LymphedemaV1, PascalFrancis, Curation, bibRecord, 000676

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Identifieur interne : 000676 ( PascalFrancis/Curation ); précédent : 000675; suivant : 000677

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Auteurs : Johanna Manner [Allemagne] ; Bernhard Radlwimmer [Allemagne] ; Peter Hohenberger [Allemagne] ; Katharina Mössinger [Allemagne] ; Stefan Küffer [Allemagne] ; Christian Sauer [Allemagne] ; Djeda Belharazem [Allemagne] ; Andreas Zettl [Suisse] ; Jean-Michel Coindre [France] ; Christian Hallermann [Allemagne] ; Jörg Thomas Hartmann [Allemagne] ; Detlef Katenkamp [Allemagne] ; Kathrin Katenkamp [Allemagne] ; Patrick Schöffski [Belgique] ; Raf Sciot [Belgique] ; Agnieszka Wozniak [Belgique] ; Peter Lichter [Allemagne] ; Alexander Marx [Allemagne] ; Philipp Strbbel [Allemagne]

Source :

The American journal of pathology [ 0002-9440 ] ; 2010.

RBID : Pascal:10-0078175

Descripteurs français

Pascal (Inist)
- Angiosarcome, Gène myc, Haut, Lymphoedème, Amplification génique, Irradiation, Chronique, Anatomopathologie, Sarcome.
Wicri :
- topic : Irradiation.

English descriptors

KwdEn :
- Anatomic pathology, Angiosarcoma, Chronic, Gene amplification, High, Irradiation, Lymphedema, Sarcoma, myc Gene.

Abstract

Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors second-ary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.

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A14	`08`			`@1 Institute of Pathology, University of Jena @3 DEU @Z 12 aut. @Z 13 aut.`
A14	`09`			`@1 Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven @2 Leuven @3 BEL @Z 14 aut. @Z 16 aut.`
A14	`10`			`@1 Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven @3 BEL @Z 15 aut.`
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C01	`01`		`ENG`	@0 Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors second-ary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.
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C03	`03`	`X`	`SPA`	`@0 Alto @5 03`
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C03	`06`	`X`	`FRE`	`@0 Irradiation @5 06`
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C03	`08`	`X`	`SPA`	`@0 Anatomía patológica @5 09`
C03	`09`	`X`	`FRE`	`@0 Sarcome @5 25`
C03	`09`	`X`	`ENG`	`@0 Sarcoma @5 25`
C03	`09`	`X`	`SPA`	`@0 Sarcoma @5 25`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 37`
C07	`01`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Tumeur maligne @2 NM @5 38`
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C07	`04`	`X`	`FRE`	`@0 Pathologie des vaisseaux sanguins @5 39`
C07	`04`	`X`	`ENG`	`@0 Vascular disease @5 39`
C07	`04`	`X`	`SPA`	`@0 Vaso sanguíneo patología @5 39`
C07	`05`	`X`	`FRE`	`@0 Pathologie des vaisseaux lymphatiques @5 40`
C07	`05`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 40`
C07	`05`	`X`	`SPA`	`@0 Linfático patología @5 40`
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N44	`01`			`@1 OTO`
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Pascal:10-0078175

Le document en format XML

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<author><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name>
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<author><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name>
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<author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name>
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<author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
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<author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name>
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<author><name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name>
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<author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
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<author><name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
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<author><name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven</s1>
<s2>Leuven</s2>
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<author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>German Cancer Research Center (DKPZ), Division of Molecular Genetics</s1>
<s2>Heidelberg</s2>
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<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
<s3>DEU</s3>
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<author><name sortKey="Strbbel, Philipp" sort="Strbbel, Philipp" uniqKey="Strbbel P" first="Philipp" last="Strbbel">Philipp Strbbel</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</title>
<author><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Radlwimmer, Bernhard" sort="Radlwimmer, Bernhard" uniqKey="Radlwimmer B" first="Bernhard" last="Radlwimmer">Bernhard Radlwimmer</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>German Cancer Research Center (DKPZ), Division of Molecular Genetics</s1>
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<author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelherg</s1>
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<author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
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<sZ>14 aut.</sZ>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Pathology, University Medical Centre Mannheim, University of Heidelherg</s1>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
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<series><title level="j" type="main">The American journal of pathology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
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<term>Gene amplification</term>
<term>High</term>
<term>Irradiation</term>
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<term>Gène myc</term>
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<front><div type="abstract" xml:lang="en">Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors second-ary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</s1>
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<fC07 i1="03" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie des vaisseaux sanguins</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vascular disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vaso sanguíneo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie des vaisseaux lymphatiques</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Linfático patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>053</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:10-0078175
   |texte=   MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema
}}

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
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Serveur d'exploration sur le lymphœdème

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

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Abstract

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