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General health status of long-term cervical cancer survivors after radiotherapy.

Identifieur interne : 009067 ( Ncbi/Merge ); précédent : 009066; suivant : 009068

General health status of long-term cervical cancer survivors after radiotherapy.

Auteurs : Lee Sung Uk ; Kim Young Ae ; Yoon Young-Ho ; Kim Yeon-Joo ; Lim Myong Cheol ; Park Sang-Yoon ; Seo Sang-Soo ; Park Ji Eun ; Kim Joo-Young [Corée du Sud]

Source :

RBID : pubmed:28492995

Descripteurs français

English descriptors

Abstract

To evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4 years after curative radiation treatment (RT).

DOI: 10.1007/s00066-017-1143-8
PubMed: 28492995

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pubmed:28492995

Le document en format XML

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<term>Adult</term>
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<term>Chemoradiotherapy</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Health Status</term>
<term>Humans</term>
<term>Hysterectomy</term>
<term>Intestines (radiation effects)</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Quality of Life (psychology)</term>
<term>Radiation Injuries (etiology)</term>
<term>Radiotherapy Dosage</term>
<term>Re-Irradiation</term>
<term>Survival Analysis</term>
<term>Survivors</term>
<term>Urinary Bladder (radiation effects)</term>
<term>Uterine Cervical Neoplasms (mortality)</term>
<term>Uterine Cervical Neoplasms (pathology)</term>
<term>Uterine Cervical Neoplasms (psychology)</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de survie</term>
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<term>Dosimétrie en radiothérapie</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
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<term>Lésions radio-induites (étiologie)</term>
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<term>Stade de la tumeur</term>
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<term>Tumeurs du col de l'utérus ()</term>
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<term>Tumeurs du col de l'utérus (mortalité)</term>
<term>Tumeurs du col de l'utérus (psychologie)</term>
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<term>Urinary Bladder</term>
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<term>Age Factors</term>
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<term>Chemoradiotherapy</term>
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<term>Follow-Up Studies</term>
<term>Health Status</term>
<term>Humans</term>
<term>Hysterectomy</term>
<term>Middle Aged</term>
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<term>Dosimétrie en radiothérapie</term>
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<front>
<div type="abstract" xml:lang="en">To evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4 years after curative radiation treatment (RT).</div>
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<DateCreated>
<Year>2017</Year>
<Month>05</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted>
<Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>08</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1439-099X</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>193</Volume>
<Issue>7</Issue>
<PubDate>
<Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]</Title>
<ISOAbbreviation>Strahlenther Onkol</ISOAbbreviation>
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<ArticleTitle>General health status of long-term cervical cancer survivors after radiotherapy.</ArticleTitle>
<Pagination>
<MedlinePgn>543-551</MedlinePgn>
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<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate the global health status of long-term cervical cancer survivors (LCCS) who survived for more than 4 years after curative radiation treatment (RT).</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Medical records of 562 women treated with RT in our institution between 2003 and 2010 were reviewed. Excluding 259 women who died of disease or were lost to follow-up, disease status and late morbidities were evaluated in 303 LCCS. Quality of life (QoL) was analyzed in 168 LCCS using a questionnaire from the European Organization for the Research and Treatment of Cancer, and the results were compared with an age-matched healthy Korean female population.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Median follow-up was 6.8 years (range 4.1-12.5 years). There were 14 deaths (7 cancer specific) and 14 recurrences (5 local recurrences and 9 distant metastases). The median time to recurrence was 6.0 years (range 4.1-8.2 years). Grade ≥2 late toxicities were frequently observed in the bladder (19%) and small/large intestine (15%). Multivariate analysis revealed a higher rate of late toxicity in patients aged ≥51 years at diagnosis (small/large intestine: hazard ratio, HR, 2.5 [1.2-5.5]; bladder: HR 2.4 [1.3-4.5]; and bone: HR 4.3 [1.2-15.8]) than patients aged <51 years. Compared to the general population, LCCS exhibited a significantly higher rate of body image concerns, sexual dysfunction, lymphedema, and peripheral neuropathy.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">New recurrences occurred in 5% of LCCS and grade ≥2 treatment-related morbidities were present in 33%. A significant proportion of LCCS also showed decreased cervical-cancer-specific QoL. These results suggest the need for long-term surveillance and follow-up care for LCCS.</AbstractText>
</Abstract>
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<Affiliation>Cancer Policy Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
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<Affiliation>Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea (Republic of).</Affiliation>
</AffiliationInfo>
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<LastName>Yeon-Joo</LastName>
<ForeName>Kim</ForeName>
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<Affiliation>Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
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<LastName>Myong Cheol</LastName>
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<Affiliation>Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Gynecologic Cancer Branch, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
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<Affiliation>Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
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<LastName>Ji Eun</LastName>
<ForeName>Park</ForeName>
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<Affiliation>Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of).</Affiliation>
</AffiliationInfo>
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<LastName>Joo-Young</LastName>
<ForeName>Kim</ForeName>
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<Affiliation>Proton Therapy Center, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of). jooyoungcasa@ncc.re.kr.</Affiliation>
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<AffiliationInfo>
<Affiliation>Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea (Republic of). jooyoungcasa@ncc.re.kr.</Affiliation>
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<AffiliationInfo>
<Affiliation>Research Institute and Hospital, National Cancer Center, 323 Ilsan-ro, 410-769, Goyang, Gyeonggi, Korea (Republic of). jooyoungcasa@ncc.re.kr.</Affiliation>
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</PublicationTypeList>
<VernacularTitle>Allgemeiner Gesundheitsstatus Langzeitüberlebender von Gebärmutterhalskrebs nach Strahlentherapie.</VernacularTitle>
<ArticleDate DateType="Electronic">
<Year>2017</Year>
<Month>05</Month>
<Day>10</Day>
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<Country>Germany</Country>
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<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
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<DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D011879" MajorTopicYN="N">Radiotherapy Dosage</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000069475" MajorTopicYN="Y">Re-Irradiation</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D017741" MajorTopicYN="Y">Survivors</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001743" MajorTopicYN="N">Urinary Bladder</DescriptorName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D002583" MajorTopicYN="N">Uterine Cervical Neoplasms</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
<QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">Gynecology</Keyword>
<Keyword MajorTopicYN="N">Quality of life</Keyword>
<Keyword MajorTopicYN="N">Side effects</Keyword>
<Keyword MajorTopicYN="N">Survival</Keyword>
<Keyword MajorTopicYN="N">Toxicity</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2016</Year>
<Month>11</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2017</Year>
<Month>04</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2017</Year>
<Month>5</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2017</Year>
<Month>8</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2017</Year>
<Month>5</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">28492995</ArticleId>
<ArticleId IdType="doi">10.1007/s00066-017-1143-8</ArticleId>
<ArticleId IdType="pii">10.1007/s00066-017-1143-8</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Corée du Sud</li>
</country>
</list>
<tree>
<noCountry>
<name sortKey="Ji Eun, Park" sort="Ji Eun, Park" uniqKey="Ji Eun P" first="Park" last="Ji Eun">Park Ji Eun</name>
<name sortKey="Myong Cheol, Lim" sort="Myong Cheol, Lim" uniqKey="Myong Cheol L" first="Lim" last="Myong Cheol">Lim Myong Cheol</name>
<name sortKey="Sang Soo, Seo" sort="Sang Soo, Seo" uniqKey="Sang Soo S" first="Seo" last="Sang-Soo">Seo Sang-Soo</name>
<name sortKey="Sang Yoon, Park" sort="Sang Yoon, Park" uniqKey="Sang Yoon P" first="Park" last="Sang-Yoon">Park Sang-Yoon</name>
<name sortKey="Sung Uk, Lee" sort="Sung Uk, Lee" uniqKey="Sung Uk L" first="Lee" last="Sung Uk">Lee Sung Uk</name>
<name sortKey="Yeon Joo, Kim" sort="Yeon Joo, Kim" uniqKey="Yeon Joo K" first="Kim" last="Yeon-Joo">Kim Yeon-Joo</name>
<name sortKey="Young Ae, Kim" sort="Young Ae, Kim" uniqKey="Young Ae K" first="Kim" last="Young Ae">Kim Young Ae</name>
<name sortKey="Young Ho, Yoon" sort="Young Ho, Yoon" uniqKey="Young Ho Y" first="Yoon" last="Young-Ho">Yoon Young-Ho</name>
</noCountry>
<country name="Corée du Sud">
<noRegion>
<name sortKey="Joo Young, Kim" sort="Joo Young, Kim" uniqKey="Joo Young K" first="Kim" last="Joo-Young">Kim Joo-Young</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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