A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia.
Identifieur interne : 008F45 ( Ncbi/Merge ); précédent : 008F44; suivant : 008F46A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia.
Auteurs : J. Brooks [Royaume-Uni] ; S J Ersser [Royaume-Uni] ; F. Cowdell [Royaume-Uni] ; E. Gardiner [Royaume-Uni] ; A. Mengistu [Éthiopie] ; P J Matts [Royaume-Uni]Source :
- The British journal of dermatology [ 1365-2133 ] ; 2017.
Abstract
Podoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk. Volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis. There is no robust evidence on optimal podoconiosis skin care regimens to improve SBF.
DOI: 10.1111/bjd.15543
PubMed: 28374907
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Cowdell</name><affiliation wicri:level="1"><nlm:affiliation>Birmingham City University, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham City University</wicri:regionArea></affiliation></author><author><name sortKey="Gardiner, E" sort="Gardiner, E" uniqKey="Gardiner E" first="E" last="Gardiner">E. Gardiner</name><affiliation wicri:level="1"><nlm:affiliation>University of Hull, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Hull</wicri:regionArea></affiliation></author><author><name sortKey="Mengistu, A" sort="Mengistu, A" uniqKey="Mengistu A" first="A" last="Mengistu">A. 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Brooks</name><affiliation wicri:level="1"><nlm:affiliation>University of Hull, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Hull</wicri:regionArea></affiliation></author><author><name sortKey="Ersser, S J" sort="Ersser, S J" uniqKey="Ersser S" first="S J" last="Ersser">S J Ersser</name><affiliation wicri:level="1"><nlm:affiliation>University of York, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of York</wicri:regionArea></affiliation></author><author><name sortKey="Cowdell, F" sort="Cowdell, F" uniqKey="Cowdell F" first="F" last="Cowdell">F. Cowdell</name><affiliation wicri:level="1"><nlm:affiliation>Birmingham City University, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham City University</wicri:regionArea></affiliation></author><author><name sortKey="Gardiner, E" sort="Gardiner, E" uniqKey="Gardiner E" first="E" last="Gardiner">E. Gardiner</name><affiliation wicri:level="1"><nlm:affiliation>University of Hull, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Hull</wicri:regionArea></affiliation></author><author><name sortKey="Mengistu, A" sort="Mengistu, A" uniqKey="Mengistu A" first="A" last="Mengistu">A. Mengistu</name><affiliation wicri:level="1"><nlm:affiliation>Sodo, Ethiopia.</nlm:affiliation><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Sodo</wicri:regionArea></affiliation></author><author><name sortKey="Matts, P J" sort="Matts, P J" uniqKey="Matts P" first="P J" last="Matts">P J Matts</name><affiliation wicri:level="1"><nlm:affiliation>Procter and Gamble, Greater London Innovation Centre, Egham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Procter and Gamble, Greater London Innovation Centre, Egham</wicri:regionArea><wicri:noRegion>Egham</wicri:noRegion></affiliation></author></analytic><series><title level="j">The British journal of dermatology</title><idno type="eISSN">1365-2133</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Podoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk. Volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis. There is no robust evidence on optimal podoconiosis skin care regimens to improve SBF.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28374907</PMID><DateCreated><Year>2017</Year><Month>04</Month><Day>04</Day></DateCreated><DateRevised><Year>2017</Year><Month>04</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2133</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Apr</Month><Day>04</Day></PubDate></JournalIssue><Title>The British journal of dermatology</Title><ISOAbbreviation>Br. J. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>A Randomised Controlled Trial to evaluate the effect of a new skin care regimen on skin barrier function in those with podoconiosis in Ethiopia.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/bjd.15543</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Podoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk. Volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis. There is no robust evidence on optimal podoconiosis skin care regimens to improve SBF.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To evaluate the effectiveness of a new, low-cost, evidence-based intervention to improve SBF in the lower limbs of those with podoconiosis.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A randomized control trial (RCT) was conducted over 3 months in two podoconiosis clinics (n=193). The intervention comprised 2% glycerine (v/v) added to a reduced amount of soaking water. The control group received the current skin care regimen. Primary outcome measures were trans-epidermal water loss (TEWL) and stratum corneum hydration (SCH) at four specific sites on the lower limbs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Improvement in SBF was observed in both groups across all measurement sites and time points, although this was significantly greater in the experimental group. TEWL reduced in both groups at all sites. For example, on top of the foot the estimated group difference in TEWL at the fourth visit was 1.751 (SE=0.0390) in favour of the experimental group (t=3.154, df=189.580, p=0.002, 95% CI (0.0656 to 2.846)), indicating a greater reduction in the experimental group. Similarly, at the same site the estimated group difference in SCH at the fourth visit was -2.041(CI=0.572) in favour of the experimental group (t=-3.565, df=186.739, p=<0.001), 95% CI (-3.168 to -0.911)), indicating a greater increase in the experimental group. There were also significantly greater reductions in odour, number of wounds and largest foot circumference in the experimental compared to the control group.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The addition of 2% glycerine (v/v) to a reduced volume (83% reduction) of soaking water significantly improved SBF (Registered trial NCT02839772) This article is protected by copyright. All rights reserved.</AbstractText><CopyrightInformation>This article is protected by copyright. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brooks</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ersser</LastName><ForeName>S J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>University of York, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowdell</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Birmingham City University, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gardiner</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mengistu</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sodo, Ethiopia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matts</LastName><ForeName>P J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Procter and Gamble, Greater London Innovation Centre, Egham, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Dermatol</MedlineTA><NlmUniqueID>0004041</NlmUniqueID><ISSNLinking>0007-0963</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>4</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28374907</ArticleId><ArticleId IdType="doi">10.1111/bjd.15543</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li><li>Éthiopie</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Brooks, J" sort="Brooks, J" uniqKey="Brooks J" first="J" last="Brooks">J. Brooks</name></noRegion><name sortKey="Cowdell, F" sort="Cowdell, F" uniqKey="Cowdell F" first="F" last="Cowdell">F. Cowdell</name><name sortKey="Ersser, S J" sort="Ersser, S J" uniqKey="Ersser S" first="S J" last="Ersser">S J Ersser</name><name sortKey="Gardiner, E" sort="Gardiner, E" uniqKey="Gardiner E" first="E" last="Gardiner">E. Gardiner</name><name sortKey="Matts, P J" sort="Matts, P J" uniqKey="Matts P" first="P J" last="Matts">P J Matts</name></country><country name="Éthiopie"><noRegion><name sortKey="Mengistu, A" sort="Mengistu, A" uniqKey="Mengistu A" first="A" last="Mengistu">A. Mengistu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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