Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection- a pilot study in a canine model
Identifieur interne : 000873 ( Pmc/Checkpoint ); précédent : 000872; suivant : 000874Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection- a pilot study in a canine model
Auteurs : Hiroo Suami [États-Unis] ; Mario F. Scaglioni [États-Unis] ; Katherine A. Dixon [États-Unis] ; Ramesh C. Tailor [États-Unis]Source :
- The Journal of surgical research [ 0022-4804 ] ; 2016.
Abstract
Vascularized lymph node transfer (VLNT) has become more wide-spread for surgical treatment of lymphedema. However, interaction between a transferred lymph node and the recipient lymphatic system in relieving lymphedema has not been identified. The aims of this study were to investigate anatomical changes in the lymphatic system in the forelimb of a canine after lymph node dissection and irradiation and to clarify the interaction between the transferred lymph node and recipient lymphatics.
Two adult female mongrel canines were used for this exploratory study. The unilateral axillary and lower neck node dissections were performed, and 15-Gy irradiation was applied on postoperative day three. After one year, a VLNT flap was harvested from the lower abdominal region and inset in the axilla with vascular anastomoses. The girth of each forelimb was determined with a tape measure at different time points. Indocyanine green fluorescence lymphography and lymphangiography were performed before and after each surgery to evaluate morphological changes in the lymphatics.
Both canines revealed identical changes in the lymphatic system but only one canine developed lymphedema. After lymph node dissection, a collateral lymphatic pathway formed a connection to the contralateral cervical node. After VLNT, an additional collateral pathway formed a connection to the internal mammary node via the transferred node in the axilla.
The findings suggest that the lymphatic system has a homing mechanism, which allows the severed lymphatic vessels to detect and connect to adjacent lymph nodes. VLNT may create new collateral pathways to relieve lymphedema.
Url:
DOI: 10.1016/j.jss.2016.05.029
PubMed: 27565078
PubMed Central: 5002893
Affiliations:
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P2">Vascularized lymph node transfer (VLNT) has become more wide-spread for surgical treatment of lymphedema. However, interaction between a transferred lymph node and the recipient lymphatic system in relieving lymphedema has not been identified. The aims of this study were to investigate anatomical changes in the lymphatic system in the forelimb of a canine after lymph node dissection and irradiation and to clarify the interaction between the transferred lymph node and recipient lymphatics.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P3">Two adult female mongrel canines were used for this exploratory study. The unilateral axillary and lower neck node dissections were performed, and 15-Gy irradiation was applied on postoperative day three. After one year, a VLNT flap was harvested from the lower abdominal region and inset in the axilla with vascular anastomoses. The girth of each forelimb was determined with a tape measure at different time points. Indocyanine green fluorescence lymphography and lymphangiography were performed before and after each surgery to evaluate morphological changes in the lymphatics.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">Both canines revealed identical changes in the lymphatic system but only one canine developed lymphedema. After lymph node dissection, a collateral lymphatic pathway formed a connection to the contralateral cervical node. After VLNT, an additional collateral pathway formed a connection to the internal mammary node via the transferred node in the axilla.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">The findings suggest that the lymphatic system has a homing mechanism, which allows the severed lymphatic vessels to detect and connect to adjacent lymph nodes. VLNT may create new collateral pathways to relieve lymphedema.</p>
</sec>
</div>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0376340</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5287</journal-id>
<journal-id journal-id-type="nlm-ta">J Surg Res</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Surg. Res.</journal-id>
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<title-group><article-title>Interaction between vascularized lymph node transfer and recipient lymphatics after lymph node dissection- a pilot study in a canine model</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Suami</surname>
<given-names>Hiroo</given-names>
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<degrees>M.D., Ph.D.</degrees>
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<contrib contrib-type="author"><name><surname>Scaglioni</surname>
<given-names>Mario F.</given-names>
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<degrees>M.D.</degrees>
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<contrib contrib-type="author"><name><surname>Dixon</surname>
<given-names>Katherine A.</given-names>
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<degrees>R.T.</degrees>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Tailor</surname>
<given-names>Ramesh C.</given-names>
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<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A3">3</xref>
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<aff id="A1"><label>1</label>
Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas</aff>
<aff id="A2"><label>2</label>
Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas</aff>
<aff id="A3"><label>3</label>
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas</aff>
<author-notes><corresp id="FN1">Corresponding Author: Hiroo Suami, M.D., Ph.D., Department of Plastic Surgery, Unit 1488, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA. Tel: +1-713-794-1247; fax: +1-713-794-5492; <email>hsuami@hotmail.com</email>
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<fn id="FN2" fn-type="present-address"><p><bold>Present Address:</bold>
Hiroo Suami, M.D., Ph.D., Faculty of Medicine and Health Sciences, Bldg F10A, 2 Technology Place, Macquarie University, NSW 2109, Australia. Tel: +61-2-9812-3547; fax: +61-2-9812-3600; <email>hiroo.suami@mq.edu.au</email>
</p>
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<pub-date pub-type="nihms-submitted"><day>5</day>
<month>6</month>
<year>2016</year>
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<pub-date pub-type="epub"><day>26</day>
<month>5</month>
<year>2016</year>
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<pub-date pub-type="ppub"><month>8</month>
<year>2016</year>
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<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2017</year>
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<volume>204</volume>
<issue>2</issue>
<fpage>418</fpage>
<lpage>427</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.jss.2016.05.029</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P2">Vascularized lymph node transfer (VLNT) has become more wide-spread for surgical treatment of lymphedema. However, interaction between a transferred lymph node and the recipient lymphatic system in relieving lymphedema has not been identified. The aims of this study were to investigate anatomical changes in the lymphatic system in the forelimb of a canine after lymph node dissection and irradiation and to clarify the interaction between the transferred lymph node and recipient lymphatics.</p>
</sec>
<sec id="S2"><title>Materials and Methods</title>
<p id="P3">Two adult female mongrel canines were used for this exploratory study. The unilateral axillary and lower neck node dissections were performed, and 15-Gy irradiation was applied on postoperative day three. After one year, a VLNT flap was harvested from the lower abdominal region and inset in the axilla with vascular anastomoses. The girth of each forelimb was determined with a tape measure at different time points. Indocyanine green fluorescence lymphography and lymphangiography were performed before and after each surgery to evaluate morphological changes in the lymphatics.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">Both canines revealed identical changes in the lymphatic system but only one canine developed lymphedema. After lymph node dissection, a collateral lymphatic pathway formed a connection to the contralateral cervical node. After VLNT, an additional collateral pathway formed a connection to the internal mammary node via the transferred node in the axilla.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">The findings suggest that the lymphatic system has a homing mechanism, which allows the severed lymphatic vessels to detect and connect to adjacent lymph nodes. VLNT may create new collateral pathways to relieve lymphedema.</p>
</sec>
</abstract>
<kwd-group><kwd>lymphatic system</kwd>
<kwd>lymph node dissection</kwd>
<kwd>lymphedema</kwd>
<kwd>canine</kwd>
<kwd>vascularized lymph node transfer</kwd>
<kwd>indocyanine green fluorescence lymphography</kwd>
<kwd>lymphangiography</kwd>
</kwd-group>
</article-meta>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>Texas</li>
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<name sortKey="Dixon, Katherine A" sort="Dixon, Katherine A" uniqKey="Dixon K" first="Katherine A." last="Dixon">Katherine A. Dixon</name>
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