Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant
Identifieur interne : 000918 ( Pmc/Checkpoint ); précédent : 000917; suivant : 000919Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant
Auteurs : Lisa Ghoufi ; Nicolas Ortonne ; Saskia Ingen-Housz-Oro ; Walid Barhoumi ; Edouard Begon ; Corinne Haioun ; Cécile Pautas ; Florence Beckerich ; Christine Robin ; Pierre Wolkenstein ; Catherine Cordonnier ; Olivier Chosidow ; Andréa TomaSource :
- Medicine [ 0025-7974 ] ; 2016.
Abstract
Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology. Overall, 22 (35.5%) and 40 (64.5%) patients had a histological diagnosis of H-SS and N-SS, respectively. Median age, sex ratio, and cutaneous lesions were similar in the 2 groups. The frequency of extra-cutaneous manifestations was similar (50% vs 37.5%,
Url:
DOI: 10.1097/MD.0000000000003033
PubMed: 27082547
PubMed Central: 4839791
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant</title><author><name sortKey="Ghoufi, Lisa" sort="Ghoufi, Lisa" uniqKey="Ghoufi L" first="Lisa" last="Ghoufi">Lisa Ghoufi</name></author><author><name sortKey="Ortonne, Nicolas" sort="Ortonne, Nicolas" uniqKey="Ortonne N" first="Nicolas" last="Ortonne">Nicolas Ortonne</name></author><author><name sortKey="Ingen Housz Oro, Saskia" sort="Ingen Housz Oro, Saskia" uniqKey="Ingen Housz Oro S" first="Saskia" last="Ingen-Housz-Oro">Saskia Ingen-Housz-Oro</name></author><author><name sortKey="Barhoumi, Walid" sort="Barhoumi, Walid" uniqKey="Barhoumi W" first="Walid" last="Barhoumi">Walid Barhoumi</name></author><author><name sortKey="Begon, Edouard" sort="Begon, Edouard" uniqKey="Begon E" first="Edouard" last="Begon">Edouard Begon</name></author><author><name sortKey="Haioun, Corinne" sort="Haioun, Corinne" uniqKey="Haioun C" first="Corinne" last="Haioun">Corinne Haioun</name></author><author><name sortKey="Pautas, Cecile" sort="Pautas, Cecile" uniqKey="Pautas C" first="Cécile" last="Pautas">Cécile Pautas</name></author><author><name sortKey="Beckerich, Florence" sort="Beckerich, Florence" uniqKey="Beckerich F" first="Florence" last="Beckerich">Florence Beckerich</name></author><author><name sortKey="Robin, Christine" sort="Robin, Christine" uniqKey="Robin C" first="Christine" last="Robin">Christine Robin</name></author><author><name sortKey="Wolkenstein, Pierre" sort="Wolkenstein, Pierre" uniqKey="Wolkenstein P" first="Pierre" last="Wolkenstein">Pierre Wolkenstein</name></author><author><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name></author><author><name sortKey="Chosidow, Olivier" sort="Chosidow, Olivier" uniqKey="Chosidow O" first="Olivier" last="Chosidow">Olivier Chosidow</name></author><author><name sortKey="Toma, Andrea" sort="Toma, Andrea" uniqKey="Toma A" first="Andréa" last="Toma">Andréa Toma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27082547</idno><idno type="pmc">4839791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839791</idno><idno type="RBID">PMC:4839791</idno><idno type="doi">10.1097/MD.0000000000003033</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000787</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000787</idno><idno type="wicri:Area/Pmc/Curation">000787</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000787</idno><idno type="wicri:Area/Pmc/Checkpoint">000918</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000918</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant</title><author><name sortKey="Ghoufi, Lisa" sort="Ghoufi, Lisa" uniqKey="Ghoufi L" first="Lisa" last="Ghoufi">Lisa Ghoufi</name></author><author><name sortKey="Ortonne, Nicolas" sort="Ortonne, Nicolas" uniqKey="Ortonne N" first="Nicolas" last="Ortonne">Nicolas Ortonne</name></author><author><name sortKey="Ingen Housz Oro, Saskia" sort="Ingen Housz Oro, Saskia" uniqKey="Ingen Housz Oro S" first="Saskia" last="Ingen-Housz-Oro">Saskia Ingen-Housz-Oro</name></author><author><name sortKey="Barhoumi, Walid" sort="Barhoumi, Walid" uniqKey="Barhoumi W" first="Walid" last="Barhoumi">Walid Barhoumi</name></author><author><name sortKey="Begon, Edouard" sort="Begon, Edouard" uniqKey="Begon E" first="Edouard" last="Begon">Edouard Begon</name></author><author><name sortKey="Haioun, Corinne" sort="Haioun, Corinne" uniqKey="Haioun C" first="Corinne" last="Haioun">Corinne Haioun</name></author><author><name sortKey="Pautas, Cecile" sort="Pautas, Cecile" uniqKey="Pautas C" first="Cécile" last="Pautas">Cécile Pautas</name></author><author><name sortKey="Beckerich, Florence" sort="Beckerich, Florence" uniqKey="Beckerich F" first="Florence" last="Beckerich">Florence Beckerich</name></author><author><name sortKey="Robin, Christine" sort="Robin, Christine" uniqKey="Robin C" first="Christine" last="Robin">Christine Robin</name></author><author><name sortKey="Wolkenstein, Pierre" sort="Wolkenstein, Pierre" uniqKey="Wolkenstein P" first="Pierre" last="Wolkenstein">Pierre Wolkenstein</name></author><author><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name></author><author><name sortKey="Chosidow, Olivier" sort="Chosidow, Olivier" uniqKey="Chosidow O" first="Olivier" last="Chosidow">Olivier Chosidow</name></author><author><name sortKey="Toma, Andrea" sort="Toma, Andrea" uniqKey="Toma A" first="Andréa" last="Toma">Andréa Toma</name></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology. Overall, 22 (35.5%) and 40 (64.5%) patients had a histological diagnosis of H-SS and N-SS, respectively. Median age, sex ratio, and cutaneous lesions were similar in the 2 groups. The frequency of extra-cutaneous manifestations was similar (50% vs 37.5%, <italic>P</italic> = 0.42). Recurrent forms were significantly more frequent in H-SS than in N-SS patients (21% vs 2.5%, <italic>P</italic> = 0.01). A hematological malignancy was diagnosed in 22 patients, 12 (55.5%) with H-SS and 10 (25%) with N-SS (<italic>P</italic> = <monospace>0</monospace>.019). Hematological malignancy was of myeloid origin in 8/22 (36.3%) H-SS and 5/40 (12.5%) N-SS patients (<italic>P</italic> = <monospace>0</monospace>.02), and of lymphoid origin without myeloid component in 4/22 (18.1%) H-SS and 4/40 (10%) N-SS patients (<italic>P</italic> = <monospace>0</monospace>.35), respectively. One N-SS patient had a hematological malignancy of mixed (myeloid and lymphoid) phenotype. A myelodysplastic syndrome (MDS) was diagnosed in 7/22 (31.8%) H-SS and 1/40 (2.5%) N-SS patients (<italic>P</italic> < <monospace>0</monospace>.001). Hematological disease was diagnosed before (in 8 H-SS and 3 N-SS patients) or at the time of the occurrence of the cutaneous lesions (in 1 H-SS and 7 N-SS patients). However, in 3 H-SS patients, all with MDS, cutaneous lesions preceded the hematological disease by ≤6 months. In conclusion, H-SS was associated with MDS in one third of patients but also with lymphoid malignancies, and cutaneous lesions could precede the hematological diagnosis in patients with MDS. A complete hematological assessment is mandatory at diagnosis, and monitoring blood cell counts should be recommended for at least 6 months after the diagnosis of H-SS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sweet, Rd" uniqKey="Sweet R">RD Sweet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Pr" uniqKey="Cohen P">PR Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petit, T" uniqKey="Petit T">T Petit</name></author><author><name sortKey="Frances, C" uniqKey="Frances C">C Frances</name></author><author><name sortKey="Marinho, E" uniqKey="Marinho E">E Marinho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Pr" uniqKey="Cohen P">PR Cohen</name></author><author><name sortKey="Talpaz, M" uniqKey="Talpaz M">M Talpaz</name></author><author><name sortKey="Kurzrock, R" uniqKey="Kurzrock R">R Kurzrock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourke, Jf" uniqKey="Bourke J">JF Bourke</name></author><author><name sortKey="Keohane, S" uniqKey="Keohane S">S Keohane</name></author><author><name sortKey="Long, Cc" uniqKey="Long C">CC Long</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bayer Garner, Ib" uniqKey="Bayer Garner I">IB Bayer-Garner</name></author><author><name sortKey="Cottler Fox, M" uniqKey="Cottler Fox M">M Cottler-Fox</name></author><author><name sortKey="Smoller, Br" uniqKey="Smoller B">BR Smoller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jordaan, Hf" uniqKey="Jordaan H">HF Jordaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delabie, J" uniqKey="Delabie J">J Delabie</name></author><author><name sortKey="De Wolf Peeters, C" uniqKey="De Wolf Peeters C">C De Wolf-Peeters</name></author><author><name sortKey="Mooren, M" uniqKey="Mooren M">M Mooren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Requena, L" uniqKey="Requena L">L Requena</name></author><author><name sortKey="Kutzner, H" uniqKey="Kutzner H">H Kutzner</name></author><author><name sortKey="Palmedo, G" uniqKey="Palmedo G">G Palmedo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vignon Pennamen, Md" uniqKey="Vignon Pennamen M">MD Vignon-Pennamen</name></author><author><name sortKey="Juillard, C" uniqKey="Juillard C">C Juillard</name></author><author><name sortKey="Rybojad, M" uniqKey="Rybojad M">M Rybojad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kakaletsis, N" uniqKey="Kakaletsis N">N Kakaletsis</name></author><author><name sortKey="Kaiafa, G" uniqKey="Kaiafa G">G Kaiafa</name></author><author><name sortKey="Savopoulos, C" uniqKey="Savopoulos C">C Savopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heymann, Wr" uniqKey="Heymann W">WR Heymann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hunermund, A" uniqKey="Hunermund A">A Hunermund</name></author><author><name sortKey="Wendel, Am" uniqKey="Wendel A">AM Wendel</name></author><author><name sortKey="Geissinger, E" uniqKey="Geissinger E">E Geissinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campo, E" uniqKey="Campo E">E Campo</name></author><author><name sortKey="Swerdlow, Sh" uniqKey="Swerdlow S">SH Swerdlow</name></author><author><name sortKey="Harris, Nl" uniqKey="Harris N">NL Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vardiman, Jw" uniqKey="Vardiman J">JW Vardiman</name></author><author><name sortKey="Thiele, J" uniqKey="Thiele J">J Thiele</name></author><author><name sortKey="Arber, Da" uniqKey="Arber D">DA Arber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magro, Cm" uniqKey="Magro C">CM Magro</name></author><author><name sortKey="Momtahen, S" uniqKey="Momtahen S">S Momtahen</name></author><author><name sortKey="Nguyen, Gh" uniqKey="Nguyen G">GH Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peroni, A" uniqKey="Peroni A">A Peroni</name></author><author><name sortKey="Colato, C" uniqKey="Colato C">C Colato</name></author><author><name sortKey="Schena, D" uniqKey="Schena D">D Schena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaiser, R" uniqKey="Kaiser R">R Kaiser</name></author><author><name sortKey="Connolly, K" uniqKey="Connolly K">K Connolly</name></author><author><name sortKey="Linker, C" uniqKey="Linker C">C Linker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chavan, Rn" uniqKey="Chavan R">RN Chavan</name></author><author><name sortKey="Cappel, Ma" uniqKey="Cappel M">MA Cappel</name></author><author><name sortKey="Ketterling, Rp" uniqKey="Ketterling R">RP Ketterling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ten Oever, J" uniqKey="Ten Oever J">J Ten Oever</name></author><author><name sortKey="Kuijper, Ph" uniqKey="Kuijper P">PH Kuijper</name></author><author><name sortKey="Kuijpers, Al" uniqKey="Kuijpers A">AL Kuijpers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinal Fernandez, I" uniqKey="Pinal Fernandez I">I Pinal-Fernandez</name></author><author><name sortKey="Ferrer Fabrega, B" uniqKey="Ferrer Fabrega B">B Ferrer Fabrega</name></author><author><name sortKey="Ramentol Sintas, M" uniqKey="Ramentol Sintas M">M Ramentol Sintas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeckler, P" uniqKey="Boeckler P">P Boeckler</name></author><author><name sortKey="Noacco, G" uniqKey="Noacco G">G Noacco</name></author><author><name sortKey="Maradeix, S" uniqKey="Maradeix S">S Maradeix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srisuttiyakorn, C" uniqKey="Srisuttiyakorn C">C Srisuttiyakorn</name></author><author><name sortKey="Reeve, J" uniqKey="Reeve J">J Reeve</name></author><author><name sortKey="Reddy, S" uniqKey="Reddy S">S Reddy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kasuya, A" uniqKey="Kasuya A">A Kasuya</name></author><author><name sortKey="Fujiyama, T" uniqKey="Fujiyama T">T Fujiyama</name></author><author><name sortKey="Hashizume, H" uniqKey="Hashizume H">H Hashizume</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murase, Je" uniqKey="Murase J">JE Murase</name></author><author><name sortKey="Wu, Jj" uniqKey="Wu J">JJ Wu</name></author><author><name sortKey="Theate, I" uniqKey="Theate I">I Theate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Js" uniqKey="Kim J">JS Kim</name></author><author><name sortKey="Roh, Hs" uniqKey="Roh H">HS Roh</name></author><author><name sortKey="Lee, Jw" uniqKey="Lee J">JW Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Llamas Velasco, M" uniqKey="Llamas Velasco M">M Llamas-Velasco</name></author><author><name sortKey="Concha Garzon, Mj" uniqKey="Concha Garzon M">MJ Concha-Garzon</name></author><author><name sortKey="Fraga, J" uniqKey="Fraga J">J Fraga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Ci" uniqKey="Liu C">CI Liu</name></author><author><name sortKey="Hsiao, Ch" uniqKey="Hsiao C">CH Hsiao</name></author><author><name sortKey="Wu, Jt" uniqKey="Wu J">JT Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apalla, Z" uniqKey="Apalla Z">Z Apalla</name></author><author><name sortKey="Kanatli, L" uniqKey="Kanatli L">L Kanatli</name></author><author><name sortKey="Sotiriou, E" uniqKey="Sotiriou E">E Sotiriou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bilgili, Sg" uniqKey="Bilgili S">SG Bilgili</name></author><author><name sortKey="Karadag, As" uniqKey="Karadag A">AS Karadag</name></author><author><name sortKey="Calka, O" uniqKey="Calka O">O Calka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Aj" uniqKey="Wu A">AJ Wu</name></author><author><name sortKey="Rodgers, T" uniqKey="Rodgers T">T Rodgers</name></author><author><name sortKey="Fullen, Dr" uniqKey="Fullen D">DR Fullen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spencer, B" uniqKey="Spencer B">B Spencer</name></author><author><name sortKey="Nanavati, A" uniqKey="Nanavati A">A Nanavati</name></author><author><name sortKey="Greene, J" uniqKey="Greene J">J Greene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camarillo, D" uniqKey="Camarillo D">D Camarillo</name></author><author><name sortKey="Mccalmont, Th" uniqKey="Mccalmont T">TH McCalmont</name></author><author><name sortKey="Frieden, Ij" uniqKey="Frieden I">IJ Frieden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Tc" uniqKey="Wilson T">TC Wilson</name></author><author><name sortKey="Stone, Ms" uniqKey="Stone M">MS Stone</name></author><author><name sortKey="Swick, Bl" uniqKey="Swick B">BL Swick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Zheng, H" uniqKey="Zheng H">H Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez Torres, Rm" uniqKey="Fernandez Torres R">RM Fernandez-Torres</name></author><author><name sortKey="Castro, S" uniqKey="Castro S">S Castro</name></author><author><name sortKey="Moreno, A" uniqKey="Moreno A">A Moreno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arima, Y" uniqKey="Arima Y">Y Arima</name></author><author><name sortKey="Namiki, T" uniqKey="Namiki T">T Namiki</name></author><author><name sortKey="Ueno, M" uniqKey="Ueno M">M Ueno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, Av" uniqKey="Evans A">AV Evans</name></author><author><name sortKey="Sabroe, Ra" uniqKey="Sabroe R">RA Sabroe</name></author><author><name sortKey="Liddell, K" uniqKey="Liddell K">K Liddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Soejima, K" uniqKey="Soejima K">K Soejima</name></author><author><name sortKey="Yokozeki, H" uniqKey="Yokozeki H">H Yokozeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avivi, I" uniqKey="Avivi I">I Avivi</name></author><author><name sortKey="Rosenbaum, H" uniqKey="Rosenbaum H">H Rosenbaum</name></author><author><name sortKey="Levy, Y" uniqKey="Levy Y">Y Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tomasini, C" uniqKey="Tomasini C">C Tomasini</name></author><author><name sortKey="Aloi, F" uniqKey="Aloi F">F Aloi</name></author><author><name sortKey="Osella Abate, S" uniqKey="Osella Abate S">S Osella-Abate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sujobert, P" uniqKey="Sujobert P">P Sujobert</name></author><author><name sortKey="Cuccuini, W" uniqKey="Cuccuini W">W Cuccuini</name></author><author><name sortKey="Vignon Pennamen, D" uniqKey="Vignon Pennamen D">D Vignon-Pennamen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Medicine (Baltimore)</journal-id><journal-id journal-id-type="iso-abbrev">Medicine (Baltimore)</journal-id><journal-id journal-id-type="publisher-id">MEDI</journal-id><journal-title-group><journal-title>Medicine</journal-title></journal-title-group><issn pub-type="ppub">0025-7974</issn><issn pub-type="epub">1536-5964</issn><publisher><publisher-name>Wolters Kluwer Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27082547</article-id><article-id pub-id-type="pmc">4839791</article-id><article-id pub-id-type="doi">10.1097/MD.0000000000003033</article-id><article-id pub-id-type="art-access-id">03033</article-id><article-categories><subj-group subj-group-type="heading"><subject>4000</subject></subj-group><subj-group><subject>Research Article</subject><subject>Observational Study</subject></subj-group></article-categories><title-group><article-title>Histiocytoid Sweet Syndrome Is More Frequently Associated With Myelodysplastic Syndromes Than the Classical Neutrophilic Variant</article-title><subtitle>A Comparative Series of 62 Patients</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ghoufi</surname><given-names>Lisa</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Ortonne</surname><given-names>Nicolas</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Ingen-Housz-Oro</surname><given-names>Saskia</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Barhoumi</surname><given-names>Walid</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Begon</surname><given-names>Edouard</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Haioun</surname><given-names>Corinne</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Pautas</surname><given-names>Cécile</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Beckerich</surname><given-names>Florence</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Robin</surname><given-names>Christine</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Wolkenstein</surname><given-names>Pierre</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Cordonnier</surname><given-names>Catherine</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Chosidow</surname><given-names>Olivier</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Toma</surname><given-names>Andréa</given-names></name><degrees>MD, PhD</degrees></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Chen.</surname><given-names>Guoqiang</given-names></name></contrib></contrib-group><aff>From the Department of Dermatology, Assistance-Publique-Hopitaux-de-Paris (AP-HP), Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France (LG, SI-HO, PW, OC); Université Paris-Est Créteil (UPEC) (NO, CH, PW, CC, OC); UMR-S 955, Faculté de Médecine, Hopital Henri Mondor, Créteil, France (NO); Department of Pathology, AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France (NO); Department of Hematology, AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France (WB, CP, FB, CR, CC, AT); Department of Dermatology, Centre Hospitalier René Dubos, Pontoise, France (EB); and Lymphoid Malignancies Unit, AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, Créteil, France (CH).</aff><author-notes><corresp>Correspondence: Andréa Toma, Departement of Hematology, AP-HP, Groupe Hospitalier Henri Mondor-Albert Chenevier, F-94010 Créteil, France (e-mail: <email>andrea.toma@aphp.fr</email>).</corresp></author-notes><pub-date pub-type="collection"><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>18</day><month>4</month><year>2016</year></pub-date><volume>95</volume><issue>15</issue><elocation-id>e3033</elocation-id><history><date date-type="received"><day>17</day><month>11</month><year>2015</year></date><date date-type="rev-recd"><day>10</day><month>2</month><year>2016</year></date><date date-type="accepted"><day>13</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0"><license-p>This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0">http://creativecommons.org/licenses/by-nc-nd/4.0</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="medi-95-e3033.pdf"></self-uri><abstract><title>Abstract</title><p>Histiocytoid Sweet syndrome (H-SS) is a histological variant of Sweet syndrome (SS) differing from classical neutrophilic SS (N-SS) by a dermal infiltrate mainly composed of lymphocytes and histiocytoid myeloperoxidase-positive cells. We aimed to report a large series of H-SS and compare the frequency and type of hematological malignancies associated to H-SS and N-SS. We included 62 patients with a coding histopathologic diagnosis of SS prospectively registered between 2005 and 2014 in the database of our Department of Pathology. Overall, 22 (35.5%) and 40 (64.5%) patients had a histological diagnosis of H-SS and N-SS, respectively. Median age, sex ratio, and cutaneous lesions were similar in the 2 groups. The frequency of extra-cutaneous manifestations was similar (50% vs 37.5%, <italic>P</italic> = 0.42). Recurrent forms were significantly more frequent in H-SS than in N-SS patients (21% vs 2.5%, <italic>P</italic> = 0.01). A hematological malignancy was diagnosed in 22 patients, 12 (55.5%) with H-SS and 10 (25%) with N-SS (<italic>P</italic> = <monospace>0</monospace>.019). Hematological malignancy was of myeloid origin in 8/22 (36.3%) H-SS and 5/40 (12.5%) N-SS patients (<italic>P</italic> = <monospace>0</monospace>.02), and of lymphoid origin without myeloid component in 4/22 (18.1%) H-SS and 4/40 (10%) N-SS patients (<italic>P</italic> = <monospace>0</monospace>.35), respectively. One N-SS patient had a hematological malignancy of mixed (myeloid and lymphoid) phenotype. A myelodysplastic syndrome (MDS) was diagnosed in 7/22 (31.8%) H-SS and 1/40 (2.5%) N-SS patients (<italic>P</italic> < <monospace>0</monospace>.001). Hematological disease was diagnosed before (in 8 H-SS and 3 N-SS patients) or at the time of the occurrence of the cutaneous lesions (in 1 H-SS and 7 N-SS patients). However, in 3 H-SS patients, all with MDS, cutaneous lesions preceded the hematological disease by ≤6 months. In conclusion, H-SS was associated with MDS in one third of patients but also with lymphoid malignancies, and cutaneous lesions could precede the hematological diagnosis in patients with MDS. A complete hematological assessment is mandatory at diagnosis, and monitoring blood cell counts should be recommended for at least 6 months after the diagnosis of H-SS.</p></abstract><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Barhoumi, Walid" sort="Barhoumi, Walid" uniqKey="Barhoumi W" first="Walid" last="Barhoumi">Walid Barhoumi</name><name sortKey="Beckerich, Florence" sort="Beckerich, Florence" uniqKey="Beckerich F" first="Florence" last="Beckerich">Florence Beckerich</name><name sortKey="Begon, Edouard" sort="Begon, Edouard" uniqKey="Begon E" first="Edouard" last="Begon">Edouard Begon</name><name sortKey="Chosidow, Olivier" sort="Chosidow, Olivier" uniqKey="Chosidow O" first="Olivier" last="Chosidow">Olivier Chosidow</name><name sortKey="Cordonnier, Catherine" sort="Cordonnier, Catherine" uniqKey="Cordonnier C" first="Catherine" last="Cordonnier">Catherine Cordonnier</name><name sortKey="Ghoufi, Lisa" sort="Ghoufi, Lisa" uniqKey="Ghoufi L" first="Lisa" last="Ghoufi">Lisa Ghoufi</name><name sortKey="Haioun, Corinne" sort="Haioun, Corinne" uniqKey="Haioun C" first="Corinne" last="Haioun">Corinne Haioun</name><name sortKey="Ingen Housz Oro, Saskia" sort="Ingen Housz Oro, Saskia" uniqKey="Ingen Housz Oro S" first="Saskia" last="Ingen-Housz-Oro">Saskia Ingen-Housz-Oro</name><name sortKey="Ortonne, Nicolas" sort="Ortonne, Nicolas" uniqKey="Ortonne N" first="Nicolas" last="Ortonne">Nicolas Ortonne</name><name sortKey="Pautas, Cecile" sort="Pautas, Cecile" uniqKey="Pautas C" first="Cécile" last="Pautas">Cécile Pautas</name><name sortKey="Robin, Christine" sort="Robin, Christine" uniqKey="Robin C" first="Christine" last="Robin">Christine Robin</name><name sortKey="Toma, Andrea" sort="Toma, Andrea" uniqKey="Toma A" first="Andréa" last="Toma">Andréa Toma</name><name sortKey="Wolkenstein, Pierre" sort="Wolkenstein, Pierre" uniqKey="Wolkenstein P" first="Pierre" last="Wolkenstein">Pierre Wolkenstein</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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