LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000A97

The effect of lymphatic oedema on the uptake of colloids to the lymph nodes

Identifieur interne : 000A97 ( PascalFrancis/Corpus ); précédent : 000A96; suivant : 000A98

The effect of lymphatic oedema on the uptake of colloids to the lymph nodes

Auteurs : A. E. Hawley ; L. Illum ; S. S. Davis

Source :

Biopharmaceutics & drug disposition [ 0142-2782 ] ; 1998.

RBID : Pascal:98-0262912

Descripteurs français

Pascal (Inist)
- Lymphoedème, Ganglion lymphatique, Système lymphatique, Capture, Rat, Animal, Exploration, Diagnostic, Styrène polymère, Copolymère séquencé, Biodégradabilité, Nanosphère.

English descriptors

KwdEn :
- Animal, Biodegradability, Block copolymer, Capture, Diagnosis, Exploration, Lymph node, Lymphatic system, Lymphedema, Rat, Styrene polymer.

Abstract

The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 BDDID8`
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A05				`@2 19`
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A08	`01`	`1`	`ENG`	`@1 The effect of lymphatic oedema on the uptake of colloids to the lymph nodes`
A11	`01`	`1`		`@1 HAWLEY (A. E.)`
A11	`02`	`1`		`@1 ILLUM (L.)`
A11	`03`	`1`		`@1 DAVIS (S. S.)`
A14	`01`			`@1 Department of Pharmaceutical Sciences, University of Nottingham @2 University Park, Nottingham NG7 2RD @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A20				`@1 193-197`
A21				`@1 1998`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 17959 @5 354000079297150090`
A44				`@0 0000 @1 © 1998 INIST-CNRS. All rights reserved.`
A45				`@0 25 ref.`
A47	`01`	`1`		`@0 98-0262912`
A60				`@1 P`
A61				`@0 A`
A64		`1`		`@0 Biopharmaceutics & drug disposition`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.
C02	`01`	`X`		`@0 002B12B04`
C03	`01`	`X`	`FRE`	`@0 Lymphoedème @5 01`
C03	`01`	`X`	`ENG`	`@0 Lymphedema @5 01`
C03	`01`	`X`	`SPA`	`@0 Linfedema @5 01`
C03	`02`	`X`	`FRE`	`@0 Ganglion lymphatique @5 04`
C03	`02`	`X`	`ENG`	`@0 Lymph node @5 04`
C03	`02`	`X`	`SPA`	`@0 Ganglio linfático @5 04`
C03	`03`	`X`	`FRE`	`@0 Système lymphatique @5 07`
C03	`03`	`X`	`ENG`	`@0 Lymphatic system @5 07`
C03	`03`	`X`	`SPA`	`@0 Sistema linfático @5 07`
C03	`04`	`X`	`FRE`	`@0 Capture @5 11`
C03	`04`	`X`	`ENG`	`@0 Capture @5 11`
C03	`04`	`X`	`SPA`	`@0 Captura @5 11`
C03	`05`	`X`	`FRE`	`@0 Rat @5 16`
C03	`05`	`X`	`ENG`	`@0 Rat @5 16`
C03	`05`	`X`	`SPA`	`@0 Rata @5 16`
C03	`06`	`X`	`FRE`	`@0 Animal @5 17`
C03	`06`	`X`	`ENG`	`@0 Animal @5 17`
C03	`06`	`X`	`SPA`	`@0 Animal @5 17`
C03	`07`	`X`	`FRE`	`@0 Exploration @5 18`
C03	`07`	`X`	`ENG`	`@0 Exploration @5 18`
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C03	`08`	`X`	`FRE`	`@0 Diagnostic @5 19`
C03	`08`	`X`	`ENG`	`@0 Diagnosis @5 19`
C03	`08`	`X`	`SPA`	`@0 Diagnóstico @5 19`
C03	`09`	`X`	`FRE`	`@0 Styrène polymère @2 NK @5 20`
C03	`09`	`X`	`ENG`	`@0 Styrene polymer @2 NK @5 20`
C03	`09`	`X`	`SPA`	`@0 Estireno polímero @2 NK @5 20`
C03	`10`	`X`	`FRE`	`@0 Copolymère séquencé @2 NK @5 21`
C03	`10`	`X`	`ENG`	`@0 Block copolymer @2 NK @5 21`
C03	`10`	`X`	`SPA`	`@0 Copolímero secuencia @2 NK @5 21`
C03	`11`	`X`	`FRE`	`@0 Biodégradabilité @5 22`
C03	`11`	`X`	`ENG`	`@0 Biodegradability @5 22`
C03	`11`	`X`	`SPA`	`@0 Biodegradabilidad @5 22`
C03	`12`	`X`	`FRE`	`@0 Nanosphère @4 INC @5 86`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 37`
C07	`04`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`04`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`05`	`X`	`FRE`	`@0 Lymphatique pathologie @5 38`
C07	`05`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 38`
C07	`05`	`X`	`SPA`	`@0 Linfático patología @5 38`
N21				`@1 173`

Format Inist (serveur)

NO :	PASCAL 98-0262912 INIST
ET :	The effect of lymphatic oedema on the uptake of colloids to the lymph nodes
AU :	HAWLEY (A. E.); ILLUM (L.); DAVIS (S. S.)
AF :	Department of Pharmaceutical Sciences, University of Nottingham/University Park, Nottingham NG7 2RD/Royaume-Uni (1 aut., 2 aut., 3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Biopharmaceutics & drug disposition; ISSN 0142-2782; Coden BDDID8; Royaume-Uni; Da. 1998; Vol. 19; No. 3; Pp. 193-197; Bibl. 25 ref.
LA :	Anglais
EA :	The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.
CC :	002B12B04
FD :	Lymphoedème; Ganglion lymphatique; Système lymphatique; Capture; Rat; Animal; Exploration; Diagnostic; Styrène polymère; Copolymère séquencé; Biodégradabilité; Nanosphère
FG :	Rodentia; Mammalia; Vertebrata; Appareil circulatoire pathologie; Lymphatique pathologie
ED :	Lymphedema; Lymph node; Lymphatic system; Capture; Rat; Animal; Exploration; Diagnosis; Styrene polymer; Block copolymer; Biodegradability
EG :	Rodentia; Mammalia; Vertebrata; Cardiovascular disease; Lymphatic vessel disease
SD :	Linfedema; Ganglio linfático; Sistema linfático; Captura; Rata; Animal; Exploración; Diagnóstico; Estireno polímero; Copolímero secuencia; Biodegradabilidad
LO :	INIST-17959.354000079297150090
ID :	98-0262912

Links to Exploration step

Pascal:98-0262912

Le document en format XML

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<front><div type="abstract" xml:lang="en">The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</div>
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<fC01 i1="01" l="ENG"><s0>The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</s0>
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<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0>
<s5>37</s5>
</fC07>
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<s5>37</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Lymphatique pathologie</s0>
<s5>38</s5>
</fC07>
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<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Linfático patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>173</s1>
</fN21>
</pA>
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<server><NO>PASCAL 98-0262912 INIST</NO>
<ET>The effect of lymphatic oedema on the uptake of colloids to the lymph nodes</ET>
<AU>HAWLEY (A. E.); ILLUM (L.); DAVIS (S. S.)</AU>
<AF>Department of Pharmaceutical Sciences, University of Nottingham/University Park, Nottingham NG7 2RD/Royaume-Uni (1 aut., 2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Biopharmaceutics & drug disposition; ISSN 0142-2782; Coden BDDID8; Royaume-Uni; Da. 1998; Vol. 19; No. 3; Pp. 193-197; Bibl. 25 ref.</SO>
<LA>Anglais</LA>
<EA>The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</EA>
<CC>002B12B04</CC>
<FD>Lymphoedème; Ganglion lymphatique; Système lymphatique; Capture; Rat; Animal; Exploration; Diagnostic; Styrène polymère; Copolymère séquencé; Biodégradabilité; Nanosphère</FD>
<FG>Rodentia; Mammalia; Vertebrata; Appareil circulatoire pathologie; Lymphatique pathologie</FG>
<ED>Lymphedema; Lymph node; Lymphatic system; Capture; Rat; Animal; Exploration; Diagnosis; Styrene polymer; Block copolymer; Biodegradability</ED>
<EG>Rodentia; Mammalia; Vertebrata; Cardiovascular disease; Lymphatic vessel disease</EG>
<SD>Linfedema; Ganglio linfático; Sistema linfático; Captura; Rata; Animal; Exploración; Diagnóstico; Estireno polímero; Copolímero secuencia; Biodegradabilidad</SD>
<LO>INIST-17959.354000079297150090</LO>
<ID>98-0262912</ID>
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</inist>
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The effect of lymphatic oedema on the uptake of colloids to the lymph nodes

The effect of lymphatic oedema on the uptake of colloids to the lymph nodes

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