An unusual case of basal cell carcinoma of the vulva with lung metastases
Identifieur interne : 008993 ( Ncbi/Merge ); précédent : 008992; suivant : 008994An unusual case of basal cell carcinoma of the vulva with lung metastases
Auteurs : Ga Watson [Irlande (pays)] ; D. Kelly [Irlande (pays)] ; L. Prior [Irlande (pays)] ; E. Stanley [Irlande (pays)] ; O. Maceneaney [Irlande (pays)] ; T. Walsh [Irlande (pays)] ; Cm Kelly [Irlande (pays)]Source :
- Gynecologic Oncology Reports [ 2352-5789 ] ; 2016.
Abstract
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases.
Url:
DOI: 10.1016/j.gore.2016.10.005
PubMed: 27830172
PubMed Central: 5094149
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002208
- to stream Pmc, to step Curation: 002207
- to stream Pmc, to step Checkpoint: 000C04
Links to Exploration step
PMC:5094149Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An unusual case of basal cell carcinoma of the vulva with lung metastases</title><author><name sortKey="Watson, Ga" sort="Watson, Ga" uniqKey="Watson G" first="Ga" last="Watson">Ga Watson</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, D" sort="Kelly, D" uniqKey="Kelly D" first="D" last="Kelly">D. Kelly</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Prior, L" sort="Prior, L" uniqKey="Prior L" first="L" last="Prior">L. Prior</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Stanley, E" sort="Stanley, E" uniqKey="Stanley E" first="E" last="Stanley">E. Stanley</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Maceneaney, O" sort="Maceneaney, O" uniqKey="Maceneaney O" first="O" last="Maceneaney">O. Maceneaney</name><affiliation wicri:level="1"><nlm:aff id="af0015">Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, T" sort="Walsh, T" uniqKey="Walsh T" first="T" last="Walsh">T. Walsh</name><affiliation wicri:level="1"><nlm:aff id="af0020">Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Cm" sort="Kelly, Cm" uniqKey="Kelly C" first="Cm" last="Kelly">Cm Kelly</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27830172</idno><idno type="pmc">5094149</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094149</idno><idno type="RBID">PMC:5094149</idno><idno type="doi">10.1016/j.gore.2016.10.005</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002208</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002208</idno><idno type="wicri:Area/Pmc/Curation">002207</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002207</idno><idno type="wicri:Area/Pmc/Checkpoint">000C04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C04</idno><idno type="wicri:Area/Ncbi/Merge">008993</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An unusual case of basal cell carcinoma of the vulva with lung metastases</title><author><name sortKey="Watson, Ga" sort="Watson, Ga" uniqKey="Watson G" first="Ga" last="Watson">Ga Watson</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, D" sort="Kelly, D" uniqKey="Kelly D" first="D" last="Kelly">D. Kelly</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Prior, L" sort="Prior, L" uniqKey="Prior L" first="L" last="Prior">L. Prior</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Stanley, E" sort="Stanley, E" uniqKey="Stanley E" first="E" last="Stanley">E. Stanley</name><affiliation wicri:level="1"><nlm:aff id="af0010">Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Maceneaney, O" sort="Maceneaney, O" uniqKey="Maceneaney O" first="O" last="Maceneaney">O. Maceneaney</name><affiliation wicri:level="1"><nlm:aff id="af0015">Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, T" sort="Walsh, T" uniqKey="Walsh T" first="T" last="Walsh">T. Walsh</name><affiliation wicri:level="1"><nlm:aff id="af0020">Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author><author><name sortKey="Kelly, Cm" sort="Kelly, Cm" uniqKey="Kelly C" first="Cm" last="Kelly">Cm Kelly</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7</wicri:regionArea><wicri:noRegion>Dublin 7</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gynecologic Oncology Reports</title><idno type="eISSN">2352-5789</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rubin, A I" uniqKey="Rubin A">A.I. Rubin</name></author><author><name sortKey="Chen, E H" uniqKey="Chen E">E.H. Chen</name></author><author><name sortKey="Ratner, D" uniqKey="Ratner D">D. Ratner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacob, A" uniqKey="Jacob A">A. Jacob</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleury, A C" uniqKey="Fleury A">A.C. Fleury</name></author><author><name sortKey="Junkins Hopkins, J M" uniqKey="Junkins Hopkins J">J.M. Junkins-Hopkins</name></author><author><name sortKey="Diaz Montes, T" uniqKey="Diaz Montes T">T. Diaz-Montes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sekulic, A" uniqKey="Sekulic A">A. Sekulic</name></author><author><name sortKey="Migden, M R" uniqKey="Migden M">M.R. Migden</name></author><author><name sortKey="Oro, A E" uniqKey="Oro A">A.E. Oro</name></author><author><name sortKey="Dirix, L" uniqKey="Dirix L">L. Dirix</name></author><author><name sortKey="Lewis, K D" uniqKey="Lewis K">K.D. Lewis</name></author><author><name sortKey="Hainsworth, J D" uniqKey="Hainsworth J">J.D. Hainsworth</name></author><author><name sortKey="Solomon, J A" uniqKey="Solomon J">J.A. Solomon</name></author><author><name sortKey="Yoo, S" uniqKey="Yoo S">S. Yoo</name></author><author><name sortKey="Arron, S T" uniqKey="Arron S">S.T. Arron</name></author><author><name sortKey="Friedlander, P A" uniqKey="Friedlander P">P.A. Friedlander</name></author><author><name sortKey="Marmur, E" uniqKey="Marmur E">E. Marmur</name></author><author><name sortKey="Rudin, C M" uniqKey="Rudin C">C.M. Rudin</name></author><author><name sortKey="Chang, A L" uniqKey="Chang A">A.L. Chang</name></author><author><name sortKey="Low, J A" uniqKey="Low J">J.A. Low</name></author><author><name sortKey="Mackey, H M" uniqKey="Mackey H">H.M. Mackey</name></author><author><name sortKey="Yauch, R L" uniqKey="Yauch R">R.L. Yauch</name></author><author><name sortKey="Graham, R A" uniqKey="Graham R">R.A. Graham</name></author><author><name sortKey="Reddy, J C" uniqKey="Reddy J">J.C. Reddy</name></author><author><name sortKey="Hauschild, A" uniqKey="Hauschild A">A. Hauschild</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Hoff, D" uniqKey="Von Hoff D">D. Von Hoff</name></author><author><name sortKey="Lorusso, P M" uniqKey="Lorusso P">P.M. LoRusso</name></author><author><name sortKey="Rudin, C M" uniqKey="Rudin C">C.M. Rudin</name></author><author><name sortKey="Reddy, J C" uniqKey="Reddy J">J.C. Reddy</name></author><author><name sortKey="Yauch, R L" uniqKey="Yauch R">R.L. Yauch</name></author><author><name sortKey="Tibes, R" uniqKey="Tibes R">R. Tibes</name></author><author><name sortKey="Weiss, G J" uniqKey="Weiss G">G.J. Weiss</name></author><author><name sortKey="Borad, M J" uniqKey="Borad M">M.J. Borad</name></author><author><name sortKey="Hann, C L" uniqKey="Hann C">C.L. Hann</name></author><author><name sortKey="Brahmer, J R" uniqKey="Brahmer J">J.R. Brahmer</name></author><author><name sortKey="Mackey, H M" uniqKey="Mackey H">H.M. Mackey</name></author><author><name sortKey="Lum, B L" uniqKey="Lum B">B.L. Lum</name></author><author><name sortKey="Darbonne, W C" uniqKey="Darbonne W">W.C. Darbonne</name></author><author><name sortKey="Marsters, J C" uniqKey="Marsters J">J.C. Marsters</name></author><author><name sortKey="De Sauvage, F J" uniqKey="De Sauvage F">F.J. de Sauvage</name></author><author><name sortKey="Low, J A" uniqKey="Low J">J.A. Low</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamagami, T" uniqKey="Yamagami T">T. Yamagami</name></author><author><name sortKey="Araki, S" uniqKey="Araki S">S. Araki</name></author><author><name sortKey="Aiko, Y" uniqKey="Aiko Y">Y. Aiko</name></author><author><name sortKey="Kato, T" uniqKey="Kato T">T. Kato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="National Cancer Registry Of Ireland" uniqKey="National Cancer Registry Of Ireland">National Cancer Registry of Ireland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nongrum, H B" uniqKey="Nongrum H">H.B. Nongrum</name></author><author><name sortKey="Bhuyan, D" uniqKey="Bhuyan D">D. Bhuyan</name></author><author><name sortKey="Royte, V" uniqKey="Royte V">V. Royte</name></author><author><name sortKey="Dkhar, H" uniqKey="Dkhar H">H. Dkhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kocak, C" uniqKey="Kocak C">C. Kocak</name></author><author><name sortKey="Metineren, M H" uniqKey="Metineren M">M.H. Metineren</name></author><author><name sortKey="Celik, H G" uniqKey="Celik H">H.G. Celik</name></author><author><name sortKey="Namdar, N D" uniqKey="Namdar N">N.D. Namdar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silverman, M K" uniqKey="Silverman M">M.K. Silverman</name></author><author><name sortKey="Kopf, A W" uniqKey="Kopf A">A.W. Kopf</name></author><author><name sortKey="Bart, R S" uniqKey="Bart R">R.S. Bart</name></author><author><name sortKey="Grin, C M" uniqKey="Grin C">C.M. Grin</name></author><author><name sortKey="Levenstein, M S" uniqKey="Levenstein M">M.S. Levenstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, G J" uniqKey="Weiss G">G.J. Weiss</name></author><author><name sortKey="Korn, R L" uniqKey="Korn R">R.L. Korn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, S H" uniqKey="Seo S">S.H. Seo</name></author><author><name sortKey="Shim, W H" uniqKey="Shim W">W.H. Shim</name></author><author><name sortKey="Shin, D H" uniqKey="Shin D">D.H. Shin</name></author><author><name sortKey="Kim, Y S" uniqKey="Kim Y">Y.S. Kim</name></author><author><name sortKey="Sung, H W" uniqKey="Sung H">H.W. Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vu, A" uniqKey="Vu A">A. Vu</name></author><author><name sortKey="Laub, D" uniqKey="Laub D">D. Laub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beadles, C F" uniqKey="Beadles C">C.F. Beadles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lattes, R" uniqKey="Lattes R">R. Lattes</name></author><author><name sortKey="Kessler, R W" uniqKey="Kessler R">R.W. Kessler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Migden, M R" uniqKey="Migden M">M.R. Migden</name></author><author><name sortKey="Guminski, A" uniqKey="Guminski A">A. Guminski</name></author><author><name sortKey="Gutzmer, R" uniqKey="Gutzmer R">R. Gutzmer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Gynecol Oncol Rep</journal-id><journal-id journal-id-type="iso-abbrev">Gynecol Oncol Rep</journal-id><journal-title-group><journal-title>Gynecologic Oncology Reports</journal-title></journal-title-group><issn pub-type="epub">2352-5789</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27830172</article-id><article-id pub-id-type="pmc">5094149</article-id><article-id pub-id-type="publisher-id">S2352-5789(16)30069-8</article-id><article-id pub-id-type="doi">10.1016/j.gore.2016.10.005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>An unusual case of basal cell carcinoma of the vulva with lung metastases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Watson</surname><given-names>GA</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>D</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Prior</surname><given-names>L</given-names></name><xref rid="af0005" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Stanley</surname><given-names>E</given-names></name><xref rid="af0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>MacEneaney</surname><given-names>O</given-names></name><xref rid="af0015" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Walsh</surname><given-names>T</given-names></name><xref rid="af0020" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Kelly</surname><given-names>CM</given-names></name><email>ckelly@mater.ie</email><xref rid="af0005" ref-type="aff">a</xref><xref rid="cr0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="af0005"><label>a</label>Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</aff><aff id="af0010"><label>b</label>Department of Radiology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</aff><aff id="af0015"><label>c</label>Department of Pathology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</aff><aff id="af0020"><label>d</label>Department of Gynaecology, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland</aff><author-notes><corresp id="cr0005"><label>⁎</label>Corresponding author at: Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.Mater Misericordiae University HospitalEccles St.Dublin 7Ireland <email>ckelly@mater.ie</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>25</day><month>10</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><month>11</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>25</day><month>10</month><year>2016</year></pub-date><volume>18</volume><fpage>32</fpage><lpage>35</lpage><history><date date-type="received"><day>1</day><month>8</month><year>2016</year></date><date date-type="rev-recd"><day>17</day><month>10</month><year>2016</year></date><date date-type="accepted"><day>23</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Authors</copyright-statement><copyright-year>2016</copyright-year><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).</license-p></license></permissions><abstract id="ab0005"><p>Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases.</p></abstract><abstract abstract-type="author-highlights" id="ab0010"><title>Highlights</title><p><list list-type="simple"><list-item id="u0005"><label>•</label><p>This case describes a rare case of basal cell carcinoma of the vulva.</p></list-item><list-item id="u0010"><label>•</label><p>In addition, metastatic spread to the lungs is another rare occurrence.</p></list-item><list-item id="u0015"><label>•</label><p>Multidisciplinary team discussion is paramount in guiding management.</p></list-item><list-item id="u0020"><label>•</label><p>Vismodegib is an exciting new treatment option for advanced disease.</p></list-item><list-item id="u0025"><label>•</label><p>Vigilant monitoring and/or early surgical excision of any suspicious skin lesions is paramount.</p></list-item></list></p></abstract><kwd-group id="ks0005"><title>Keywords</title><kwd>Basal cell carcinoma</kwd><kwd>Vulva</kwd><kwd>Lung metastasis</kwd><kwd>Hedgehog pathway</kwd><kwd>SMO inhibitors</kwd><kwd>Vismodegib</kwd></kwd-group></article-meta></front><floats-group><fig id="f0005"><label>Fig. 1</label><caption><p>(A) Axial contrast enhanced CT through the lower pelvis demonstrates a 2.5 cm distal right external iliac lymph node. (B) Axial CT image through the mid thorax on lung windows demonstrates multiple rounded nodules, imaging features consistent with pulmonary metastases.</p></caption><alt-text id="al0005">Fig. 1</alt-text><graphic xlink:href="gr1"></graphic></fig><fig id="f0010"><label>Fig. 2</label><caption><p>Right-sided groin lymph node core biopsy. Figure shows hematoxylin and eosin stain of tumour at 200 × (A) and immunohistochemistry for BerEP4 (B) CK5/6 (C) and p16 (D).</p></caption><alt-text id="al0010">Fig. 2</alt-text><graphic xlink:href="gr2"></graphic></fig><fig id="f0015"><label>Fig. 3</label><caption><p>Axial CT image through the mid thorax acquired five months later demonstrates a good response to treatment. Many lesions have disappeared while others have decreased in size.</p></caption><alt-text id="al0015">Fig. 3</alt-text><graphic xlink:href="gr3"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Irlande (pays)</li></country></list><tree><country name="Irlande (pays)"><noRegion><name sortKey="Watson, Ga" sort="Watson, Ga" uniqKey="Watson G" first="Ga" last="Watson">Ga Watson</name></noRegion><name sortKey="Kelly, Cm" sort="Kelly, Cm" uniqKey="Kelly C" first="Cm" last="Kelly">Cm Kelly</name><name sortKey="Kelly, D" sort="Kelly, D" uniqKey="Kelly D" first="D" last="Kelly">D. Kelly</name><name sortKey="Maceneaney, O" sort="Maceneaney, O" uniqKey="Maceneaney O" first="O" last="Maceneaney">O. Maceneaney</name><name sortKey="Prior, L" sort="Prior, L" uniqKey="Prior L" first="L" last="Prior">L. Prior</name><name sortKey="Stanley, E" sort="Stanley, E" uniqKey="Stanley E" first="E" last="Stanley">E. Stanley</name><name sortKey="Walsh, T" sort="Walsh, T" uniqKey="Walsh T" first="T" last="Walsh">T. Walsh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008993 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 008993 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5094149
|texte= An unusual case of basal cell carcinoma of the vulva with lung metastases
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27830172" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |