LymphedemaV1, PascalFrancis, Corpus, bibRecord, 000167

Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature

Identifieur interne : 000167 ( PascalFrancis/Corpus ); précédent : 000166; suivant : 000168

Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature

Auteurs : Wonwoo Shon ; Christiane M. Ida ; Jennifer M. Boland-Froemming ; Peter S. Rose ; Andrew Folpe

Source :

Journal of cutaneous pathology [ 0303-6987 ] ; 2011.

RBID : Pascal:11-0295121

Descripteurs français

Pascal (Inist)
- Angiosarcome, Lymphoedème, Obésité, Peau, Localisé, Revue bibliographique, Dermatologie, Anatomopathologie, Sarcome, Etat nutritionnel.

English descriptors

KwdEn :
- Anatomic pathology, Angiosarcoma, Bibliographic review, Dermatology, Localized, Lymphedema, Nutritional status, Obesity, Sarcoma, Skin.

Abstract

A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm²; range: 37.6-68.5 kg/cm²) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 JCUPBN`
A03		`1`		`@0 J. cutan. pathol.`
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A08	`01`	`1`	`ENG`	`@1 Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature`
A11	`01`	`1`		`@1 SHON (Wonwoo)`
A11	`02`	`1`		`@1 IDA (Christiane M.)`
A11	`03`	`1`		`@1 BOLAND-FROEMMING (Jennifer M.)`
A11	`04`	`1`		`@1 ROSE (Peter S.)`
A11	`05`	`1`		`@1 FOLPE (Andrew)`
A14	`01`			`@1 Department of Laboratory Medicine and Pathology, Mayo Clinic @2 Rochester, MN 55905 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
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A21				`@1 2011`
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A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 16 ref.`
A47	`01`	`1`		`@0 11-0295121`
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A64	`01`	`1`		`@0 Journal of cutaneous pathology`
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C01	`01`		`ENG`	@0 A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm²; range: 37.6-68.5 kg/cm²) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.
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C02	`02`	`X`		`@0 002B12B04`
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C03	`01`	`X`	`ENG`	`@0 Angiosarcoma @5 01`
C03	`01`	`X`	`SPA`	`@0 Angiosarcoma @5 01`
C03	`02`	`X`	`FRE`	`@0 Lymphoedème @5 02`
C03	`02`	`X`	`ENG`	`@0 Lymphedema @5 02`
C03	`02`	`X`	`SPA`	`@0 Linfedema @5 02`
C03	`03`	`X`	`FRE`	`@0 Obésité @5 03`
C03	`03`	`X`	`ENG`	`@0 Obesity @5 03`
C03	`03`	`X`	`SPA`	`@0 Obesidad @5 03`
C03	`04`	`X`	`FRE`	`@0 Peau @5 07`
C03	`04`	`X`	`ENG`	`@0 Skin @5 07`
C03	`04`	`X`	`SPA`	`@0 Piel @5 07`
C03	`05`	`X`	`FRE`	`@0 Localisé @5 08`
C03	`05`	`X`	`ENG`	`@0 Localized @5 08`
C03	`05`	`X`	`SPA`	`@0 Localizado @5 08`
C03	`06`	`X`	`FRE`	`@0 Revue bibliographique @5 09`
C03	`06`	`X`	`ENG`	`@0 Bibliographic review @5 09`
C03	`06`	`X`	`SPA`	`@0 Revista bibliográfica @5 09`
C03	`07`	`X`	`FRE`	`@0 Dermatologie @5 13`
C03	`07`	`X`	`ENG`	`@0 Dermatology @5 13`
C03	`07`	`X`	`SPA`	`@0 Dermatología @5 13`
C03	`08`	`X`	`FRE`	`@0 Anatomopathologie @5 30`
C03	`08`	`X`	`ENG`	`@0 Anatomic pathology @5 30`
C03	`08`	`X`	`SPA`	`@0 Anatomía patológica @5 30`
C03	`09`	`X`	`FRE`	`@0 Sarcome @5 31`
C03	`09`	`X`	`ENG`	`@0 Sarcoma @5 31`
C03	`09`	`X`	`SPA`	`@0 Sarcoma @5 31`
C03	`10`	`X`	`FRE`	`@0 Etat nutritionnel @5 32`
C03	`10`	`X`	`ENG`	`@0 Nutritional status @5 32`
C03	`10`	`X`	`SPA`	`@0 Estado nutricional @5 32`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 37`
C07	`01`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Tumeur maligne @2 NM @5 38`
C07	`02`	`X`	`ENG`	`@0 Malignant tumor @2 NM @5 38`
C07	`02`	`X`	`SPA`	`@0 Tumor maligno @2 NM @5 38`
C07	`03`	`X`	`FRE`	`@0 Cancer @2 NM`
C07	`03`	`X`	`ENG`	`@0 Cancer @2 NM`
C07	`03`	`X`	`SPA`	`@0 Cáncer @2 NM`
C07	`04`	`X`	`FRE`	`@0 Pathologie des vaisseaux sanguins @5 39`
C07	`04`	`X`	`ENG`	`@0 Vascular disease @5 39`
C07	`04`	`X`	`SPA`	`@0 Vaso sanguíneo patología @5 39`
C07	`05`	`X`	`FRE`	`@0 Pathologie des vaisseaux lymphatiques @5 40`
C07	`05`	`X`	`ENG`	`@0 Lymphatic vessel disease @5 40`
C07	`05`	`X`	`SPA`	`@0 Linfático patología @5 40`
C07	`06`	`X`	`FRE`	`@0 Trouble de la nutrition @5 41`
C07	`06`	`X`	`ENG`	`@0 Nutrition disorder @5 41`
C07	`06`	`X`	`SPA`	`@0 Trastorno nutricíon @5 41`
N21				`@1 199`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 11-0295121 INIST
ET :	Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature
AU :	SHON (Wonwoo); IDA (Christiane M.); BOLAND-FROEMMING (Jennifer M.); ROSE (Peter S.); FOLPE (Andrew)
AF :	Department of Laboratory Medicine and Pathology, Mayo Clinic/Rochester, MN 55905/Etats-Unis (1 aut., 2 aut., 3 aut., 5 aut.); Department of Orthopedic Surgery, Mayo Clinic/Rochester, MN 55905/Etats-Unis (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of cutaneous pathology; ISSN 0303-6987; Coden JCUPBN; Etats-Unis; Da. 2011; Vol. 38; No. 7; Pp. 560-564; Bibl. 16 ref.
LA :	Anglais
EA :	A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm²; range: 37.6-68.5 kg/cm²) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.
CC :	002B08; 002B12B04; 002B22B
FD :	Angiosarcome; Lymphoedème; Obésité; Peau; Localisé; Revue bibliographique; Dermatologie; Anatomopathologie; Sarcome; Etat nutritionnel
FG :	Pathologie de l'appareil circulatoire; Tumeur maligne; Cancer; Pathologie des vaisseaux sanguins; Pathologie des vaisseaux lymphatiques; Trouble de la nutrition
ED :	Angiosarcoma; Lymphedema; Obesity; Skin; Localized; Bibliographic review; Dermatology; Anatomic pathology; Sarcoma; Nutritional status
EG :	Cardiovascular disease; Malignant tumor; Cancer; Vascular disease; Lymphatic vessel disease; Nutrition disorder
SD :	Angiosarcoma; Linfedema; Obesidad; Piel; Localizado; Revista bibliográfica; Dermatología; Anatomía patológica; Sarcoma; Estado nutricional
LO :	INIST-16275.354000190362510050
ID :	11-0295121

Links to Exploration step

Pascal:11-0295121

Le document en format XML

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<front><div type="abstract" xml:lang="en">A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm<sup>2</sup>
; range: 37.6-68.5 kg/cm<sup>2</sup>
) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.</div>
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<fC01 i1="01" l="ENG"><s0>A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm<sup>2</sup>
; range: 37.6-68.5 kg/cm<sup>2</sup>
) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.</s0>
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<fC03 i1="01" i2="X" l="FRE"><s0>Angiosarcome</s0>
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<fC03 i1="01" i2="X" l="ENG"><s0>Angiosarcoma</s0>
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<fC03 i1="04" i2="X" l="SPA"><s0>Piel</s0>
<s5>07</s5>
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<fC03 i1="05" i2="X" l="FRE"><s0>Localisé</s0>
<s5>08</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Localized</s0>
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<fC03 i1="05" i2="X" l="SPA"><s0>Localizado</s0>
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<s5>13</s5>
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<s5>30</s5>
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<s5>30</s5>
</fC03>
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<s5>30</s5>
</fC03>
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<s5>31</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Sarcoma</s0>
<s5>31</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Sarcoma</s0>
<s5>31</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Etat nutritionnel</s0>
<s5>32</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nutritional status</s0>
<s5>32</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Estado nutricional</s0>
<s5>32</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
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<s5>37</s5>
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<fC07 i1="02" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Malignant tumor</s0>
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<s5>38</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
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<s2>NM</s2>
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<fC07 i1="03" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
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<fC07 i1="04" i2="X" l="ENG"><s0>Vascular disease</s0>
<s5>39</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Vaso sanguíneo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie des vaisseaux lymphatiques</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Linfático patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Trouble de la nutrition</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Nutrition disorder</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Trastorno nutricíon</s0>
<s5>41</s5>
</fC07>
<fN21><s1>199</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<server><NO>PASCAL 11-0295121 INIST</NO>
<ET>Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature</ET>
<AU>SHON (Wonwoo); IDA (Christiane M.); BOLAND-FROEMMING (Jennifer M.); ROSE (Peter S.); FOLPE (Andrew)</AU>
<AF>Department of Laboratory Medicine and Pathology, Mayo Clinic/Rochester, MN 55905/Etats-Unis (1 aut., 2 aut., 3 aut., 5 aut.); Department of Orthopedic Surgery, Mayo Clinic/Rochester, MN 55905/Etats-Unis (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of cutaneous pathology; ISSN 0303-6987; Coden JCUPBN; Etats-Unis; Da. 2011; Vol. 38; No. 7; Pp. 560-564; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart-Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body mass index = 47.2 kg/cm<sup>2</sup>
; range: 37.6-68.5 kg/cm<sup>2</sup>
) and had long-standing soft tissue changes of MLL. The tumors arose in the thigh (two cases), lower leg (two cases) and abdomen/proximal thigh (one case) and ranged from 6 to 28.5 cm in size (mean: 15.9 cm). All tumors were conventional high-grade angiosarcomas and microscopically exhibited an admixture of vasoformative, spindled and epithelioid features. Microscopic changes of MLL, including dermal fibrosis, expansion of interlobular fibrous septa and lymphangiectasia, were identified in all cases. Clinical follow-up (four cases; mean: 13.8 months; range: 2-32 months) showed one patient to be dead of disease, one patient to be dead from therapy-related complications and two patients to be alive without disease. One case was too recent for meaningful clinical follow-up. We conclude that lymphedema secondary to obesity should be recognized as a significant risk factor for the development of angiosarcoma. The clinical and pathological features of angiosarcoma arising in this distinctive clinical setting appear to be identical to those of other lymphedema-associated angiosarcomas. With the continuing epidemic of obesity in Western societies, the incidence of obesity-related angiosarcoma is probably to increase. Consequently, it is critical that lymphedematous areas in obese patients be carefully examined for clinical evidence of early angiosarcoma, with the hope that timely diagnosis may lead to improved patient outcome.</EA>
<CC>002B08; 002B12B04; 002B22B</CC>
<FD>Angiosarcome; Lymphoedème; Obésité; Peau; Localisé; Revue bibliographique; Dermatologie; Anatomopathologie; Sarcome; Etat nutritionnel</FD>
<FG>Pathologie de l'appareil circulatoire; Tumeur maligne; Cancer; Pathologie des vaisseaux sanguins; Pathologie des vaisseaux lymphatiques; Trouble de la nutrition</FG>
<ED>Angiosarcoma; Lymphedema; Obesity; Skin; Localized; Bibliographic review; Dermatology; Anatomic pathology; Sarcoma; Nutritional status</ED>
<EG>Cardiovascular disease; Malignant tumor; Cancer; Vascular disease; Lymphatic vessel disease; Nutrition disorder</EG>
<SD>Angiosarcoma; Linfedema; Obesidad; Piel; Localizado; Revista bibliográfica; Dermatología; Anatomía patológica; Sarcoma; Estado nutricional</SD>
<LO>INIST-16275.354000190362510050</LO>
<ID>11-0295121</ID>
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Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature

Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature

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