Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study
Identifieur interne : 008929 ( Ncbi/Merge ); précédent : 008928; suivant : 008930Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study
Auteurs : Sindhu M. Ganvir ; Pratima G. Khobragade ; Swati A. Bamane ; Ramnivas Kumavat ; Amit DalmiaSource :
- Journal of Oral Biology and Craniofacial Research [ 2212-4268 ] ; 2016.
Abstract
The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth and to examine its role in progression and invasion of tumors.
Thirty paraffin embedded specimens AM (15 were non-aggressive ameloblastomas and 15 ameloblastoma showing aggressive behavior), 15 paraffin embedded specimens of AOT, 15 paraffin embedded specimens of CEOT, 15 paraffin embedded specimens of CCOT were obtained and were analyzed by immunohistochemistry using anti-human podoplanin. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, along with calculation of the percentage of positive odontogenic cells.
Podoplanin was expressed strongly at the invasive front (in the peripheral odontogenic epithelial cells) of most tumors and dental follicles. Membranous expression of podoplanin in ameloblastomas was stronger in cases of ameloblastomas showing aggressive behavior than (NA) non-aggressive ameloblastomas.
Expression of podoplanin at the invasive front (in peripheral cells) of odontogenic tumors considered to be associated with neoplastic odontogenic tissues. This molecule might play a role in progression and local invasion of odontogenic tumors. The migration and invasion mediated by podoplanin in odontogenic tumors could be related to cytoskeletal reorganization.
Url:
DOI: 10.1016/j.jobcr.2016.07.001
PubMed: 27761382
PubMed Central: 5065002
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002F78
- to stream Pmc, to step Curation: 002F77
- to stream Pmc, to step Checkpoint: 000618
Links to Exploration step
PMC:5065002Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study</title><author><name sortKey="Ganvir, Sindhu M" sort="Ganvir, Sindhu M" uniqKey="Ganvir S" first="Sindhu M." last="Ganvir">Sindhu M. Ganvir</name></author><author><name sortKey="Khobragade, Pratima G" sort="Khobragade, Pratima G" uniqKey="Khobragade P" first="Pratima G." last="Khobragade">Pratima G. Khobragade</name></author><author><name sortKey="Bamane, Swati A" sort="Bamane, Swati A" uniqKey="Bamane S" first="Swati A." last="Bamane">Swati A. Bamane</name></author><author><name sortKey="Kumavat, Ramnivas" sort="Kumavat, Ramnivas" uniqKey="Kumavat R" first="Ramnivas" last="Kumavat">Ramnivas Kumavat</name></author><author><name sortKey="Dalmia, Amit" sort="Dalmia, Amit" uniqKey="Dalmia A" first="Amit" last="Dalmia">Amit Dalmia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27761382</idno><idno type="pmc">5065002</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065002</idno><idno type="RBID">PMC:5065002</idno><idno type="doi">10.1016/j.jobcr.2016.07.001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002F78</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F78</idno><idno type="wicri:Area/Pmc/Curation">002F77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F77</idno><idno type="wicri:Area/Pmc/Checkpoint">000618</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000618</idno><idno type="wicri:Area/Ncbi/Merge">008929</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study</title><author><name sortKey="Ganvir, Sindhu M" sort="Ganvir, Sindhu M" uniqKey="Ganvir S" first="Sindhu M." last="Ganvir">Sindhu M. Ganvir</name></author><author><name sortKey="Khobragade, Pratima G" sort="Khobragade, Pratima G" uniqKey="Khobragade P" first="Pratima G." last="Khobragade">Pratima G. Khobragade</name></author><author><name sortKey="Bamane, Swati A" sort="Bamane, Swati A" uniqKey="Bamane S" first="Swati A." last="Bamane">Swati A. Bamane</name></author><author><name sortKey="Kumavat, Ramnivas" sort="Kumavat, Ramnivas" uniqKey="Kumavat R" first="Ramnivas" last="Kumavat">Ramnivas Kumavat</name></author><author><name sortKey="Dalmia, Amit" sort="Dalmia, Amit" uniqKey="Dalmia A" first="Amit" last="Dalmia">Amit Dalmia</name></author></analytic><series><title level="j">Journal of Oral Biology and Craniofacial Research</title><idno type="ISSN">2212-4268</idno><idno type="eISSN">2212-4276</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth and to examine its role in progression and invasion of tumors.</p></sec><sec><title>Method</title><p>Thirty paraffin embedded specimens AM (15 were non-aggressive ameloblastomas and 15 ameloblastoma showing aggressive behavior), 15 paraffin embedded specimens of AOT, 15 paraffin embedded specimens of CEOT, 15 paraffin embedded specimens of CCOT were obtained and were analyzed by immunohistochemistry using anti-human podoplanin. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, along with calculation of the percentage of positive odontogenic cells.</p></sec><sec><title>Results</title><p>Podoplanin was expressed strongly at the invasive front (in the peripheral odontogenic epithelial cells) of most tumors and dental follicles. Membranous expression of podoplanin in ameloblastomas was stronger in cases of ameloblastomas showing aggressive behavior than (NA) non-aggressive ameloblastomas.</p></sec><sec><title>Conclusion</title><p>Expression of podoplanin at the invasive front (in peripheral cells) of odontogenic tumors considered to be associated with neoplastic odontogenic tissues. This molecule might play a role in progression and local invasion of odontogenic tumors. The migration and invasion mediated by podoplanin in odontogenic tumors could be related to cytoskeletal reorganization.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Biol Craniofac Res</journal-id><journal-id journal-id-type="iso-abbrev">J Oral Biol Craniofac Res</journal-id><journal-title-group><journal-title>Journal of Oral Biology and Craniofacial Research</journal-title></journal-title-group><issn pub-type="ppub">2212-4268</issn><issn pub-type="epub">2212-4276</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27761382</article-id><article-id pub-id-type="pmc">5065002</article-id><article-id pub-id-type="publisher-id">S2212-4268(16)30062-8</article-id><article-id pub-id-type="doi">10.1016/j.jobcr.2016.07.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ganvir</surname><given-names>Sindhu M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Khobragade</surname><given-names>Pratima G.</given-names></name><email>pratimak237@gmail.com</email><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author"><name><surname>Bamane</surname><given-names>Swati A.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kumavat</surname><given-names>Ramnivas</given-names></name></contrib><contrib contrib-type="author"><name><surname>Dalmia</surname><given-names>Amit</given-names></name></contrib></contrib-group><aff id="aff0005">Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, India</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Near New Bus Stand, Behind Talathi Office, Vidyanagar, Bramhapuri, Chandrapur, Maharashtra 441206, India. Tel.: +91 09503833379.Department of Oral Pathology and Microbiology, Government Dental College and HospitalNear New Bus Stand, Behind Talathi Office, Vidyanagar, BramhapuriChandrapurMaharashtra441206India <email>pratimak237@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>14</day><month>7</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><season>Sep-Dec</season><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>7</month><year>2016</year></pub-date><volume>6</volume><issue>3</issue><fpage>187</fpage><lpage>193</lpage><history><date date-type="received"><day>25</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>5</day><month>7</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Craniofacial Research Foundation. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Craniofacial Research Foundation</copyright-holder></permissions><abstract id="abs0005"><sec><title>Background</title><p>The aim of this study was to investigate the podoplanin expression in epithelial odontogenic tumors both non-aggressive and aggressive, tumors with and without ectomesenchyme and remnants of the odontogenic epithelium from dental follicles (DF) of unerupted teeth and to examine its role in progression and invasion of tumors.</p></sec><sec><title>Method</title><p>Thirty paraffin embedded specimens AM (15 were non-aggressive ameloblastomas and 15 ameloblastoma showing aggressive behavior), 15 paraffin embedded specimens of AOT, 15 paraffin embedded specimens of CEOT, 15 paraffin embedded specimens of CCOT were obtained and were analyzed by immunohistochemistry using anti-human podoplanin. Podoplanin expression in odontogenic epithelial cells was evaluated using a scoring method, along with calculation of the percentage of positive odontogenic cells.</p></sec><sec><title>Results</title><p>Podoplanin was expressed strongly at the invasive front (in the peripheral odontogenic epithelial cells) of most tumors and dental follicles. Membranous expression of podoplanin in ameloblastomas was stronger in cases of ameloblastomas showing aggressive behavior than (NA) non-aggressive ameloblastomas.</p></sec><sec><title>Conclusion</title><p>Expression of podoplanin at the invasive front (in peripheral cells) of odontogenic tumors considered to be associated with neoplastic odontogenic tissues. This molecule might play a role in progression and local invasion of odontogenic tumors. The migration and invasion mediated by podoplanin in odontogenic tumors could be related to cytoskeletal reorganization.</p></sec></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Dental follicle (DF)</kwd><kwd>Adenomatoid odontogenic tumor (AOT)</kwd><kwd>Calcifying epithelial odontogenic tumor (CEOT)</kwd><kwd>Calcifying cystic odontogenic tumor (CCOT)</kwd><kwd>Ameloblastoma (AM)</kwd><kwd>Non-aggressive ameloblastoma (NA)</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bamane, Swati A" sort="Bamane, Swati A" uniqKey="Bamane S" first="Swati A." last="Bamane">Swati A. Bamane</name><name sortKey="Dalmia, Amit" sort="Dalmia, Amit" uniqKey="Dalmia A" first="Amit" last="Dalmia">Amit Dalmia</name><name sortKey="Ganvir, Sindhu M" sort="Ganvir, Sindhu M" uniqKey="Ganvir S" first="Sindhu M." last="Ganvir">Sindhu M. Ganvir</name><name sortKey="Khobragade, Pratima G" sort="Khobragade, Pratima G" uniqKey="Khobragade P" first="Pratima G." last="Khobragade">Pratima G. Khobragade</name><name sortKey="Kumavat, Ramnivas" sort="Kumavat, Ramnivas" uniqKey="Kumavat R" first="Ramnivas" last="Kumavat">Ramnivas Kumavat</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008929 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 008929 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5065002
|texte= Role of podoplanin expression in deciding the invasive potential of ameloblastoma – A retrospective IHC study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27761382" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |