Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype.
Identifieur interne : 00BB36 ( Ncbi/Merge ); précédent : 00BB35; suivant : 00BB37Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype.
Auteurs : A. Kurniawan-Atmadja [Indonésie] ; E. Sartono ; F. Partono ; M. Yazdanbakhsh ; R M MaizelsSource :
- Parasite immunology [ 0141-9838 ] ; 1998.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (analyse), Anticorps antihelminthe (immunologie), Antigènes d'helminthe (immunologie), Antigènes de surface (immunologie), Brugia malayi (immunologie), Facteurs de l'âge, Filariose lymphatique (immunologie), Filarioses (immunologie), Humains, Immunoglobuline G (analyse), Immunoglobuline G (immunologie), Immunoglobuline M (analyse), Immunoglobuline M (immunologie), Isotypes des immunoglobulines (analyse), Isotypes des immunoglobulines (immunologie), Microfilaria (immunologie), Technique d'immunofluorescence indirecte, Épitopes (immunologie).
- MESH :
- analyse : Anticorps antihelminthe, Immunoglobuline G, Immunoglobuline M, Isotypes des immunoglobulines.
- immunologie : Anticorps antihelminthe, Antigènes d'helminthe, Antigènes de surface, Brugia malayi, Filariose lymphatique, Filarioses, Immunoglobuline G, Immunoglobuline M, Isotypes des immunoglobulines, Microfilaria, Épitopes.
- Animaux, Facteurs de l'âge, Humains, Technique d'immunofluorescence indirecte.
English descriptors
- KwdEn :
- Age Factors, Animals, Antibodies, Helminth (analysis), Antibodies, Helminth (immunology), Antigens, Helminth (immunology), Antigens, Surface (immunology), Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Epitopes (immunology), Filariasis (immunology), Fluorescent Antibody Technique, Indirect, Humans, Immunoglobulin G (analysis), Immunoglobulin G (immunology), Immunoglobulin Isotypes (analysis), Immunoglobulin Isotypes (immunology), Immunoglobulin M (analysis), Immunoglobulin M (immunology), Microfilariae (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin Isotypes, Immunoglobulin M.
- chemical , immunology : Antibodies, Helminth, Antigens, Helminth, Antigens, Surface, Epitopes, Immunoglobulin G, Immunoglobulin Isotypes, Immunoglobulin M.
- immunology : Brugia malayi, Elephantiasis, Filarial, Filariasis, Microfilariae.
- Age Factors, Animals, Fluorescent Antibody Technique, Indirect, Humans.
Abstract
The humoral immune response in humans to filarial parasites is generally dominated by the IgG4 isotype, when measured by ELISA against somatic adult worm extract. In contrast, as we report here, antibodies reactive to somatic extracts of infective larvae are more equally represented by IgG1 and IgG4. Moreover, binding to surface exposed epitopes in immunofluorescence on larval stages is mediated foremost by IgG1 and IgM, secondarily by IgG2 and IgG3, and very little by IgG4. Both anti-L3 surface and somatic antibodies are strongest in elephantiasis patients, and tend to increase with age. Antibody to the L3 surface is also present in most microfilaraemic individuals who bear no detectable antibodies to the surface of the microfilarial stage. These results demonstrate that a stage- and isotype-specific response is mounted to the L3 surface which should be considered as a possible mediator of concomitant immunity in filariasis.
PubMed: 9491413
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Yazdanbakhsh</name></author><author><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antibodies, Helminth (immunology)</term><term>Antigens, Helminth (immunology)</term><term>Antigens, Surface (immunology)</term><term>Brugia malayi (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Epitopes (immunology)</term><term>Filariasis (immunology)</term><term>Fluorescent Antibody Technique, Indirect</term><term>Humans</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin G (immunology)</term><term>Immunoglobulin Isotypes (analysis)</term><term>Immunoglobulin Isotypes (immunology)</term><term>Immunoglobulin M (analysis)</term><term>Immunoglobulin M (immunology)</term><term>Microfilariae (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Anticorps antihelminthe (immunologie)</term><term>Antigènes d'helminthe (immunologie)</term><term>Antigènes de surface (immunologie)</term><term>Brugia malayi (immunologie)</term><term>Facteurs de l'âge</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Humains</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline G (immunologie)</term><term>Immunoglobuline M (analyse)</term><term>Immunoglobuline M (immunologie)</term><term>Isotypes des immunoglobulines (analyse)</term><term>Isotypes des immunoglobulines (immunologie)</term><term>Microfilaria (immunologie)</term><term>Technique d'immunofluorescence indirecte</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin Isotypes</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Antigens, Surface</term><term>Epitopes</term><term>Immunoglobulin G</term><term>Immunoglobulin Isotypes</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term><term>Isotypes des immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term><term>Antigènes de surface</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term><term>Isotypes des immunoglobulines</term><term>Microfilaria</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Microfilariae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Fluorescent Antibody Technique, Indirect</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de l'âge</term><term>Humains</term><term>Technique d'immunofluorescence indirecte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The humoral immune response in humans to filarial parasites is generally dominated by the IgG4 isotype, when measured by ELISA against somatic adult worm extract. In contrast, as we report here, antibodies reactive to somatic extracts of infective larvae are more equally represented by IgG1 and IgG4. Moreover, binding to surface exposed epitopes in immunofluorescence on larval stages is mediated foremost by IgG1 and IgM, secondarily by IgG2 and IgG3, and very little by IgG4. Both anti-L3 surface and somatic antibodies are strongest in elephantiasis patients, and tend to increase with age. Antibody to the L3 surface is also present in most microfilaraemic individuals who bear no detectable antibodies to the surface of the microfilarial stage. These results demonstrate that a stage- and isotype-specific response is mounted to the L3 surface which should be considered as a possible mediator of concomitant immunity in filariasis.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9491413</PMID><DateCreated><Year>1998</Year><Month>04</Month><Day>10</Day></DateCreated><DateCompleted><Year>1998</Year><Month>04</Month><Day>10</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0141-9838</ISSN><JournalIssue CitedMedium="Print"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>1998</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Parasite immunology</Title><ISOAbbreviation>Parasite Immunol.</ISOAbbreviation></Journal><ArticleTitle>Antibody responses to filarial infective larvae are not dominated by the IgG4 isotype.</ArticleTitle><Pagination><MedlinePgn>9-17</MedlinePgn></Pagination><Abstract><AbstractText>The humoral immune response in humans to filarial parasites is generally dominated by the IgG4 isotype, when measured by ELISA against somatic adult worm extract. In contrast, as we report here, antibodies reactive to somatic extracts of infective larvae are more equally represented by IgG1 and IgG4. Moreover, binding to surface exposed epitopes in immunofluorescence on larval stages is mediated foremost by IgG1 and IgM, secondarily by IgG2 and IgG3, and very little by IgG4. Both anti-L3 surface and somatic antibodies are strongest in elephantiasis patients, and tend to increase with age. Antibody to the L3 surface is also present in most microfilaraemic individuals who bear no detectable antibodies to the surface of the microfilarial stage. These results demonstrate that a stage- and isotype-specific response is mounted to the L3 surface which should be considered as a possible mediator of concomitant immunity in filariasis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kurniawan-Atmadja</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sartono</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Partono</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Yazdanbakhsh</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Maizels</LastName><ForeName>R M</ForeName><Initials>RM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parasite Immunol</MedlineTA><NlmUniqueID>7910948</NlmUniqueID><ISSNLinking>0141-9838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000947">Antigens, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000954">Antigens, Surface</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007132">Immunoglobulin 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MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017178" MajorTopicYN="N">Brugia malayi</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000939" MajorTopicYN="N">Epitopes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005368" MajorTopicYN="N">Filariasis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019084" MajorTopicYN="N">Fluorescent Antibody Technique, Indirect</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007132" MajorTopicYN="N">Immunoglobulin Isotypes</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007075" MajorTopicYN="N">Immunoglobulin M</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008842" MajorTopicYN="N">Microfilariae</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>3</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>3</Month><Day>10</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>3</Month><Day>10</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9491413</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Indonésie</li></country></list><tree><noCountry><name sortKey="Maizels, R M" sort="Maizels, R M" uniqKey="Maizels R" first="R M" last="Maizels">R M Maizels</name><name sortKey="Partono, F" sort="Partono, F" uniqKey="Partono F" first="F" last="Partono">F. Partono</name><name sortKey="Sartono, E" sort="Sartono, E" uniqKey="Sartono E" first="E" last="Sartono">E. Sartono</name><name sortKey="Yazdanbakhsh, M" sort="Yazdanbakhsh, M" uniqKey="Yazdanbakhsh M" first="M" last="Yazdanbakhsh">M. Yazdanbakhsh</name></noCountry><country name="Indonésie"><noRegion><name sortKey="Kurniawan Atmadja, A" sort="Kurniawan Atmadja, A" uniqKey="Kurniawan Atmadja A" first="A" last="Kurniawan-Atmadja">A. Kurniawan-Atmadja</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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