[Postoperative administration of octreotide to reduce lymphorrhea, lymphocele, lymphedema and lymphatic ascites after lymphadenectomy in gynecological malignancies].
Identifieur interne : 009162 ( Ncbi/Merge ); précédent : 009161; suivant : 009163[Postoperative administration of octreotide to reduce lymphorrhea, lymphocele, lymphedema and lymphatic ascites after lymphadenectomy in gynecological malignancies].
Auteurs : V. Weinberger ; L. Miná ; M. Felsinger ; D. Seidlová ; P. Ovesná ; M. Bedna Ková ; E. Jandáková ; I. RovnSource :
- Ceska gynekologie [ 1210-7832 ] ; 2017.
Abstract
Octreotide is a synthetic analogue of natural somatostatin. Octreotide effect on lymphorrhea reduction in gynecological malignancies has only been assessed in case studies.
PubMed: 28585840
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Postoperative administration of octreotide to reduce lymphorrhea, lymphocele, lymphedema and lymphatic ascites after lymphadenectomy in gynecological malignancies].</title><author><name sortKey="Weinberger, V" sort="Weinberger, V" uniqKey="Weinberger V" first="V" last="Weinberger">V. Weinberger</name></author><author><name sortKey="Mina, L" sort="Mina, L" uniqKey="Mina L" first="L" last="Miná">L. Miná</name></author><author><name sortKey="Felsinger, M" sort="Felsinger, M" uniqKey="Felsinger M" first="M" last="Felsinger">M. Felsinger</name></author><author><name sortKey="Seidlova, D" sort="Seidlova, D" uniqKey="Seidlova D" first="D" last="Seidlová">D. Seidlová</name></author><author><name sortKey="Ovesna, P" sort="Ovesna, P" uniqKey="Ovesna P" first="P" last="Ovesná">P. Ovesná</name></author><author><name sortKey="Bedna Kova, M" sort="Bedna Kova, M" uniqKey="Bedna Kova M" first="M" last="Bedna Ková">M. Bedna Ková</name></author><author><name sortKey="Jandakova, E" sort="Jandakova, E" uniqKey="Jandakova E" first="E" last="Jandáková">E. Jandáková</name></author><author><name sortKey="Rovn, I" sort="Rovn, I" uniqKey="Rovn I" first="I" last="Rovn">I. Rovn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28585840</idno><idno type="pmid">28585840</idno><idno type="wicri:Area/PubMed/Corpus">000160</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000160</idno><idno type="wicri:Area/PubMed/Curation">000160</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000160</idno><idno type="wicri:Area/PubMed/Checkpoint">000160</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000160</idno><idno type="wicri:Area/Ncbi/Merge">009162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Postoperative administration of octreotide to reduce lymphorrhea, lymphocele, lymphedema and lymphatic ascites after lymphadenectomy in gynecological malignancies].</title><author><name sortKey="Weinberger, V" sort="Weinberger, V" uniqKey="Weinberger V" first="V" last="Weinberger">V. Weinberger</name></author><author><name sortKey="Mina, L" sort="Mina, L" uniqKey="Mina L" first="L" last="Miná">L. Miná</name></author><author><name sortKey="Felsinger, M" sort="Felsinger, M" uniqKey="Felsinger M" first="M" last="Felsinger">M. Felsinger</name></author><author><name sortKey="Seidlova, D" sort="Seidlova, D" uniqKey="Seidlova D" first="D" last="Seidlová">D. Seidlová</name></author><author><name sortKey="Ovesna, P" sort="Ovesna, P" uniqKey="Ovesna P" first="P" last="Ovesná">P. Ovesná</name></author><author><name sortKey="Bedna Kova, M" sort="Bedna Kova, M" uniqKey="Bedna Kova M" first="M" last="Bedna Ková">M. Bedna Ková</name></author><author><name sortKey="Jandakova, E" sort="Jandakova, E" uniqKey="Jandakova E" first="E" last="Jandáková">E. Jandáková</name></author><author><name sortKey="Rovn, I" sort="Rovn, I" uniqKey="Rovn I" first="I" last="Rovn">I. Rovn</name></author></analytic><series><title level="j">Ceska gynekologie</title><idno type="ISSN">1210-7832</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Octreotide is a synthetic analogue of natural somatostatin. Octreotide effect on lymphorrhea reduction in gynecological malignancies has only been assessed in case studies.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28585840</PMID><DateCreated><Year>2017</Year><Month>06</Month><Day>06</Day></DateCreated><DateRevised><Year>2017</Year><Month>06</Month><Day>06</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1210-7832</ISSN><JournalIssue CitedMedium="Print"><Volume>82</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Season>Spring</Season></PubDate></JournalIssue><Title>Ceska gynekologie</Title><ISOAbbreviation>Ceska Gynekol</ISOAbbreviation></Journal><ArticleTitle>[Postoperative administration of octreotide to reduce lymphorrhea, lymphocele, lymphedema and lymphatic ascites after lymphadenectomy in gynecological malignancies].</ArticleTitle><Pagination><MedlinePgn>92-99</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Octreotide is a synthetic analogue of natural somatostatin. Octreotide effect on lymphorrhea reduction in gynecological malignancies has only been assessed in case studies.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Original work.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Gynecologic Oncology Center, Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In 2014 there was a prospective, randomized, one-institution study. Patients underwent surgery including pelvic or pelvic and paraaortic lymphadenectomy for cervical, uterine and ovarian cancer. The informed consent was signed. Octreotide was evaluated in relation to diagnosis, surgery (laparoscopy versus laparotomy), pelvic and/or paraaortic lymphadenectomy, number of removed lymph nodes and their positivity, neoadjuvant chemotherapy, adjuvant chemotherapy, adjuvant radiotherapy, albumin, BMI, number of days with drains postoperatively, number of days in hospital, blood loss during surgery, time of surgery, total number of drains placed into abdominal cavity. In follow up period, within 1 year after surgery, we searched for lymphocele, lymph-edema of lower extremities and lymphatic ascites in relation to lymphorrhea.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">44 patients (9 cervical, 19 endometrial and 16 ovarian cancer) were enrolled in two statistically comparable randomized groups. "Octreotide group", which paradoxically showed lymphorrhea of 4082 ml on average, (without 1992 ml, p = 0.001), needed drainage for more days (p = 0.001). The diagnosis had no influence on lymphorrhea in both groups (p = 0.966). The neoadjuvant chemotherapy was administered (p = 0.026), the more lymph nodes were removed (p = 0.018), the more days the drainage was in place (p < 0.001), the bigger the lymphorrhea; no relationship between lymphorrhea and age (p = 0.631), albumin level (p = 0.584), BMI ( p= 0.966) or number of positive nodes (p = 0.259), length of surgery (p = 0.206), blood loss (p = 0.494). Nor lymphedema (p = 0.404), nor lymphocele (p = 0.086), correlated with postoperative lymphorrhea. Lymphatic ascites was associated with lymphorrhea (p = 0.048).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Octreotide did not reduce lymphorrhea and the incidence of lymphocele, lymphedema of lower extremities and lymphatic ascites within one year of follow-up period after surgery. According to our results, we do not recommend to administer the octreotide in oncogynecological patients after pelvic and/or paraaortic lymphadenectomy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Weinberger</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Minář</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Felsinger</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Seidlová</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Ovesná</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bednaříková</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Jandáková</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rovný</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>cze</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Vliv pooperačního podání oktreotidu na redukci lymforey a následně vzniku lymfocyst, lymfedému a lymfatického ascitu po lymfadenektomii u gynekologických malignit.</VernacularTitle></Article><MedlineJournalInfo><Country>Czech Republic</Country><MedlineTA>Ceska Gynekol</MedlineTA><NlmUniqueID>9423768</NlmUniqueID><ISSNLinking>1210-7832</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">lymphadenectomy</Keyword><Keyword MajorTopicYN="N">lymphatic ascites</Keyword><Keyword MajorTopicYN="N">lymphedema</Keyword><Keyword MajorTopicYN="N">lymphocele octreotide.</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28585840</ArticleId><ArticleId IdType="pii">61056</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Bedna Kova, M" sort="Bedna Kova, M" uniqKey="Bedna Kova M" first="M" last="Bedna Ková">M. Bedna Ková</name><name sortKey="Felsinger, M" sort="Felsinger, M" uniqKey="Felsinger M" first="M" last="Felsinger">M. Felsinger</name><name sortKey="Jandakova, E" sort="Jandakova, E" uniqKey="Jandakova E" first="E" last="Jandáková">E. Jandáková</name><name sortKey="Mina, L" sort="Mina, L" uniqKey="Mina L" first="L" last="Miná">L. Miná</name><name sortKey="Ovesna, P" sort="Ovesna, P" uniqKey="Ovesna P" first="P" last="Ovesná">P. Ovesná</name><name sortKey="Rovn, I" sort="Rovn, I" uniqKey="Rovn I" first="I" last="Rovn">I. Rovn</name><name sortKey="Seidlova, D" sort="Seidlova, D" uniqKey="Seidlova D" first="D" last="Seidlová">D. Seidlová</name><name sortKey="Weinberger, V" sort="Weinberger, V" uniqKey="Weinberger V" first="V" last="Weinberger">V. Weinberger</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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