The role of radiotherapy in the management of localized soft tissue sarcomas
Identifieur interne : 008970 ( Ncbi/Merge ); précédent : 008969; suivant : 008971The role of radiotherapy in the management of localized soft tissue sarcomas
Auteurs : Siaw Sze Tiong [Canada] ; Colleen Dickie [Canada] ; Rick L. Haas [Pays-Bas] ; Brian O Ullivan [Canada]Source :
- Cancer Biology & Medicine [ 2095-3941 ] ; 2016.
Abstract
The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.
Url:
DOI: 10.20892/j.issn.2095-3941.2016.0028
PubMed: 27807504
PubMed Central: 5069839
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PMC:5069839Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Biol Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancer Biol Med</journal-id>
<journal-id journal-id-type="publisher-id">CBM</journal-id>
<journal-title-group><journal-title>Cancer Biology & Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">2095-3941</issn>
<publisher><publisher-name>Chinese Anti-Cancer Association</publisher-name>
<publisher-loc>Tianjing China</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27807504</article-id>
<article-id pub-id-type="pmc">5069839</article-id>
<article-id pub-id-type="publisher-id">CBM-2016-0028</article-id>
<article-id pub-id-type="doi">10.20892/j.issn.2095-3941.2016.0028</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>The role of radiotherapy in the management of localized soft tissue sarcomas</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tiong</surname>
<given-names>Siaw Sze</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dickie</surname>
<given-names>Colleen</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haas</surname>
<given-names>Rick L.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>O’Sullivan</surname>
<given-names>Brian</given-names>
</name>
<xref ref-type="corresp" rid="cor1"></xref>
<xref ref-type="aff" rid="aff1">1</xref>
<email>brian.osullivan@rmp.webmail.uhn.on.ca</email>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Department of Radiation Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto M5G 2M9, ON, Canada</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam 1066, CX, The Netherlands</addr-line>
</aff>
<author-notes><corresp id="cor1">Brian O’Sullivan E-mail:
<email>brian.osullivan@rmp.webmail.uhn.on.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2016</year>
</pub-date>
<volume>13</volume>
<issue>3</issue>
<fpage>373</fpage>
<lpage>383</lpage>
<history><date date-type="received"><day>12</day>
<month>2</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>16</day>
<month>7</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>Copyright 2016 Cancer Biology & Medicine</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/">http://creativecommons.org/licenses/by-nc-sa/4.0/</ext-link>
</license-p>
</license>
</permissions>
<abstract><p>The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases. Finally, technology advances through the use of intensity-modulated radiotherapy (IMRT), image-guided IMRT, intraoperative radiotherapy (IORT) and particle therapy will also be discussed.</p>
</abstract>
<kwd-group kwd-group-type="author-created"><kwd>Sarcoma</kwd>
<kwd>radiotherapy</kwd>
<kwd>retroperitoneal sarcoma</kwd>
<kwd>surgery</kwd>
<kwd>extremity sarcoma</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>Pays-Bas</li>
</country>
<region><li>Ontario</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Tiong, Siaw Sze" sort="Tiong, Siaw Sze" uniqKey="Tiong S" first="Siaw Sze" last="Tiong">Siaw Sze Tiong</name>
</region>
<name sortKey="Dickie, Colleen" sort="Dickie, Colleen" uniqKey="Dickie C" first="Colleen" last="Dickie">Colleen Dickie</name>
<name sortKey="O Ullivan, Brian" sort="O Ullivan, Brian" uniqKey="O Ullivan B" first="Brian" last="O Ullivan">Brian O Ullivan</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Haas, Rick L" sort="Haas, Rick L" uniqKey="Haas R" first="Rick L." last="Haas">Rick L. Haas</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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