LymphedemaV1, Ncbi, Merge, bibRecord, 009C18

The effects of calcium dobesilate on acute lymphedema (with and without macrophages), and on burn edema.

Identifieur interne : 009C18 ( Ncbi/Merge ); précédent : 009C17; suivant : 009C19

The effects of calcium dobesilate on acute lymphedema (with and without macrophages), and on burn edema.

Auteurs : J R Casley-Smith ; J R Casley-Smith

Source :

Lymphology [ 0024-7766 ] ; 1985.

RBID : pubmed:4010341

Descripteurs français

KwdFr :
- Animaux, Benzènesulfonates (usage thérapeutique), Brûlures (anatomopathologie), Brûlures (traitement médicamenteux), Dobésilate de calcium (usage thérapeutique), Lymphoedème (anatomopathologie), Lymphoedème (traitement médicamenteux), Macrophages (), Macrophages (anatomopathologie), Mâle, Oedème (anatomopathologie), Oedème (traitement médicamenteux), Rats.
MESH :
- anatomopathologie : Brûlures, Lymphoedème, Macrophages, Oedème.
- traitement médicamenteux : Brûlures, Lymphoedème, Oedème.
- usage thérapeutique : Benzènesulfonates, Dobésilate de calcium.
- Animaux, Macrophages, Mâle, Rats.

English descriptors

KwdEn :
- Animals, Benzenesulfonates (therapeutic use), Burns (drug therapy), Burns (pathology), Calcium Dobesilate (therapeutic use), Edema (drug therapy), Edema (pathology), Lymphedema (drug therapy), Lymphedema (pathology), Macrophages (drug effects), Macrophages (pathology), Male, Rats.
MESH :
- chemical , therapeutic use : Benzenesulfonates, Calcium Dobesilate.
- drug effects : Macrophages.
- drug therapy : Burns, Edema, Lymphedema.
- pathology : Burns, Edema, Lymphedema, Macrophages.
- Animals, Male, Rats.

Abstract

Calcium dobesilate ("Doxium", O.M. Laboratories, Geneva) was tested in two high-protein edemas. While at a high dose level it had no effect on burn edema of the ratfoot, it did at a low dose. It greatly reduced (to 26%) acute lymphedema in the rat thigh (although not in the foot). Electron microscopy confirmed these findings, and showed that the drug increased the number of macrophages in the tissues and reduced the protein concentrations. If, however, the macrophages were destroyed (by silica) this effect on acute lymphedema was lost (as with benzo-pyrones). Calcium dobesilate also reduces high-protein edemas in other models, and in many ways its actions resemble those of benzo-pyrones. Hence it is suggested that this substituted benzene ring may be the basic structure responsible for this action in high-protein edema, and that the pyrone ring (and any side-chains) in the benzo-pyrones are not essential to their enhancement of proteolytic activity by macrophages.

PubMed: 4010341

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pubmed:4010341

Le document en format XML

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<term>Burns (pathology)</term>
<term>Calcium Dobesilate (therapeutic use)</term>
<term>Edema (drug therapy)</term>
<term>Edema (pathology)</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (pathology)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (pathology)</term>
<term>Male</term>
<term>Rats</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Benzènesulfonates (usage thérapeutique)</term>
<term>Brûlures (anatomopathologie)</term>
<term>Brûlures (traitement médicamenteux)</term>
<term>Dobésilate de calcium (usage thérapeutique)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (traitement médicamenteux)</term>
<term>Macrophages ()</term>
<term>Macrophages (anatomopathologie)</term>
<term>Mâle</term>
<term>Oedème (anatomopathologie)</term>
<term>Oedème (traitement médicamenteux)</term>
<term>Rats</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Benzenesulfonates</term>
<term>Calcium Dobesilate</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Brûlures</term>
<term>Lymphoedème</term>
<term>Macrophages</term>
<term>Oedème</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Burns</term>
<term>Edema</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Burns</term>
<term>Edema</term>
<term>Lymphedema</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Brûlures</term>
<term>Lymphoedème</term>
<term>Oedème</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Benzènesulfonates</term>
<term>Dobésilate de calcium</term>
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<term>Male</term>
<term>Rats</term>
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<term>Macrophages</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Calcium dobesilate ("Doxium", O.M. Laboratories, Geneva) was tested in two high-protein edemas. While at a high dose level it had no effect on burn edema of the ratfoot, it did at a low dose. It greatly reduced (to 26%) acute lymphedema in the rat thigh (although not in the foot). Electron microscopy confirmed these findings, and showed that the drug increased the number of macrophages in the tissues and reduced the protein concentrations. If, however, the macrophages were destroyed (by silica) this effect on acute lymphedema was lost (as with benzo-pyrones). Calcium dobesilate also reduces high-protein edemas in other models, and in many ways its actions resemble those of benzo-pyrones. Hence it is suggested that this substituted benzene ring may be the basic structure responsible for this action in high-protein edema, and that the pyrone ring (and any side-chains) in the benzo-pyrones are not essential to their enhancement of proteolytic activity by macrophages.</div>
</front>
</TEI>
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<DateCreated><Year>1985</Year>
<Month>08</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>1985</Year>
<Month>08</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<Issue>1</Issue>
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<Month>Mar</Month>
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<Title>Lymphology</Title>
<ISOAbbreviation>Lymphology</ISOAbbreviation>
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<ArticleTitle>The effects of calcium dobesilate on acute lymphedema (with and without macrophages), and on burn edema.</ArticleTitle>
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<Abstract><AbstractText>Calcium dobesilate ("Doxium", O.M. Laboratories, Geneva) was tested in two high-protein edemas. While at a high dose level it had no effect on burn edema of the ratfoot, it did at a low dose. It greatly reduced (to 26%) acute lymphedema in the rat thigh (although not in the foot). Electron microscopy confirmed these findings, and showed that the drug increased the number of macrophages in the tissues and reduced the protein concentrations. If, however, the macrophages were destroyed (by silica) this effect on acute lymphedema was lost (as with benzo-pyrones). Calcium dobesilate also reduces high-protein edemas in other models, and in many ways its actions resemble those of benzo-pyrones. Hence it is suggested that this substituted benzene ring may be the basic structure responsible for this action in high-protein edema, and that the pyrone ring (and any side-chains) in the benzo-pyrones are not essential to their enhancement of proteolytic activity by macrophages.</AbstractText>
</Abstract>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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<MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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The effects of calcium dobesilate on acute lymphedema (with and without macrophages), and on burn edema.

The effects of calcium dobesilate on acute lymphedema (with and without macrophages), and on burn edema.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki