Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area
Identifieur interne : 000521 ( PascalFrancis/Checkpoint ); précédent : 000520; suivant : 000522Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area
Auteurs : T. Mcpherson [Royaume-Uni] ; S. Persaud [Guyana] ; S. Singh [Guyana] ; M. P. Fay [États-Unis] ; D. Addiss [États-Unis] ; T. B. Nutman [États-Unis] ; R. Hay [Royaume-Uni]Source :
- British journal of dermatology : (1951) [ 0007-0963 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance. Objectives To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema. Methods The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti. Results More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P < 0.005 compared with controls). The number of lesions was the strongest predictor of frequency of ADLA. Only 18% of the lesions had positive microscopy or culture for fungi (dermatophytes and Scytalidium). Conclusions These findings highlight the importance of interdigital entry lesions as risk factors for episodes of ADLA and have implications for the control of morbidity from filarial lymphoedema.
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Persaud</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ministry of Health</s1><s3>GUY</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Guyana</country><wicri:noRegion>Ministry of Health</wicri:noRegion></affiliation></author><author><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ministry of Health</s1><s3>GUY</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Guyana</country><wicri:noRegion>Ministry of Health</wicri:noRegion></affiliation></author><author><name sortKey="Fay, M P" sort="Fay, M P" uniqKey="Fay M" first="M. P." last="Fay">M. P. Fay</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Biostatistic Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Addiss, D" sort="Addiss, D" uniqKey="Addiss D" first="D." last="Addiss">D. Addiss</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T. B." last="Nutman">T. B. Nutman</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hay, R" sort="Hay, R" uniqKey="Hay R" first="R." last="Hay">R. Hay</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queen's University</s1><s2>Belfast</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen's University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0223795</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0223795 INIST</idno><idno type="RBID">Pascal:06-0223795</idno><idno type="wicri:Area/PascalFrancis/Corpus">000536</idno><idno type="wicri:Area/PascalFrancis/Curation">000424</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000521</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000521</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area</title><author><name sortKey="Mcpherson, T" sort="Mcpherson, T" uniqKey="Mcpherson T" first="T." last="Mcpherson">T. Mcpherson</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Mycology, St John's Institute of Dermatology, King's College</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Persaud, S" sort="Persaud, S" uniqKey="Persaud S" first="S." last="Persaud">S. Persaud</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ministry of Health</s1><s3>GUY</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Guyana</country><wicri:noRegion>Ministry of Health</wicri:noRegion></affiliation></author><author><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Ministry of Health</s1><s3>GUY</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Guyana</country><wicri:noRegion>Ministry of Health</wicri:noRegion></affiliation></author><author><name sortKey="Fay, M P" sort="Fay, M P" uniqKey="Fay M" first="M. P." last="Fay">M. P. Fay</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Biostatistic Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Addiss, D" sort="Addiss, D" uniqKey="Addiss D" first="D." last="Addiss">D. Addiss</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T. B." last="Nutman">T. B. Nutman</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Hay, R" sort="Hay, R" uniqKey="Hay R" first="R." last="Hay">R. Hay</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Queen's University</s1><s2>Belfast</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Queen's University</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">British journal of dermatology : (1951)</title><title level="j" type="abbreviated">Br. j. dermatol. : (1951)</title><idno type="ISSN">0007-0963</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dermatology</term><term>Filariosis</term><term>Human</term><term>Lymphatic system</term><term>Lymphedema</term><term>Skin</term><term>Skin disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lymphoedème</term><term>Filariose</term><term>Peau</term><term>Homme</term><term>Peau pathologie</term><term>Système lymphatique</term><term>Dermatologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance. Objectives To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema. Methods The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti. Results More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P < 0.005 compared with controls). The number of lesions was the strongest predictor of frequency of ADLA. Only 18% of the lesions had positive microscopy or culture for fungi (dermatophytes and Scytalidium). Conclusions These findings highlight the importance of interdigital entry lesions as risk factors for episodes of ADLA and have implications for the control of morbidity from filarial lymphoedema.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0007-0963</s0></fA01><fA02 i1="01"><s0>BJDEAZ</s0></fA02><fA03 i2="1"><s0>Br. j. dermatol. : (1951)</s0></fA03><fA05><s2>154</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area</s1></fA08><fA11 i1="01" i2="1"><s1>MCPHERSON (T.)</s1></fA11><fA11 i1="02" i2="1"><s1>PERSAUD (S.)</s1></fA11><fA11 i1="03" i2="1"><s1>SINGH (S.)</s1></fA11><fA11 i1="04" i2="1"><s1>FAY (M. P.)</s1></fA11><fA11 i1="05" i2="1"><s1>ADDISS (D.)</s1></fA11><fA11 i1="06" i2="1"><s1>NUTMAN (T. B.)</s1></fA11><fA11 i1="07" i2="1"><s1>HAY (R.)</s1></fA11><fA14 i1="01"><s1>Department of Mycology, St John's Institute of Dermatology, King's College</s1><s2>London</s2><s3>GBR</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Ministry of Health</s1><s3>GUY</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="03"><s1>Biostatistic Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</s1><s2>Bethesda, MD</s2><s3>USA</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Queen's University</s1><s2>Belfast</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA20><s1>933-941</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>1043</s2><s5>354000153256580200</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>64 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>06-0223795</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>British journal of dermatology : (1951)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background Lymphatic filariasis (LF) is a mosquito-borne nematode infection that causes permanent lymphatic dysfunction in virtually all infected individuals and clinical disease in a subset of these. One major sequel of infection is lymphoedema of the limbs. Lymphoedema of the leg affects an estimated 15 million persons in LF-endemic areas worldwide. Acute dermatolymphangioadenitis (ADLA) in people with filarial lymphoedema causes acute morbidity and increasingly severe lymphoedema. Episodes of ADLA are believed to be caused by bacteria, and it has been shown that entry lesions in the skin play a causative role. Clinical observations suggest that interdigital skin lesions of the feet, often assumed to be fungal, may be of particular importance. Objectives To investigate the epidemiology and aetiology of interdigital lesions (IDL) of the feet in filarial lymphoedema. Methods The frequency and mycological aetiology of IDL in 73 patients with filarial lymphoedema were compared with 74 individuals without lymphoedema in a region of Guyana highly endemic for Wuchereria bancrofti. Results More than 50% of patients with lymphoedema had one or more IDL (odds ratio 2.69; 95% confidence interval 1.31-5.66; P < 0.005 compared with controls). The number of lesions was the strongest predictor of frequency of ADLA. Only 18% of the lesions had positive microscopy or culture for fungi (dermatophytes and Scytalidium). Conclusions These findings highlight the importance of interdigital entry lesions as risk factors for episodes of ADLA and have implications for the control of morbidity from filarial lymphoedema.</s0></fC01><fC02 i1="01" i2="X"><s0>002B08</s0></fC02><fC02 i1="02" i2="X"><s0>002B12B04</s0></fC02><fC02 i1="03" i2="X"><s0>002B05E03B4D</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Lymphoedème</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Lymphedema</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Linfedema</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Filariose</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Filariosis</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Filariosis</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Peau</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Skin</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Piel</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Homme</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Human</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Hombre</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Peau pathologie</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Skin disease</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Piel patología</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Système lymphatique</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Lymphatic system</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Sistema linfático</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Dermatologie</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Dermatology</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Dermatología</s0><s5>14</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Nématodose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nematode disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Nematodosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Helminthiase</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Helminthiasis</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Helmintiasis</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Parasitose</s0></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Parasitosis</s0></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Parasitosis</s0></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>37</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Lymphatique pathologie</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Lymphatic vessel disease</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Linfático patología</s0><s5>38</s5></fC07><fN21><s1>142</s1></fN21></pA></standard></inist><affiliations><list><country><li>Guyana</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Maryland</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mcpherson, T" sort="Mcpherson, T" uniqKey="Mcpherson T" first="T." last="Mcpherson">T. Mcpherson</name></region><name sortKey="Hay, R" sort="Hay, R" uniqKey="Hay R" first="R." last="Hay">R. Hay</name></country><country name="Guyana"><noRegion><name sortKey="Persaud, S" sort="Persaud, S" uniqKey="Persaud S" first="S." last="Persaud">S. Persaud</name></noRegion><name sortKey="Singh, S" sort="Singh, S" uniqKey="Singh S" first="S." last="Singh">S. Singh</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Fay, M P" sort="Fay, M P" uniqKey="Fay M" first="M. P." last="Fay">M. P. Fay</name></region><name sortKey="Addiss, D" sort="Addiss, D" uniqKey="Addiss D" first="D." last="Addiss">D. Addiss</name><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T. B." last="Nutman">T. B. Nutman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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