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Cellular composition of lymph in experimental lymphedema.

Identifieur interne : 009501 ( Ncbi/Merge ); précédent : 009500; suivant : 009502

Cellular composition of lymph in experimental lymphedema.

Auteurs : H. Galkowska ; W L Olszewski

Source :

RBID : pubmed:2951567

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English descriptors

Abstract

Lymph cell populations were characterized immunologically in dogs with chronic post-surgical lymphedema. There was a 10- to 30-fold increase in lymph total cell count as compared with normal (control) dogs. Morphologically, these were predominantly small lymphocytes with approximately 4-6% monocytes and veiled cells. In contrast, lymph from normal dogs contained 33% granulocytes and 27% monocytes. The Fc-R+ and C3b-R+ mononuclear nonadherent cells were less represented in lymph in chronic stasis than in normals. A high autotransformation rate of lymph cells and marked responsiveness to PHA and Con A were also observed. In chronic lymphedema K-cell and NK-cell cytotoxicity were lower than in normal lymph. Interruption or retardation of the lymphocyte recirculation pathway with lymph stasis may alter regulation of immune responsiveness in lymphedematous tissue.

PubMed: 2951567

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Le document en format XML

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<term>Lymph (immunology)</term>
<term>Lymphedema (immunology)</term>
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<term>Activation des lymphocytes</term>
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<term>Chiens</term>
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<term>Lymphe (cytologie)</term>
<term>Lymphe (immunologie)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (immunologie)</term>
<term>Mitogènes (pharmacologie)</term>
<term>Numération cellulaire</term>
<term>Récepteur Fc</term>
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<term>Lymphoedème</term>
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<term>Lymphe</term>
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<div type="abstract" xml:lang="en">Lymph cell populations were characterized immunologically in dogs with chronic post-surgical lymphedema. There was a 10- to 30-fold increase in lymph total cell count as compared with normal (control) dogs. Morphologically, these were predominantly small lymphocytes with approximately 4-6% monocytes and veiled cells. In contrast, lymph from normal dogs contained 33% granulocytes and 27% monocytes. The Fc-R+ and C3b-R+ mononuclear nonadherent cells were less represented in lymph in chronic stasis than in normals. A high autotransformation rate of lymph cells and marked responsiveness to PHA and Con A were also observed. In chronic lymphedema K-cell and NK-cell cytotoxicity were lower than in normal lymph. Interruption or retardation of the lymphocyte recirculation pathway with lymph stasis may alter regulation of immune responsiveness in lymphedematous tissue.</div>
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