The use of ivermectin for scabies.
Identifieur interne : 00B434 ( Ncbi/Merge ); précédent : 00B433; suivant : 00B435The use of ivermectin for scabies.
Auteurs : S K Kar ; J. Mania ; S. PatnaikSource :
- The National medical journal of India [ 0970-258X ]
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Gale.
- usage thérapeutique : Ivermectine.
- Adolescent, Adulte, Filariose lymphatique, Gale, Humains, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Ivermectin.
- complications : Elephantiasis, Filarial, Scabies.
- drug therapy : Scabies.
- Adolescent, Adult, Humans, Male.
Abstract
Ivermectin, a modified avermectin, is widely known to be an ectoparasiticidal agent in animals but its effect on human ectoparasites is not known.
PubMed: 8156025
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pubmed:8156025Le document en format XML
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<author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name>
<affiliation><nlm:affiliation>Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, Orissa.</nlm:affiliation>
<wicri:noCountry code="subField">Orissa</wicri:noCountry>
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<author><name sortKey="Mania, J" sort="Mania, J" uniqKey="Mania J" first="J" last="Mania">J. Mania</name>
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<author><name sortKey="Patnaik, S" sort="Patnaik, S" uniqKey="Patnaik S" first="S" last="Patnaik">S. Patnaik</name>
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<author><name sortKey="Kar, S K" sort="Kar, S K" uniqKey="Kar S" first="S K" last="Kar">S K Kar</name>
<affiliation><nlm:affiliation>Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, Orissa.</nlm:affiliation>
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<author><name sortKey="Mania, J" sort="Mania, J" uniqKey="Mania J" first="J" last="Mania">J. Mania</name>
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<series><title level="j">The National medical journal of India</title>
<idno type="ISSN">0970-258X</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Elephantiasis, Filarial (complications)</term>
<term>Humans</term>
<term>Ivermectin (therapeutic use)</term>
<term>Male</term>
<term>Scabies (complications)</term>
<term>Scabies (drug therapy)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Filariose lymphatique ()</term>
<term>Gale ()</term>
<term>Gale (traitement médicamenteux)</term>
<term>Humains</term>
<term>Ivermectine (usage thérapeutique)</term>
<term>Mâle</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ivermectin</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Scabies</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Scabies</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Gale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Ivermectine</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Filariose lymphatique</term>
<term>Gale</term>
<term>Humains</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Ivermectin, a modified avermectin, is widely known to be an ectoparasiticidal agent in animals but its effect on human ectoparasites is not known.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8156025</PMID>
<DateCreated><Year>1994</Year>
<Month>05</Month>
<Day>19</Day>
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<DateCompleted><Year>1994</Year>
<Month>05</Month>
<Day>19</Day>
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<DateRevised><Year>2010</Year>
<Month>03</Month>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0970-258X</ISSN>
<JournalIssue CitedMedium="Print"><Volume>7</Volume>
<Issue>1</Issue>
<PubDate><MedlineDate>1994 Jan-Feb</MedlineDate>
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<Title>The National medical journal of India</Title>
<ISOAbbreviation>Natl Med J India</ISOAbbreviation>
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<ArticleTitle>The use of ivermectin for scabies.</ArticleTitle>
<Pagination><MedlinePgn>15-6</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Ivermectin, a modified avermectin, is widely known to be an ectoparasiticidal agent in animals but its effect on human ectoparasites is not known.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">As a part of a chemotherapy trial with ivermectin against Wuchereria bancrofti microfilaraemia, two males with clinical scabies were studied. Three skin scrapings were taken from the lesions of each of the cases and examined with potassium hydroxide solution for the presence of eggs, larvae or adult mites.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Following a single oral dose of ivermectin at either 100 micrograms or 20 micrograms/kg body weight both the itching and eruptions were reduced and the lesions healed after 14 days of treatment. Skin scrapings taken on days 7 and 30 after administering the drug did not reveal any mites. However, the lesions reappeared after 3 months.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The beneficial results on the healing of scabetic lesions following ivermectin therapy indicates that the drug may have a scabicidal effect. Reappearance of the lesions may have been due to an inadequate dose. This emphasizes the need for future controlled trials on the efficacy of ivermectin against human scabies infection. If proven, this may be an additional advantage in mass chemotherapy campaigns, when there is co-existence of filariasis, intestinal helminthiasis and scabies.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kar</LastName>
<ForeName>S K</ForeName>
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<AffiliationInfo><Affiliation>Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, Orissa.</Affiliation>
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<Author ValidYN="Y"><LastName>Mania</LastName>
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<Author ValidYN="Y"><LastName>Patnaik</LastName>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
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<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D004605" MajorTopicYN="N">Elephantiasis, Filarial</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D007559" MajorTopicYN="N">Ivermectin</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D012532" MajorTopicYN="N">Scabies</DescriptorName>
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