Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)
Identifieur interne : 009236 ( Ncbi/Merge ); précédent : 009235; suivant : 009237Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)
Auteurs : L. M. Van Roozendaal [Pays-Bas] ; M. L. G. Vane [Pays-Bas] ; T. Van Dalen [Pays-Bas] ; J. A. Van Der Hage [Pays-Bas] ; L. J. A. Strobbe [Pays-Bas] ; L. J. Boersma [Pays-Bas] ; S. C. Linn [Pays-Bas] ; M. B. I. Lobbes [Pays-Bas] ; P. M. P. Poortmans [Pays-Bas] ; V. C. G. Tjan-Heijnen [Pays-Bas] ; K. K. B. T. Van De Vijver [Pays-Bas] ; J. De Vries [Pays-Bas] ; A. H. Westenberg [Pays-Bas] ; A. G. H. Kessels [Pays-Bas] ; J. H. W. De Wilt [Pays-Bas] ; M. L. Smidt [Pays-Bas]Source :
- BMC Cancer [ 1471-2407 ] ; 2017.
Abstract
Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of the sentinel lymph node biopsy has no clinical consequence, the value of the procedure itself is being questioned. The aim of the BOOG 2013–08 trial is to investigate whether the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients treated with breast conserving therapy.
The BOOG 2013–08 is a Dutch prospective non-inferiority randomized multicentre trial. Women with pathologically confirmed clinically node negative T1–2 invasive breast cancer undergoing breast conserving therapy will be randomized for sentinel lymph node biopsy versus no sentinel lymph node biopsy. Endpoints include regional recurrence after 5 (primary endpoint) and 10 years of follow-up, distant-disease free and overall survival, quality of life, morbidity and cost-effectiveness. Previous data indicate a 5-year regional recurrence free survival rate of 99% for the control arm and 96% for the study arm. In combination with a non-inferiority limit of 5% and probability of 0.8, this result in a sample size of 1.644 patients including a lost to follow-up rate of 10%. Primary and secondary endpoints will be reported after 5 and 10 years of follow-up.
If the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients undergoing breast conserving therapy, this study will cost-effectively lead to a decreased axillary morbidity rate and thereby improved quality of life with non-inferior regional control, distant-disease free survival and overall survival.
The BOOG 2013–08 study is registered in
Url:
DOI: 10.1186/s12885-017-3443-x
PubMed: 28668073
PubMed Central: 5494134
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000C47
- to stream Pmc, to step Curation: 000C46
- to stream Pmc, to step Checkpoint: 000354
Links to Exploration step
PMC:5494134Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)</title><author><name sortKey="Van Roozendaal, L M" sort="Van Roozendaal, L M" uniqKey="Van Roozendaal L" first="L. M." last="Van Roozendaal">L. M. Van Roozendaal</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Vane, M L G" sort="Vane, M L G" uniqKey="Vane M" first="M. L. G." last="Vane">M. L. G. Vane</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Van Dalen, T" sort="Van Dalen, T" uniqKey="Van Dalen T" first="T." last="Van Dalen">T. Van Dalen</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0631 9258</institution-id><institution-id institution-id-type="GRID">grid.413681.9</institution-id><institution></institution><institution>Division of Surgical Oncology, Diakonessenhuis Hospital,</institution></institution-wrap>Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Hage, J A" sort="Van Der Hage, J A" uniqKey="Van Der Hage J" first="J. A." last="Van Der Hage">J. A. Van Der Hage</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Surgical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Strobbe, L J A" sort="Strobbe, L J A" uniqKey="Strobbe L" first="L. J. A." last="Strobbe">L. J. A. Strobbe</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9008</institution-id><institution-id institution-id-type="GRID">grid.413327.0</institution-id><institution></institution><institution>Division of Surgical Oncology, Canisius-Wilhelmina Hospital,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Boersma, L J" sort="Boersma, L J" uniqKey="Boersma L" first="L. J." last="Boersma">L. J. Boersma</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiation Oncology,</institution><institution>Maastricht University Medical Centre (MAASTRO clinic),</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Linn, S C" sort="Linn, S C" uniqKey="Linn S" first="S. C." last="Linn">S. C. Linn</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Medical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lobbes, M B I" sort="Lobbes, M B I" uniqKey="Lobbes M" first="M. B. I." last="Lobbes">M. B. I. Lobbes</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiology and Nuclear Medicine,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Poortmans, P M P" sort="Poortmans, P M P" uniqKey="Poortmans P" first="P. M. P." last="Poortmans">P. M. P. Poortmans</name><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Department of Radiation Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Tjan Heijnen, V C G" sort="Tjan Heijnen, V C G" uniqKey="Tjan Heijnen V" first="V. C. G." last="Tjan-Heijnen">V. C. G. Tjan-Heijnen</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Medical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Van De Vijver, K K B T" sort="Van De Vijver, K K B T" uniqKey="Van De Vijver K" first="K. K. B. T." last="Van De Vijver">K. K. B. T. Van De Vijver</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Department of Pathology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Vries, J" sort="De Vries, J" uniqKey="De Vries J" first="J." last="De Vries">J. De Vries</name><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0943 3265</institution-id><institution-id institution-id-type="GRID">grid.12295.3d</institution-id><institution>Department of Medical and Clinical Psychology,</institution><institution>Tilburg University,</institution></institution-wrap>Tilburg, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Tilburg</wicri:regionArea></affiliation></author><author><name sortKey="Westenberg, A H" sort="Westenberg, A H" uniqKey="Westenberg A" first="A. H." last="Westenberg">A. H. Westenberg</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Radiation Oncology, Radiotherapy group, Arnhem, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Radiation Oncology, Radiotherapy group, Arnhem</wicri:regionArea><wicri:noRegion>Arnhem</wicri:noRegion></affiliation></author><author><name sortKey="Kessels, A G H" sort="Kessels, A G H" uniqKey="Kessels A" first="A. G. H." last="Kessels">A. G. H. Kessels</name><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Clinical Epidemiology and Medical Technology Assessment,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="De Wilt, J H W" sort="De Wilt, J H W" uniqKey="De Wilt J" first="J. H. W." last="De Wilt">J. H. W. De Wilt</name><affiliation wicri:level="1"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Division of Surgical Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Smidt, M L" sort="Smidt, M L" uniqKey="Smidt M" first="M. L." last="Smidt">M. L. Smidt</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28668073</idno><idno type="pmc">5494134</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494134</idno><idno type="RBID">PMC:5494134</idno><idno type="doi">10.1186/s12885-017-3443-x</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C47</idno><idno type="wicri:Area/Pmc/Curation">000C46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C46</idno><idno type="wicri:Area/Pmc/Checkpoint">000354</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000354</idno><idno type="wicri:Area/Ncbi/Merge">009236</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)</title><author><name sortKey="Van Roozendaal, L M" sort="Van Roozendaal, L M" uniqKey="Van Roozendaal L" first="L. M." last="Van Roozendaal">L. M. Van Roozendaal</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Vane, M L G" sort="Vane, M L G" uniqKey="Vane M" first="M. L. G." last="Vane">M. L. G. Vane</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Van Dalen, T" sort="Van Dalen, T" uniqKey="Van Dalen T" first="T." last="Van Dalen">T. Van Dalen</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0631 9258</institution-id><institution-id institution-id-type="GRID">grid.413681.9</institution-id><institution></institution><institution>Division of Surgical Oncology, Diakonessenhuis Hospital,</institution></institution-wrap>Utrecht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Utrecht</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Hage, J A" sort="Van Der Hage, J A" uniqKey="Van Der Hage J" first="J. A." last="Van Der Hage">J. A. Van Der Hage</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Surgical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Strobbe, L J A" sort="Strobbe, L J A" uniqKey="Strobbe L" first="L. J. A." last="Strobbe">L. J. A. Strobbe</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9008</institution-id><institution-id institution-id-type="GRID">grid.413327.0</institution-id><institution></institution><institution>Division of Surgical Oncology, Canisius-Wilhelmina Hospital,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Boersma, L J" sort="Boersma, L J" uniqKey="Boersma L" first="L. J." last="Boersma">L. J. Boersma</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiation Oncology,</institution><institution>Maastricht University Medical Centre (MAASTRO clinic),</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Linn, S C" sort="Linn, S C" uniqKey="Linn S" first="S. C." last="Linn">S. C. Linn</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Medical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lobbes, M B I" sort="Lobbes, M B I" uniqKey="Lobbes M" first="M. B. I." last="Lobbes">M. B. I. Lobbes</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiology and Nuclear Medicine,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Poortmans, P M P" sort="Poortmans, P M P" uniqKey="Poortmans P" first="P. M. P." last="Poortmans">P. M. P. Poortmans</name><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Department of Radiation Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Tjan Heijnen, V C G" sort="Tjan Heijnen, V C G" uniqKey="Tjan Heijnen V" first="V. C. G." last="Tjan-Heijnen">V. C. G. Tjan-Heijnen</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Medical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="Van De Vijver, K K B T" sort="Van De Vijver, K K B T" uniqKey="Van De Vijver K" first="K. K. B. T." last="Van De Vijver">K. K. B. T. Van De Vijver</name><affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Department of Pathology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Vries, J" sort="De Vries, J" uniqKey="De Vries J" first="J." last="De Vries">J. De Vries</name><affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0943 3265</institution-id><institution-id institution-id-type="GRID">grid.12295.3d</institution-id><institution>Department of Medical and Clinical Psychology,</institution><institution>Tilburg University,</institution></institution-wrap>Tilburg, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Tilburg</wicri:regionArea></affiliation></author><author><name sortKey="Westenberg, A H" sort="Westenberg, A H" uniqKey="Westenberg A" first="A. H." last="Westenberg">A. H. Westenberg</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Radiation Oncology, Radiotherapy group, Arnhem, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Radiation Oncology, Radiotherapy group, Arnhem</wicri:regionArea><wicri:noRegion>Arnhem</wicri:noRegion></affiliation></author><author><name sortKey="Kessels, A G H" sort="Kessels, A G H" uniqKey="Kessels A" first="A. G. H." last="Kessels">A. G. H. Kessels</name><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Clinical Epidemiology and Medical Technology Assessment,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author><author><name sortKey="De Wilt, J H W" sort="De Wilt, J H W" uniqKey="De Wilt J" first="J. H. W." last="De Wilt">J. H. W. De Wilt</name><affiliation wicri:level="1"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Division of Surgical Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Smidt, M L" sort="Smidt, M L" uniqKey="Smidt M" first="M. L." last="Smidt">M. L. Smidt</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>P.O. Box 5800, 6202 AZ Maastricht</wicri:regionArea><wicri:noRegion>6202 AZ Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Maastricht</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of the sentinel lymph node biopsy has no clinical consequence, the value of the procedure itself is being questioned. The aim of the BOOG 2013–08 trial is to investigate whether the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients treated with breast conserving therapy.</p></sec><sec><title>Methods</title><p id="Par2">The BOOG 2013–08 is a Dutch prospective non-inferiority randomized multicentre trial. Women with pathologically confirmed clinically node negative T1–2 invasive breast cancer undergoing breast conserving therapy will be randomized for sentinel lymph node biopsy versus no sentinel lymph node biopsy. Endpoints include regional recurrence after 5 (primary endpoint) and 10 years of follow-up, distant-disease free and overall survival, quality of life, morbidity and cost-effectiveness. Previous data indicate a 5-year regional recurrence free survival rate of 99% for the control arm and 96% for the study arm. In combination with a non-inferiority limit of 5% and probability of 0.8, this result in a sample size of 1.644 patients including a lost to follow-up rate of 10%. Primary and secondary endpoints will be reported after 5 and 10 years of follow-up.</p></sec><sec><title>Discussion</title><p id="Par3">If the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients undergoing breast conserving therapy, this study will cost-effectively lead to a decreased axillary morbidity rate and thereby improved quality of life with non-inferior regional control, distant-disease free survival and overall survival.</p></sec><sec><title>Trial registration</title><p id="Par4">The BOOG 2013–08 study is registered in <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov">ClinicalTrials.gov</ext-link> since October 20, 2014, Identifier: NCT02271828. <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02271828">https://clinicaltrials.gov/ct2/show/NCT02271828</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Voogd, Ac" uniqKey="Voogd A">AC Voogd</name></author><author><name sortKey="Coebergh, Jw" uniqKey="Coebergh J">JW Coebergh</name></author><author><name sortKey="Repelaer Van Driel, Oj" uniqKey="Repelaer Van Driel O">OJ Repelaer van Driel</name></author><author><name sortKey="Roumen, Rm" uniqKey="Roumen R">RM Roumen</name></author><author><name sortKey="Van Beek, Mw" uniqKey="Van Beek M">MW van Beek</name></author><author><name sortKey="Vreugdenhil, A" uniqKey="Vreugdenhil A">A Vreugdenhil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krag, Dn" uniqKey="Krag D">DN Krag</name></author><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name></author><author><name sortKey="Julian, Tb" uniqKey="Julian T">TB Julian</name></author><author><name sortKey="Brown, Am" uniqKey="Brown A">AM Brown</name></author><author><name sortKey="Harlow, Sp" uniqKey="Harlow S">SP Harlow</name></author><author><name sortKey="Ashikaga, T" uniqKey="Ashikaga T">T Ashikaga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peintinger, F" uniqKey="Peintinger F">F Peintinger</name></author><author><name sortKey="Reitsamer, R" uniqKey="Reitsamer R">R Reitsamer</name></author><author><name sortKey="Stranzl, H" uniqKey="Stranzl H">H Stranzl</name></author><author><name sortKey="Ralph, G" uniqKey="Ralph G">G Ralph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulze, T" uniqKey="Schulze T">T Schulze</name></author><author><name sortKey="Mucke, J" uniqKey="Mucke J">J Mucke</name></author><author><name sortKey="Markwardt, J" uniqKey="Markwardt J">J Markwardt</name></author><author><name sortKey="Schlag, Pm" uniqKey="Schlag P">PM Schlag</name></author><author><name sortKey="Bembenek, A" uniqKey="Bembenek A">A Bembenek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ohsumi Sk, S" uniqKey="Ohsumi Sk S">S Ohsumi SK</name></author><author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name></author><author><name sortKey="Hara, F" uniqKey="Hara F">F Hara</name></author><author><name sortKey="Takabatake, D" uniqKey="Takabatake D">D Takabatake</name></author><author><name sortKey="Takashima, S" uniqKey="Takashima S">S Takashima</name></author><author><name sortKey="Aogi, K" uniqKey="Aogi K">K Aogi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucci, A" uniqKey="Lucci A">A Lucci</name></author><author><name sortKey="Mccall, Lm" uniqKey="Mccall L">LM McCall</name></author><author><name sortKey="Beitsch, Pd" uniqKey="Beitsch P">PD Beitsch</name></author><author><name sortKey="Whitworth, Pw" uniqKey="Whitworth P">PW Whitworth</name></author><author><name sortKey="Reintgen, Ds" uniqKey="Reintgen D">DS Reintgen</name></author><author><name sortKey="Blumencranz, Pw" uniqKey="Blumencranz P">PW Blumencranz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ashikaga, T" uniqKey="Ashikaga T">T Ashikaga</name></author><author><name sortKey="Krag, Dn" uniqKey="Krag D">DN Krag</name></author><author><name sortKey="Land, Sr" uniqKey="Land S">SR Land</name></author><author><name sortKey="Julian, Tb" uniqKey="Julian T">TB Julian</name></author><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name></author><author><name sortKey="Brown, Am" uniqKey="Brown A">AM Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fisher, B" uniqKey="Fisher B">B Fisher</name></author><author><name sortKey="Anderson, S" uniqKey="Anderson S">S Anderson</name></author><author><name sortKey="Bryant, J" uniqKey="Bryant J">J Bryant</name></author><author><name sortKey="Margolese, Rg" uniqKey="Margolese R">RG Margolese</name></author><author><name sortKey="Deutsch, M" uniqKey="Deutsch M">M Deutsch</name></author><author><name sortKey="Fisher, Er" uniqKey="Fisher E">ER Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Ballman, Kv" uniqKey="Ballman K">KV Ballman</name></author><author><name sortKey="Beitsch, Pd" uniqKey="Beitsch P">PD Beitsch</name></author><author><name sortKey="Whitworth, Pw" uniqKey="Whitworth P">PW Whitworth</name></author><author><name sortKey="Blumencranz, Pw" uniqKey="Blumencranz P">PW Blumencranz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author><author><name sortKey="Cole, Bf" uniqKey="Cole B">BF Cole</name></author><author><name sortKey="Zurrida, S" uniqKey="Zurrida S">S Zurrida</name></author><author><name sortKey="Viale, G" uniqKey="Viale G">G Viale</name></author><author><name sortKey="Luini, A" uniqKey="Luini A">A Luini</name></author><author><name sortKey="Veronesi, P" uniqKey="Veronesi P">P Veronesi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kvistad, Ka" uniqKey="Kvistad K">KA Kvistad</name></author><author><name sortKey="Rydland, J" uniqKey="Rydland J">J Rydland</name></author><author><name sortKey="Smethurst, Hb" uniqKey="Smethurst H">HB Smethurst</name></author><author><name sortKey="Lundgren, S" uniqKey="Lundgren S">S Lundgren</name></author><author><name sortKey="Fjosne, He" uniqKey="Fjosne H">HE Fjosne</name></author><author><name sortKey="Haraldseth, O" uniqKey="Haraldseth O">O Haraldseth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nori, J" uniqKey="Nori J">J Nori</name></author><author><name sortKey="Vanzi, E" uniqKey="Vanzi E">E Vanzi</name></author><author><name sortKey="Bazzocchi, M" uniqKey="Bazzocchi M">M Bazzocchi</name></author><author><name sortKey="Bufalini, Fn" uniqKey="Bufalini F">FN Bufalini</name></author><author><name sortKey="Distante, V" uniqKey="Distante V">V Distante</name></author><author><name sortKey="Branconi, F" uniqKey="Branconi F">F Branconi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pamilo, M" uniqKey="Pamilo M">M Pamilo</name></author><author><name sortKey="Soiva, M" uniqKey="Soiva M">M Soiva</name></author><author><name sortKey="Lavast, Em" uniqKey="Lavast E">EM Lavast</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valente, Sa" uniqKey="Valente S">SA Valente</name></author><author><name sortKey="Levine, Gm" uniqKey="Levine G">GM Levine</name></author><author><name sortKey="Silverstein, Mj" uniqKey="Silverstein M">MJ Silverstein</name></author><author><name sortKey="Rayhanabad, Ja" uniqKey="Rayhanabad J">JA Rayhanabad</name></author><author><name sortKey="Weng Grumley, Jg" uniqKey="Weng Grumley J">JG Weng-Grumley</name></author><author><name sortKey="Ji, L" uniqKey="Ji L">L Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Houssami, N" uniqKey="Houssami N">N Houssami</name></author><author><name sortKey="Ciatto, S" uniqKey="Ciatto S">S Ciatto</name></author><author><name sortKey="Turner, Rm" uniqKey="Turner R">RM Turner</name></author><author><name sortKey="Cody, Hs" uniqKey="Cody H">HS Cody</name></author><author><name sortKey="Macaskill, P" uniqKey="Macaskill P">P Macaskill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neal, Ch" uniqKey="Neal C">CH Neal</name></author><author><name sortKey="Daly, Cp" uniqKey="Daly C">CP Daly</name></author><author><name sortKey="Nees, Av" uniqKey="Nees A">AV Nees</name></author><author><name sortKey="Helvie, Ma" uniqKey="Helvie M">MA Helvie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schipper, Rj" uniqKey="Schipper R">RJ Schipper</name></author><author><name sortKey="Van Roozendaal, Lm" uniqKey="Van Roozendaal L">LM van Roozendaal</name></author><author><name sortKey="De Vries, B" uniqKey="De Vries B">B de Vries</name></author><author><name sortKey="Pijnappel, Rm" uniqKey="Pijnappel R">RM Pijnappel</name></author><author><name sortKey="Beets Tan, Rg" uniqKey="Beets Tan R">RG Beets-Tan</name></author><author><name sortKey="Lobbes, Mb" uniqKey="Lobbes M">MB Lobbes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Wely, Bj" uniqKey="Van Wely B">BJ van Wely</name></author><author><name sortKey="De Wilt, Jh" uniqKey="De Wilt J">JH de Wilt</name></author><author><name sortKey="Francissen, C" uniqKey="Francissen C">C Francissen</name></author><author><name sortKey="Teerenstra, S" uniqKey="Teerenstra S">S Teerenstra</name></author><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darby, S" uniqKey="Darby S">S Darby</name></author><author><name sortKey="Mcgale, P" uniqKey="Mcgale P">P McGale</name></author><author><name sortKey="Correa, C" uniqKey="Correa C">C Correa</name></author><author><name sortKey="Taylor, C" uniqKey="Taylor C">C Taylor</name></author><author><name sortKey="Arriagada, R" uniqKey="Arriagada R">R Arriagada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rastogi, P" uniqKey="Rastogi P">P Rastogi</name></author><author><name sortKey="Anderson, Sj" uniqKey="Anderson S">SJ Anderson</name></author><author><name sortKey="Bear, Hd" uniqKey="Bear H">HD Bear</name></author><author><name sortKey="Geyer, Ce" uniqKey="Geyer C">CE Geyer</name></author><author><name sortKey="Kahlenberg, Ms" uniqKey="Kahlenberg M">MS Kahlenberg</name></author><author><name sortKey="Robidoux, A" uniqKey="Robidoux A">A Robidoux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Straver, Me" uniqKey="Straver M">ME Straver</name></author><author><name sortKey="Rutgers, Ej" uniqKey="Rutgers E">EJ Rutgers</name></author><author><name sortKey="Russell, Ns" uniqKey="Russell N">NS Russell</name></author><author><name sortKey="Oldenburg, Hs" uniqKey="Oldenburg H">HS Oldenburg</name></author><author><name sortKey="Rodenhuis, S" uniqKey="Rodenhuis S">S Rodenhuis</name></author><author><name sortKey="Wesseling, J" uniqKey="Wesseling J">J Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouzier, R" uniqKey="Rouzier R">R Rouzier</name></author><author><name sortKey="Extra, Jm" uniqKey="Extra J">JM Extra</name></author><author><name sortKey="Klijanienko, J" uniqKey="Klijanienko J">J Klijanienko</name></author><author><name sortKey="Falcou, Mc" uniqKey="Falcou M">MC Falcou</name></author><author><name sortKey="Asselain, B" uniqKey="Asselain B">B Asselain</name></author><author><name sortKey="Vincent Salomon, A" uniqKey="Vincent Salomon A">A Vincent-Salomon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarado, R" uniqKey="Alvarado R">R Alvarado</name></author><author><name sortKey="Yi, M" uniqKey="Yi M">M Yi</name></author><author><name sortKey="Le Petross, H" uniqKey="Le Petross H">H Le-Petross</name></author><author><name sortKey="Gilcrease, M" uniqKey="Gilcrease M">M Gilcrease</name></author><author><name sortKey="Mittendorf, Ea" uniqKey="Mittendorf E">EA Mittendorf</name></author><author><name sortKey="Bedrosian, I" uniqKey="Bedrosian I">I Bedrosian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Roozendaal, Lm" uniqKey="Van Roozendaal L">LM van Roozendaal</name></author><author><name sortKey="Schipper, Rj" uniqKey="Schipper R">RJ Schipper</name></author><author><name sortKey="Van De Vijver, Kk" uniqKey="Van De Vijver K">KK Van de Vijver</name></author><author><name sortKey="Haekens, Cm" uniqKey="Haekens C">CM Haekens</name></author><author><name sortKey="Lobbes, Mb" uniqKey="Lobbes M">MB Lobbes</name></author><author><name sortKey="Tjan Heijnen, Vc" uniqKey="Tjan Heijnen V">VC Tjan-Heijnen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Wely, Bj" uniqKey="Van Wely B">BJ van Wely</name></author><author><name sortKey="Teerenstra, S" uniqKey="Teerenstra S">S Teerenstra</name></author><author><name sortKey="Schinagl, Da" uniqKey="Schinagl D">DA Schinagl</name></author><author><name sortKey="Aufenacker, Tj" uniqKey="Aufenacker T">TJ Aufenacker</name></author><author><name sortKey="De Wilt, Jh" uniqKey="De Wilt J">JH de Wilt</name></author><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, Dr" uniqKey="Reed D">DR Reed</name></author><author><name sortKey="Lindsley, Sk" uniqKey="Lindsley S">SK Lindsley</name></author><author><name sortKey="Mann, Gn" uniqKey="Mann G">GN Mann</name></author><author><name sortKey="Austin Seymour, M" uniqKey="Austin Seymour M">M Austin-Seymour</name></author><author><name sortKey="Korssjoen, T" uniqKey="Korssjoen T">T Korssjoen</name></author><author><name sortKey="Anderson, Bo" uniqKey="Anderson B">BO Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, Ma" uniqKey="Chung M">MA Chung</name></author><author><name sortKey="Dipetrillo, T" uniqKey="Dipetrillo T">T DiPetrillo</name></author><author><name sortKey="Hernandez, S" uniqKey="Hernandez S">S Hernandez</name></author><author><name sortKey="Masko, G" uniqKey="Masko G">G Masko</name></author><author><name sortKey="Wazer, D" uniqKey="Wazer D">D Wazer</name></author><author><name sortKey="Cady, B" uniqKey="Cady B">B Cady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabinovitch, R" uniqKey="Rabinovitch R">R Rabinovitch</name></author><author><name sortKey="Ballonoff, A" uniqKey="Ballonoff A">A Ballonoff</name></author><author><name sortKey="Newman, F" uniqKey="Newman F">F Newman</name></author><author><name sortKey="Finlayson, C" uniqKey="Finlayson C">C Finlayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Roozendaal, Lm" uniqKey="Van Roozendaal L">LM van Roozendaal</name></author><author><name sortKey="Schipper, Rj" uniqKey="Schipper R">RJ Schipper</name></author><author><name sortKey="Smit, Lh" uniqKey="Smit L">LH Smit</name></author><author><name sortKey="Brans, Bt" uniqKey="Brans B">BT Brans</name></author><author><name sortKey="Beets Tan, Rg" uniqKey="Beets Tan R">RG Beets-Tan</name></author><author><name sortKey="Lobbes, Mb" uniqKey="Lobbes M">MB Lobbes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Roozendaal, Lm" uniqKey="Van Roozendaal L">LM van Roozendaal</name></author><author><name sortKey="De Wilt, Jh" uniqKey="De Wilt J">JH de Wilt</name></author><author><name sortKey="Van Dalen, T" uniqKey="Van Dalen T">T van Dalen</name></author><author><name sortKey="Van Der Hage, Ja" uniqKey="Van Der Hage J">JA van der Hage</name></author><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author><author><name sortKey="Boersma, Lj" uniqKey="Boersma L">LJ Boersma</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Abe, H" uniqKey="Abe H">H Abe</name></author><author><name sortKey="Schmidt, Ra" uniqKey="Schmidt R">RA Schmidt</name></author><author><name sortKey="Kulkarni, K" uniqKey="Kulkarni K">K Kulkarni</name></author><author><name sortKey="Sennett, Ca" uniqKey="Sennett C">CA Sennett</name></author><author><name sortKey="Mueller, Js" uniqKey="Mueller J">JS Mueller</name></author><author><name sortKey="Newstead, Gm" uniqKey="Newstead G">GM Newstead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koelliker, Sl" uniqKey="Koelliker S">SL Koelliker</name></author><author><name sortKey="Chung, Ma" uniqKey="Chung M">MA Chung</name></author><author><name sortKey="Mainiero, Mb" uniqKey="Mainiero M">MB Mainiero</name></author><author><name sortKey="Steinhoff, Mm" uniqKey="Steinhoff M">MM Steinhoff</name></author><author><name sortKey="Cady, B" uniqKey="Cady B">B Cady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Offersen, Bv" uniqKey="Offersen B">BV Offersen</name></author><author><name sortKey="Boersma, Lj" uniqKey="Boersma L">LJ Boersma</name></author><author><name sortKey="Kirkove, C" uniqKey="Kirkove C">C Kirkove</name></author><author><name sortKey="Hol, S" uniqKey="Hol S">S Hol</name></author><author><name sortKey="Aznar, Mc" uniqKey="Aznar M">MC Aznar</name></author><author><name sortKey="Biete Sola, A" uniqKey="Biete Sola A">A Biete Sola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aaronson, Nk" uniqKey="Aaronson N">NK Aaronson</name></author><author><name sortKey="Ahmedzai, S" uniqKey="Ahmedzai S">S Ahmedzai</name></author><author><name sortKey="Bergman, B" uniqKey="Bergman B">B Bergman</name></author><author><name sortKey="Bullinger, M" uniqKey="Bullinger M">M Bullinger</name></author><author><name sortKey="Cull, A" uniqKey="Cull A">A Cull</name></author><author><name sortKey="Duez, Nj" uniqKey="Duez N">NJ Duez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sprangers, Ma" uniqKey="Sprangers M">MA Sprangers</name></author><author><name sortKey="Groenvold, M" uniqKey="Groenvold M">M Groenvold</name></author><author><name sortKey="Arraras, Ji" uniqKey="Arraras J">JI Arraras</name></author><author><name sortKey="Franklin, J" uniqKey="Franklin J">J Franklin</name></author><author><name sortKey="Te Velde, A" uniqKey="Te Velde A">A te Velde</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devoogdt, N" uniqKey="Devoogdt N">N Devoogdt</name></author><author><name sortKey="Van Kampen, M" uniqKey="Van Kampen M">M Van Kampen</name></author><author><name sortKey="Geraerts, I" uniqKey="Geraerts I">I Geraerts</name></author><author><name sortKey="Coremans, T" uniqKey="Coremans T">T Coremans</name></author><author><name sortKey="Christiaens, Mr" uniqKey="Christiaens M">MR Christiaens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Bij, Ak" uniqKey="Van Der Bij A">AK van der Bij</name></author><author><name sortKey="De Weerd, S" uniqKey="De Weerd S">S de Weerd</name></author><author><name sortKey="Cikot, Rj" uniqKey="Cikot R">RJ Cikot</name></author><author><name sortKey="Steegers, Ea" uniqKey="Steegers E">EA Steegers</name></author><author><name sortKey="Braspenning, Jc" uniqKey="Braspenning J">JC Braspenning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Steeg, Af" uniqKey="Van Der Steeg A">AF van der Steeg</name></author><author><name sortKey="De Vries, J" uniqKey="De Vries J">J De Vries</name></author><author><name sortKey="Van Der Ent, Fw" uniqKey="Van Der Ent F">FW van der Ent</name></author><author><name sortKey="Roukema, Ja" uniqKey="Roukema J">JA Roukema</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Moossdorff, M" uniqKey="Moossdorff M">M Moossdorff</name></author><author><name sortKey="Van Roozendaal, Lm" uniqKey="Van Roozendaal L">LM van Roozendaal</name></author><author><name sortKey="Schipper, Rj" uniqKey="Schipper R">RJ Schipper</name></author><author><name sortKey="Strobbe, Lj" uniqKey="Strobbe L">LJ Strobbe</name></author><author><name sortKey="Voogd, Ac" uniqKey="Voogd A">AC Voogd</name></author><author><name sortKey="Tjan Heijnen, Vc" uniqKey="Tjan Heijnen V">VC Tjan-Heijnen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Cancer</journal-id><journal-id journal-id-type="iso-abbrev">BMC Cancer</journal-id><journal-title-group><journal-title>BMC Cancer</journal-title></journal-title-group><issn pub-type="epub">1471-2407</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28668073</article-id><article-id pub-id-type="pmc">5494134</article-id><article-id pub-id-type="publisher-id">3443</article-id><article-id pub-id-type="doi">10.1186/s12885-017-3443-x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Study Protocol</subject></subj-group></article-categories><title-group><article-title>Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>van Roozendaal</surname><given-names>L. M.</given-names></name><address><email>lorivanroozendaal@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name><surname>Vane</surname><given-names>M. L. G.</given-names></name><address><phone>+31 43 388 1574</phone><email>marissa.vane@mumc.nl</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>van Dalen</surname><given-names>T.</given-names></name><address><email>TvDalen@diakhuis.nl</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>van der Hage</surname><given-names>J. A.</given-names></name><address><email>j.vd.hage@nki.nl</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Strobbe</surname><given-names>L. J. A.</given-names></name><address><email>ljastrobbe@cwz.nl</email></address><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Boersma</surname><given-names>L. J.</given-names></name><address><email>liesbeth.boersma@maastro.nl</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Linn</surname><given-names>S. C.</given-names></name><address><email>s.linn@nki.nl</email></address><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lobbes</surname><given-names>M. B. I.</given-names></name><address><email>marc.lobbes@mumc.nl</email></address><xref ref-type="aff" rid="Aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Poortmans</surname><given-names>P. M. P.</given-names></name><address><email>philip.poortmans@radboudumc.nl</email></address><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Tjan-Heijnen</surname><given-names>V. C. G.</given-names></name><address><email>vcg.tjan.heijnen@mumc.nl</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Van de Vijver</surname><given-names>K. K. B. T.</given-names></name><address><email>k.vd.vijver@nki.nl</email></address><xref ref-type="aff" rid="Aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>de Vries</surname><given-names>J.</given-names></name><address><email>J.deVries@uvt.nl</email></address><xref ref-type="aff" rid="Aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Westenberg</surname><given-names>A. H.</given-names></name><address><email>H.Westenberg@arnhemrti.nl</email></address><xref ref-type="aff" rid="Aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Kessels</surname><given-names>A. G. H.</given-names></name><address><email>fons.kessels@mumc.nl</email></address><xref ref-type="aff" rid="Aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>de Wilt</surname><given-names>J. H. W.</given-names></name><address><email>hans.deWilt@radboudumc.nl</email></address><xref ref-type="aff" rid="Aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Smidt</surname><given-names>M. L.</given-names></name><address><email>m.smidt@mumc.nl</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Surgical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>P.O. Box 5800, 6202 AZ Maastricht, The Netherlands</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>GROW - School for Oncology and Developmental Biology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0631 9258</institution-id><institution-id institution-id-type="GRID">grid.413681.9</institution-id><institution></institution><institution>Division of Surgical Oncology, Diakonessenhuis Hospital,</institution></institution-wrap>Utrecht, the Netherlands</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Surgical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9008</institution-id><institution-id institution-id-type="GRID">grid.413327.0</institution-id><institution></institution><institution>Division of Surgical Oncology, Canisius-Wilhelmina Hospital,</institution></institution-wrap>Nijmegen, the Netherlands</aff><aff id="Aff6"><label>6</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiation Oncology,</institution><institution>Maastricht University Medical Centre (MAASTRO clinic),</institution></institution-wrap>Maastricht, the Netherlands</aff><aff id="Aff7"><label>7</label><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Division of Medical Oncology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</aff><aff id="Aff8"><label>8</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Radiology and Nuclear Medicine,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</aff><aff id="Aff9"><label>9</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Department of Radiation Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</aff><aff id="Aff10"><label>10</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Division of Medical Oncology,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</aff><aff id="Aff11"><label>11</label><institution-wrap><institution-id institution-id-type="GRID">grid.430814.a</institution-id><institution>Department of Pathology,</institution><institution>Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital,</institution></institution-wrap>Amsterdam, the Netherlands</aff><aff id="Aff12"><label>12</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0943 3265</institution-id><institution-id institution-id-type="GRID">grid.12295.3d</institution-id><institution>Department of Medical and Clinical Psychology,</institution><institution>Tilburg University,</institution></institution-wrap>Tilburg, the Netherlands</aff><aff id="Aff13"><label>13</label>Radiation Oncology, Radiotherapy group, Arnhem, the Netherlands</aff><aff id="Aff14"><label>14</label><institution-wrap><institution-id institution-id-type="GRID">grid.412966.e</institution-id><institution>Department of Clinical Epidemiology and Medical Technology Assessment,</institution><institution>Maastricht University Medical Centre,</institution></institution-wrap>Maastricht, the Netherlands</aff><aff id="Aff15"><label>15</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0444 9382</institution-id><institution-id institution-id-type="GRID">grid.10417.33</institution-id><institution>Division of Surgical Oncology,</institution><institution>Radboud University Medical Centre,</institution></institution-wrap>Nijmegen, the Netherlands</aff></contrib-group><pub-date pub-type="epub"><day>1</day><month>7</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>17</volume><elocation-id>459</elocation-id><history><date date-type="received"><day>24</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>22</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s). 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">Studies showed that axillary lymph node dissection can be safely omitted in presence of positive sentinel lymph node(s) in breast cancer patients treated with breast conserving therapy. Since the outcome of the sentinel lymph node biopsy has no clinical consequence, the value of the procedure itself is being questioned. The aim of the BOOG 2013–08 trial is to investigate whether the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients treated with breast conserving therapy.</p></sec><sec><title>Methods</title><p id="Par2">The BOOG 2013–08 is a Dutch prospective non-inferiority randomized multicentre trial. Women with pathologically confirmed clinically node negative T1–2 invasive breast cancer undergoing breast conserving therapy will be randomized for sentinel lymph node biopsy versus no sentinel lymph node biopsy. Endpoints include regional recurrence after 5 (primary endpoint) and 10 years of follow-up, distant-disease free and overall survival, quality of life, morbidity and cost-effectiveness. Previous data indicate a 5-year regional recurrence free survival rate of 99% for the control arm and 96% for the study arm. In combination with a non-inferiority limit of 5% and probability of 0.8, this result in a sample size of 1.644 patients including a lost to follow-up rate of 10%. Primary and secondary endpoints will be reported after 5 and 10 years of follow-up.</p></sec><sec><title>Discussion</title><p id="Par3">If the sentinel lymph node biopsy can be safely omitted in clinically node negative breast cancer patients undergoing breast conserving therapy, this study will cost-effectively lead to a decreased axillary morbidity rate and thereby improved quality of life with non-inferior regional control, distant-disease free survival and overall survival.</p></sec><sec><title>Trial registration</title><p id="Par4">The BOOG 2013–08 study is registered in <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov">ClinicalTrials.gov</ext-link> since October 20, 2014, Identifier: NCT02271828. <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02271828">https://clinicaltrials.gov/ct2/show/NCT02271828</ext-link></p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Breast neoplasms</kwd><kwd>Breast cancer</kwd><kwd>Sentinel lymph node biopsy</kwd><kwd>Breast conserving therapy</kwd></kwd-group><funding-group><award-group><funding-source><institution>Centraal Ziekenfonds (CZ)</institution></funding-source><award-id>201400316</award-id></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100001826</institution-id><institution>ZonMw</institution></institution-wrap></funding-source><award-id>843002624</award-id></award-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100004622</institution-id><institution>KWF Kankerbestrijding</institution></institution-wrap></funding-source><award-id>20146679</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Van Roozendaal, L M" sort="Van Roozendaal, L M" uniqKey="Van Roozendaal L" first="L. M." last="Van Roozendaal">L. M. Van Roozendaal</name></noRegion><name sortKey="Boersma, L J" sort="Boersma, L J" uniqKey="Boersma L" first="L. J." last="Boersma">L. J. Boersma</name><name sortKey="Boersma, L J" sort="Boersma, L J" uniqKey="Boersma L" first="L. J." last="Boersma">L. J. Boersma</name><name sortKey="De Vries, J" sort="De Vries, J" uniqKey="De Vries J" first="J." last="De Vries">J. De Vries</name><name sortKey="De Wilt, J H W" sort="De Wilt, J H W" uniqKey="De Wilt J" first="J. H. W." last="De Wilt">J. H. W. De Wilt</name><name sortKey="Kessels, A G H" sort="Kessels, A G H" uniqKey="Kessels A" first="A. G. H." last="Kessels">A. G. H. Kessels</name><name sortKey="Linn, S C" sort="Linn, S C" uniqKey="Linn S" first="S. C." last="Linn">S. C. Linn</name><name sortKey="Lobbes, M B I" sort="Lobbes, M B I" uniqKey="Lobbes M" first="M. B. I." last="Lobbes">M. B. I. Lobbes</name><name sortKey="Poortmans, P M P" sort="Poortmans, P M P" uniqKey="Poortmans P" first="P. M. P." last="Poortmans">P. M. P. Poortmans</name><name sortKey="Smidt, M L" sort="Smidt, M L" uniqKey="Smidt M" first="M. L." last="Smidt">M. L. Smidt</name><name sortKey="Smidt, M L" sort="Smidt, M L" uniqKey="Smidt M" first="M. L." last="Smidt">M. L. Smidt</name><name sortKey="Strobbe, L J A" sort="Strobbe, L J A" uniqKey="Strobbe L" first="L. J. A." last="Strobbe">L. J. A. Strobbe</name><name sortKey="Tjan Heijnen, V C G" sort="Tjan Heijnen, V C G" uniqKey="Tjan Heijnen V" first="V. C. G." last="Tjan-Heijnen">V. C. G. Tjan-Heijnen</name><name sortKey="Tjan Heijnen, V C G" sort="Tjan Heijnen, V C G" uniqKey="Tjan Heijnen V" first="V. C. G." last="Tjan-Heijnen">V. C. G. Tjan-Heijnen</name><name sortKey="Van Dalen, T" sort="Van Dalen, T" uniqKey="Van Dalen T" first="T." last="Van Dalen">T. Van Dalen</name><name sortKey="Van De Vijver, K K B T" sort="Van De Vijver, K K B T" uniqKey="Van De Vijver K" first="K. K. B. T." last="Van De Vijver">K. K. B. T. Van De Vijver</name><name sortKey="Van Der Hage, J A" sort="Van Der Hage, J A" uniqKey="Van Der Hage J" first="J. A." last="Van Der Hage">J. A. Van Der Hage</name><name sortKey="Van Roozendaal, L M" sort="Van Roozendaal, L M" uniqKey="Van Roozendaal L" first="L. M." last="Van Roozendaal">L. M. Van Roozendaal</name><name sortKey="Vane, M L G" sort="Vane, M L G" uniqKey="Vane M" first="M. L. G." last="Vane">M. L. G. Vane</name><name sortKey="Vane, M L G" sort="Vane, M L G" uniqKey="Vane M" first="M. L. G." last="Vane">M. L. G. Vane</name><name sortKey="Westenberg, A H" sort="Westenberg, A H" uniqKey="Westenberg A" first="A. H." last="Westenberg">A. H. Westenberg</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009236 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 009236 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5494134
|texte= Clinically node negative breast cancer patients undergoing breast conserving therapy, sentinel lymph node procedure versus follow-up: a Dutch randomized controlled multicentre trial (BOOG 2013-08)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:28668073" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |