Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study
Identifieur interne : 007271 ( Ncbi/Merge ); précédent : 007270; suivant : 007272Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study
Auteurs : Chuanming Li [République populaire de Chine] ; Shan Meng [République populaire de Chine] ; Xinhua Yang [République populaire de Chine] ; Daiquan Zhou [République populaire de Chine] ; Jian Wang [République populaire de Chine] ; Jiani Hu [États-Unis]Source :
- BMC Cancer [ 1471-2407 ] ; 2015.
Abstract
Sentinel lymph node (SLN) mapping is the standard method for axillary lymph node staging in patients with breast cancer. Blue dye and radioisotopes are commonly used agents to localize SLNs, but both have several disadvantages. The purpose of this study was to evaluate magnetic resonance lymphography with a gadolinium-based contrast agent (Gd-MRL) in sentinel lymph node identification and metastasis detection in patients with breast cancer.
Sixty patients (mean age: 46.2 ± 8.8 years) with stage T1- 2 breast cancer and clinically negative axillary lymph nodes participated in this study. After 0.9 ml of contrast material and 0.1 ml of mepivacaine hydrochloride 1% were mixed and injected intradermally into the upper-outer periareolar areas, axillary lymph flow was tracked and sentinel lymph nodes were identified by Gd-MRL. After SLN biopsy and/or surgery, the efficacy of SLN identification and metastasis detection of Gd-MRL were examined.
Ninety-six lymph nodes were identified by Gd-MRL as SLNs (M-SLN), and 135 lymph nodes were detected by blue dye-guided methods as SLNs (D-SLN). There was a strong correlation (P < 0.001) between the SLN numbers found by these two methods. Using blue dye-guided methods as the gold standard, the sensitivity of Gd-MRL was 95.65% and the false-negative rate was 4.3% for axillary lymphatic metastasis detection. With heterogeneous enhancement and enhancement defect as the diagnostic criteria, Gd-MRL gave a sensitivity of 89.29% and specificity of 89.66% in discriminating malignant from benign SLNs.
Gd-MRL offers a new method for SLN identification and metastasis detection in patients with breast cancer.
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DOI: 10.1186/s12885-015-1255-4
PubMed: 25886638
PubMed Central: 4391121
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Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Xinhua" sort="Yang, Xinhua" uniqKey="Yang X" first="Xinhua" last="Yang">Xinhua Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Daiquan" sort="Zhou, 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Chine</country><wicri:regionArea>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Shan" sort="Meng, Shan" uniqKey="Meng S" first="Shan" last="Meng">Shan Meng</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Xinhua" sort="Yang, Xinhua" uniqKey="Yang X" first="Xinhua" last="Yang">Xinhua Yang</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Daiquan" sort="Zhou, Daiquan" uniqKey="Zhou D" first="Daiquan" last="Zhou">Daiquan Zhou</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing</wicri:regionArea><wicri:noRegion>Chongqing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Jiani" sort="Hu, Jiani" uniqKey="Hu J" first="Jiani" last="Hu">Jiani Hu</name><affiliation wicri:level="2"><nlm:aff id="Aff3">Department of Radiology, Wayne State University, Detroit, MI 48331 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Radiology, Wayne State University, Detroit</wicri:cityArea></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Sentinel lymph node (SLN) mapping is the standard method for axillary lymph node staging in patients with breast cancer. Blue dye and radioisotopes are commonly used agents to localize SLNs, but both have several disadvantages. The purpose of this study was to evaluate magnetic resonance lymphography with a gadolinium-based contrast agent (Gd-MRL) in sentinel lymph node identification and metastasis detection in patients with breast cancer.</p></sec><sec><title>Methods</title><p>Sixty patients (mean age: 46.2 ± 8.8 years) with stage T1- 2 breast cancer and clinically negative axillary lymph nodes participated in this study. After 0.9 ml of contrast material and 0.1 ml of mepivacaine hydrochloride 1% were mixed and injected intradermally into the upper-outer periareolar areas, axillary lymph flow was tracked and sentinel lymph nodes were identified by Gd-MRL. After SLN biopsy and/or surgery, the efficacy of SLN identification and metastasis detection of Gd-MRL were examined.</p></sec><sec><title>Results</title><p>Ninety-six lymph nodes were identified by Gd-MRL as SLNs (M-SLN), and 135 lymph nodes were detected by blue dye-guided methods as SLNs (D-SLN). There was a strong correlation (P < 0.001) between the SLN numbers found by these two methods. Using blue dye-guided methods as the gold standard, the sensitivity of Gd-MRL was 95.65% and the false-negative rate was 4.3% for axillary lymphatic metastasis detection. With heterogeneous enhancement and enhancement defect as the diagnostic criteria, Gd-MRL gave a sensitivity of 89.29% and specificity of 89.66% in discriminating malignant from benign SLNs.</p></sec><sec><title>Conclusion</title><p>Gd-MRL offers a new method for SLN identification and metastasis detection in patients with breast cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wittekind, C" uniqKey="Wittekind C">C Wittekind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rashid, Om" uniqKey="Rashid O">OM Rashid</name></author><author><name sortKey="Takabe, K" uniqKey="Takabe K">K Takabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Gf" uniqKey="Schwartz G">GF Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matrai, Z" uniqKey="Matrai Z">Z Mátrai</name></author><author><name sortKey="Banhidy, F" uniqKey="Banhidy F">F Bánhidy</name></author><author><name sortKey="Teglas, M" uniqKey="Teglas M">M Téglás</name></author><author><name sortKey="Kovacs, E" uniqKey="Kovacs E">E Kovács</name></author><author><name sortKey="Savolt, A" uniqKey="Savolt A">A Sávolt</name></author><author><name sortKey="Udvarhelyi, N" uniqKey="Udvarhelyi N">N Udvarhelyi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Cb" uniqKey="Johnson C">CB Johnson</name></author><author><name sortKey="Boneti, C" uniqKey="Boneti C">C Boneti</name></author><author><name sortKey="Korourian, S" uniqKey="Korourian S">S Korourian</name></author><author><name sortKey="Adkins, L" uniqKey="Adkins L">L Adkins</name></author><author><name sortKey="Klimberg, Vs" uniqKey="Klimberg V">VS Klimberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borgstein, Pj" uniqKey="Borgstein P">PJ Borgstein</name></author><author><name sortKey="Meijer, S" uniqKey="Meijer S">S Meijer</name></author><author><name sortKey="Pijpers, R" uniqKey="Pijpers R">R Pijpers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakaria, S" uniqKey="Zakaria S">S Zakaria</name></author><author><name sortKey="Hoskin, Tl" uniqKey="Hoskin T">TL Hoskin</name></author><author><name sortKey="Degnim, Ac" uniqKey="Degnim A">AC Degnim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montgomery, Ll" uniqKey="Montgomery L">LL Montgomery</name></author><author><name sortKey="Thorne, Ac" uniqKey="Thorne A">AC Thorne</name></author><author><name sortKey="Van Zee, Kj" uniqKey="Van Zee K">KJ Van Zee</name></author><author><name sortKey="Fey, J" uniqKey="Fey J">J Fey</name></author><author><name sortKey="Heerdt, As" uniqKey="Heerdt A">AS Heerdt</name></author><author><name sortKey="Gemignani, M" uniqKey="Gemignani M">M Gemignani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimakakos, E" uniqKey="Dimakakos E">E Dimakakos</name></author><author><name sortKey="Koureas, A" uniqKey="Koureas A">A Koureas</name></author><author><name sortKey="Koutoulidis, V" uniqKey="Koutoulidis V">V Koutoulidis</name></author><author><name sortKey="Skiadas, V" uniqKey="Skiadas V">V Skiadas</name></author><author><name sortKey="Katsenis, K" uniqKey="Katsenis K">K Katsenis</name></author><author><name sortKey="Arkadopoulos, N" uniqKey="Arkadopoulos N">N Arkadopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loo, Bw" uniqKey="Loo B">BW Loo</name></author><author><name sortKey="Draney, Mt" uniqKey="Draney M">MT Draney</name></author><author><name sortKey="Sivanandan, R" uniqKey="Sivanandan R">R Sivanandan</name></author><author><name sortKey="Ruehm, Sg" uniqKey="Ruehm S">SG Ruehm</name></author><author><name sortKey="Pawlicki, T" uniqKey="Pawlicki T">T Pawlicki</name></author><author><name sortKey="Xing, L" uniqKey="Xing L">L Xing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruehm, Sg" uniqKey="Ruehm S">SG Ruehm</name></author><author><name sortKey="Corot, C" uniqKey="Corot C">C Corot</name></author><author><name sortKey="Debatin, Jf" uniqKey="Debatin J">JF Debatin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Nf" uniqKey="Liu N">NF Liu</name></author><author><name sortKey="Lu, Q" uniqKey="Lu Q">Q Lu</name></author><author><name sortKey="Jiang, Zh" uniqKey="Jiang Z">ZH Jiang</name></author><author><name sortKey="Wang, Cg" uniqKey="Wang C">CG Wang</name></author><author><name sortKey="Zhou, Jg" uniqKey="Zhou J">JG Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, P" uniqKey="Narayanan P">P Narayanan</name></author><author><name sortKey="Iyngkaran, T" uniqKey="Iyngkaran T">T Iyngkaran</name></author><author><name sortKey="Sohaib, Sa" uniqKey="Sohaib S">SA Sohaib</name></author><author><name sortKey="Reznek, Rh" uniqKey="Reznek R">RH Reznek</name></author><author><name sortKey="Rockall, Ag" uniqKey="Rockall A">AG Rockall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suga, K" uniqKey="Suga K">K Suga</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Ogasawara, N" uniqKey="Ogasawara N">N Ogasawara</name></author><author><name sortKey="Okada, M" uniqKey="Okada M">M Okada</name></author><author><name sortKey="Matsunaga, N" uniqKey="Matsunaga N">N Matsunaga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Q" uniqKey="Lu Q">Q Lu</name></author><author><name sortKey="Hua, J" uniqKey="Hua J">J Hua</name></author><author><name sortKey="Kassir, Mm" uniqKey="Kassir M">MM Kassir</name></author><author><name sortKey="Delproposto, Z" uniqKey="Delproposto Z">Z Delproposto</name></author><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y Dai</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Povoski, Sp" uniqKey="Povoski S">SP Povoski</name></author><author><name sortKey="Young, Dc" uniqKey="Young D">DC Young</name></author><author><name sortKey="Walker, Mj" uniqKey="Walker M">MJ Walker</name></author><author><name sortKey="Carson, We" uniqKey="Carson W">WE Carson</name></author><author><name sortKey="Yee, Ld" uniqKey="Yee L">LD Yee</name></author><author><name sortKey="Agnese, Dm" uniqKey="Agnese D">DM Agnese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henck, Me" uniqKey="Henck M">ME Henck</name></author><author><name sortKey="Simpson, El" uniqKey="Simpson E">EL Simpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tien, R" uniqKey="Tien R">R Tien</name></author><author><name sortKey="Newton, Th" uniqKey="Newton T">TH Newton</name></author><author><name sortKey="Dillon, Wp" uniqKey="Dillon W">WP Dillon</name></author><author><name sortKey="Mcdermott, Mw" uniqKey="Mcdermott M">MW McDermott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mansel, Re" uniqKey="Mansel R">RE Mansel</name></author><author><name sortKey="Fallowfield, L" uniqKey="Fallowfield L">L Fallowfield</name></author><author><name sortKey="Kissin, M" uniqKey="Kissin M">M Kissin</name></author><author><name sortKey="Goyal, A" uniqKey="Goyal A">A Goyal</name></author><author><name sortKey="Newcombe, Rg" uniqKey="Newcombe R">RG Newcombe</name></author><author><name sortKey="Dixon, Jm" uniqKey="Dixon J">JM Dixon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beenken, Sw" uniqKey="Beenken S">SW Beenken</name></author><author><name sortKey="Urist, Mm" uniqKey="Urist M">MM Urist</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Desmond, R" uniqKey="Desmond R">R Desmond</name></author><author><name sortKey="Krontiras, H" uniqKey="Krontiras H">H Krontiras</name></author><author><name sortKey="Medina, H" uniqKey="Medina H">H Medina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lale Atahan, I" uniqKey="Lale Atahan I">I Lale Atahan</name></author><author><name sortKey="Yildiz, F" uniqKey="Yildiz F">F Yildiz</name></author><author><name sortKey="Ozyigit, G" uniqKey="Ozyigit G">G Ozyigit</name></author><author><name sortKey="Sari, S" uniqKey="Sari S">S Sari</name></author><author><name sortKey="Gurkaynak, M" uniqKey="Gurkaynak M">M Gurkaynak</name></author><author><name sortKey="Selek, U" uniqKey="Selek U">U Selek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, T" uniqKey="Kang T">T Kang</name></author><author><name sortKey="Yi, M" uniqKey="Yi M">M Yi</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Mittendorf, Ea" uniqKey="Mittendorf E">EA Mittendorf</name></author><author><name sortKey="Babiera, Gv" uniqKey="Babiera G">GV Babiera</name></author><author><name sortKey="Kuerer, H" uniqKey="Kuerer H">H Kuerer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linehan, Dc" uniqKey="Linehan D">DC Linehan</name></author><author><name sortKey="Hill, Ad" uniqKey="Hill A">AD Hill</name></author><author><name sortKey="Akhurst, T" uniqKey="Akhurst T">T Akhurst</name></author><author><name sortKey="Yeung, H" uniqKey="Yeung H">H Yeung</name></author><author><name sortKey="Yeh, Sd" uniqKey="Yeh S">SD Yeh</name></author><author><name sortKey="Tran, Kn" uniqKey="Tran K">KN Tran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakaria, S" uniqKey="Zakaria S">S Zakaria</name></author><author><name sortKey="Degnim, Ac" uniqKey="Degnim A">AC Degnim</name></author><author><name sortKey="Kleer, Cg" uniqKey="Kleer C">CG Kleer</name></author><author><name sortKey="Diehl, Ka" uniqKey="Diehl K">KA Diehl</name></author><author><name sortKey="Cimmino, Vm" uniqKey="Cimmino V">VM Cimmino</name></author><author><name sortKey="Chang, Ae" uniqKey="Chang A">AE Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shiozawa, M" uniqKey="Shiozawa M">M Shiozawa</name></author><author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S Kobayashi</name></author><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y Sato</name></author><author><name sortKey="Maeshima, H" uniqKey="Maeshima H">H Maeshima</name></author><author><name sortKey="Hozumi, Y" uniqKey="Hozumi Y">Y Hozumi</name></author><author><name sortKey="Lefor, At" uniqKey="Lefor A">AT Lefor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tangoku, A" uniqKey="Tangoku A">A Tangoku</name></author><author><name sortKey="Yamamoto, S" uniqKey="Yamamoto S">S Yamamoto</name></author><author><name sortKey="Suga, K" uniqKey="Suga K">K Suga</name></author><author><name sortKey="Ueda, K" uniqKey="Ueda K">K Ueda</name></author><author><name sortKey="Nagashima, Y" uniqKey="Nagashima Y">Y Nagashima</name></author><author><name sortKey="Hida, M" uniqKey="Hida M">M Hida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, R" uniqKey="Nakamura R">R Nakamura</name></author><author><name sortKey="Nagashima, T" uniqKey="Nagashima T">T Nagashima</name></author><author><name sortKey="Sakakibara, M" uniqKey="Sakakibara M">M Sakakibara</name></author><author><name sortKey="Sangai, T" uniqKey="Sangai T">T Sangai</name></author><author><name sortKey="Fujimoto, H" uniqKey="Fujimoto H">H Fujimoto</name></author><author><name sortKey="Arai, M" uniqKey="Arai M">M Arai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kvistad, Ka" uniqKey="Kvistad K">KA Kvistad</name></author><author><name sortKey="Rydland, J" uniqKey="Rydland J">J Rydland</name></author><author><name sortKey="Smethurst, Hb" uniqKey="Smethurst H">HB Smethurst</name></author><author><name sortKey="Lundgren, S" uniqKey="Lundgren S">S Lundgren</name></author><author><name sortKey="Fj Sne, He" uniqKey="Fj Sne H">HE Fjøsne</name></author><author><name sortKey="Haraldseth, O" uniqKey="Haraldseth O">O Haraldseth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Ad" uniqKey="Murray A">AD Murray</name></author><author><name sortKey="Staff, Rt" uniqKey="Staff R">RT Staff</name></author><author><name sortKey="Redpath, Tw" uniqKey="Redpath T">TW Redpath</name></author><author><name sortKey="Gilbert, Fj" uniqKey="Gilbert F">FJ Gilbert</name></author><author><name sortKey="Ah See, Ak" uniqKey="Ah See A">AK Ah-See</name></author><author><name sortKey="Brookes, Ja" uniqKey="Brookes J">JA Brookes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortellaro, Ve" uniqKey="Mortellaro V">VE Mortellaro</name></author><author><name sortKey="Marshall, J" uniqKey="Marshall J">J Marshall</name></author><author><name sortKey="Singer, L" uniqKey="Singer L">L Singer</name></author><author><name sortKey="Hochwald, Sn" uniqKey="Hochwald S">SN Hochwald</name></author><author><name sortKey="Chang, M" uniqKey="Chang M">M Chang</name></author><author><name sortKey="Copeland, Em" uniqKey="Copeland E">EM Copeland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heusner, Ta" uniqKey="Heusner T">TA Heusner</name></author><author><name sortKey="Kuemmel, S" uniqKey="Kuemmel S">S Kuemmel</name></author><author><name sortKey="Koeninger, A" uniqKey="Koeninger A">A Koeninger</name></author><author><name sortKey="Hamami, Me" uniqKey="Hamami M">ME Hamami</name></author><author><name sortKey="Hahn, S" uniqKey="Hahn S">S Hahn</name></author><author><name sortKey="Quinsten, A" uniqKey="Quinsten A">A Quinsten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, N" uniqKey="He N">N He</name></author><author><name sortKey="Xie, C" uniqKey="Xie C">C Xie</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author><author><name sortKey="Pan, C" uniqKey="Pan C">C Pan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Lv, N" uniqKey="Lv N">N Lv</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, Nm" uniqKey="Hansen N">NM Hansen</name></author><author><name sortKey="Grube, B" uniqKey="Grube B">B Grube</name></author><author><name sortKey="Ye, X" uniqKey="Ye X">X Ye</name></author><author><name sortKey="Turner, Rr" uniqKey="Turner R">RR Turner</name></author><author><name sortKey="Brenner, Rj" uniqKey="Brenner R">RJ Brenner</name></author><author><name sortKey="Sim, Ms" uniqKey="Sim M">MS Sim</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Cancer</journal-id><journal-id journal-id-type="iso-abbrev">BMC Cancer</journal-id><journal-title-group><journal-title>BMC Cancer</journal-title></journal-title-group><issn pub-type="epub">1471-2407</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25886638</article-id><article-id pub-id-type="pmc">4391121</article-id><article-id pub-id-type="publisher-id">1255</article-id><article-id pub-id-type="doi">10.1186/s12885-015-1255-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Li</surname><given-names>Chuanming</given-names></name><address><email>li_chuanming@yeah.net</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Meng</surname><given-names>Shan</given-names></name><address><email>suzanmeng@163.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Xinhua</given-names></name><address><email>451173005@qq.com</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Daiquan</given-names></name><address><email>zhou_daiquan@sohu.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname><given-names>Jian</given-names></name><address><email>jhu@med.wayne.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Hu</surname><given-names>Jiani</given-names></name><address><email>wangjian_811@yahoo.com</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label>Department of Radiology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</aff><aff id="Aff2"><label>2</label>Department of Breast Surgery, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Road, Chongqing, 400038 China</aff><aff id="Aff3"><label>3</label>Department of Radiology, Wayne State University, Detroit, MI 48331 USA</aff></contrib-group><pub-date pub-type="epub"><day>2</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>2</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>15</volume><elocation-id>213</elocation-id><history><date date-type="received"><day>12</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>25</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>© Li et al.; licensee BioMed Central. 2015</copyright-statement><license license-type="open-access"><license-p>This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Sentinel lymph node (SLN) mapping is the standard method for axillary lymph node staging in patients with breast cancer. Blue dye and radioisotopes are commonly used agents to localize SLNs, but both have several disadvantages. The purpose of this study was to evaluate magnetic resonance lymphography with a gadolinium-based contrast agent (Gd-MRL) in sentinel lymph node identification and metastasis detection in patients with breast cancer.</p></sec><sec><title>Methods</title><p>Sixty patients (mean age: 46.2 ± 8.8 years) with stage T1- 2 breast cancer and clinically negative axillary lymph nodes participated in this study. After 0.9 ml of contrast material and 0.1 ml of mepivacaine hydrochloride 1% were mixed and injected intradermally into the upper-outer periareolar areas, axillary lymph flow was tracked and sentinel lymph nodes were identified by Gd-MRL. After SLN biopsy and/or surgery, the efficacy of SLN identification and metastasis detection of Gd-MRL were examined.</p></sec><sec><title>Results</title><p>Ninety-six lymph nodes were identified by Gd-MRL as SLNs (M-SLN), and 135 lymph nodes were detected by blue dye-guided methods as SLNs (D-SLN). There was a strong correlation (P < 0.001) between the SLN numbers found by these two methods. Using blue dye-guided methods as the gold standard, the sensitivity of Gd-MRL was 95.65% and the false-negative rate was 4.3% for axillary lymphatic metastasis detection. With heterogeneous enhancement and enhancement defect as the diagnostic criteria, Gd-MRL gave a sensitivity of 89.29% and specificity of 89.66% in discriminating malignant from benign SLNs.</p></sec><sec><title>Conclusion</title><p>Gd-MRL offers a new method for SLN identification and metastasis detection in patients with breast cancer.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Breast cancer</kwd><kwd>Lymph node</kwd><kwd>Metastasis</kwd><kwd>Magnetic resonance lymphangiography</kwd><kwd>Gadolinium</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Chuanming" sort="Li, Chuanming" uniqKey="Li C" first="Chuanming" last="Li">Chuanming Li</name></noRegion><name sortKey="Meng, Shan" sort="Meng, Shan" uniqKey="Meng S" first="Shan" last="Meng">Shan Meng</name><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name><name sortKey="Yang, Xinhua" sort="Yang, Xinhua" uniqKey="Yang X" first="Xinhua" last="Yang">Xinhua Yang</name><name sortKey="Zhou, Daiquan" sort="Zhou, Daiquan" uniqKey="Zhou D" first="Daiquan" last="Zhou">Daiquan Zhou</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Hu, Jiani" sort="Hu, Jiani" uniqKey="Hu J" first="Jiani" last="Hu">Jiani Hu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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