E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma
Identifieur interne : 000316 ( Pmc/Checkpoint ); précédent : 000315; suivant : 000317E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma
Auteurs : Yi Lv [République populaire de Chine] ; Jia Xiao [République populaire de Chine] ; Jing Liu [République populaire de Chine] ; Feiyue Xing [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2017.
Abstract
E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development. Although E2F8 and E2F7 perform complementary and overlapping functions in many cell metabolisms, E2F8, but not E2F7, overexpresses remarkably in hepatocellular carcinoma (HCC) to facilitate the HCC occurrence and development
Url:
DOI: 10.7150/jca.18255
PubMed: 28607595
PubMed Central: 5463435
Affiliations:
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Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xiao, Jia" sort="Xiao, Jia" uniqKey="Xiao J" first="Jia" last="Xiao">Jia Xiao</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Stomatology, Jinan University, Guangzhou, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xing, Feiyue" sort="Xing, Feiyue" uniqKey="Xing F" first="Feiyue" last="Xing">Feiyue Xing</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28607595</idno><idno type="pmc">5463435</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463435</idno><idno type="RBID">PMC:5463435</idno><idno type="doi">10.7150/jca.18255</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004B03</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004B03</idno><idno type="wicri:Area/Pmc/Curation">004B02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004B02</idno><idno type="wicri:Area/Pmc/Checkpoint">000316</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000316</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma</title><author><name sortKey="Lv, Yi" sort="Lv, Yi" uniqKey="Lv Y" first="Yi" last="Lv">Yi Lv</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xiao, Jia" sort="Xiao, Jia" uniqKey="Xiao J" first="Jia" last="Xiao">Jia Xiao</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Stomatology, Jinan University, Guangzhou, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xing, Feiyue" sort="Xing, Feiyue" uniqKey="Xing F" first="Feiyue" last="Xing">Feiyue Xing</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2">Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China;</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Cancer</title><idno type="eISSN">1837-9664</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development. Although E2F8 and E2F7 perform complementary and overlapping functions in many cell metabolisms, E2F8, but not E2F7, overexpresses remarkably in hepatocellular carcinoma (HCC) to facilitate the HCC occurrence and development <italic>via</italic> activating a E2F1/ Cyclin D1 signaling pathway to regulate the G1- to S-phase transition of cell cycle progression or transcriptionally suppressing CDK1 to induce hepatocyte polyploidization. It also involves closely a variety of cellular physiological functions and pathological processes, which may bring a new breakthrough for the treatment of certain diseases, especially the HCC. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">J Cancer</journal-id><journal-id journal-id-type="publisher-id">jca</journal-id><journal-title-group><journal-title>Journal of Cancer</journal-title></journal-title-group><issn pub-type="epub">1837-9664</issn><publisher><publisher-name>Ivyspring International Publisher</publisher-name><publisher-loc>Sydney</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28607595</article-id><article-id pub-id-type="pmc">5463435</article-id><article-id pub-id-type="doi">10.7150/jca.18255</article-id><article-id pub-id-type="publisher-id">jcav08p1205</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>E2F8 is a Potential Therapeutic Target for Hepatocellular Carcinoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lv</surname><given-names>Yi</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Xiao</surname><given-names>Jia</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib><contrib contrib-type="author"><name><surname>Xing</surname><given-names>Feiyue</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China;</aff><aff id="A2"><label>2</label>Key Laboratory of Functional Protein Research of Guangdong, Higher Education Institutes, Jinan University, Guangzhou, China;</aff><aff id="A3"><label>3</label>Department of Stomatology, Jinan University, Guangzhou, China.</aff><author-notes><corresp id="FNA_envelop">✉ Corresponding authors: Professors Feiyue Xing and Jing Liu, Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China. E-mail: <email>tfyxing@jnu.edu.cn</email> or <email>tjliu@jnu.edu.cn</email></corresp><fn fn-type="COI-statement"><p>Competing Interests: The authors have declared that no competing interest exists.</p></fn></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>9</day><month>4</month><year>2017</year></pub-date><volume>8</volume><issue>7</issue><fpage>1205</fpage><lpage>1213</lpage><history><date date-type="received"><day>8</day><month>11</month><year>2016</year></date><date date-type="accepted"><day>11</day><month>1</month><year>2017</year></date></history><permissions><copyright-statement>© Ivyspring International Publisher</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>). See <ext-link ext-link-type="uri" xlink:href="http://ivyspring.com/terms">http://ivyspring.com/terms</ext-link> for full terms and conditions.</license-p></license></permissions><abstract><p>E2F transcriptional factors are widely expressed in a number of tissues and organs, possessing many regulatory functions related to cellular proliferation, differentiation, DNA repair, cell-cycle and cell apoptosis. E2F8 is a recently identified member of the E2F family with a duplicated DNA-binding domain feature discriminated from E2F1-6, controlling gene expression in a dimerization partner-independent manner. It is indispensable for angiogenesis, lymphangiogenesis and embryonic development. Although E2F8 and E2F7 perform complementary and overlapping functions in many cell metabolisms, E2F8, but not E2F7, overexpresses remarkably in hepatocellular carcinoma (HCC) to facilitate the HCC occurrence and development <italic>via</italic> activating a E2F1/ Cyclin D1 signaling pathway to regulate the G1- to S-phase transition of cell cycle progression or transcriptionally suppressing CDK1 to induce hepatocyte polyploidization. It also involves closely a variety of cellular physiological functions and pathological processes, which may bring a new breakthrough for the treatment of certain diseases, especially the HCC. Here, we summarize the latest progress of E2F8 on its relevant functions and mechanisms as well as potential application.</p></abstract><kwd-group><kwd>E2F8</kwd><kwd>Hepatocellular carcinoma</kwd><kwd>angiogenesis</kwd><kwd>lymphangiogenesis</kwd><kwd>polyploidization</kwd><kwd>DNA damage.</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold> Structures of the E2F family members:</bold> E2F8 has the duplicated DNA-binding domain (DBD), but lacks the dimerization partner (DP) and retinoblastoma-binding (RB) domains.</p></caption><graphic xlink:href="jcav08p1205g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p><bold>Mechanisms by which E2F8 mediates the cell metabolic functions and histological development</bold>: E2F8 regulates the functions related to cell cycle, proliferation, DNA repair, apoptosis, polyploidization, angiogenesis and lymphangiogenesis.</p></caption><graphic xlink:href="jcav08p1205g002"></graphic></fig><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Main similarities and differences between E2F7 and E2F8</p></caption><table frame="hsides" rules="groups"><thead valign="top"><tr><th rowspan="1" colspan="1">Object</th><th rowspan="1" colspan="1">Similarity</th><th rowspan="1" colspan="1">Difference</th><th rowspan="1" colspan="1">Reference</th></tr></thead><tbody valign="top"><tr><td rowspan="1" colspan="1">Structure</td><td rowspan="1" colspan="1">a. With two distinct DBD domains<break></break>b. Lacking DP-dimerization and retinoblastoma-binding domains<break></break>c. Absence of transcriptional activation domains</td><td rowspan="1" colspan="1">E2F7 has two highly relevant isoforms, but not E2F8.</td><td rowspan="1" colspan="1">2,6,7,17,19</td></tr><tr><td rowspan="1" colspan="1">Methods and functions of regulating gene</td><td rowspan="1" colspan="1">a. Controlling cell cycle genes through homodimers or heterodimers by DBD<break></break>b. Functioning predominantly as transcriptional repressors</td><td rowspan="1" colspan="1">Efficiency for the both to form dimerization is not equivalent.</td><td rowspan="1" colspan="1">5,16,18</td></tr><tr><td rowspan="1" colspan="1">Embryo and postnatal development</td><td rowspan="1" colspan="1">Being necessary for embryonic development and viability</td><td rowspan="1" colspan="1">E2F7 appears more important than E2F8 in mice postnatal development.</td><td rowspan="1" colspan="1">16</td></tr><tr><td rowspan="1" colspan="1">Angiogenesis and lymphangiogenesis</td><td rowspan="1" colspan="1">a. Being necessary for angiogenesis<break></break>b. Being essential for lymphangiogenesis</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">16,30,51,51</td></tr><tr><td rowspan="1" colspan="1">DNA demage</td><td rowspan="1" colspan="1">Resisting DNA damage</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">4,18</td></tr><tr><td rowspan="1" colspan="1">Cell polyploidization</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">E2F8 plays a vital role in the process of cell polyploidization, but E2F7 only has a modest effect.</td><td rowspan="1" colspan="1">69</td></tr><tr><td rowspan="1" colspan="1">HCC</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">E2F8 shows overexpression in HCC, but not E2F7.</td><td rowspan="1" colspan="1">3,6,11</td></tr></tbody></table><table-wrap-foot><fn><p>DBD: DNA-binding domains; DP: dimerization partner; HCC: hepatocellular carcinoma</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Lv, Yi" sort="Lv, Yi" uniqKey="Lv Y" first="Yi" last="Lv">Yi Lv</name></region><name sortKey="Liu, Jing" sort="Liu, Jing" uniqKey="Liu J" first="Jing" last="Liu">Jing Liu</name><name sortKey="Lv, Yi" sort="Lv, Yi" uniqKey="Lv Y" first="Yi" last="Lv">Yi Lv</name><name sortKey="Xiao, Jia" sort="Xiao, Jia" uniqKey="Xiao J" first="Jia" last="Xiao">Jia Xiao</name><name sortKey="Xing, Feiyue" sort="Xing, Feiyue" uniqKey="Xing F" first="Feiyue" last="Xing">Feiyue Xing</name><name sortKey="Xing, Feiyue" sort="Xing, Feiyue" uniqKey="Xing F" first="Feiyue" last="Xing">Feiyue Xing</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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