Humoral immune response during filarial fever in Bancroftian filariasis.
Identifieur interne : 00B518 ( Ncbi/Merge ); précédent : 00B517; suivant : 00B519Humoral immune response during filarial fever in Bancroftian filariasis.
Auteurs : S K Kar [Inde] ; J. Mania ; P K KarSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ]
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (biosynthèse), Complexe antigène-anticorps (biosynthèse), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Fièvre, Granulocytes neutrophiles (immunologie), Granulocytes éosinophiles (immunologie), Humains, Immunoglobuline G (biosynthèse), Mâle, Numération des leucocytes, Protéines bactériennes, Streptolysines (immunologie), Wuchereria bancrofti (immunologie), Wuchereria bancrofti (isolement et purification).
- MESH :
- biosynthèse : Anticorps antihelminthe, Complexe antigène-anticorps, Immunoglobuline G.
- immunologie : Filariose lymphatique, Granulocytes neutrophiles, Granulocytes éosinophiles, Streptolysines, Wuchereria bancrofti.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- Animaux, Femelle, Fièvre, Humains, Mâle, Numération des leucocytes, Protéines bactériennes.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antigen-Antibody Complex (biosynthesis), Bacterial Proteins, Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Eosinophils (immunology), Female, Fever, Humans, Immunoglobulin G (biosynthesis), Leukocyte Count, Male, Neutrophils (immunology), Streptolysins (immunology), Wuchereria bancrofti (immunology), Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Antigen-Antibody Complex, Immunoglobulin G.
- immunology : Elephantiasis, Filarial, Eosinophils, Neutrophils, Streptolysins, Wuchereria bancrofti.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Bacterial Proteins, Female, Fever, Humans, Leukocyte Count, Male.
Abstract
Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.
PubMed: 8337737
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Humoral immune response during filarial fever in Bancroftian filariasis.</title><author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division, Regional Medical Research Centre (ICMR), Orissa, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Clinical Division, Regional Medical Research Centre (ICMR), Orissa</wicri:regionArea><wicri:noRegion>Orissa</wicri:noRegion></affiliation></author><author><name sortKey="Mania, J" sort="Mania, J" uniqKey="Mania J" first="J" last="Mania">J. Mania</name></author><author><name sortKey="Kar, P K" sort="Kar, P K" uniqKey="Kar P" first="P K" last="Kar">P K Kar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1993 Mar-Apr</MedlineDate></PubDate></date><idno type="RBID">pubmed:8337737</idno><idno type="pmid">8337737</idno><idno type="wicri:Area/PubMed/Corpus">005772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005772</idno><idno type="wicri:Area/PubMed/Curation">005772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005772</idno><idno type="wicri:Area/PubMed/Checkpoint">005772</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005772</idno><idno type="wicri:Area/Ncbi/Merge">00B518</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Humoral immune response during filarial fever in Bancroftian filariasis.</title><author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Division, Regional Medical Research Centre (ICMR), Orissa, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Clinical Division, Regional Medical Research Centre (ICMR), Orissa</wicri:regionArea><wicri:noRegion>Orissa</wicri:noRegion></affiliation></author><author><name sortKey="Mania, J" sort="Mania, J" uniqKey="Mania J" first="J" last="Mania">J. Mania</name></author><author><name sortKey="Kar, P K" sort="Kar, P K" uniqKey="Kar P" first="P K" last="Kar">P K Kar</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antigen-Antibody Complex (biosynthesis)</term><term>Bacterial Proteins</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Eosinophils (immunology)</term><term>Female</term><term>Fever</term><term>Humans</term><term>Immunoglobulin G (biosynthesis)</term><term>Leukocyte Count</term><term>Male</term><term>Neutrophils (immunology)</term><term>Streptolysins (immunology)</term><term>Wuchereria bancrofti (immunology)</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Complexe antigène-anticorps (biosynthèse)</term><term>Femelle</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Fièvre</term><term>Granulocytes neutrophiles (immunologie)</term><term>Granulocytes éosinophiles (immunologie)</term><term>Humains</term><term>Immunoglobuline G (biosynthèse)</term><term>Mâle</term><term>Numération des leucocytes</term><term>Protéines bactériennes</term><term>Streptolysines (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term><term>Wuchereria bancrofti (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigen-Antibody Complex</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Complexe antigène-anticorps</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Granulocytes neutrophiles</term><term>Granulocytes éosinophiles</term><term>Streptolysines</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Eosinophils</term><term>Neutrophils</term><term>Streptolysins</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Bacterial Proteins</term><term>Female</term><term>Fever</term><term>Humans</term><term>Leukocyte Count</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Fièvre</term><term>Humains</term><term>Mâle</term><term>Numération des leucocytes</term><term>Protéines bactériennes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8337737</PMID><DateCreated><Year>1993</Year><Month>08</Month><Day>25</Day></DateCreated><DateCompleted><Year>1993</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0035-9203</ISSN><JournalIssue CitedMedium="Print"><Volume>87</Volume><Issue>2</Issue><PubDate><MedlineDate>1993 Mar-Apr</MedlineDate></PubDate></JournalIssue><Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title><ISOAbbreviation>Trans. R. Soc. Trop. Med. Hyg.</ISOAbbreviation></Journal><ArticleTitle>Humoral immune response during filarial fever in Bancroftian filariasis.</ArticleTitle><Pagination><MedlinePgn>230-3</MedlinePgn></Pagination><Abstract><AbstractText>Humoral immune responses against filarial parasitic infection were studied in 62 cases of acute filarial disease presenting with filarial fever with adenolymphangitis, in a community where Bancroftian filariasis was endemic, during and about one month before and after the febrile episode. Their total leucocyte and differential peripheral blood cell counts and anti-streptolysin O titre were determined and compared. Polymorphonuclear cellular responses and anti-streptolysin O titre did not show any significant alteration during and after fever. Three of 53 previously amicrofilaraemic subjects (9 of whom were initially microfilaraemic) had microfilaria in their circulation during fever, with a significant increase in their geometric mean microfilaria count. Titres of specific immunoglobulin (Ig) G and IgG4 antibody to Wuchereria bancrofti microfilarial excretory/secretory antigens (measured by enzyme-linked immunosorbent assay) decreased significantly during the fever and the lower levels were maintained one month after fever. The mean circulating immune complex level increased significantly during fever, and a significant percentage of cases demonstrated circulating filarial antigen during fever, which declined after one month, suggesting the release of filarial antigen into the circulation during fever which bound to antibodies to form immune complexes. These observations do not support the suggestion that bacterial infection is the aetiology of filarial fever. It is postulated that antigens released from parasites into the circulation during parturition by adult worms may evoke an allergic response in the host, causing periodic febrile episodes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kar</LastName><ForeName>S K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Clinical Division, Regional Medical Research Centre (ICMR), Orissa, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mania</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kar</LastName><ForeName>P K</ForeName><Initials>PK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trans R Soc Trop Med Hyg</MedlineTA><NlmUniqueID>7506129</NlmUniqueID><ISSNLinking>0035-9203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000909">Antibodies, Helminth</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000936">Antigen-Antibody Complex</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001426">Bacterial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013301">Streptolysins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C025964">streptolysin O</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000909" MajorTopicYN="N">Antibodies, Helminth</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000936" MajorTopicYN="N">Antigen-Antibody Complex</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001426" MajorTopicYN="N">Bacterial Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004804" MajorTopicYN="N">Eosinophils</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005334" MajorTopicYN="N">Fever</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007958" MajorTopicYN="N">Leukocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013301" MajorTopicYN="N">Streptolysins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014958" MajorTopicYN="N">Wuchereria bancrofti</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8337737</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Kar, P K" sort="Kar, P K" uniqKey="Kar P" first="P K" last="Kar">P K Kar</name><name sortKey="Mania, J" sort="Mania, J" uniqKey="Mania J" first="J" last="Mania">J. Mania</name></noCountry><country name="Inde"><noRegion><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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