LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000230

Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations

Identifieur interne : 000230 ( PascalFrancis/Corpus ); précédent : 000229; suivant : 000231

Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations

Auteurs : Mads R. Jensen ; Lene Simonsen ; Tonny Karlsmark ; Jens Bülow

Source :

Clinical physiology and functional imaging : (Print) [ 1475-0961 ] ; 2010.

RBID : Pascal:10-0479117

Descripteurs français

Pascal (Inist)
- Extrémité inférieure, Physiopathologie, Chronique, Liquide interstitiel, Système lymphatique, Rythme, Mammalia, Lymphoedème.

English descriptors

KwdEn :
- Chronic, Interstitial fluid, Lower extremity, Lymphatic system, Lymphedema, Mammalia, Pathophysiology, Rhythm.

Abstract

Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08	`01`	`1`	`ENG`	`@1 Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations`
A11	`01`	`1`		`@1 JENSEN (Mads R.)`
A11	`02`	`1`		`@1 SIMONSEN (Lene)`
A11	`03`	`1`		`@1 KARLSMARK (Tonny)`
A11	`04`	`1`		`@1 BÜLOW (Jens)`
A14	`01`			`@1 Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen @2 Copenhagen NV @3 DNK @Z 1 aut. @Z 2 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen @2 Copenhagen NV @3 DNK @Z 3 aut.`
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C01	`01`		`ENG`	@0 Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.
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C03	`01`	`X`	`SPA`	`@0 Extremidad inferior @5 01`
C03	`02`	`X`	`FRE`	`@0 Physiopathologie @5 02`
C03	`02`	`X`	`ENG`	`@0 Pathophysiology @5 02`
C03	`02`	`X`	`SPA`	`@0 Fisiopatología @5 02`
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C03	`04`	`X`	`FRE`	`@0 Liquide interstitiel @5 04`
C03	`04`	`X`	`ENG`	`@0 Interstitial fluid @5 04`
C03	`04`	`X`	`SPA`	`@0 Líquido intersticial @5 04`
C03	`05`	`X`	`FRE`	`@0 Système lymphatique @5 05`
C03	`05`	`X`	`ENG`	`@0 Lymphatic system @5 05`
C03	`05`	`X`	`SPA`	`@0 Sistema linfático @5 05`
C03	`06`	`X`	`FRE`	`@0 Rythme @5 06`
C03	`06`	`X`	`ENG`	`@0 Rhythm @5 06`
C03	`06`	`X`	`SPA`	`@0 Ritmo @5 06`
C03	`07`	`X`	`FRE`	`@0 Mammalia @2 NS @5 07`
C03	`07`	`X`	`ENG`	`@0 Mammalia @2 NS @5 07`
C03	`07`	`X`	`SPA`	`@0 Mammalia @2 NS @5 07`
C03	`08`	`X`	`FRE`	`@0 Lymphoedème @5 09`
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C03	`08`	`X`	`SPA`	`@0 Linfedema @5 09`
C07	`01`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`01`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`01`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 20`
C07	`02`	`X`	`ENG`	`@0 Cardiovascular disease @5 20`
C07	`02`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 20`
C07	`03`	`X`	`FRE`	`@0 Pathologie des vaisseaux lymphatiques @5 21`
C07	`03`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 21`
C07	`03`	`X`	`SPA`	`@0 Linfático patología @5 21`
N21				`@1 312`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0479117 INIST
ET :	Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations
AU :	JENSEN (Mads R.); SIMONSEN (Lene); KARLSMARK (Tonny); BÜLOW (Jens)
AF :	Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen/Copenhagen NV/Danemark (1 aut., 2 aut., 4 aut.); Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen/Copenhagen NV/Danemark (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Clinical physiology and functional imaging : (Print); ISSN 1475-0961; Royaume-Uni; Da. 2010; Vol. 30; No. 6; Pp. 389-398; Bibl. 2 p.1/4
LA :	Anglais
EA :	Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.
CC :	002A16
FD :	Extrémité inférieure; Physiopathologie; Chronique; Liquide interstitiel; Système lymphatique; Rythme; Mammalia; Lymphoedème
FG :	Vertebrata; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques
ED :	Lower extremity; Pathophysiology; Chronic; Interstitial fluid; Lymphatic system; Rhythm; Mammalia; Lymphedema
EG :	Vertebrata; Cardiovascular disease; Lymphatic vessel disease
SD :	Extremidad inferior; Fisiopatología; Crónico; Líquido intersticial; Sistema linfático; Ritmo; Mammalia; Linfedema
LO :	INIST-19275.354000193243270020
ID :	10-0479117

Links to Exploration step

Pascal:10-0479117

Le document en format XML

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<front><div type="abstract" xml:lang="en">Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.</div>
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<fC01 i1="01" l="ENG"><s0>Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.</s0>
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<s5>09</s5>
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<s5>21</s5>
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<fN21><s1>312</s1>
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<server><NO>PASCAL 10-0479117 INIST</NO>
<ET>Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations</ET>
<AU>JENSEN (Mads R.); SIMONSEN (Lene); KARLSMARK (Tonny); BÜLOW (Jens)</AU>
<AF>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen/Copenhagen NV/Danemark (1 aut., 2 aut., 4 aut.); Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen/Copenhagen NV/Danemark (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical physiology and functional imaging : (Print); ISSN 1475-0961; Royaume-Uni; Da. 2010; Vol. 30; No. 6; Pp. 389-398; Bibl. 2 p.1/4</SO>
<LA>Anglais</LA>
<EA>Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature-based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.</EA>
<CC>002A16</CC>
<FD>Extrémité inférieure; Physiopathologie; Chronique; Liquide interstitiel; Système lymphatique; Rythme; Mammalia; Lymphoedème</FD>
<FG>Vertebrata; Pathologie de l'appareil circulatoire; Pathologie des vaisseaux lymphatiques</FG>
<ED>Lower extremity; Pathophysiology; Chronic; Interstitial fluid; Lymphatic system; Rhythm; Mammalia; Lymphedema</ED>
<EG>Vertebrata; Cardiovascular disease; Lymphatic vessel disease</EG>
<SD>Extremidad inferior; Fisiopatología; Crónico; Líquido intersticial; Sistema linfático; Ritmo; Mammalia; Linfedema</SD>
<LO>INIST-19275.354000193243270020</LO>
<ID>10-0479117</ID>
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Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations

Lymphoedema of the lower extremities - background, pathophysiology and diagnostic considerations

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