><author><name sortKey="Sgobio, C" uniqKey="Sgobio C">C. Sgobio</name></author><author><name sortKey="Biamonte, F" uniqKey="Biamonte F">F. Biamonte</name></author><author><name sortKey="Marrone, C" uniqKey="Marrone C">C. Marrone</name></author><author><name sortKey="Mercuri, N B" uniqKey="Mercuri N">N. B. Mercuri</name></author><author><name sortKey="Keller, F" uniqKey="Keller F">F. Keller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beffert, U" uniqKey="Beffert U">U. Beffert</name></author><author><name sortKey="Durudas, A" uniqKey="Durudas A">A. Durudas</name></author><author><name sortKey="Weeber, E J" uniqKey="Weeber E">E. J. Weeber</name></author><author><name sortKey="Stolt, P C" uniqKey="Stolt P">P. C. Stolt</name></author><author><name sortKey="Giehl, K M" uniqKey="Giehl K">K. M. Giehl</name></author><author><name sortKey="Sweatt, J D" uniqKey="Sweatt J">J. D. Sweatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benes, F M" uniqKey="Benes F">F. M. Benes</name></author><author><name sortKey="Lim, B" uniqKey="Lim B">B. Lim</name></author><author><name sortKey="Matzilevich, D" uniqKey="Matzilevich D">D. Matzilevich</name></author><author><name sortKey="Walsh, J P" uniqKey="Walsh J">J. P. Walsh</name></author><author><name sortKey="Subburaju, S" uniqKey="Subburaju S">S. Subburaju</name></author><author><name sortKey="Minns, M" uniqKey="Minns M">M. Minns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blaze, J" uniqKey="Blaze J">J. Blaze</name></author><author><name sortKey="Scheuing, L" uniqKey="Scheuing L">L. Scheuing</name></author><author><name sortKey="Roth, T L" uniqKey="Roth T">T. L. Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bock, H H" uniqKey="Bock H">H. H. Bock</name></author><author><name sortKey="Jossin, Y" uniqKey="Jossin Y">Y. Jossin</name></author><author><name sortKey="May, P" uniqKey="May P">P. May</name></author><author><name sortKey="Bergner, O" uniqKey="Bergner O">O. Bergner</name></author><author><name sortKey="Herz, J" uniqKey="Herz J">J. Herz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brigman, J L" uniqKey="Brigman J">J. L. Brigman</name></author><author><name sortKey="Padukiewicz, K E" uniqKey="Padukiewicz K">K. E. Padukiewicz</name></author><author><name sortKey="Sutherland, M L" uniqKey="Sutherland M">M. L. Sutherland</name></author><author><name sortKey="Rothblat, L A" uniqKey="Rothblat L">L. A. Rothblat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author><author><name sortKey="Dopeso Reyes, I G" uniqKey="Dopeso Reyes I">I. G. Dopeso-Reyes</name></author><author><name sortKey="Loza, M I" uniqKey="Loza M">M. I. Loza</name></author><author><name sortKey="Rodriguez, M A" uniqKey="Rodriguez M">M. A. Rodríguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author><author><name sortKey="Agis Balboa, R C" uniqKey="Agis Balboa R">R. C. Agis-Balboa</name></author><author><name sortKey="Pinna, G" uniqKey="Pinna G">G. Pinna</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Sharma, R P" uniqKey="Sharma R">R. P. Sharma</name></author><author><name sortKey="Costa, R H" uniqKey="Costa R">R. H. Costa</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, S M" uniqKey="Cohen S">S. M. Cohen</name></author><author><name sortKey="Nichols, A" uniqKey="Nichols A">A. Nichols</name></author><author><name sortKey="Wyatt, R" uniqKey="Wyatt R">R. Wyatt</name></author><author><name sortKey="Pollin, W" uniqKey="Pollin W">W. Pollin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Davis, J" uniqKey="Davis J">J. Davis</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Noh, J S" uniqKey="Noh J">J. S. Noh</name></author><author><name sortKey="Tremolizzo, L" uniqKey="Tremolizzo L">L. Tremolizzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Davis, J" uniqKey="Davis J">J. Davis</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Pappas, G D" uniqKey="Pappas G">G. D. Pappas</name></author><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author><author><name sortKey="Homayouni, R" uniqKey="Homayouni R">R. Homayouni</name></author><author><name sortKey="Keshvara, L" uniqKey="Keshvara L">L. Keshvara</name></author><author><name sortKey="Rice, D S" uniqKey="Rice D">D. S. Rice</name></author><author><name sortKey="Sheldon, M" uniqKey="Sheldon M">M. Sheldon</name></author><author><name sortKey="Curran, T" uniqKey="Curran T">T. Curran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author><author><name sortKey="Miao, G G" uniqKey="Miao G">G. G. Miao</name></author><author><name sortKey="Chen, S C" uniqKey="Chen S">S. C. Chen</name></author><author><name sortKey="Soares, H D" uniqKey="Soares H">H. D. Soares</name></author><author><name sortKey="Morgan, J I" uniqKey="Morgan J">J. I. Morgan</name></author><author><name sortKey="Curran, T" uniqKey="Curran T">T. Curran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dazzo, E" uniqKey="Dazzo E">E. Dazzo</name></author><author><name sortKey="Fanciulli, M" uniqKey="Fanciulli M">M. Fanciulli</name></author><author><name sortKey="Serioli, E" uniqKey="Serioli E">E. Serioli</name></author><author><name sortKey="Minervini, G" uniqKey="Minervini G">G. Minervini</name></author><author><name sortKey="Pulitano, P" uniqKey="Pulitano P">P. Pulitano</name></author><author><name sortKey="Binelli, S" uniqKey="Binelli S">S. Binelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Agis Balboa, R C" uniqKey="Agis Balboa R">R. C. Agis-Balboa</name></author><author><name sortKey="Simonini, M V" uniqKey="Simonini M">M. V. Simonini</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Caruncho, H" uniqKey="Caruncho H">H. Caruncho</name></author><author><name sortKey="Liu, W S" uniqKey="Liu W">W. S. Liu</name></author><author><name sortKey="Smalheiser, N R" uniqKey="Smalheiser N">N. R. Smalheiser</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author><author><name sortKey="Matrisciano, F" uniqKey="Matrisciano F">F. Matrisciano</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fatemi, S H" uniqKey="Fatemi S">S. H. Fatemi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fatemi, S H" uniqKey="Fatemi S">S. H. Fatemi</name></author><author><name sortKey="Earle, J A" uniqKey="Earle J">J. A. Earle</name></author><author><name sortKey="Mcmenomy, T" uniqKey="Mcmenomy T">T. McMenomy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fenton, E Y" uniqKey="Fenton E">E. Y. Fenton</name></author><author><name sortKey="Fournier, N M" uniqKey="Fournier N">N. M. Fournier</name></author><author><name sortKey="Lussier, A L" uniqKey="Lussier A">A. L. Lussier</name></author><author><name sortKey="Romay Tallon, R" uniqKey="Romay Tallon R">R. Romay-Tallon</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author><author><name sortKey="Kalynchuk, L E" uniqKey="Kalynchuk L">L. E. Kalynchuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Folsom, T D" uniqKey="Folsom T">T. D. Folsom</name></author><author><name sortKey="Fatemi, S H" uniqKey="Fatemi S">S. H. Fatemi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glantz, L A" uniqKey="Glantz L">L. A. Glantz</name></author><author><name sortKey="Lewis, D A" uniqKey="Lewis D">D. A. Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldowitz, D" uniqKey="Goldowitz D">D. Goldowitz</name></author><author><name sortKey="Koch, J" uniqKey="Koch J">J. Koch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Jia, X" uniqKey="Jia X">X. Jia</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Sharma, R P" uniqKey="Sharma R">R. P. Sharma</name></author><author><name sortKey="Mitchell, C P" uniqKey="Mitchell C">C. P. Mitchell</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Auta, J" uniqKey="Auta J">J. Auta</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author><author><name sortKey="Di Giorgi Gerevni, V" uniqKey="Di Giorgi Gerevni V">V. Di-Giorgi-Gerevni</name></author><author><name sortKey="Dwivedi, Y" uniqKey="Dwivedi Y">Y. Dwivedi</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Ruzicka, W" uniqKey="Ruzicka W">W. Ruzicka</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Pinna, G" uniqKey="Pinna G">G. Pinna</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hadj Sahraoui, N" uniqKey="Hadj Sahraoui N">N. Hadj-Sahraoui</name></author><author><name sortKey="Frederic, F" uniqKey="Frederic F">F. Frédéric</name></author><author><name sortKey="Delhaye Bouchaud, N" uniqKey="Delhaye Bouchaud N">N. Delhaye-Bouchaud</name></author><author><name sortKey="Mariani, J" uniqKey="Mariani J">J. Mariani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herz, J" uniqKey="Herz J">J. Herz</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiesberger, T" uniqKey="Hiesberger T">T. Hiesberger</name></author><author><name sortKey="Trommsdorff, M" uniqKey="Trommsdorff M">M. Trommsdorff</name></author><author><name sortKey="Howell, B W" uniqKey="Howell B">B. W. Howell</name></author><author><name sortKey="Goffinet, A" uniqKey="Goffinet A">A. Goffinet</name></author><author><name sortKey="Mumby, M C" uniqKey="Mumby M">M. C. Mumby</name></author><author><name sortKey="Cooper, J A" uniqKey="Cooper J">J. A. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, S E" uniqKey="Hong S">S. E. Hong</name></author><author><name sortKey="Shugart, Y Y" uniqKey="Shugart Y">Y. Y. Shugart</name></author><author><name sortKey="Huang, D T" uniqKey="Huang D">D. T. Huang</name></author><author><name sortKey="Shahwan, S A" uniqKey="Shahwan S">S. A. Shahwan</name></author><author><name sortKey="Grant, P E" uniqKey="Grant P">P. E. Grant</name></author><author><name sortKey="Hourihane, J O" uniqKey="Hourihane J">J. O. Hourihane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hourihane, J O" uniqKey="Hourihane J">J. O. Hourihane</name></author><author><name sortKey="Bennett, C P" uniqKey="Bennett C">C. P. Bennett</name></author><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Robb, S A" uniqKey="Robb S">S. A. Robb</name></author><author><name sortKey="Martin, N D" uniqKey="Martin N">N. D. Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howell, K R" uniqKey="Howell K">K. R. Howell</name></author><author><name sortKey="Pillai, A" uniqKey="Pillai A">A. Pillai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, H S" uniqKey="Huang H">H. S. Huang</name></author><author><name sortKey="Matevossian, A" uniqKey="Matevossian A">A. Matevossian</name></author><author><name sortKey="Whittle, C" uniqKey="Whittle C">C. Whittle</name></author><author><name sortKey="Kim, S Y" uniqKey="Kim S">S. Y. Kim</name></author><author><name sortKey="Schumacher, A" uniqKey="Schumacher A">A. Schumacher</name></author><author><name sortKey="Baker, S P" uniqKey="Baker S">S. P. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iafrati, J" uniqKey="Iafrati J">J. Iafrati</name></author><author><name sortKey="Orejarena, M J" uniqKey="Orejarena M">M. J. Orejarena</name></author><author><name sortKey="Lassalle, O" uniqKey="Lassalle O">O. Lassalle</name></author><author><name sortKey="Bouamrane, L" uniqKey="Bouamrane L">L. Bouamrane</name></author><author><name sortKey="Gonzalez Campo, C" uniqKey="Gonzalez Campo C">C. Gonzalez-Campo</name></author><author><name sortKey="Chavis, P" uniqKey="Chavis P">P. Chavis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Impagnatiello, F" uniqKey="Impagnatiello F">F. Impagnatiello</name></author><author><name sortKey="Guidotti, A R" uniqKey="Guidotti A">A. R. Guidotti</name></author><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author><author><name sortKey="Dwivedi, Y" uniqKey="Dwivedi Y">Y. Dwivedi</name></author><author><name sortKey="Caruncho, H" uniqKey="Caruncho H">H. Caruncho</name></author><author><name sortKey="Pisu, M G" uniqKey="Pisu M">M. G. Pisu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jossin, Y" uniqKey="Jossin Y">Y. Jossin</name></author><author><name sortKey="Bar, I" uniqKey="Bar I">I. Bar</name></author><author><name sortKey="Ignatova, N" uniqKey="Ignatova N">N. Ignatova</name></author><author><name sortKey="Tissir, F" uniqKey="Tissir F">F. Tissir</name></author><author><name sortKey="De Rouvroit, C L" uniqKey="De Rouvroit C">C. L. De Rouvroit</name></author><author><name sortKey="Goffinet, A M" uniqKey="Goffinet A">A. M. Goffinet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kadriu, B" uniqKey="Kadriu B">B. Kadriu</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kobow, K" uniqKey="Kobow K">K. Kobow</name></author><author><name sortKey="Jeske, I" uniqKey="Jeske I">I. Jeske</name></author><author><name sortKey="Hildebrandt, M" uniqKey="Hildebrandt M">M. Hildebrandt</name></author><author><name sortKey="Hauke, J" uniqKey="Hauke J">J. Hauke</name></author><author><name sortKey="Hahnen, E" uniqKey="Hahnen E">E. Hahnen</name></author><author><name sortKey="Buslei, R" uniqKey="Buslei R">R. Buslei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krueger, D D" uniqKey="Krueger D">D. D. Krueger</name></author><author><name sortKey="Howell, J L" uniqKey="Howell J">J. L. Howell</name></author><author><name sortKey="Hebert, B F" uniqKey="Hebert B">B. F. Hebert</name></author><author><name sortKey="Olausson, P" uniqKey="Olausson P">P. Olausson</name></author><author><name sortKey="Taylor, J R" uniqKey="Taylor J">J. R. Taylor</name></author><author><name sortKey="Nairn, A C" uniqKey="Nairn A">A. C. Nairn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, G" uniqKey="Kuo G">G. Kuo</name></author><author><name sortKey="Arnaud, L" uniqKey="Arnaud L">L. Arnaud</name></author><author><name sortKey="Kronstad O Rien, P" uniqKey="Kronstad O Rien P">P. Kronstad-O’Brien</name></author><author><name sortKey="Cooper, J A" uniqKey="Cooper J">J. A. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacor, P N" uniqKey="Lacor P">P. N. Lacor</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Auta, J" uniqKey="Auta J">J. Auta</name></author><author><name sortKey="Sugaya, I" uniqKey="Sugaya I">I. Sugaya</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levenson, J M" uniqKey="Levenson J">J. M. Levenson</name></author><author><name sortKey="Qiu, S" uniqKey="Qiu S">S. Qiu</name></author><author><name sortKey="Weeber, E J" uniqKey="Weeber E">E. J. Weeber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levenson, J M" uniqKey="Levenson J">J. M. Levenson</name></author><author><name sortKey="Roth, T L" uniqKey="Roth T">T. L. Roth</name></author><author><name sortKey="Lubin, F D" uniqKey="Lubin F">F. D. Lubin</name></author><author><name sortKey="Miller, C A" uniqKey="Miller C">C. A. Miller</name></author><author><name sortKey="Huang, I C" uniqKey="Huang I">I. C. Huang</name></author><author><name sortKey="Desai, P" uniqKey="Desai P">P. Desai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lintas, C" uniqKey="Lintas C">C. Lintas</name></author><author><name sortKey="Persico, A M" uniqKey="Persico A">A. M. Persico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W S" uniqKey="Liu W">W. S. Liu</name></author><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author><author><name sortKey="Rodriguez, M A" uniqKey="Rodriguez M">M. A. Rodriguez</name></author><author><name sortKey="Carboni, G" uniqKey="Carboni G">G. Carboni</name></author><author><name sortKey="Auta, J" uniqKey="Auta J">J. Auta</name></author><author><name sortKey="Lacor, P" uniqKey="Lacor P">P. Lacor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lussier, A L" uniqKey="Lussier A">A. L. Lussier</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author><author><name sortKey="Kalynchuk, L E" uniqKey="Kalynchuk L">L. E. Kalynchuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lussier, A L" uniqKey="Lussier A">A. L. Lussier</name></author><author><name sortKey="Lebedeva, K" uniqKey="Lebedeva K">K. Lebedeva</name></author><author><name sortKey="Fenton, E Y" uniqKey="Fenton E">E. Y. Fenton</name></author><author><name sortKey="Guskjolen, A" uniqKey="Guskjolen A">A. Guskjolen</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author><author><name sortKey="Kalynchuk, L L E" uniqKey="Kalynchuk L">L. L. E. Kalynchuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lussier, A L" uniqKey="Lussier A">A. L. Lussier</name></author><author><name sortKey="Romay Tall N, R" uniqKey="Romay Tall N R">R. Romay-Tallón</name></author><author><name sortKey="Kalynchuk, L E" uniqKey="Kalynchuk L">L. E. Kalynchuk</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maloku, E" uniqKey="Maloku E">E. Maloku</name></author><author><name sortKey="Covelo, I R" uniqKey="Covelo I">I. R. Covelo</name></author><author><name sortKey="Hanbauer, I" uniqKey="Hanbauer I">I. Hanbauer</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Kadriu, B" uniqKey="Kadriu B">B. Kadriu</name></author><author><name sortKey="Hu, Q" uniqKey="Hu Q">Q. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marrone, M C" uniqKey="Marrone M">M. C. Marrone</name></author><author><name sortKey="Marinelli, S" uniqKey="Marinelli S">S. Marinelli</name></author><author><name sortKey="Biamonte, F" uniqKey="Biamonte F">F. Biamonte</name></author><author><name sortKey="Keller, F" uniqKey="Keller F">F. Keller</name></author><author><name sortKey="Sgobio, C A" uniqKey="Sgobio C">C. A. Sgobio</name></author><author><name sortKey="Ammassari Teule, M" uniqKey="Ammassari Teule M">M. Ammassari-Teule</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrisciano, F" uniqKey="Matrisciano F">F. Matrisciano</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Gavin, D P" uniqKey="Gavin D">D. P. Gavin</name></author><author><name sortKey="Nicoletti, F" uniqKey="Nicoletti F">F. Nicoletti</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrisciano, F" uniqKey="Matrisciano F">F. Matrisciano</name></author><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author><author><name sortKey="Dalal, I" uniqKey="Dalal I">I. Dalal</name></author><author><name sortKey="Kadriu, B" uniqKey="Kadriu B">B. Kadriu</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mill, J" uniqKey="Mill J">J. Mill</name></author><author><name sortKey="Tang, T" uniqKey="Tang T">T. Tang</name></author><author><name sortKey="Kaminsky, Z" uniqKey="Kaminsky Z">Z. Kaminsky</name></author><author><name sortKey="Khare, T" uniqKey="Khare T">T. Khare</name></author><author><name sortKey="Yazdanpanah, S" uniqKey="Yazdanpanah S">S. Yazdanpanah</name></author><author><name sortKey="Bouchard, L" uniqKey="Bouchard L">L. Bouchard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitchell, C P" uniqKey="Mitchell C">C. P. Mitchell</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Kundakovic, M" uniqKey="Kundakovic M">M. Kundakovic</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niu, S" uniqKey="Niu S">S. Niu</name></author><author><name sortKey="Renfro, A" uniqKey="Renfro A">A. Renfro</name></author><author><name sortKey="Quattrocchi, C C" uniqKey="Quattrocchi C">C. C. Quattrocchi</name></author><author><name sortKey="Sheldon, M" uniqKey="Sheldon M">M. Sheldon</name></author><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niu, S" uniqKey="Niu S">S. Niu</name></author><author><name sortKey="Yabut, O" uniqKey="Yabut O">O. Yabut</name></author><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noh, J S" uniqKey="Noh J">J. S. Noh</name></author><author><name sortKey="Sharma, R P" uniqKey="Sharma R">R. P. Sharma</name></author><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Salvacion, A A" uniqKey="Salvacion A">A. A. Salvacion</name></author><author><name sortKey="Jia, X" uniqKey="Jia X">X. Jia</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ognibene, E" uniqKey="Ognibene E">E. Ognibene</name></author><author><name sortKey="Adriani, W" uniqKey="Adriani W">W. Adriani</name></author><author><name sortKey="Macri, S" uniqKey="Macri S">S. Macrì</name></author><author><name sortKey="Laviola, G" uniqKey="Laviola G">G. Laviola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palacios Garcia, I" uniqKey="Palacios Garcia I">I. Palacios-Garcia</name></author><author><name sortKey="Lara Vasquez, A" uniqKey="Lara Vasquez A">A. Lara-Vásquez</name></author><author><name sortKey="Montiel, J F" uniqKey="Montiel J">J. F. Montiel</name></author><author><name sortKey="Diaz Veliz, G F" uniqKey="Diaz Veliz G">G. F. Díaz-Véliz</name></author><author><name sortKey="Sepulveda, H" uniqKey="Sepulveda H">H. Sepúlveda</name></author><author><name sortKey="Utreras, E" uniqKey="Utreras E">E. Utreras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author><author><name sortKey="Impagnatiello, F" uniqKey="Impagnatiello F">F. Impagnatiello</name></author><author><name sortKey="Pisu, M G" uniqKey="Pisu M">M. G. Pisu</name></author><author><name sortKey="Uzunov, D P" uniqKey="Uzunov D">D. P. Uzunov</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author><author><name sortKey="Liu, W S" uniqKey="Liu W">W. S. Liu</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ptak, C" uniqKey="Ptak C">C. Ptak</name></author><author><name sortKey="Petronis, A" uniqKey="Petronis A">A. Petronis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pujadas, L" uniqKey="Pujadas L">L. Pujadas</name></author><author><name sortKey="Gruart, A" uniqKey="Gruart A">A. Gruart</name></author><author><name sortKey="Bosch, C" uniqKey="Bosch C">C. Bosch</name></author><author><name sortKey="Delgado, L" uniqKey="Delgado L">L. Delgado</name></author><author><name sortKey="Teixeira, C M" uniqKey="Teixeira C">C. M. Teixeira</name></author><author><name sortKey="Rossi, D" uniqKey="Rossi D">D. Rossi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, L" uniqKey="Qin L">L. Qin</name></author><author><name sortKey="Tu, W" uniqKey="Tu W">W. Tu</name></author><author><name sortKey="Sun, W" uniqKey="Sun W">W. Sun</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Razin, A" uniqKey="Razin A">A. Razin</name></author><author><name sortKey="Shemer, R" uniqKey="Shemer R">R. Shemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rice, D S" uniqKey="Rice D">D. S. Rice</name></author><author><name sortKey="Sheldon, M" uniqKey="Sheldon M">M. Sheldon</name></author><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author><author><name sortKey="Nakajima, K" uniqKey="Nakajima K">K. Nakajima</name></author><author><name sortKey="Goldowitz, D" uniqKey="Goldowitz D">D. Goldowitz</name></author><author><name sortKey="Curran, T" uniqKey="Curran T">T. Curran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, M A" uniqKey="Rodriguez M">M. A. Rodriguez</name></author><author><name sortKey="Pesold, C" uniqKey="Pesold C">C. Pesold</name></author><author><name sortKey="Liu, W S" uniqKey="Liu W">W. S. Liu</name></author><author><name sortKey="Kriho, V" uniqKey="Kriho V">V. Kriho</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Pappas, G D" uniqKey="Pappas G">G. D. Pappas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, J T" uniqKey="Rogers J">J. T. Rogers</name></author><author><name sortKey="Rusiana, I" uniqKey="Rusiana I">I. Rusiana</name></author><author><name sortKey="Trotter, J" uniqKey="Trotter J">J. Trotter</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E. Donaldson</name></author><author><name sortKey="Pak, D T" uniqKey="Pak D">D. T. Pak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, J T" uniqKey="Rogers J">J. T. Rogers</name></author><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author><author><name sortKey="Trotter, J H" uniqKey="Trotter J">J. H. Trotter</name></author><author><name sortKey="Rusiana, I" uniqKey="Rusiana I">I. Rusiana</name></author><author><name sortKey="Peters, M M" uniqKey="Peters M">M. M. Peters</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruzicka, W B" uniqKey="Ruzicka W">W. B. Ruzicka</name></author><author><name sortKey="Zhubi, A" uniqKey="Zhubi A">A. Zhubi</name></author><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Satta, R" uniqKey="Satta R">R. Satta</name></author><author><name sortKey="Maloku, E" uniqKey="Maloku E">E. Maloku</name></author><author><name sortKey="Zhubi, A" uniqKey="Zhubi A">A. Zhubi</name></author><author><name sortKey="Pibiri, F" uniqKey="Pibiri F">F. Pibiri</name></author><author><name sortKey="Hajos, M" uniqKey="Hajos M">M. Hajos</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, R P" uniqKey="Sharma R">R. P. Sharma</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Gavin, D P" uniqKey="Gavin D">D. P. Gavin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shifman, S" uniqKey="Shifman S">S. Shifman</name></author><author><name sortKey="Johannesson, M" uniqKey="Johannesson M">M. Johannesson</name></author><author><name sortKey="Bronstein, M" uniqKey="Bronstein M">M. Bronstein</name></author><author><name sortKey="Chen, S X" uniqKey="Chen S">S. X. Chen</name></author><author><name sortKey="Collier, D A" uniqKey="Collier D">D. A. Collier</name></author><author><name sortKey="Craddock, N J" uniqKey="Craddock N">N. J. Craddock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stranahan, A M" uniqKey="Stranahan A">A. M. Stranahan</name></author><author><name sortKey="Salas Vega, S" uniqKey="Salas Vega S">S. Salas-Vega</name></author><author><name sortKey="Jiam, N T" uniqKey="Jiam N">N. T. Jiam</name></author><author><name sortKey="Gallagher, M" uniqKey="Gallagher M">M. Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strasser, V" uniqKey="Strasser V">V. Strasser</name></author><author><name sortKey="Fasching, D" uniqKey="Fasching D">D. Fasching</name></author><author><name sortKey="Hauser, C" uniqKey="Hauser C">C. Hauser</name></author><author><name sortKey="Mayer, H" uniqKey="Mayer H">H. Mayer</name></author><author><name sortKey="Bock, H H" uniqKey="Bock H">H. H. Bock</name></author><author><name sortKey="Hiesberger, T" uniqKey="Hiesberger T">T. Hiesberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, L" uniqKey="Sui L">L. Sui</name></author><author><name sortKey="Li, B M" uniqKey="Li B">B.-M. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, L" uniqKey="Sui L">L. Sui</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Ju, L H" uniqKey="Ju L">L.-H. Ju</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szyf, M" uniqKey="Szyf M">M. Szyf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tochigi, M" uniqKey="Tochigi M">M. Tochigi</name></author><author><name sortKey="Iwamoto, K" uniqKey="Iwamoto K">K. Iwamoto</name></author><author><name sortKey="Bundo, M" uniqKey="Bundo M">M. Bundo</name></author><author><name sortKey="Komori, A" uniqKey="Komori A">A. Komori</name></author><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T. Sasaki</name></author><author><name sortKey="Kato, N" uniqKey="Kato N">N. Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremolizzo, L" uniqKey="Tremolizzo L">L. Tremolizzo</name></author><author><name sortKey="Carboni, G" uniqKey="Carboni G">G. Carboni</name></author><author><name sortKey="Ruzicka, W B" uniqKey="Ruzicka W">W. B. Ruzicka</name></author><author><name sortKey="Mitchell, C P" uniqKey="Mitchell C">C. P. Mitchell</name></author><author><name sortKey="Sugaya, I" uniqKey="Sugaya I">I. Sugaya</name></author><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tremolizzo, L" uniqKey="Tremolizzo L">L. Tremolizzo</name></author><author><name sortKey="Doueiri, M S" uniqKey="Doueiri M">M. S. Doueiri</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author><author><name sortKey="Davis, J" uniqKey="Davis J">J. Davis</name></author><author><name sortKey="Pinna, G" uniqKey="Pinna G">G. Pinna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trommsdorff, M" uniqKey="Trommsdorff M">M. Trommsdorff</name></author><author><name sortKey="Gotthardt, M" uniqKey="Gotthardt M">M. Gotthardt</name></author><author><name sortKey="Hiesberger, T" uniqKey="Hiesberger T">T. Hiesberger</name></author><author><name sortKey="Shelton, J" uniqKey="Shelton J">J. Shelton</name></author><author><name sortKey="Stockinger, W" uniqKey="Stockinger W">W. Stockinger</name></author><author><name sortKey="Nimpf, J" uniqKey="Nimpf J">J. Nimpf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author><author><name sortKey="Dwivedi, Y" uniqKey="Dwivedi Y">Y. Dwivedi</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Impagnatiello, F" uniqKey="Impagnatiello F">F. Impagnatiello</name></author><author><name sortKey="Manev, R" uniqKey="Manev R">R. Manev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Pibiri, F" uniqKey="Pibiri F">F. Pibiri</name></author><author><name sortKey="Kadriu, B" uniqKey="Kadriu B">B. Kadriu</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tueting, P" uniqKey="Tueting P">P. Tueting</name></author><author><name sortKey="Doueiri, M S" uniqKey="Doueiri M">M. S. Doueiri</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author><author><name sortKey="Costa, E" uniqKey="Costa E">E. Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Caruncho, H J" uniqKey="Caruncho H">H. J. Caruncho</name></author><author><name sortKey="Liu, W S" uniqKey="Liu W">W. S. Liu</name></author><author><name sortKey="Davis, J" uniqKey="Davis J">J. Davis</name></author><author><name sortKey="Satta, R" uniqKey="Satta R">R. Satta</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veldic, M" uniqKey="Veldic M">M. Veldic</name></author><author><name sortKey="Kadriu, B" uniqKey="Kadriu B">B. Kadriu</name></author><author><name sortKey="Maloku, E" uniqKey="Maloku E">E. Maloku</name></author><author><name sortKey="Agis Balboa, R C" uniqKey="Agis Balboa R">R. C. Agis-Balboa</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Davis, J M" uniqKey="Davis J">J. M. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventruti, A" uniqKey="Ventruti A">A. Ventruti</name></author><author><name sortKey="Kazdoba, T M" uniqKey="Kazdoba T">T. M. Kazdoba</name></author><author><name sortKey="Niu, S" uniqKey="Niu S">S. Niu</name></author><author><name sortKey="D Rcangelo, G" uniqKey="D Rcangelo G">G. D’Arcangelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Hong, Y" uniqKey="Hong Y">Y. Hong</name></author><author><name sortKey="Zou, L" uniqKey="Zou L">L. Zou</name></author><author><name sortKey="Zhong, R" uniqKey="Zhong R">R. Zhong</name></author><author><name sortKey="Zhu, B" uniqKey="Zhu B">B. Zhu</name></author><author><name sortKey="Shen, N" uniqKey="Shen N">N. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weaver, I C" uniqKey="Weaver I">I. C. Weaver</name></author><author><name sortKey="Champagne, F A" uniqKey="Champagne F">F. A. Champagne</name></author><author><name sortKey="Brown, S E" uniqKey="Brown S">S. E. Brown</name></author><author><name sortKey="Dymov, S" uniqKey="Dymov S">S. Dymov</name></author><author><name sortKey="Sharma, S" uniqKey="Sharma S">S. Sharma</name></author><author><name sortKey="Meaney, M J" uniqKey="Meaney M">M. J. Meaney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weaver, I C" uniqKey="Weaver I">I. C. Weaver</name></author><author><name sortKey="Meaney, M J" uniqKey="Meaney M">M. J. Meaney</name></author><author><name sortKey="Szyf, M" uniqKey="Szyf M">M. Szyf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wedenoja, J" uniqKey="Wedenoja J">J. Wedenoja</name></author><author><name sortKey="Tuulio Henriksson, A" uniqKey="Tuulio Henriksson A">A. Tuulio-Henriksson</name></author><author><name sortKey="Suvisaari, J" uniqKey="Suvisaari J">J. Suvisaari</name></author><author><name sortKey="Loukola, A" uniqKey="Loukola A">A. Loukola</name></author><author><name sortKey="Paunio, T" uniqKey="Paunio T">T. Paunio</name></author><author><name sortKey="Partonen, T" uniqKey="Partonen T">T. Partonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wyatt, R J" uniqKey="Wyatt R">R. J. Wyatt</name></author><author><name sortKey="Benedict, A" uniqKey="Benedict A">A. Benedict</name></author><author><name sortKey="Davis, J" uniqKey="Davis J">J. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Mundo, E" uniqKey="Mundo E">E. Mundo</name></author><author><name sortKey="Macciardi, F" uniqKey="Macciardi F">F. Macciardi</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhubi, A" uniqKey="Zhubi A">A. Zhubi</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Dong, E" uniqKey="Dong E">E. Dong</name></author><author><name sortKey="Cook, E H" uniqKey="Cook E">E. H. Cook</name></author><author><name sortKey="Guidotti, A" uniqKey="Guidotti A">A. Guidotti</name></author><author><name sortKey="Grayson, D R" uniqKey="Grayson D">D. R. Grayson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">Front Cell Neurosci</journal-id><journal-id journal-id-type="publisher-id">Front. Cell. Neurosci.</journal-id><journal-title-group><journal-title>Frontiers in Cellular Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1662-5102</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27092053</article-id><article-id pub-id-type="pmc">4820443</article-id><article-id pub-id-type="doi">10.3389/fncel.2016.00089</article-id><article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Guidotti</surname><given-names>Alessandro</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/10307/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Grayson</surname><given-names>Dennis R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/22915/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Caruncho</surname><given-names>Hector J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago</institution><country>Chicago, IL, USA</country></aff><aff id="aff2"><sup>2</sup><institution>College of Pharmacy and Nutrition, University of Saskatchewan</institution><country>Saskatoon, SK, Canada</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Gabriella D’Arcangelo, Rutgers, The State Univesity of New Jersey, USA</p></fn><fn fn-type="edited-by"><p>Reviewed by: Marija Kundakovic, Fordham University, USA; Tania L. Roth, University of Delaware, USA</p></fn><corresp id="fn001">*Correspondence: Alessandro Guidotti <email xlink:type="simple">aguidotti@psych.uic.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>05</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>10</volume><elocation-id>89</elocation-id><history><date date-type="received"><day>22</day><month>1</month><year>2016</year></date><date date-type="accepted"><day>21</day><month>3</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Guidotti, Grayson and Caruncho.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Guidotti, Grayson and Caruncho</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix (ECM), RELN binds to VLDL, APOE2, and α3β2 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal neurons. Reduced levels of RELN expression in the adult brain induce cognitive impairment and dendritic spine density deficits. RELN supplementation recovers these deficits suggesting a trophic action for RELN in synaptic plasticity. We and others have shown that altered RELN expression in schizophrenia (SZ) and bipolar (BP) disorder patients is difficult to reconcile with classical Mendelian genetic disorders and it is instead plausible to associate these disorders with altered epigenetic homeostasis. Support for the contribution of altered epigenetic mechanisms in the down-regulation of RELN expression in corticolimbic structures of psychotic patients includes the concomitant increase of DNA-methyltransferases and the increased levels of the methyl donor S-adenosylmethionine (SAM). It is hypothesized that these conditions lead to RELN promoter hypermethylation and a reduction in RELN protein amounts in psychotic patients. The decreased synthesis and release of RELN from GABAergic corticolimbic neurons could serve as a model to elucidate the epigenetic pathophysiological mechanisms acting at pyramidal neuron dendrites that regulate synaptic plasticity and cognition in psychotic and non-psychotic subjects.</p></abstract><kwd-group><kwd>RELN</kwd><kwd>synaptic plasticity</kwd><kwd>promoter methylation</kwd><kwd>schizophrenia</kwd><kwd>bipolar disorder</kwd><kwd>Dab1</kwd></kwd-group><counts><fig-count count="3"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="105"></ref-count><page-count count="11"></page-count><word-count count="8357"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Guidotti, Alessandro" sort="Guidotti, Alessandro" uniqKey="Guidotti A" first="Alessandro" last="Guidotti">Alessandro Guidotti</name></noRegion><name sortKey="Grayson, Dennis R" sort="Grayson, Dennis R" uniqKey="Grayson D" first="Dennis R." last="Grayson">Dennis R. Grayson</name></country><country name="Canada"><noRegion><name sortKey="Caruncho, Hector J" sort="Caruncho, Hector J" uniqKey="Caruncho H" first="Hector J." last="Caruncho">Hector J. Caruncho</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000988 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000988 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:4820443
|texte= Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:27092053" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |