LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000681

Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema

Identifieur interne : 000681 ( PascalFrancis/Corpus ); précédent : 000680; suivant : 000682

Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema

Auteurs : Beatrice R. Amann-Vesti ; Gabriele Gitzelmann ; Renate Koppensteiner ; Ulrich K. Franzeck

Source :

Journal of vascular research [ 1018-1172 ] ; 2003.

RBID : Pascal:03-0339695

Descripteurs français

Pascal (Inist)
- Prostaglandine F2α, Lymphe, Pression capillaire, Microlymphographie, Lymphoedème, Homme.

English descriptors

KwdEn :
- Capillary pressure, Human, Lymph, Lymphedema, Microlymphography, Prostaglandin F2α.

Abstract

In patients with lymphedema, reduced lymph drainage capacity results in an overloaded superficial microlymphatic network and microlymphatic hypertension. In in vitro experiments, it has been shown that 8-epi-prostaglandin F2α(PGF) induced contractions in human lymphatics. Since lymphatic contractility plays a crucial role in the regulation and generation of lymph transport, we studied the effect of PGF on microlymphatic dynamics by measuring lymph capillary pressure (LCP). Twenty healthy volunteers and 13 patients with primary lymphedema were studied after either PGF or placebo was applied to the skin and occlusively covered for 30 min. Glass micropipettes (7-9 μm) were inserted under microscopic control into initial lymphatics visualized by fluorescence microlymphography and pressure measurements were performed using the servo-nulling technique. The mean LCP in patients with lymphedema was significantly higher (19.8 ± 12.1 mm Hg) than that in healthy controls (8.4 ± 4.1 mm Hg) at the placebo-treated site and decreased to normal values after PGF (10.0 ± 7.7 mm Hg). In healthy volunteers, there was no significant decrease of LCP with PGF compared to placebo. PGF normalizes microlymphatic hypertension in patients with lymphedema by improving lymph transport into deeper channels.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 AMANN-VESTI (Beatrice R.)`
A11	`02`	`1`		`@1 GITZELMANN (Gabriele)`
A11	`03`	`1`		`@1 KOPPENSTEINER (Renate)`
A11	`04`	`1`		`@1 FRANZECK (Ulrich K.)`
A14	`01`			`@1 Department of Medicine, Angiology Division, University Hospital @2 Zurich @3 CHE @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
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A60				`@1 P @3 PR`
A61				`@0 A`
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C03	`05`	`X`	`FRE`	`@0 Lymphoedème @5 12`
C03	`05`	`X`	`ENG`	`@0 Lymphedema @5 12`
C03	`05`	`X`	`SPA`	`@0 Linfedema @5 12`
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C07	`01`	`X`	`ENG`	`@0 Arachidonic acid derivatives @5 20`
C07	`01`	`X`	`SPA`	`@0 Araquidónico ácido derivado @5 20`
C07	`02`	`X`	`FRE`	`@0 Eicosanoïde @5 21`
C07	`02`	`X`	`ENG`	`@0 Eicosanoid @5 21`
C07	`02`	`X`	`SPA`	`@0 Eicosanoide @5 21`
C07	`03`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 22`
C07	`03`	`X`	`ENG`	`@0 Cardiovascular disease @5 22`
C07	`03`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 22`
C07	`04`	`X`	`FRE`	`@0 Lymphatique pathologie @5 23`
C07	`04`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 23`
C07	`04`	`X`	`SPA`	`@0 Linfático patología @5 23`
N21				`@1 237`

Format Inist (serveur)

NO :	PASCAL 03-0339695 INIST
ET :	Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema
AU :	AMANN-VESTI (Beatrice R.); GITZELMANN (Gabriele); KOPPENSTEINER (Renate); FRANZECK (Ulrich K.)
AF :	Department of Medicine, Angiology Division, University Hospital/Zurich/Suisse (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Papier de recherche; Niveau analytique
SO :	Journal of vascular research; ISSN 1018-1172; Suisse; Da. 2003; Vol. 40; No. 1; Pp. 77-82; Bibl. 31 ref.
LA :	Anglais
EA :	In patients with lymphedema, reduced lymph drainage capacity results in an overloaded superficial microlymphatic network and microlymphatic hypertension. In in vitro experiments, it has been shown that 8-epi-prostaglandin F2α(PGF) induced contractions in human lymphatics. Since lymphatic contractility plays a crucial role in the regulation and generation of lymph transport, we studied the effect of PGF on microlymphatic dynamics by measuring lymph capillary pressure (LCP). Twenty healthy volunteers and 13 patients with primary lymphedema were studied after either PGF or placebo was applied to the skin and occlusively covered for 30 min. Glass micropipettes (7-9 μm) were inserted under microscopic control into initial lymphatics visualized by fluorescence microlymphography and pressure measurements were performed using the servo-nulling technique. The mean LCP in patients with lymphedema was significantly higher (19.8 ± 12.1 mm Hg) than that in healthy controls (8.4 ± 4.1 mm Hg) at the placebo-treated site and decreased to normal values after PGF (10.0 ± 7.7 mm Hg). In healthy volunteers, there was no significant decrease of LCP with PGF compared to placebo. PGF normalizes microlymphatic hypertension in patients with lymphedema by improving lymph transport into deeper channels.
CC :	002B12B04
FD :	Prostaglandine F2α; Lymphe; Pression capillaire; Microlymphographie; Lymphoedème; Homme
FG :	Arachidonique acide dérivé; Eicosanoïde; Appareil circulatoire pathologie; Lymphatique pathologie
ED :	Prostaglandin F2α; Lymph; Capillary pressure; Microlymphography; Lymphedema; Human
EG :	Arachidonic acid derivatives; Eicosanoid; Cardiovascular disease; Lymphatic vessel disease
SD :	Prostaglandina F2α; Linfa; Presión capilar; Microlinfografía; Linfedema; Hombre
LO :	INIST-11498.354000109550460080
ID :	03-0339695

Links to Exploration step

Pascal:03-0339695

Le document en format XML

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<front><div type="abstract" xml:lang="en">In patients with lymphedema, reduced lymph drainage capacity results in an overloaded superficial microlymphatic network and microlymphatic hypertension. In in vitro experiments, it has been shown that 8-epi-prostaglandin F2α(PGF) induced contractions in human lymphatics. Since lymphatic contractility plays a crucial role in the regulation and generation of lymph transport, we studied the effect of PGF on microlymphatic dynamics by measuring lymph capillary pressure (LCP). Twenty healthy volunteers and 13 patients with primary lymphedema were studied after either PGF or placebo was applied to the skin and occlusively covered for 30 min. Glass micropipettes (7-9 μm) were inserted under microscopic control into initial lymphatics visualized by fluorescence microlymphography and pressure measurements were performed using the servo-nulling technique. The mean LCP in patients with lymphedema was significantly higher (19.8 ± 12.1 mm Hg) than that in healthy controls (8.4 ± 4.1 mm Hg) at the placebo-treated site and decreased to normal values after PGF (10.0 ± 7.7 mm Hg). In healthy volunteers, there was no significant decrease of LCP with PGF compared to placebo. PGF normalizes microlymphatic hypertension in patients with lymphedema by improving lymph transport into deeper channels.</div>
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<server><NO>PASCAL 03-0339695 INIST</NO>
<ET>Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema</ET>
<AU>AMANN-VESTI (Beatrice R.); GITZELMANN (Gabriele); KOPPENSTEINER (Renate); FRANZECK (Ulrich K.)</AU>
<AF>Department of Medicine, Angiology Division, University Hospital/Zurich/Suisse (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Journal of vascular research; ISSN 1018-1172; Suisse; Da. 2003; Vol. 40; No. 1; Pp. 77-82; Bibl. 31 ref.</SO>
<LA>Anglais</LA>
<EA>In patients with lymphedema, reduced lymph drainage capacity results in an overloaded superficial microlymphatic network and microlymphatic hypertension. In in vitro experiments, it has been shown that 8-epi-prostaglandin F2α(PGF) induced contractions in human lymphatics. Since lymphatic contractility plays a crucial role in the regulation and generation of lymph transport, we studied the effect of PGF on microlymphatic dynamics by measuring lymph capillary pressure (LCP). Twenty healthy volunteers and 13 patients with primary lymphedema were studied after either PGF or placebo was applied to the skin and occlusively covered for 30 min. Glass micropipettes (7-9 μm) were inserted under microscopic control into initial lymphatics visualized by fluorescence microlymphography and pressure measurements were performed using the servo-nulling technique. The mean LCP in patients with lymphedema was significantly higher (19.8 ± 12.1 mm Hg) than that in healthy controls (8.4 ± 4.1 mm Hg) at the placebo-treated site and decreased to normal values after PGF (10.0 ± 7.7 mm Hg). In healthy volunteers, there was no significant decrease of LCP with PGF compared to placebo. PGF normalizes microlymphatic hypertension in patients with lymphedema by improving lymph transport into deeper channels.</EA>
<CC>002B12B04</CC>
<FD>Prostaglandine F2α; Lymphe; Pression capillaire; Microlymphographie; Lymphoedème; Homme</FD>
<FG>Arachidonique acide dérivé; Eicosanoïde; Appareil circulatoire pathologie; Lymphatique pathologie</FG>
<ED>Prostaglandin F2α; Lymph; Capillary pressure; Microlymphography; Lymphedema; Human</ED>
<EG>Arachidonic acid derivatives; Eicosanoid; Cardiovascular disease; Lymphatic vessel disease</EG>
<SD>Prostaglandina F2α; Linfa; Presión capilar; Microlinfografía; Linfedema; Hombre</SD>
<LO>INIST-11498.354000109550460080</LO>
<ID>03-0339695</ID>
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Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema

Isoprostane 8-epi-prostaglandin F2a decreases lymph capillary pressure in patients with primary lymphedema

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