Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage
Identifieur interne : 009168 ( Ncbi/Merge ); précédent : 009167; suivant : 009169Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage
Auteurs : Christopher M. Stone [Suisse, États-Unis] ; Randee Kastner [Suisse] ; Peter Steinmann [Suisse] ; Nakul Chitnis [Suisse] ; Marcel Tanner [Suisse] ; Fabrizio Tediosi [Suisse]Source :
- BMJ Global Health [ 2059-7908 ] ; 2016.
Abstract
A global programme to eliminate lymphatic filariasis (GPELF) is underway, yet two key programmatic features are currently still lacking: (1) the extension of efforts to all lymphatic filariasis (LF) endemic countries, and (2) the expansion of geographic coverage of mass drug administration (MDA) within countries. For varying levels of scale-up of MDA, we assessed the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity.
We extended an LF transmission model to track hydrocele and lymphoedema incidence in order to obtain estimates of the disability adjusted life years (DALYs) averted due to scaling up MDA over a period of 50 years. We then estimated the ICERs and the cost-effectiveness acceptability curves associated with different rates of MDA scale-up. Health systems savings were estimated by considering the averted morbidity, treatment-seeking behaviour and morbidity management costs. Gains in worker productivity were estimated by multiplying estimated working days lost as a result of morbidity with country-specific per-worker agricultural wages.
Our projections indicate that a massive scaling-up of MDA could lead to 4.38 million incremental DALYs averted over a 50-year time horizon compared to a scenario which mirrors current efforts against LF. In comparison to maintaining the current rate of progress against LF, massive scaling-up of MDA—pursuing LF eradication as soon as possible—was most likely to be cost-effective above a willingness to pay threshold of US$71.5/DALY averted. Intensified MDA scale-up was also associated with lower ICERs. Furthermore, this could result in health systems savings up to US$483 million. Extending coverage to all endemic areas could generate additional economic benefits through gains in worker productivity between US$3.4 and US$14.4 billion.
In addition to ethical and political motivations for scaling-up MDA rapidly, this analysis provides economic support for increasing the intensity of MDA programmes.
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DOI: 10.1136/bmjgh-2015-000021
PubMed: 28588916
PubMed Central: 5321305
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Stone</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Statistics</addr-line>,<institution>North Carolina State University</institution>,<addr-line>Raleigh, North Carolina</addr-line>,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kastner, Randee" sort="Kastner, Randee" uniqKey="Kastner R" first="Randee" last="Kastner">Randee Kastner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steinmann, Peter" sort="Steinmann, Peter" uniqKey="Steinmann P" first="Peter" last="Steinmann">Peter Steinmann</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Nakul" sort="Chitnis, Nakul" uniqKey="Chitnis N" first="Nakul" last="Chitnis">Nakul Chitnis</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanner, Marcel" sort="Tanner, Marcel" uniqKey="Tanner M" first="Marcel" last="Tanner">Marcel Tanner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tediosi, Fabrizio" sort="Tediosi, Fabrizio" uniqKey="Tediosi F" first="Fabrizio" last="Tediosi">Fabrizio Tediosi</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Global Health</title><idno type="eISSN">2059-7908</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>A global programme to eliminate lymphatic filariasis (GPELF) is underway, yet two key programmatic features are currently still lacking: (1) the extension of efforts to all lymphatic filariasis (LF) endemic countries, and (2) the expansion of geographic coverage of mass drug administration (MDA) within countries. For varying levels of scale-up of MDA, we assessed the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity.</p></sec><sec><title>Methods</title><p>We extended an LF transmission model to track hydrocele and lymphoedema incidence in order to obtain estimates of the disability adjusted life years (DALYs) averted due to scaling up MDA over a period of 50 years. We then estimated the ICERs and the cost-effectiveness acceptability curves associated with different rates of MDA scale-up. Health systems savings were estimated by considering the averted morbidity, treatment-seeking behaviour and morbidity management costs. Gains in worker productivity were estimated by multiplying estimated working days lost as a result of morbidity with country-specific per-worker agricultural wages.</p></sec><sec><title>Results</title><p>Our projections indicate that a massive scaling-up of MDA could lead to 4.38 million incremental DALYs averted over a 50-year time horizon compared to a scenario which mirrors current efforts against LF. In comparison to maintaining the current rate of progress against LF, massive scaling-up of MDA—pursuing LF eradication as soon as possible—was most likely to be cost-effective above a willingness to pay threshold of US$71.5/DALY averted. Intensified MDA scale-up was also associated with lower ICERs. Furthermore, this could result in health systems savings up to US$483 million. Extending coverage to all endemic areas could generate additional economic benefits through gains in worker productivity between US$3.4 and US$14.4 billion.</p></sec><sec><title>Conclusions</title><p>In addition to ethical and political motivations for scaling-up MDA rapidly, this analysis provides economic support for increasing the intensity of MDA programmes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fenner, F" uniqKey="Fenner F">F Fenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairncross, S" uniqKey="Cairncross S">S Cairncross</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Muller</name></author><author><name sortKey="Zagaria, N" uniqKey="Zagaria N">N Zagaria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Hopkins, Dr" 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first="Christopher M" last="Stone">Christopher M. Stone</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Statistics</addr-line>,<institution>North Carolina State University</institution>,<addr-line>Raleigh, North Carolina</addr-line>,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kastner, Randee" sort="Kastner, Randee" uniqKey="Kastner R" first="Randee" last="Kastner">Randee Kastner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steinmann, Peter" sort="Steinmann, Peter" uniqKey="Steinmann P" first="Peter" last="Steinmann">Peter Steinmann</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Nakul" sort="Chitnis, Nakul" uniqKey="Chitnis N" first="Nakul" last="Chitnis">Nakul Chitnis</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanner, Marcel" sort="Tanner, Marcel" uniqKey="Tanner M" first="Marcel" last="Tanner">Marcel Tanner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tediosi, Fabrizio" sort="Tediosi, Fabrizio" uniqKey="Tediosi F" first="Fabrizio" last="Tediosi">Fabrizio Tediosi</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28588916</idno><idno type="pmc">5321305</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321305</idno><idno type="RBID">PMC:5321305</idno><idno type="doi">10.1136/bmjgh-2015-000021</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003B78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003B78</idno><idno type="wicri:Area/Pmc/Curation">003B77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003B77</idno><idno type="wicri:Area/Pmc/Checkpoint">000775</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000775</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage</title><author><name sortKey="Stone, Christopher M" sort="Stone, Christopher M" uniqKey="Stone C" first="Christopher M" last="Stone">Christopher M. Stone</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Statistics</addr-line>,<institution>North Carolina State University</institution>,<addr-line>Raleigh, North Carolina</addr-line>,<country>USA</country>.</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kastner, Randee" sort="Kastner, Randee" uniqKey="Kastner R" first="Randee" last="Kastner">Randee Kastner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steinmann, Peter" sort="Steinmann, Peter" uniqKey="Steinmann P" first="Peter" last="Steinmann">Peter Steinmann</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chitnis, Nakul" sort="Chitnis, Nakul" uniqKey="Chitnis N" first="Nakul" last="Chitnis">Nakul Chitnis</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tanner, Marcel" sort="Tanner, Marcel" uniqKey="Tanner M" first="Marcel" last="Tanner">Marcel Tanner</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tediosi, Fabrizio" sort="Tediosi, Fabrizio" uniqKey="Tediosi F" first="Fabrizio" last="Tediosi">Fabrizio Tediosi</name><affiliation wicri:level="1"><nlm:aff id="af1"><institution>Swiss Tropical and Public Health Institute</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af2"><institution>Universität Basel</institution>,<addr-line>Basel</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Global Health</title><idno type="eISSN">2059-7908</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>A global programme to eliminate lymphatic filariasis (GPELF) is underway, yet two key programmatic features are currently still lacking: (1) the extension of efforts to all lymphatic filariasis (LF) endemic countries, and (2) the expansion of geographic coverage of mass drug administration (MDA) within countries. For varying levels of scale-up of MDA, we assessed the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity.</p></sec><sec><title>Methods</title><p>We extended an LF transmission model to track hydrocele and lymphoedema incidence in order to obtain estimates of the disability adjusted life years (DALYs) averted due to scaling up MDA over a period of 50 years. We then estimated the ICERs and the cost-effectiveness acceptability curves associated with different rates of MDA scale-up. Health systems savings were estimated by considering the averted morbidity, treatment-seeking behaviour and morbidity management costs. Gains in worker productivity were estimated by multiplying estimated working days lost as a result of morbidity with country-specific per-worker agricultural wages.</p></sec><sec><title>Results</title><p>Our projections indicate that a massive scaling-up of MDA could lead to 4.38 million incremental DALYs averted over a 50-year time horizon compared to a scenario which mirrors current efforts against LF. In comparison to maintaining the current rate of progress against LF, massive scaling-up of MDA—pursuing LF eradication as soon as possible—was most likely to be cost-effective above a willingness to pay threshold of US$71.5/DALY averted. Intensified MDA scale-up was also associated with lower ICERs. Furthermore, this could result in health systems savings up to US$483 million. Extending coverage to all endemic areas could generate additional economic benefits through gains in worker productivity between US$3.4 and US$14.4 billion.</p></sec><sec><title>Conclusions</title><p>In addition to ethical and political motivations for scaling-up MDA rapidly, this analysis provides economic support for increasing the intensity of MDA programmes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fenner, F" uniqKey="Fenner F">F Fenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairncross, S" uniqKey="Cairncross S">S Cairncross</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Muller</name></author><author><name sortKey="Zagaria, N" uniqKey="Zagaria N">N Zagaria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Hopkins, Dr" 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Ca" uniqKey="Goodman C">CA Goodman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santatiwongchai, B" uniqKey="Santatiwongchai B">B Santatiwongchai</name></author><author><name sortKey="Chantarastapornchit, V" uniqKey="Chantarastapornchit V">V Chantarastapornchit</name></author><author><name sortKey="Wilkinson, T" uniqKey="Wilkinson T">T Wilkinson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sabot, O" uniqKey="Sabot O">O Sabot</name></author><author><name sortKey="Cohen, Jm" uniqKey="Cohen J">JM Cohen</name></author><author><name sortKey="Hsiang, Ms" uniqKey="Hsiang M">MS Hsiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Hooper, Pj" uniqKey="Hooper P">PJ Hooper</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geerts, S" uniqKey="Geerts S">S Geerts</name></author><author><name sortKey="Gryseels, B" uniqKey="Gryseels B">B Gryseels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, Cm" uniqKey="Stone C">CM Stone</name></author><author><name sortKey="Lindsay, Sw" uniqKey="Lindsay S">SW Lindsay</name></author><author><name sortKey="Chitnis, N" uniqKey="Chitnis N">N Chitnis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reimer, Lj" uniqKey="Reimer L">LJ Reimer</name></author><author><name sortKey="Thomsen, Ek" uniqKey="Thomsen E">EK Thomsen</name></author><author><name sortKey="Tisch, Dj" uniqKey="Tisch D">DJ Tisch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramaiah, Kd" uniqKey="Ramaiah K">KD Ramaiah</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomsen, Ek" uniqKey="Thomsen E">EK Thomsen</name></author><author><name sortKey="Sanuku, N" uniqKey="Sanuku N">N Sanuku</name></author><author><name sortKey="Baea, M" uniqKey="Baea M">M Baea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michael, E" uniqKey="Michael E">E Michael</name></author><author><name sortKey="Malecela, Mn" uniqKey="Malecela M">MN Malecela</name></author><author><name sortKey="Zervos, M" uniqKey="Zervos M">M Zervos</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage.</title><author><name sortKey="Stone, Christopher M" sort="Stone, Christopher M" uniqKey="Stone C" first="Christopher M" last="Stone">Christopher M. Stone</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Kastner, Randee" sort="Kastner, Randee" uniqKey="Kastner R" first="Randee" last="Kastner">Randee Kastner</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Steinmann, Peter" sort="Steinmann, Peter" uniqKey="Steinmann P" first="Peter" last="Steinmann">Peter Steinmann</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Chitnis, Nakul" sort="Chitnis, Nakul" uniqKey="Chitnis N" first="Nakul" last="Chitnis">Nakul Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tanner, Marcel" sort="Tanner, Marcel" uniqKey="Tanner M" first="Marcel" last="Tanner">Marcel Tanner</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tediosi, Fabrizio" sort="Tediosi, Fabrizio" uniqKey="Tediosi F" first="Fabrizio" last="Tediosi">Fabrizio Tediosi</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:28588916</idno><idno type="pmid">28588916</idno><idno type="doi">10.1136/bmjgh-2015-000021</idno><idno type="wicri:Area/PubMed/Corpus">000899</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000899</idno><idno type="wicri:Area/PubMed/Curation">000899</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000899</idno><idno type="wicri:Area/PubMed/Checkpoint">000899</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000899</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage.</title><author><name sortKey="Stone, Christopher M" sort="Stone, Christopher M" uniqKey="Stone C" first="Christopher M" last="Stone">Christopher M. Stone</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Kastner, Randee" sort="Kastner, Randee" uniqKey="Kastner R" first="Randee" last="Kastner">Randee Kastner</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Steinmann, Peter" sort="Steinmann, Peter" uniqKey="Steinmann P" first="Peter" last="Steinmann">Peter Steinmann</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Chitnis, Nakul" sort="Chitnis, Nakul" uniqKey="Chitnis N" first="Nakul" last="Chitnis">Nakul Chitnis</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tanner, Marcel" sort="Tanner, Marcel" uniqKey="Tanner M" first="Marcel" last="Tanner">Marcel Tanner</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tediosi, Fabrizio" sort="Tediosi, Fabrizio" uniqKey="Tediosi F" first="Fabrizio" last="Tediosi">Fabrizio Tediosi</name><affiliation wicri:level="1"><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Tropical and Public Health Institute, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMJ global health</title><idno type="ISSN">2059-7908</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A global programme to eliminate lymphatic filariasis (GPELF) is underway, yet two key programmatic features are currently still lacking: (1) the extension of efforts to all lymphatic filariasis (LF) endemic countries, and (2) the expansion of geographic coverage of mass drug administration (MDA) within countries. For varying levels of scale-up of MDA, we assessed the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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