LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000315

Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep

Identifieur interne : 000315 ( PascalFrancis/Corpus ); précédent : 000314; suivant : 000316

Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep

Auteurs : Dalia Tobbia ; John Semple ; Amy Baker ; Dan Dumont ; Adam Semple ; Miles Johnston

Source :

Journal of vascular research [ 1018-1172 ] ; 2009.

RBID : Pascal:09-0354185

Descripteurs français

Pascal (Inist)
- Développement, Lymphatique, Ganglion lymphatique, Lymphe, Appareil circulatoire, Mammalia, Lymphoedème, Mouton.

English descriptors

KwdEn :
- Circulatory system, Development, Lymph, Lymph node, Lymphatic, Lymphedema, Mammalia, Sheep.

Abstract

Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, ¹²¹I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 J. vasc. res.`
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A08	`01`	`1`	`ENG`	`@1 Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep`
A11	`01`	`1`		`@1 TOBBIA (Dalia)`
A11	`02`	`1`		`@1 SEMPLE (John)`
A11	`03`	`1`		`@1 BAKER (Amy)`
A11	`04`	`1`		`@1 DUMONT (Dan)`
A11	`05`	`1`		`@1 SEMPLE (Adam)`
A11	`06`	`1`		`@1 JOHNSTON (Miles)`
A14	`01`			`@1 Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre @3 CAN @Z 3 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 Department of Surgery, Women's College Hospital @3 CAN @Z 1 aut. @Z 2 aut.`
A14	`03`			`@1 Molecular and Cell Biology, Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto @2 Toronto, Ont. @3 CAN @Z 4 aut.`
A20				`@1 426-434`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 11498 @5 354000172566120050`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 32 ref.`
A47	`01`	`1`		`@0 09-0354185`
A60				`@1 P @3 PR`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of vascular research`
A66	`01`			`@0 CHE`
C01	`01`		`ENG`	@0 Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, ¹²¹I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.
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C03	`07`	`X`	`FRE`	`@0 Lymphoedème @5 09`
C03	`07`	`X`	`ENG`	`@0 Lymphedema @5 09`
C03	`07`	`X`	`SPA`	`@0 Linfedema @5 09`
C03	`08`	`X`	`FRE`	`@0 Mouton @5 54`
C03	`08`	`X`	`ENG`	`@0 Sheep @5 54`
C03	`08`	`X`	`SPA`	`@0 Carnero @5 54`
C07	`01`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`01`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`01`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 20`
C07	`02`	`X`	`ENG`	`@0 Cardiovascular disease @5 20`
C07	`02`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 20`
C07	`03`	`X`	`FRE`	`@0 Pathologie des vaisseaux lymphatiques @5 21`
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C07	`04`	`X`	`FRE`	`@0 Artiodactyla @2 NS`
C07	`04`	`X`	`ENG`	`@0 Artiodactyla @2 NS`
C07	`04`	`X`	`SPA`	`@0 Artiodactyla @2 NS`
C07	`05`	`X`	`FRE`	`@0 Ungulata @2 NS`
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N21				`@1 257`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 09-0354185 INIST
ET :	Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep
AU :	TOBBIA (Dalia); SEMPLE (John); BAKER (Amy); DUMONT (Dan); SEMPLE (Adam); JOHNSTON (Miles)
AF :	Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre/Canada (3 aut., 5 aut., 6 aut.); Department of Surgery, Women's College Hospital/Canada (1 aut., 2 aut.); Molecular and Cell Biology, Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto/Toronto, Ont./Canada (4 aut.)
DT :	Publication en série; Papier de recherche; Niveau analytique
SO :	Journal of vascular research; ISSN 1018-1172; Suisse; Da. 2009; Vol. 46; No. 5; Pp. 426-434; Bibl. 32 ref.
LA :	Anglais
EA :	Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, ¹²¹I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.
CC :	002A22; 002B12B04
FD :	Développement; Lymphatique; Ganglion lymphatique; Lymphe; Appareil circulatoire; Mammalia; Lymphoedème; Mouton
FG :	Vertebrata; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques; Artiodactyla; Ungulata
ED :	Development; Lymphatic; Lymph node; Lymph; Circulatory system; Mammalia; Lymphedema; Sheep
EG :	Vertebrata; Cardiovascular disease; Lymphatic vessel disease; Artiodactyla; Ungulata
SD :	Desarrollo; Linfático; Ganglio linfático; Linfa; Aparato circulatorio; Mammalia; Linfedema; Carnero
LO :	INIST-11498.354000172566120050
ID :	09-0354185

Links to Exploration step

Pascal:09-0354185

Le document en format XML

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<term>Mammalia</term>
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<front><div type="abstract" xml:lang="en">Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, <sup>121</sup>
I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.</div>
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<fC01 i1="01" l="ENG"><s0>Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, <sup>121</sup>
I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.</s0>
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<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Circulatory system</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Lymphoedème</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Lymphedema</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Linfedema</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Mouton</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Sheep</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Carnero</s0>
<s5>54</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>20</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie des vaisseaux lymphatiques</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Linfático patología</s0>
<s5>21</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Artiodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>257</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0354185 INIST</NO>
<ET>Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep</ET>
<AU>TOBBIA (Dalia); SEMPLE (John); BAKER (Amy); DUMONT (Dan); SEMPLE (Adam); JOHNSTON (Miles)</AU>
<AF>Neuroscience Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook Health Sciences Centre/Canada (3 aut., 5 aut., 6 aut.); Department of Surgery, Women's College Hospital/Canada (1 aut., 2 aut.); Molecular and Cell Biology, Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto/Toronto, Ont./Canada (4 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>Journal of vascular research; ISSN 1018-1172; Suisse; Da. 2009; Vol. 46; No. 5; Pp. 426-434; Bibl. 32 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Our objective was to develop an animal model of postsurgical lymphedema that would permit quantitation of edema and lymphatic function after the removal of a single popliteal lymph node in sheep. Methods: As a measure of lymph transport, <sup>121</sup>
I - human serum albumin was injected into prenodal vessels at 8,12 and 16 weeks after nodal excision, and plasma levels of the protein tracer were used to calculate the transport rate of the tracer to blood (percent injected per hour). Edema was quantified from the circumferential measurement of the hind limbs. Results and Conclusions: Following nodal excision, the limbs became progressively more edematous up to 3 days after nodectomy. After this, the swelling decreased but had not resolved even at 16 weeks after surgery. Compared with control limbs (17.2 ± 0.6; n = 7), lymphatic function was depressed at 8 weeks after surgery (10.6 ± 1.5; n = 7). At 12 (14.4 ± 1.0; n = 7) and 16 weeks (13.9 ± 1.0; n = 6), regeneration of lymphatic vessels at the excision site helped to restore about 80% of lymphatic capacity. These techniques may be helpful in understanding the pathophysiology associated with cancer-related postsurgical lymphedema and may facilitate the development of new strategies to treat or prevent this condition.</EA>
<CC>002A22; 002B12B04</CC>
<FD>Développement; Lymphatique; Ganglion lymphatique; Lymphe; Appareil circulatoire; Mammalia; Lymphoedème; Mouton</FD>
<FG>Vertebrata; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques; Artiodactyla; Ungulata</FG>
<ED>Development; Lymphatic; Lymph node; Lymph; Circulatory system; Mammalia; Lymphedema; Sheep</ED>
<EG>Vertebrata; Cardiovascular disease; Lymphatic vessel disease; Artiodactyla; Ungulata</EG>
<SD>Desarrollo; Linfático; Ganglio linfático; Linfa; Aparato circulatorio; Mammalia; Linfedema; Carnero</SD>
<LO>INIST-11498.354000172566120050</LO>
<ID>09-0354185</ID>
</server>
</inist>
</record>

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Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep

Lymphedema Development and Lymphatic Function following Lymph Node Excision in Sheep

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