Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients
Identifieur interne : 000871 ( Pmc/Checkpoint ); précédent : 000870; suivant : 000872Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients
Auteurs : Leanne K. Jackson ; Sheila H. Ridner ; Jie Deng ; Carmin Bartow ; Kyle Mannion ; Ken Niermann ; Jill Gilbert ; Mary S. Dietrich ; Anthony J. Cmelak ; Barbara A. MurphySource :
- Journal of Palliative Medicine [ 1096-6218 ] ; 2016.
Abstract
Url:
DOI: 10.1089/jpm.2016.0018
PubMed: 27227341
PubMed Central: 5011629
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients</title>
<author><name sortKey="Jackson, Leanne K" sort="Jackson, Leanne K" uniqKey="Jackson L" first="Leanne K." last="Jackson">Leanne K. Jackson</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ridner, Sheila H" sort="Ridner, Sheila H" uniqKey="Ridner S" first="Sheila H." last="Ridner">Sheila H. Ridner</name>
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<author><name sortKey="Deng, Jie" sort="Deng, Jie" uniqKey="Deng J" first="Jie" last="Deng">Jie Deng</name>
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<author><name sortKey="Bartow, Carmin" sort="Bartow, Carmin" uniqKey="Bartow C" first="Carmin" last="Bartow">Carmin Bartow</name>
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<author><name sortKey="Mannion, Kyle" sort="Mannion, Kyle" uniqKey="Mannion K" first="Kyle" last="Mannion">Kyle Mannion</name>
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<author><name sortKey="Niermann, Ken" sort="Niermann, Ken" uniqKey="Niermann K" first="Ken" last="Niermann">Ken Niermann</name>
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<author><name sortKey="Gilbert, Jill" sort="Gilbert, Jill" uniqKey="Gilbert J" first="Jill" last="Gilbert">Jill Gilbert</name>
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<author><name sortKey="Dietrich, Mary S" sort="Dietrich, Mary S" uniqKey="Dietrich M" first="Mary S." last="Dietrich">Mary S. Dietrich</name>
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<author><name sortKey="Cmelak, Anthony J" sort="Cmelak, Anthony J" uniqKey="Cmelak A" first="Anthony J." last="Cmelak">Anthony J. Cmelak</name>
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</affiliation>
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<author><name sortKey="Murphy, Barbara A" sort="Murphy, Barbara A" uniqKey="Murphy B" first="Barbara A." last="Murphy">Barbara A. Murphy</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients</title>
<author><name sortKey="Jackson, Leanne K" sort="Jackson, Leanne K" uniqKey="Jackson L" first="Leanne K." last="Jackson">Leanne K. Jackson</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
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<author><name sortKey="Ridner, Sheila H" sort="Ridner, Sheila H" uniqKey="Ridner S" first="Sheila H." last="Ridner">Sheila H. Ridner</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deng, Jie" sort="Deng, Jie" uniqKey="Deng J" first="Jie" last="Deng">Jie Deng</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bartow, Carmin" sort="Bartow, Carmin" uniqKey="Bartow C" first="Carmin" last="Bartow">Carmin Bartow</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mannion, Kyle" sort="Mannion, Kyle" uniqKey="Mannion K" first="Kyle" last="Mannion">Kyle Mannion</name>
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</affiliation>
</author>
<author><name sortKey="Niermann, Ken" sort="Niermann, Ken" uniqKey="Niermann K" first="Ken" last="Niermann">Ken Niermann</name>
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<author><name sortKey="Gilbert, Jill" sort="Gilbert, Jill" uniqKey="Gilbert J" first="Jill" last="Gilbert">Jill Gilbert</name>
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<author><name sortKey="Dietrich, Mary S" sort="Dietrich, Mary S" uniqKey="Dietrich M" first="Mary S." last="Dietrich">Mary S. Dietrich</name>
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</affiliation>
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<author><name sortKey="Cmelak, Anthony J" sort="Cmelak, Anthony J" uniqKey="Cmelak A" first="Anthony J." last="Cmelak">Anthony J. Cmelak</name>
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<author><name sortKey="Murphy, Barbara A" sort="Murphy, Barbara A" uniqKey="Murphy B" first="Barbara A." last="Murphy">Barbara A. Murphy</name>
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<series><title level="j">Journal of Palliative Medicine</title>
<idno type="ISSN">1096-6218</idno>
<idno type="eISSN">1557-7740</idno>
<imprint><date when="2016">2016</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background:</italic>
</bold>
Tumor/treatment-related internal lymphedema (IL) and/or external lymphedema (EL) are associated with functional deficits and increased symptom burden in head and neck cancer patients (HNCP). Previously, we noted association between EL/IL and patient-reported dysphagia using the Vanderbilt Head and Neck Symptom Survey (VHNSS) version 1.0.</p>
<p><bold><italic>Objective:</italic>
</bold>
To determine the relationship between IL/EL and subjective and objective measures of swallowing function.</p>
<p><bold><italic>Methods:</italic>
</bold>
Eighty-one HNCP completed: (1) VHNSS version 2.0, including 13 swallowing/nutrition-related questions grouped into three clusters: swallow solids (ss), swallow liquids (sl), and nutrition(nt); (2) physical assessment of EL using Foldi scale; (3) endoscopic assessment of IL using Patterson scale (<italic>n</italic>
= 56); and (4) modified barium swallow study rated by dysphagia outcome and severity scale (DOSS) and in conjunction with a swallow evaluation by National Outcomes Measurement System (NOMS). Examinations were performed at varied time points to assess lymphedema spectrum, from baseline (<italic>n</italic>
= 15, 18.1%) to 18 months post-therapy (<italic>n</italic>
= 20, 24.1%).</p>
<p><bold><italic>Results:</italic>
</bold>
VHNSS swallow/nutrition items scores correlated with NOMS/DOSS ratings (<italic>p</italic>
< 0.001). Highest correlation was with NOMS: ss (−0.73); sl (−0.61); nt (−0.56). VHNSS swallow/nutrition scores correlated with maximum grade of swelling for any single structure on Patterson scale: ss (0.43; <italic>p</italic>
= 0.001); sl (0.38; <italic>p</italic>
= 0.004); nt (0.41; <italic>p</italic>
= 0.002). IL of aryepiglottic/pharyngoepiglottic folds, epiglottis, and pyriform sinus were most strongly correlated with VHNSS and NOMS ratings. NOMS/DOSS ratings correlated with EL (> = −0.34; <italic>p</italic>
< 0.01). No meaningful correlations exist between VHNSS swallow/nutrition items and EL (< ± 0.15, <italic>p</italic>
> 0.20).</p>
<p><bold><italic>Conclusions:</italic>
</bold>
IL correlated with subjective and objective measures of swallow dysfunction. Longitudinal analysis of trajectory and impact of IL/EL on dysphagia is ongoing.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Palliat Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J Palliat Med</journal-id>
<journal-id journal-id-type="publisher-id">jpm</journal-id>
<journal-title-group><journal-title>Journal of Palliative Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1096-6218</issn>
<issn pub-type="epub">1557-7740</issn>
<publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27227341</article-id>
<article-id pub-id-type="pmc">5011629</article-id>
<article-id pub-id-type="publisher-id">10.1089/jpm.2016.0018</article-id>
<article-id pub-id-type="doi">10.1089/jpm.2016.0018</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Internal Lymphedema Correlates with Subjective and Objective Measures of Dysphagia in Head and Neck Cancer Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Jackson</surname>
<given-names>Leanne K.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ridner</surname>
<given-names>Sheila H.</given-names>
</name>
<degrees>PhD, RN</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Deng</surname>
<given-names>Jie</given-names>
</name>
<degrees>PhD, RN</degrees>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bartow</surname>
<given-names>Carmin</given-names>
</name>
<degrees>MS, CCC-SLP</degrees>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mannion</surname>
<given-names>Kyle</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Niermann</surname>
<given-names>Ken</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gilbert</surname>
<given-names>Jill</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dietrich</surname>
<given-names>Mary S.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cmelak</surname>
<given-names>Anthony J.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Murphy</surname>
<given-names>Barbara A.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<aff id="aff1"><label><sup>1</sup>
</label>
Department of Medicine,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
<aff id="aff2"><label><sup>2</sup>
</label>
School of Nursing,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
<aff id="aff3"><label><sup>3</sup>
</label>
Dept of Speech Sciences,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
<aff id="aff4"><label><sup>4</sup>
</label>
Dept of Surgery,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
<aff id="aff5"><label><sup>5</sup>
</label>
Department of Radiation Oncology,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
<aff id="aff6"><label><sup>6</sup>
</label>
Department of Biostatistics, Schools of Medicine and Nursing,<institution>Vanderbilt University Medical Center</institution>
, Nashville, Tennessee.</aff>
</contrib-group>
<author-notes><corresp><addr-line>Address correspondence to:</addr-line>
<addr-line><italic>Leanne K. Jackson, MD</italic>
</addr-line>
<institution><italic>Michael E. DeBakey Veterans Affairs Medical Center</italic>
</institution>
<addr-line><italic>2002 Holcombe Boulevard</italic>
</addr-line>
<addr-line><italic>Houston, TX 77030</italic>
</addr-line>
<italic>E-mail:</italic>
<email xlink:href="mailto:leanne.jackson2@va.gov">leanne.jackson2@va.gov</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>9</month>
<year>2016</year>
<pmc-comment>string-date: September 2016</pmc-comment>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>9</month>
<year>2016</year>
</pub-date>
<volume>19</volume>
<issue>9</issue>
<fpage>949</fpage>
<lpage>956</lpage>
<history><date date-type="accepted"><day>13</day>
<month>4</month>
<year>2016</year>
<pmc-comment>string-date: Accepted April 13, 2016</pmc-comment>
</date>
</history>
<permissions><copyright-statement>Copyright 2016, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2016</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="jpm.2016.0018.pdf"></self-uri>
<abstract><title>Abstract</title>
<p><bold><italic>Background:</italic>
</bold>
Tumor/treatment-related internal lymphedema (IL) and/or external lymphedema (EL) are associated with functional deficits and increased symptom burden in head and neck cancer patients (HNCP). Previously, we noted association between EL/IL and patient-reported dysphagia using the Vanderbilt Head and Neck Symptom Survey (VHNSS) version 1.0.</p>
<p><bold><italic>Objective:</italic>
</bold>
To determine the relationship between IL/EL and subjective and objective measures of swallowing function.</p>
<p><bold><italic>Methods:</italic>
</bold>
Eighty-one HNCP completed: (1) VHNSS version 2.0, including 13 swallowing/nutrition-related questions grouped into three clusters: swallow solids (ss), swallow liquids (sl), and nutrition(nt); (2) physical assessment of EL using Foldi scale; (3) endoscopic assessment of IL using Patterson scale (<italic>n</italic>
= 56); and (4) modified barium swallow study rated by dysphagia outcome and severity scale (DOSS) and in conjunction with a swallow evaluation by National Outcomes Measurement System (NOMS). Examinations were performed at varied time points to assess lymphedema spectrum, from baseline (<italic>n</italic>
= 15, 18.1%) to 18 months post-therapy (<italic>n</italic>
= 20, 24.1%).</p>
<p><bold><italic>Results:</italic>
</bold>
VHNSS swallow/nutrition items scores correlated with NOMS/DOSS ratings (<italic>p</italic>
< 0.001). Highest correlation was with NOMS: ss (−0.73); sl (−0.61); nt (−0.56). VHNSS swallow/nutrition scores correlated with maximum grade of swelling for any single structure on Patterson scale: ss (0.43; <italic>p</italic>
= 0.001); sl (0.38; <italic>p</italic>
= 0.004); nt (0.41; <italic>p</italic>
= 0.002). IL of aryepiglottic/pharyngoepiglottic folds, epiglottis, and pyriform sinus were most strongly correlated with VHNSS and NOMS ratings. NOMS/DOSS ratings correlated with EL (> = −0.34; <italic>p</italic>
< 0.01). No meaningful correlations exist between VHNSS swallow/nutrition items and EL (< ± 0.15, <italic>p</italic>
> 0.20).</p>
<p><bold><italic>Conclusions:</italic>
</bold>
IL correlated with subjective and objective measures of swallow dysfunction. Longitudinal analysis of trajectory and impact of IL/EL on dysphagia is ongoing.</p>
</abstract>
<counts><table-count count="6"></table-count>
<ref-count count="20"></ref-count>
<page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Bartow, Carmin" sort="Bartow, Carmin" uniqKey="Bartow C" first="Carmin" last="Bartow">Carmin Bartow</name>
<name sortKey="Cmelak, Anthony J" sort="Cmelak, Anthony J" uniqKey="Cmelak A" first="Anthony J." last="Cmelak">Anthony J. Cmelak</name>
<name sortKey="Deng, Jie" sort="Deng, Jie" uniqKey="Deng J" first="Jie" last="Deng">Jie Deng</name>
<name sortKey="Dietrich, Mary S" sort="Dietrich, Mary S" uniqKey="Dietrich M" first="Mary S." last="Dietrich">Mary S. Dietrich</name>
<name sortKey="Gilbert, Jill" sort="Gilbert, Jill" uniqKey="Gilbert J" first="Jill" last="Gilbert">Jill Gilbert</name>
<name sortKey="Jackson, Leanne K" sort="Jackson, Leanne K" uniqKey="Jackson L" first="Leanne K." last="Jackson">Leanne K. Jackson</name>
<name sortKey="Mannion, Kyle" sort="Mannion, Kyle" uniqKey="Mannion K" first="Kyle" last="Mannion">Kyle Mannion</name>
<name sortKey="Murphy, Barbara A" sort="Murphy, Barbara A" uniqKey="Murphy B" first="Barbara A." last="Murphy">Barbara A. Murphy</name>
<name sortKey="Niermann, Ken" sort="Niermann, Ken" uniqKey="Niermann K" first="Ken" last="Niermann">Ken Niermann</name>
<name sortKey="Ridner, Sheila H" sort="Ridner, Sheila H" uniqKey="Ridner S" first="Sheila H." last="Ridner">Sheila H. Ridner</name>
</noCountry>
</tree>
</affiliations>
</record>
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