Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
Identifieur interne : 007176 ( Ncbi/Merge ); précédent : 007175; suivant : 007177Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
Auteurs : Brian G. Coon ; Nicolas Baeyens ; Jinah Han ; Madhusudhan Budatha ; Tyler D. Ross ; Jennifer S. Fang ; Sanguk Yun ; Jeon-Leon Thomas ; Martin A. SchwartzSource :
- The Journal of Cell Biology [ 0021-9525 ] ; 2015.
Abstract
VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.
Url:
DOI: 10.1083/jcb.201408103
PubMed: 25800053
PubMed Central: 4384728
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PMC:4384728Le document en format XML
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Coon</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Baeyens, Nicolas" sort="Baeyens, Nicolas" uniqKey="Baeyens N" first="Nicolas" last="Baeyens">Nicolas Baeyens</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Han, Jinah" sort="Han, Jinah" uniqKey="Han J" first="Jinah" last="Han">Jinah Han</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Budatha, Madhusudhan" sort="Budatha, Madhusudhan" uniqKey="Budatha M" first="Madhusudhan" last="Budatha">Madhusudhan Budatha</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Ross, Tyler D" sort="Ross, Tyler D" uniqKey="Ross T" first="Tyler D." last="Ross">Tyler D. 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Coon</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Baeyens, Nicolas" sort="Baeyens, Nicolas" uniqKey="Baeyens N" first="Nicolas" last="Baeyens">Nicolas Baeyens</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Han, Jinah" sort="Han, Jinah" uniqKey="Han J" first="Jinah" last="Han">Jinah Han</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Budatha, Madhusudhan" sort="Budatha, Madhusudhan" uniqKey="Budatha M" first="Madhusudhan" last="Budatha">Madhusudhan Budatha</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Ross, Tyler D" sort="Ross, Tyler D" uniqKey="Ross T" first="Tyler D." last="Ross">Tyler D. Ross</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Fang, Jennifer S" sort="Fang, Jennifer S" uniqKey="Fang J" first="Jennifer S." last="Fang">Jennifer S. Fang</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Yun, Sanguk" sort="Yun, Sanguk" uniqKey="Yun S" first="Sanguk" last="Yun">Sanguk Yun</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation></author><author><name sortKey="Thomas, Jeon Leon" sort="Thomas, Jeon Leon" uniqKey="Thomas J" first="Jeon-Leon" last="Thomas">Jeon-Leon Thomas</name><affiliation><nlm:aff id="aff2"><institution>Université Pierre and Marie Curie–Paris 6, 75005 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique U-1127/UMR-7225, 75654 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Assistance Publique–Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Department of Neurology, Yale University, New Haven, CT 06520</institution></nlm:aff></affiliation></author><author><name sortKey="Schwartz, Martin A" sort="Schwartz, Martin A" uniqKey="Schwartz M" first="Martin A." last="Schwartz">Martin A. Schwartz</name><affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Yale Cardiovascular Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff1"><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Department of Cell Biology</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff5"><institution>Department of Biomedical Engineering</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Cell Biology</title><idno type="ISSN">0021-9525</idno><idno type="eISSN">1540-8140</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Andersen, O S" uniqKey="Andersen O">O.S. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cell Biol</journal-id><journal-id journal-id-type="iso-abbrev">J. Cell Biol</journal-id><journal-id journal-id-type="hwp">jcb</journal-id><journal-id journal-id-type="publisher-id">jcb</journal-id><journal-title-group><journal-title>The Journal of Cell Biology</journal-title></journal-title-group><issn pub-type="ppub">0021-9525</issn><issn pub-type="epub">1540-8140</issn><publisher><publisher-name>The Rockefeller University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25800053</article-id><article-id pub-id-type="pmc">4384728</article-id><article-id pub-id-type="publisher-id">201408103</article-id><article-id pub-id-type="doi">10.1083/jcb.201408103</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject><subj-group><subject>Article</subject></subj-group></subj-group></article-categories><title-group><article-title>Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex</article-title><alt-title alt-title-type="short">The VE-cadherin–VEGFR mechanosensory complex</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coon</surname><given-names>Brian G.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Baeyens</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Jinah</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Budatha</surname><given-names>Madhusudhan</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Ross</surname><given-names>Tyler D.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Fang</surname><given-names>Jennifer S.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Yun</surname><given-names>Sanguk</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Jeon-Leon</given-names></name><xref ref-type="aff" rid="aff2">3</xref><xref ref-type="aff" rid="aff3">4</xref><xref ref-type="aff" rid="aff4">5</xref><xref ref-type="aff" rid="aff5">8</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Schwartz</surname><given-names>Martin A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="aff" rid="aff5">6</xref><xref ref-type="aff" rid="aff5">7</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Yale Cardiovascular Research Center</institution> and<label>2</label><institution>Department of Internal Medicine, Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510</institution></aff><aff id="aff2"><label>3</label><institution>Université Pierre and Marie Curie–Paris 6, 75005 Paris, France</institution></aff><aff id="aff3"><label>4</label><institution>Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique U-1127/UMR-7225, 75654 Paris, France</institution></aff><aff id="aff4"><label>5</label><institution>Assistance Publique–Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France</institution></aff><aff id="aff5"><label>6</label><institution>Department of Cell Biology</institution>,<label>7</label><institution>Department of Biomedical Engineering</institution>, and<label>8</label><institution>Department of Neurology, Yale University, New Haven, CT 06520</institution></aff><author-notes><corresp>Correspondence to Martin A. Schwartz: <email>Martin.Schwartz@yale.edu</email></corresp></author-notes><pub-date pub-type="ppub"><day>30</day><month>3</month><year>2015</year></pub-date><volume>208</volume><issue>7</issue><fpage>975</fpage><lpage>986</lpage><history><date date-type="received"><day>26</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Coon et al.</copyright-statement><copyright-year>2015</copyright-year><license license-type="openaccess"><license-p>This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see <ext-link ext-link-type="uri" xlink:href="http://www.rupress.org/terms">http://www.rupress.org/terms</ext-link>). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/">http://creativecommons.org/licenses/by-nc-sa/3.0/</ext-link>).</license-p></license></permissions><self-uri xlink:role="icon" xlink:href="JCB_201408103_thumb.gif"></self-uri><abstract abstract-type="precis"><p>VE-cadherin plays a critical role in endothelial shear stress mechanotransduction by interacting with VEGFRs through their transmembrane domains.</p></abstract><abstract><p>Endothelial responses to fluid shear stress are essential for vascular development and physiology, and determine the formation of atherosclerotic plaques at regions of disturbed flow. Previous work identified VE-cadherin as an essential component, along with PECAM-1 and VEGFR2, of a complex that mediates flow signaling. However, VE-cadherin’s precise role is poorly understood. We now show that the transmembrane domain of VE-cadherin mediates an essential adapter function by binding directly to the transmembrane domain of VEGFR2, as well as VEGFR3, which we now identify as another component of the junctional mechanosensory complex. VEGFR2 and VEGFR3 signal redundantly downstream of VE-cadherin. Furthermore, VEGFR3 expression is observed in the aortic endothelium, where it contributes to flow responses in vivo. In summary, this study identifies a novel adapter function for VE-cadherin mediated by transmembrane domain association with VEGFRs.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Baeyens, Nicolas" sort="Baeyens, Nicolas" uniqKey="Baeyens N" first="Nicolas" last="Baeyens">Nicolas Baeyens</name><name sortKey="Budatha, Madhusudhan" sort="Budatha, Madhusudhan" uniqKey="Budatha M" first="Madhusudhan" last="Budatha">Madhusudhan Budatha</name><name sortKey="Coon, Brian G" sort="Coon, Brian G" uniqKey="Coon B" first="Brian G." last="Coon">Brian G. Coon</name><name sortKey="Fang, Jennifer S" sort="Fang, Jennifer S" uniqKey="Fang J" first="Jennifer S." last="Fang">Jennifer S. Fang</name><name sortKey="Han, Jinah" sort="Han, Jinah" uniqKey="Han J" first="Jinah" last="Han">Jinah Han</name><name sortKey="Ross, Tyler D" sort="Ross, Tyler D" uniqKey="Ross T" first="Tyler D." last="Ross">Tyler D. Ross</name><name sortKey="Schwartz, Martin A" sort="Schwartz, Martin A" uniqKey="Schwartz M" first="Martin A." last="Schwartz">Martin A. Schwartz</name><name sortKey="Thomas, Jeon Leon" sort="Thomas, Jeon Leon" uniqKey="Thomas J" first="Jeon-Leon" last="Thomas">Jeon-Leon Thomas</name><name sortKey="Yun, Sanguk" sort="Yun, Sanguk" uniqKey="Yun S" first="Sanguk" last="Yun">Sanguk Yun</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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