The effect of lymphatic oedema on the uptake of colloids to the lymph nodes
Identifieur interne : 000A97 ( PascalFrancis/Corpus ); précédent : 000A96; suivant : 000A98The effect of lymphatic oedema on the uptake of colloids to the lymph nodes
Auteurs : A. E. Hawley ; L. Illum ; S. S. DavisSource :
- Biopharmaceutics & drug disposition [ 0142-2782 ] ; 1998.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 98-0262912 INIST |
---|---|
ET : | The effect of lymphatic oedema on the uptake of colloids to the lymph nodes |
AU : | HAWLEY (A. E.); ILLUM (L.); DAVIS (S. S.) |
AF : | Department of Pharmaceutical Sciences, University of Nottingham/University Park, Nottingham NG7 2RD/Royaume-Uni (1 aut., 2 aut., 3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Biopharmaceutics & drug disposition; ISSN 0142-2782; Coden BDDID8; Royaume-Uni; Da. 1998; Vol. 19; No. 3; Pp. 193-197; Bibl. 25 ref. |
LA : | Anglais |
EA : | The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system. |
CC : | 002B12B04 |
FD : | Lymphoedème; Ganglion lymphatique; Système lymphatique; Capture; Rat; Animal; Exploration; Diagnostic; Styrène polymère; Copolymère séquencé; Biodégradabilité; Nanosphère |
FG : | Rodentia; Mammalia; Vertebrata; Appareil circulatoire pathologie; Lymphatique pathologie |
ED : | Lymphedema; Lymph node; Lymphatic system; Capture; Rat; Animal; Exploration; Diagnosis; Styrene polymer; Block copolymer; Biodegradability |
EG : | Rodentia; Mammalia; Vertebrata; Cardiovascular disease; Lymphatic vessel disease |
SD : | Linfedema; Ganglio linfático; Sistema linfático; Captura; Rata; Animal; Exploración; Diagnóstico; Estireno polímero; Copolímero secuencia; Biodegradabilidad |
LO : | INIST-17959.354000079297150090 |
ID : | 98-0262912 |
Links to Exploration step
Pascal:98-0262912Le document en format XML
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<front><div type="abstract" xml:lang="en">The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</div>
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<ET>The effect of lymphatic oedema on the uptake of colloids to the lymph nodes</ET>
<AU>HAWLEY (A. E.); ILLUM (L.); DAVIS (S. S.)</AU>
<AF>Department of Pharmaceutical Sciences, University of Nottingham/University Park, Nottingham NG7 2RD/Royaume-Uni (1 aut., 2 aut., 3 aut.)</AF>
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<EA>The majority of pathological conditions of the lymphatic system can result in some degree of lymphoedema, which in turn causes a reduced rate of lymph flow. In some cases, such as when nodes are invaded by tumour metastases, blockage of the lymphatic vessels may occur. In order to investigate the effect of such pathology on nanosphere uptake in regional lymph nodes, the fate of model polystyrene nanospheres, surface modified with block co-polymers of the poloxamine series, was determined following subcutaneous administration in a rat model with lymphoedema (induced by the administration of λ-carrageenan). A drastic reduction of injection site drainage and lymph node uptake of nanospheres was observed in the inflammation model compared to control animals. The observations suggest that biodegradable nanospheres based on these will be suitable for the detection of oedema in the lymphatic system.</EA>
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