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Regeneration of Autotransplanted Avascular Lymph Nodes in the Rat Is Improved by Platelet-Rich Plasma

Identifieur interne : 000644 ( PascalFrancis/Curation ); précédent : 000643; suivant : 000645

Regeneration of Autotransplanted Avascular Lymph Nodes in the Rat Is Improved by Platelet-Rich Plasma

Auteurs : Catarina Hadamitzky [Allemagne] ; Katrin S. Blum [Allemagne] ; Reinhard Pabst [Allemagne]

Source :

RBID : Pascal:09-0354192

Descripteurs français

English descriptors

Abstract

The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.
pA  
A01 01  1    @0 1018-1172
A03   1    @0 J. vasc. res.
A05       @2 46
A06       @2 5
A08 01  1  ENG  @1 Regeneration of Autotransplanted Avascular Lymph Nodes in the Rat Is Improved by Platelet-Rich Plasma
A11 01  1    @1 HADAMITZKY (Catarina)
A11 02  1    @1 BLUM (Katrin S.)
A11 03  1    @1 PABST (Reinhard)
A14 01      @1 Institute for Functional and Applied Anatomy, Hannover Medical School @2 Hannover @3 DEU @Z 1 aut. @Z 3 aut.
A14 02      @1 Clinic for Diagnostic Radiology, Hannover Medical School @2 Hannover @3 DEU @Z 2 aut.
A20       @1 389-396
A21       @1 2009
A23 01      @0 ENG
A43 01      @1 INIST @2 11498 @5 354000172566120010
A44       @0 0000 @1 © 2009 INIST-CNRS. All rights reserved.
A45       @0 23 ref.
A47 01  1    @0 09-0354192
A60       @1 P
A61       @0 A
A64 01  1    @0 Journal of vascular research
A66 01      @0 CHE
C01 01    ENG  @0 The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.
C02 01  X    @0 002A22
C02 02  X    @0 002B12B04
C03 01  X  FRE  @0 Régénération @5 01
C03 01  X  ENG  @0 Regeneration @5 01
C03 01  X  SPA  @0 Regeneración @5 01
C03 02  X  FRE  @0 Ganglion lymphatique @5 02
C03 02  X  ENG  @0 Lymph node @5 02
C03 02  X  SPA  @0 Ganglio linfático @5 02
C03 03  X  FRE  @0 Thrombocyte @5 03
C03 03  X  ENG  @0 Platelet @5 03
C03 03  X  SPA  @0 Trombocito @5 03
C03 04  X  FRE  @0 Transplantation @5 04
C03 04  X  ENG  @0 Transplantation @5 04
C03 04  X  SPA  @0 Trasplantación @5 04
C03 05  X  FRE  @0 Lymphatique @5 05
C03 05  X  ENG  @0 Lymphatic @5 05
C03 05  X  SPA  @0 Linfático @5 05
C03 06  X  FRE  @0 Facteur croissance @5 06
C03 06  X  ENG  @0 Growth factor @5 06
C03 06  X  SPA  @0 Factor crecimiento @5 06
C03 07  X  FRE  @0 Prévention @5 07
C03 07  X  ENG  @0 Prevention @5 07
C03 07  X  SPA  @0 Prevención @5 07
C03 08  X  FRE  @0 Modèle @5 08
C03 08  X  ENG  @0 Models @5 08
C03 08  X  SPA  @0 Modelo @5 08
C03 09  X  FRE  @0 Lymphoedème @5 09
C03 09  X  ENG  @0 Lymphedema @5 09
C03 09  X  SPA  @0 Linfedema @5 09
C03 10  X  FRE  @0 Appareil circulatoire @5 10
C03 10  X  ENG  @0 Circulatory system @5 10
C03 10  X  SPA  @0 Aparato circulatorio @5 10
C03 11  X  FRE  @0 Mammalia @2 NS @5 11
C03 11  X  ENG  @0 Mammalia @2 NS @5 11
C03 11  X  SPA  @0 Mammalia @2 NS @5 11
C03 12  X  FRE  @0 Rat @5 54
C03 12  X  ENG  @0 Rat @5 54
C03 12  X  SPA  @0 Rata @5 54
C07 01  X  FRE  @0 Vertebrata @2 NS
C07 01  X  ENG  @0 Vertebrata @2 NS
C07 01  X  SPA  @0 Vertebrata @2 NS
C07 02  X  FRE  @0 Pathologie de l'appareil circulatoire @5 20
C07 02  X  ENG  @0 Cardiovascular disease @5 20
C07 02  X  SPA  @0 Aparato circulatorio patología @5 20
C07 03  X  FRE  @0 Pathologie des vaisseaux lymphatiques @5 21
C07 03  X  ENG  @0 Lymphatic vessel disease @5 21
C07 03  X  SPA  @0 Linfático patología @5 21
C07 04  X  FRE  @0 Rodentia @2 NS
C07 04  X  ENG  @0 Rodentia @2 NS
C07 04  X  SPA  @0 Rodentia @2 NS
N21       @1 257
N44 01      @1 OTO
N82       @1 OTO

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Pascal:09-0354192

Le document en format XML

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<term>Facteur croissance</term>
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<div type="abstract" xml:lang="en">The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.</div>
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<fA66 i1="01">
<s0>CHE</s0>
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<fC01 i1="01" l="ENG">
<s0>The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.</s0>
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<s0>002A22</s0>
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<fC02 i1="02" i2="X">
<s0>002B12B04</s0>
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<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG">
<s0>Regeneration</s0>
<s5>01</s5>
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<s0>Regeneración</s0>
<s5>01</s5>
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<s5>02</s5>
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<s5>02</s5>
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<s0>Thrombocyte</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Platelet</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Trombocito</s0>
<s5>03</s5>
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<fC03 i1="04" i2="X" l="FRE">
<s0>Transplantation</s0>
<s5>04</s5>
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<s0>Transplantation</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Trasplantación</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Lymphatique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Lymphatic</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Linfático</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
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<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
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<s5>06</s5>
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<s5>06</s5>
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<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Prevention</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Prevención</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Modèle</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Models</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Modelo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Lymphoedème</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Lymphedema</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Linfedema</s0>
<s5>09</s5>
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<s5>10</s5>
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<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
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<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
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<s2>NS</s2>
<s5>11</s5>
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<s2>NS</s2>
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<s5>54</s5>
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<fC03 i1="12" i2="X" l="ENG">
<s0>Rat</s0>
<s5>54</s5>
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<fC03 i1="12" i2="X" l="SPA">
<s0>Rata</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Pathologie de l'appareil circulatoire</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Cardiovascular disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Aparato circulatorio patología</s0>
<s5>20</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Pathologie des vaisseaux lymphatiques</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Lymphatic vessel disease</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Linfático patología</s0>
<s5>21</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fN21>
<s1>257</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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