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Clinical report: A novel VEGFR3 mutation causes milroy disease

Identifieur interne : 000470 ( PascalFrancis/Corpus ); précédent : 000469; suivant : 000471

Clinical report: A novel VEGFR3 mutation causes milroy disease

Auteurs : Matthew G. Butler ; Susan L. Dagenais ; Stanley G. Rockson ; Thomas W. Glover

Source :

RBID : Pascal:07-0289344

Descripteurs français

English descriptors

Abstract

Milroy disease, also known as primary congenital lymphedema, is a hereditary form of lymphedema with autosomal dominant inheritance. Individuals with Milroy disease are typically characterized by congenital onset of lymphedema of the lower limbs due to hypoplasia of the lymphatic vessels. The genetic basis of most cases of Milroy disease has not been established, although mutations in the vascular endothelial growth factor receptor VEGFR3 (FLT-4) are responsible for some cases with 17 mutations described to date. In this report, we describe a novel VEGFR3 mutation in exon 22 in a four-generation family in which congenital lymphedema segregates in an autosomal dominant manner. In addition to lymphedema, affected family members had other clinical manifestations associated with Milroy disease including hydrocele, ski jump toenails, large caliber veins, and subcutaneous thickening. We screened VEGFR3 for mutations which revealed a novel 3059A > T transversion in exon 22 resulting in Q1020L missense mutation in the second tyrosine kinase domain of VEGFR3. This mutant allele segregated with lymphedema among affected individuals with incomplete penetrance. This is the first report of an exon 22 mutation in Milroy disease.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03   1    @0 Am. j. med. genet., Part A
A05       @2 143
A06       @2 11
A08 01  1  ENG  @1 Clinical report: A novel VEGFR3 mutation causes milroy disease
A11 01  1    @1 BUTLER (Matthew G.)
A11 02  1    @1 DAGENAIS (Susan L.)
A11 03  1    @1 ROCKSON (Stanley G.)
A11 04  1    @1 GLOVER (Thomas W.)
A14 01      @1 Department of Human Genetics, University of Michigan @2 Ann Arbor, Michigan @3 USA @Z 1 aut. @Z 2 aut. @Z 4 aut.
A14 02      @1 Stanford School of Medicine, Stanford University @2 Stanford, California @3 USA @Z 3 aut.
A14 03      @1 Department of Pediatrics, University of Michigan @2 Ann Arbor, Michigan @3 USA @Z 4 aut.
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A64 01  1    @0 American journal of medical genetics. Part A
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C01 01    ENG  @0 Milroy disease, also known as primary congenital lymphedema, is a hereditary form of lymphedema with autosomal dominant inheritance. Individuals with Milroy disease are typically characterized by congenital onset of lymphedema of the lower limbs due to hypoplasia of the lymphatic vessels. The genetic basis of most cases of Milroy disease has not been established, although mutations in the vascular endothelial growth factor receptor VEGFR3 (FLT-4) are responsible for some cases with 17 mutations described to date. In this report, we describe a novel VEGFR3 mutation in exon 22 in a four-generation family in which congenital lymphedema segregates in an autosomal dominant manner. In addition to lymphedema, affected family members had other clinical manifestations associated with Milroy disease including hydrocele, ski jump toenails, large caliber veins, and subcutaneous thickening. We screened VEGFR3 for mutations which revealed a novel 3059A > T transversion in exon 22 resulting in Q1020L missense mutation in the second tyrosine kinase domain of VEGFR3. This mutant allele segregated with lymphedema among affected individuals with incomplete penetrance. This is the first report of an exon 22 mutation in Milroy disease.
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C03 01  X  ENG  @0 Lymphedema @5 01
C03 01  X  SPA  @0 Linfedema @5 01
C03 02  X  FRE  @0 Etude cas @5 09
C03 02  X  ENG  @0 Case study @5 09
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C03 03  X  FRE  @0 Mutation @5 10
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C07 01  X  SPA  @0 Aparato circulatorio patología @5 37
C07 02  X  FRE  @0 Lymphatique pathologie @5 38
C07 02  X  ENG  @0 Lymphatic vessel disease @5 38
C07 02  X  SPA  @0 Linfático patología @5 38
N21       @1 190
N44 01      @1 OTO
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Format Inist (serveur)

NO : PASCAL 07-0289344 INIST
ET : Clinical report: A novel VEGFR3 mutation causes milroy disease
AU : BUTLER (Matthew G.); DAGENAIS (Susan L.); ROCKSON (Stanley G.); GLOVER (Thomas W.)
AF : Department of Human Genetics, University of Michigan/Ann Arbor, Michigan/Etats-Unis (1 aut., 2 aut., 4 aut.); Stanford School of Medicine, Stanford University/Stanford, California/Etats-Unis (3 aut.); Department of Pediatrics, University of Michigan/Ann Arbor, Michigan/Etats-Unis (4 aut.)
DT : Publication en série; Niveau analytique
SO : American journal of medical genetics. Part A; ISSN 1552-4825; Etats-Unis; Da. 2007; Vol. 143; No. 11; Pp. 1212-1217; Bibl. 1/2 p.
LA : Anglais
EA : Milroy disease, also known as primary congenital lymphedema, is a hereditary form of lymphedema with autosomal dominant inheritance. Individuals with Milroy disease are typically characterized by congenital onset of lymphedema of the lower limbs due to hypoplasia of the lymphatic vessels. The genetic basis of most cases of Milroy disease has not been established, although mutations in the vascular endothelial growth factor receptor VEGFR3 (FLT-4) are responsible for some cases with 17 mutations described to date. In this report, we describe a novel VEGFR3 mutation in exon 22 in a four-generation family in which congenital lymphedema segregates in an autosomal dominant manner. In addition to lymphedema, affected family members had other clinical manifestations associated with Milroy disease including hydrocele, ski jump toenails, large caliber veins, and subcutaneous thickening. We screened VEGFR3 for mutations which revealed a novel 3059A > T transversion in exon 22 resulting in Q1020L missense mutation in the second tyrosine kinase domain of VEGFR3. This mutant allele segregated with lymphedema among affected individuals with incomplete penetrance. This is the first report of an exon 22 mutation in Milroy disease.
CC : 002B23; 002B12B04
FD : Lymphoedème; Etude cas; Mutation; Maladie
FG : Appareil circulatoire pathologie; Lymphatique pathologie
ED : Lymphedema; Case study; Mutation; Disease
EG : Cardiovascular disease; Lymphatic vessel disease
SD : Linfedema; Estudio caso; Mutación; Enfermedad
LO : INIST-17405A.354000149881340110
ID : 07-0289344

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Pascal:07-0289344

Le document en format XML

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