LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000500

Podoconiosis: a tropical model for gene-environment interactions?

Identifieur interne : 000500 ( PascalFrancis/Corpus ); précédent : 000499; suivant : 000501

Podoconiosis: a tropical model for gene-environment interactions?

Auteurs : Gail Davey ; Ewenat Gebrehanna ; Adebowale Adeyemo ; Charles Rotimi ; Melanie Newport ; Kelemu Desta

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007.

RBID : Pascal:07-0027190

Descripteurs français

Pascal (Inist)
- Lymphoedème, Eléphantiasis, Modèle, Interaction génotype environnement, Génétique, Sensibilité, Prédisposition, Héritabilité, Médecine tropicale, Homme, Ethiopie, Podoconiose.

English descriptors

KwdEn :
- Elephantiasis, Ethiopia, Genetics, Genotype environment interaction, Heritability, Human, Lymphedema, Models, Podoconiosis, Predisposition, Sensitivity, Tropical medicine.

Abstract

Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ_s) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ_s to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10^-7). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Podoconiosis: a tropical model for gene-environment interactions?`
A11	`01`	`1`		`@1 DAVEY (Gail)`
A11	`02`	`1`		`@1 GEBREHANNA (Ewenat)`
A11	`03`	`1`		`@1 ADEYEMO (Adebowale)`
A11	`04`	`1`		`@1 ROTIMI (Charles)`
A11	`05`	`1`		`@1 NEWPORT (Melanie)`
A11	`06`	`1`		`@1 DESTA (Kelemu)`
A14	`01`			`@1 Department of Community Health, Addis Ababa University, P.O. Box 26905/1000 @2 Addis Ababa @3 ETH @Z 1 aut. @Z 2 aut.`
A14	`02`			`@1 National Human Genome Center, Howard University, 2041 Georgia Avenue NW, Cancer Center Building, Room 61 @2 Washington DC 20060 @3 USA @Z 3 aut. @Z 4 aut.`
A14	`03`			`@1 Brighton and Sussex Medical School, University of Sussex @2 Falmer, Brighton BN1 9PS @3 GBR @Z 5 aut.`
A14	`04`			`@1 Mossy Foot Prevention and Treatment Association, P.O. Box 251 @2 Sodo, Wolaitta @3 ETH @Z 6 aut.`
A20				`@1 91-96`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 3084 @5 354000143175990120`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 26 ref.`
A47	`01`	`1`		`@0 07-0027190`
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A64	`01`	`1`		`@0 Transactions of the Royal Society of Tropical Medicine and Hygiene`
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C01	`01`		`ENG`	@0 Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ_s) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ_s to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10^-7). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.
C02	`01`	`X`		`@0 002B12B04`
C03	`01`	`X`	`FRE`	`@0 Lymphoedème @5 01`
C03	`01`	`X`	`ENG`	`@0 Lymphedema @5 01`
C03	`01`	`X`	`SPA`	`@0 Linfedema @5 01`
C03	`02`	`X`	`FRE`	`@0 Eléphantiasis @5 02`
C03	`02`	`X`	`ENG`	`@0 Elephantiasis @5 02`
C03	`02`	`X`	`SPA`	`@0 Elefantiasis @5 02`
C03	`03`	`X`	`FRE`	`@0 Modèle @5 09`
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C03	`03`	`X`	`SPA`	`@0 Modelo @5 09`
C03	`04`	`X`	`FRE`	`@0 Interaction génotype environnement @5 10`
C03	`04`	`X`	`ENG`	`@0 Genotype environment interaction @5 10`
C03	`04`	`X`	`SPA`	`@0 Interacción genotipo ambiente @5 10`
C03	`05`	`X`	`FRE`	`@0 Génétique @5 11`
C03	`05`	`X`	`ENG`	`@0 Genetics @5 11`
C03	`05`	`X`	`SPA`	`@0 Genética @5 11`
C03	`06`	`X`	`FRE`	`@0 Sensibilité @5 12`
C03	`06`	`X`	`ENG`	`@0 Sensitivity @5 12`
C03	`06`	`X`	`SPA`	`@0 Sensibilidad @5 12`
C03	`07`	`X`	`FRE`	`@0 Prédisposition @5 13`
C03	`07`	`X`	`ENG`	`@0 Predisposition @5 13`
C03	`07`	`X`	`SPA`	`@0 Predisposición @5 13`
C03	`08`	`X`	`FRE`	`@0 Héritabilité @5 14`
C03	`08`	`X`	`ENG`	`@0 Heritability @5 14`
C03	`08`	`X`	`SPA`	`@0 Heredabilidad @5 14`
C03	`09`	`X`	`FRE`	`@0 Médecine tropicale @5 15`
C03	`09`	`X`	`ENG`	`@0 Tropical medicine @5 15`
C03	`09`	`X`	`SPA`	`@0 Medicina tropical @5 15`
C03	`10`	`X`	`FRE`	`@0 Homme @5 16`
C03	`10`	`X`	`ENG`	`@0 Human @5 16`
C03	`10`	`X`	`SPA`	`@0 Hombre @5 16`
C03	`11`	`X`	`FRE`	`@0 Ethiopie @2 NG @5 17`
C03	`11`	`X`	`ENG`	`@0 Ethiopia @2 NG @5 17`
C03	`11`	`X`	`SPA`	`@0 Etiopia @2 NG @5 17`
C03	`12`	`X`	`FRE`	`@0 Podoconiose @4 CD @5 96`
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C07	`01`	`X`	`FRE`	`@0 Afrique @2 NG`
C07	`01`	`X`	`ENG`	`@0 Africa @2 NG`
C07	`01`	`X`	`SPA`	`@0 Africa @2 NG`
C07	`02`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 37`
C07	`02`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`02`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`03`	`X`	`FRE`	`@0 Lymphatique pathologie @5 38`
C07	`03`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 38`
C07	`03`	`X`	`SPA`	`@0 Linfático patología @5 38`
N21				`@1 015`

Format Inist (serveur)

NO :	PASCAL 07-0027190 INIST
ET :	Podoconiosis: a tropical model for gene-environment interactions?
AU :	DAVEY (Gail); GEBREHANNA (Ewenat); ADEYEMO (Adebowale); ROTIMI (Charles); NEWPORT (Melanie); DESTA (Kelemu)
AF :	Department of Community Health, Addis Ababa University, P.O. Box 26905/1000/Addis Ababa/Ethiopie (1 aut., 2 aut.); National Human Genome Center, Howard University, 2041 Georgia Avenue NW, Cancer Center Building, Room 61/Washington DC 20060/Etats-Unis (3 aut., 4 aut.); Brighton and Sussex Medical School, University of Sussex/Falmer, Brighton BN1 9PS/Royaume-Uni (5 aut.); Mossy Foot Prevention and Treatment Association, P.O. Box 251/Sodo, Wolaitta/Ethiopie (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Transactions of the Royal Society of Tropical Medicine and Hygiene; ISSN 0035-9203; Coden TRSTAZ; Royaume-Uni; Da. 2007; Vol. 101; No. 1; Pp. 91-96; Bibl. 26 ref.
LA :	Anglais
EA :	Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ_s) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ_s to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10^-7). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.
CC :	002B12B04
FD :	Lymphoedème; Eléphantiasis; Modèle; Interaction génotype environnement; Génétique; Sensibilité; Prédisposition; Héritabilité; Médecine tropicale; Homme; Ethiopie; Podoconiose
FG :	Afrique; Appareil circulatoire pathologie; Lymphatique pathologie
ED :	Lymphedema; Elephantiasis; Models; Genotype environment interaction; Genetics; Sensitivity; Predisposition; Heritability; Tropical medicine; Human; Ethiopia; Podoconiosis
EG :	Africa; Cardiovascular disease; Lymphatic vessel disease
SD :	Linfedema; Elefantiasis; Modelo; Interacción genotipo ambiente; Genética; Sensibilidad; Predisposición; Heredabilidad; Medicina tropical; Hombre; Etiopia
LO :	INIST-3084.354000143175990120
ID :	07-0027190

Links to Exploration step

Pascal:07-0027190

Le document en format XML

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<front><div type="abstract" xml:lang="en">Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ<sub>s</sub>
) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ<sub>s</sub>
 to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10<sup>-7</sup>
). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</div>
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<fC01 i1="01" l="ENG"><s0>Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ<sub>s</sub>
) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ<sub>s</sub>
 to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10<sup>-7</sup>
). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</s0>
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</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Lymphoedème</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Lymphedema</s0>
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<s5>02</s5>
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<fC03 i1="02" i2="X" l="SPA"><s0>Elefantiasis</s0>
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<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Sensitivity</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Sensibilidad</s0>
<s5>12</s5>
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<s5>13</s5>
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<s5>13</s5>
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<s5>13</s5>
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<fC03 i1="08" i2="X" l="FRE"><s0>Héritabilité</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Heritability</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Heredabilidad</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Médecine tropicale</s0>
<s5>15</s5>
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<s5>15</s5>
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<s5>15</s5>
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</fC03>
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<s5>16</s5>
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<s2>NG</s2>
<s5>17</s5>
</fC03>
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<s2>NG</s2>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Etiopia</s0>
<s2>NG</s2>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Podoconiose</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Podoconiosis</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Afrique</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Africa</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Africa</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Lymphatique pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Linfático patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>015</s1>
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<server><NO>PASCAL 07-0027190 INIST</NO>
<ET>Podoconiosis: a tropical model for gene-environment interactions?</ET>
<AU>DAVEY (Gail); GEBREHANNA (Ewenat); ADEYEMO (Adebowale); ROTIMI (Charles); NEWPORT (Melanie); DESTA (Kelemu)</AU>
<AF>Department of Community Health, Addis Ababa University, P.O. Box 26905/1000/Addis Ababa/Ethiopie (1 aut., 2 aut.); National Human Genome Center, Howard University, 2041 Georgia Avenue NW, Cancer Center Building, Room 61/Washington DC 20060/Etats-Unis (3 aut., 4 aut.); Brighton and Sussex Medical School, University of Sussex/Falmer, Brighton BN1 9PS/Royaume-Uni (5 aut.); Mossy Foot Prevention and Treatment Association, P.O. Box 251/Sodo, Wolaitta/Ethiopie (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Transactions of the Royal Society of Tropical Medicine and Hygiene; ISSN 0035-9203; Coden TRSTAZ; Royaume-Uni; Da. 2007; Vol. 101; No. 1; Pp. 91-96; Bibl. 26 ref.</SO>
<LA>Anglais</LA>
<EA>Podoconiosis (endemic non-filarial elephantiasis) is a geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It is a chronic, debilitating disorder and a considerable public health problem in at least 10 countries in tropical Africa, Central America and northern India. Only a small proportion of individuals exposed to red clay develop disease and familial clustering of cases occurs, so we tested the hypothesis that disease occurs in genetically susceptible individuals on exposure to an environmental element in soil. Using multiple statistical genetic techniques we estimated sibling recurrence risk ratio (λ<sub>s</sub>
) and heritability for podoconiosis, and conducted segregation analysis on 59 multi-generational affected families from Wolaitta Zone, southern Ethiopia. We estimated the λ<sub>s</sub>
 to be 5.07. The heritability of podoconiosis was estimated to be 0.629 (SE 0.069, P=1 × 10<sup>-7</sup>
). Segregation analysis showed that the most parsimonious model was that of an autosomal co-dominant major gene. Age and use of footwear were significant covariates in the final model. Host genetic factors are important determinants of susceptibility to podoconiosis. Identification of the gene(s) involved will lead to better understanding of the gene-environment interactions involved in the pathogenesis of podoconiosis and other complex multifactorial conditions.</EA>
<CC>002B12B04</CC>
<FD>Lymphoedème; Eléphantiasis; Modèle; Interaction génotype environnement; Génétique; Sensibilité; Prédisposition; Héritabilité; Médecine tropicale; Homme; Ethiopie; Podoconiose</FD>
<FG>Afrique; Appareil circulatoire pathologie; Lymphatique pathologie</FG>
<ED>Lymphedema; Elephantiasis; Models; Genotype environment interaction; Genetics; Sensitivity; Predisposition; Heritability; Tropical medicine; Human; Ethiopia; Podoconiosis</ED>
<EG>Africa; Cardiovascular disease; Lymphatic vessel disease</EG>
<SD>Linfedema; Elefantiasis; Modelo; Interacción genotipo ambiente; Genética; Sensibilidad; Predisposición; Heredabilidad; Medicina tropical; Hombre; Etiopia</SD>
<LO>INIST-3084.354000143175990120</LO>
<ID>07-0027190</ID>
</server>
</inist>
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Podoconiosis: a tropical model for gene-environment interactions?

Podoconiosis: a tropical model for gene-environment interactions?

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