Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema
Identifieur interne : 006E67 ( Ncbi/Merge ); précédent : 006E66; suivant : 006E68Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema
Auteurs : Jeremy S. Torrisi ; Walter J. Joseph ; Swapna Ghanta ; Daniel A. Cuzzone ; Nicholas J. Albano ; Ira L. Savetsky ; Jason C. Gardenier ; Roman Skoracki ; David Chang ; Babak J. MehraraSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Biopsie, Facteur de croissance transformant bêta-1 (métabolisme), Femelle, Fibrose, Greffe vasculaire (), Humains, Kératose (anatomopathologie), Kératose (métabolisme), Lymphangiogenèse, Lymphoedème (), Lymphoedème (diagnostic), Lymphoedème (étiologie), Membre supérieur (anatomopathologie), Peau (anatomopathologie), Tumeurs du sein (), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Kératose, Membre supérieur, Peau.
- diagnostic : Lymphoedème.
- métabolisme : Facteur de croissance transformant bêta-1, Kératose, Vaisseaux lymphatiques.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Biopsie, Femelle, Fibrose, Greffe vasculaire, Humains, Lymphangiogenèse, Lymphoedème, Tumeurs du sein.
English descriptors
- KwdEn :
- Adult, Biopsy, Breast Neoplasms (complications), Female, Fibrosis, Humans, Keratosis (metabolism), Keratosis (pathology), Lymphangiogenesis, Lymphatic Vessels (metabolism), Lymphedema (diagnosis), Lymphedema (etiology), Lymphedema (surgery), Middle Aged, Skin (pathology), Transforming Growth Factor beta1 (metabolism), Upper Extremity (pathology), Vascular Grafting (methods).
- MESH :
- chemical , metabolism : Transforming Growth Factor beta1.
- complications : Breast Neoplasms.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- metabolism : Keratosis, Lymphatic Vessels.
- methods : Vascular Grafting.
- pathology : Keratosis, Skin, Upper Extremity.
- surgery : Lymphedema.
- Adult, Biopsy, Female, Fibrosis, Humans, Lymphangiogenesis, Middle Aged.
Abstract
Url:
DOI: 10.1089/lrb.2014.0022
PubMed: 25521197
PubMed Central: 4365441
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003048
- to stream Pmc, to step Curation: 003047
- to stream Pmc, to step Checkpoint: 001104
- to stream PubMed, to step Corpus: 001129
- to stream PubMed, to step Curation: 001129
- to stream PubMed, to step Checkpoint: 001129
Links to Exploration step
PMC:4365441Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J." last="Joseph">Walter J. Joseph</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A." last="Cuzzone">Daniel A. Cuzzone</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J." last="Albano">Nicholas J. Albano</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25521197</idno>
<idno type="pmc">4365441</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365441</idno>
<idno type="RBID">PMC:4365441</idno>
<idno type="doi">10.1089/lrb.2014.0022</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003048</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003048</idno>
<idno type="wicri:Area/Pmc/Curation">003047</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003047</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001104</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001104</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001129</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001129</idno>
<idno type="wicri:Area/PubMed/Curation">001129</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001129</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001129</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001129</idno>
<idno type="wicri:Area/Ncbi/Merge">006E67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J." last="Joseph">Walter J. Joseph</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A." last="Cuzzone">Daniel A. Cuzzone</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J." last="Albano">Nicholas J. Albano</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Lymphatic Research and Biology</title>
<idno type="ISSN">1539-6851</idno>
<idno type="eISSN">1557-8585</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Biopsy</term>
<term>Breast Neoplasms (complications)</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Keratosis (metabolism)</term>
<term>Keratosis (pathology)</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphedema (diagnosis)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (surgery)</term>
<term>Middle Aged</term>
<term>Skin (pathology)</term>
<term>Transforming Growth Factor beta1 (metabolism)</term>
<term>Upper Extremity (pathology)</term>
<term>Vascular Grafting (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Facteur de croissance transformant bêta-1 (métabolisme)</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Greffe vasculaire ()</term>
<term>Humains</term>
<term>Kératose (anatomopathologie)</term>
<term>Kératose (métabolisme)</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème ()</term>
<term>Lymphoedème (diagnostic)</term>
<term>Lymphoedème (étiologie)</term>
<term>Membre supérieur (anatomopathologie)</term>
<term>Peau (anatomopathologie)</term>
<term>Tumeurs du sein ()</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Transforming Growth Factor beta1</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Kératose</term>
<term>Membre supérieur</term>
<term>Peau</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Keratosis</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vascular Grafting</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance transformant bêta-1</term>
<term>Kératose</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Keratosis</term>
<term>Skin</term>
<term>Upper Extremity</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Biopsy</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Greffe vasculaire</term>
<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème</term>
<term>Tumeurs du sein</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Introduction:</italic>
</bold>
Recent advances in microsurgery such as lymphaticovenous bypass (LVB) have been shown to decrease limb volumes and improve subjective symptoms in patients with lymphedema. However, to date, it remains unknown if these procedures can reverse the pathological tissue changes associated with lymphedema. Therefore, the purpose of this study was to analyze skin tissue changes in patients before and after LVB.</p>
<p><bold><italic>Methods and Results:</italic>
</bold>
Matched skin biopsy samples were collected from normal and lymphedematous limbs of 6 patients with unilateral breast cancer-related upper extremity lymphedema before and 6 months after LVB. Biopsy specimens were fixed and analyzed for inflammation, fibrosis, hyperkeratosis, and lymphangiogenesis. Six months following LVB, 83% of patients had symptomatic improvement in their lymphedema. Histological analysis at this time demonstrated a significant decrease in tissue CD4<sup>+</sup>
cell inflammation in lymphedematous limb (but not normal limb) biopsies (<italic>p</italic>
<0.01). These changes were associated with significantly decreased tissue fibrosis as demonstrated by decreased collagen type I deposition and TGF-β1 expression (all <italic>p</italic>
<0.01). In addition, we found a significant decrease in epidermal thickness, decreased numbers of proliferating basal keratinocytes, and decreased number of LYVE-1<sup>+</sup>
lymphatic vessels in lymphedematous limbs after LVB.</p>
<p><bold><italic>Conclusions:</italic>
</bold>
We have shown, for the first time, that microsurgical LVB not only improves symptomatology of lymphedema but also helps to improve pathologic changes in the skin. These findings suggest that the some of the pathologic changes of lymphedema are reversible and may be related to lymphatic fluid stasis.</p>
</div>
</front>
</TEI>
<double pmid="25521197"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J." last="Joseph">Walter J. Joseph</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A." last="Cuzzone">Daniel A. Cuzzone</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J." last="Albano">Nicholas J. Albano</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25521197</idno>
<idno type="pmc">4365441</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365441</idno>
<idno type="RBID">PMC:4365441</idno>
<idno type="doi">10.1089/lrb.2014.0022</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003048</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003048</idno>
<idno type="wicri:Area/Pmc/Curation">003047</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003047</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001104</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001104</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J." last="Joseph">Walter J. Joseph</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A." last="Cuzzone">Daniel A. Cuzzone</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J." last="Albano">Nicholas J. Albano</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
<affiliation><nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
<affiliation><nlm:aff id="aff3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Lymphatic Research and Biology</title>
<idno type="ISSN">1539-6851</idno>
<idno type="eISSN">1557-8585</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Introduction:</italic>
</bold>
Recent advances in microsurgery such as lymphaticovenous bypass (LVB) have been shown to decrease limb volumes and improve subjective symptoms in patients with lymphedema. However, to date, it remains unknown if these procedures can reverse the pathological tissue changes associated with lymphedema. Therefore, the purpose of this study was to analyze skin tissue changes in patients before and after LVB.</p>
<p><bold><italic>Methods and Results:</italic>
</bold>
Matched skin biopsy samples were collected from normal and lymphedematous limbs of 6 patients with unilateral breast cancer-related upper extremity lymphedema before and 6 months after LVB. Biopsy specimens were fixed and analyzed for inflammation, fibrosis, hyperkeratosis, and lymphangiogenesis. Six months following LVB, 83% of patients had symptomatic improvement in their lymphedema. Histological analysis at this time demonstrated a significant decrease in tissue CD4<sup>+</sup>
cell inflammation in lymphedematous limb (but not normal limb) biopsies (<italic>p</italic>
<0.01). These changes were associated with significantly decreased tissue fibrosis as demonstrated by decreased collagen type I deposition and TGF-β1 expression (all <italic>p</italic>
<0.01). In addition, we found a significant decrease in epidermal thickness, decreased numbers of proliferating basal keratinocytes, and decreased number of LYVE-1<sup>+</sup>
lymphatic vessels in lymphedematous limbs after LVB.</p>
<p><bold><italic>Conclusions:</italic>
</bold>
We have shown, for the first time, that microsurgical LVB not only improves symptomatology of lymphedema but also helps to improve pathologic changes in the skin. These findings suggest that the some of the pathologic changes of lymphedema are reversible and may be related to lymphatic fluid stasis.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphaticovenous bypass decreases pathologic skin changes in upper extremity breast cancer-related lymphedema.</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S" last="Torrisi">Jeremy S. Torrisi</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center , New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>1 Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center , New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J" last="Joseph">Walter J. Joseph</name>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A" last="Cuzzone">Daniel A. Cuzzone</name>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J" last="Albano">Nicholas J. Albano</name>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L" last="Savetsky">Ira L. Savetsky</name>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C" last="Gardenier">Jason C. Gardenier</name>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25521197</idno>
<idno type="pmid">25521197</idno>
<idno type="doi">10.1089/lrb.2014.0022</idno>
<idno type="wicri:Area/PubMed/Corpus">001129</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001129</idno>
<idno type="wicri:Area/PubMed/Curation">001129</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001129</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001129</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001129</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphaticovenous bypass decreases pathologic skin changes in upper extremity breast cancer-related lymphedema.</title>
<author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S" last="Torrisi">Jeremy S. Torrisi</name>
<affiliation wicri:level="2"><nlm:affiliation>1 Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center , New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>1 Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan-Kettering Cancer Center , New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Joseph, Walter J" sort="Joseph, Walter J" uniqKey="Joseph W" first="Walter J" last="Joseph">Walter J. Joseph</name>
</author>
<author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name>
</author>
<author><name sortKey="Cuzzone, Daniel A" sort="Cuzzone, Daniel A" uniqKey="Cuzzone D" first="Daniel A" last="Cuzzone">Daniel A. Cuzzone</name>
</author>
<author><name sortKey="Albano, Nicholas J" sort="Albano, Nicholas J" uniqKey="Albano N" first="Nicholas J" last="Albano">Nicholas J. Albano</name>
</author>
<author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L" last="Savetsky">Ira L. Savetsky</name>
</author>
<author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C" last="Gardenier">Jason C. Gardenier</name>
</author>
<author><name sortKey="Skoracki, Roman" sort="Skoracki, Roman" uniqKey="Skoracki R" first="Roman" last="Skoracki">Roman Skoracki</name>
</author>
<author><name sortKey="Chang, David" sort="Chang, David" uniqKey="Chang D" first="David" last="Chang">David Chang</name>
</author>
<author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J" last="Mehrara">Babak J. Mehrara</name>
</author>
</analytic>
<series><title level="j">Lymphatic research and biology</title>
<idno type="eISSN">1557-8585</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Biopsy</term>
<term>Breast Neoplasms (complications)</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Keratosis (metabolism)</term>
<term>Keratosis (pathology)</term>
<term>Lymphangiogenesis</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphedema (diagnosis)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphedema (surgery)</term>
<term>Middle Aged</term>
<term>Skin (pathology)</term>
<term>Transforming Growth Factor beta1 (metabolism)</term>
<term>Upper Extremity (pathology)</term>
<term>Vascular Grafting (methods)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Facteur de croissance transformant bêta-1 (métabolisme)</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Greffe vasculaire ()</term>
<term>Humains</term>
<term>Kératose (anatomopathologie)</term>
<term>Kératose (métabolisme)</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème ()</term>
<term>Lymphoedème (diagnostic)</term>
<term>Lymphoedème (étiologie)</term>
<term>Membre supérieur (anatomopathologie)</term>
<term>Peau (anatomopathologie)</term>
<term>Tumeurs du sein ()</term>
<term>Vaisseaux lymphatiques (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Transforming Growth Factor beta1</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Kératose</term>
<term>Membre supérieur</term>
<term>Peau</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Keratosis</term>
<term>Lymphatic Vessels</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vascular Grafting</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance transformant bêta-1</term>
<term>Kératose</term>
<term>Vaisseaux lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Keratosis</term>
<term>Skin</term>
<term>Upper Extremity</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Biopsy</term>
<term>Female</term>
<term>Fibrosis</term>
<term>Humans</term>
<term>Lymphangiogenesis</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Femelle</term>
<term>Fibrose</term>
<term>Greffe vasculaire</term>
<term>Humains</term>
<term>Lymphangiogenèse</term>
<term>Lymphoedème</term>
<term>Tumeurs du sein</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent advances in microsurgery such as lymphaticovenous bypass (LVB) have been shown to decrease limb volumes and improve subjective symptoms in patients with lymphedema. However, to date, it remains unknown if these procedures can reverse the pathological tissue changes associated with lymphedema. Therefore, the purpose of this study was to analyze skin tissue changes in patients before and after LVB.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006E67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 006E67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:4365441 |texte= Lymphaticovenous Bypass Decreases Pathologic Skin Changes in Upper Extremity Breast Cancer-Related Lymphedema }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:25521197" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |