LymphedemaV1, Ncbi, Merge, bibRecord, 006A56

Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1–2 tumor and 1–3 axillary lymph node(s) metastasis

Identifieur interne : 006A56 ( Ncbi/Merge ); précédent : 006A55; suivant : 006A57

Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1–2 tumor and 1–3 axillary lymph node(s) metastasis

Auteurs : Yu-Li Su [Taïwan] ; Shan-Hsuan Li [Taïwan] ; Yen-Yang Chen [Taïwan] ; Hui-Chun Chen [Taïwan] ; Yen Tang [Taïwan] ; Cheng-Hua Huang [Taïwan] ; Fong-Fu Chou [Taïwan] ; Shih-Chung Wu [Taïwan] ; Kun-Ming Rau [Taïwan]

Source :

Radiology and Oncology [ 1318-2099 ] ; 2014.

RBID : PMC:4110089

Abstract

Background

To determine the role of postmastectomy radiotherapy (PMRT) in breast cancer patients with T1–2 and N1 disease.

Patients and methods.

A total of 207 postmastectomy women were enrolled. The 5-year Kaplan-Meier estimates of locoregional recurrence rate (LRR), distant recurrence rate (DRR) and overall survival (OS) were analyzed by different tumor characteristics. Multivariate analyses were performed using Cox proportional hazards modeling.

Results

With median follow-up 59.5 months, the 5-year LRR, DRR and OS were 9.1%, 20.3% and 84.4%, respectively. On univariate analysis, age < 40 years old (p = 0.003) and Her-2/neu over-expression (p = 0.016) were associated with higher LRR, whereas presence of LVI significantly predicted higher DRR (p = 0.026). Negative estrogen status (p = 0.033), Her-2/neu overexpression (p = 0.001) and LVI (p = 0.01) were significantly correlated with worse OS. PMRT didn’t prove to reduce 5-year LRR (p = 0.107), as well as 5-year OS (p = 0.918). In subgroup analysis, PMRT showed significant benefits of improvement LRR and OS in patients with positive LVI.

Conclusions

For patients with T1–2 and N1 stage breast cancer, PMRT can decrease locoregional recurrence and increase overall survival only in patients with lymphovascular invasion.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110089

DOI: 10.2478/raon-2013-0085
PubMed: 25177247
PubMed Central: 4110089

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PMC:4110089

Le document en format XML

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<author><name sortKey="Chou, Fong Fu" sort="Chou, Fong Fu" uniqKey="Chou F" first="Fong-Fu" last="Chou">Fong-Fu Chou</name>
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<affiliation wicri:level="1"><nlm:aff id="af1-rado-48-03-314"> Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</nlm:aff>
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<wicri:regionArea> Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung</wicri:regionArea>
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<author><name sortKey="Chen, Yen Yang" sort="Chen, Yen Yang" uniqKey="Chen Y" first="Yen-Yang" last="Chen">Yen-Yang Chen</name>
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<author><name sortKey="Chen, Hui Chun" sort="Chen, Hui Chun" uniqKey="Chen H" first="Hui-Chun" last="Chen">Hui-Chun Chen</name>
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<country xml:lang="fr">Taïwan</country>
<wicri:regionArea> Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung</wicri:regionArea>
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<author><name sortKey="Tang, Yen" sort="Tang, Yen" uniqKey="Tang Y" first="Yen" last="Tang">Yen Tang</name>
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<author><name sortKey="Huang, Cheng Hua" sort="Huang, Cheng Hua" uniqKey="Huang C" first="Cheng-Hua" last="Huang">Cheng-Hua Huang</name>
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<author><name sortKey="Chou, Fong Fu" sort="Chou, Fong Fu" uniqKey="Chou F" first="Fong-Fu" last="Chou">Fong-Fu Chou</name>
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<country xml:lang="fr">Taïwan</country>
<wicri:regionArea> Chang Gung University, College of Medicine, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="af5-rado-48-03-314"> Department of General Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</nlm:aff>
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<author><name sortKey="Wu, Shih Chung" sort="Wu, Shih Chung" uniqKey="Wu S" first="Shih-Chung" last="Wu">Shih-Chung Wu</name>
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<country xml:lang="fr">Taïwan</country>
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<author><name sortKey="Rau, Kun Ming" sort="Rau, Kun Ming" uniqKey="Rau K" first="Kun-Ming" last="Rau">Kun-Ming Rau</name>
<affiliation wicri:level="1"><nlm:aff id="af1-rado-48-03-314"> Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea> Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="af2-rado-48-03-314"> Chang Gung University, College of Medicine, Taoyuan, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea> Chang Gung University, College of Medicine, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6-rado-48-03-314"> Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea> Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung</wicri:regionArea>
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<idno type="ISSN">1318-2099</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>To determine the role of postmastectomy radiotherapy (PMRT) in breast cancer patients with T1–2 and N1 disease.</p>
</sec>
<sec><title>Patients and methods.</title>
<p>A total of 207 postmastectomy women were enrolled. The 5-year Kaplan-Meier estimates of locoregional recurrence rate (LRR), distant recurrence rate (DRR) and overall survival (OS) were analyzed by different tumor characteristics. Multivariate analyses were performed using Cox proportional hazards modeling.</p>
</sec>
<sec><title>Results</title>
<p>With median follow-up 59.5 months, the 5-year LRR, DRR and OS were 9.1%, 20.3% and 84.4%, respectively. On univariate analysis, age < 40 years old (p = 0.003) and Her-2/neu over-expression (p = 0.016) were associated with higher LRR, whereas presence of LVI significantly predicted higher DRR (p = 0.026). Negative estrogen status (p = 0.033), Her-2/neu overexpression (p = 0.001) and LVI (p = 0.01) were significantly correlated with worse OS. PMRT didn’t prove to reduce 5-year LRR (p = 0.107), as well as 5-year OS (p = 0.918). In subgroup analysis, PMRT showed significant benefits of improvement LRR and OS in patients with positive LVI.</p>
</sec>
<sec><title>Conclusions</title>
<p>For patients with T1–2 and N1 stage breast cancer, PMRT can decrease locoregional recurrence and increase overall survival only in patients with lymphovascular invasion.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Radiol Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Radiol Oncol</journal-id>
<journal-id journal-id-type="publisher-id">RADO</journal-id>
<journal-title-group><journal-title>Radiology and Oncology</journal-title>
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<issn pub-type="ppub">1318-2099</issn>
<issn pub-type="epub">1581-3207</issn>
<publisher><publisher-name>Versita, Warsaw</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25177247</article-id>
<article-id pub-id-type="pmc">4110089</article-id>
<article-id pub-id-type="doi">10.2478/raon-2013-0085</article-id>
<article-id pub-id-type="publisher-id">rado-48-03-314</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1–2 tumor and 1–3 axillary lymph node(s) metastasis</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Su</surname>
<given-names>Yu-Li</given-names>
</name>
<xref ref-type="aff" rid="af1-rado-48-03-314"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Shan-Hsuan</given-names>
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<xref ref-type="aff" rid="af1-rado-48-03-314"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="af2-rado-48-03-314"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Yen-Yang</given-names>
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<xref ref-type="aff" rid="af1-rado-48-03-314"><sup>1</sup>
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</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Hui-Chun</given-names>
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<xref ref-type="aff" rid="af3-rado-48-03-314"><sup>3</sup>
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</contrib>
<contrib contrib-type="author"><name><surname>Tang</surname>
<given-names>Yen</given-names>
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<xref ref-type="aff" rid="af4-rado-48-03-314"><sup>4</sup>
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<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Cheng-Hua</given-names>
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<xref ref-type="aff" rid="af1-rado-48-03-314"><sup>1</sup>
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</contrib>
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<given-names>Fong-Fu</given-names>
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<xref ref-type="aff" rid="af2-rado-48-03-314"><sup>2</sup>
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<xref ref-type="aff" rid="af5-rado-48-03-314"><sup>5</sup>
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<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Shih-Chung</given-names>
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<xref ref-type="aff" rid="af5-rado-48-03-314"><sup>5</sup>
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<given-names>Kun-Ming</given-names>
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<xref ref-type="aff" rid="af1-rado-48-03-314"><sup>1</sup>
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<xref ref-type="aff" rid="af2-rado-48-03-314"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="af6-rado-48-03-314"><sup>6</sup>
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<xref rid="c1-rado-48-03-314" ref-type="corresp"></xref>
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</contrib-group>
<aff id="af1-rado-48-03-314"><label>1</label>
 Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</aff>
<aff id="af2-rado-48-03-314"><label>2</label>
 Chang Gung University, College of Medicine, Taoyuan, Taiwan</aff>
<aff id="af3-rado-48-03-314"><label>3</label>
 Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</aff>
<aff id="af4-rado-48-03-314"><label>4</label>
 Division of Hematology-Oncology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan</aff>
<aff id="af5-rado-48-03-314"><label>5</label>
 Department of General Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</aff>
<aff id="af6-rado-48-03-314"><label>6</label>
 Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan</aff>
<author-notes><corresp id="c1-rado-48-03-314">Correspondence to: Kun-Ming Rau, M.D., Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taiwan, No.123, Dapi Rd., Niaosong Dist., Kaohsiung City 833, Taiwan (R.O.C.). Phone: +886-7-7317123 ext. 8303; Fax: +886-7-7322402; E-mail: <email>kmrau58@adm.cgmh.org.tw</email>
</corresp>
<fn id="fn1-rado-48-03-314"><p>Disclosure: No potential conflicts of interest were disclosed.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>7</month>
<year>2014</year>
</pub-date>
<volume>48</volume>
<issue>3</issue>
<fpage>314</fpage>
<lpage>322</lpage>
<history><date date-type="received"><day>26</day>
<month>7</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>20</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © by Association of Radiology & Oncology</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>To determine the role of postmastectomy radiotherapy (PMRT) in breast cancer patients with T1–2 and N1 disease.</p>
</sec>
<sec><title>Patients and methods.</title>
<p>A total of 207 postmastectomy women were enrolled. The 5-year Kaplan-Meier estimates of locoregional recurrence rate (LRR), distant recurrence rate (DRR) and overall survival (OS) were analyzed by different tumor characteristics. Multivariate analyses were performed using Cox proportional hazards modeling.</p>
</sec>
<sec><title>Results</title>
<p>With median follow-up 59.5 months, the 5-year LRR, DRR and OS were 9.1%, 20.3% and 84.4%, respectively. On univariate analysis, age < 40 years old (p = 0.003) and Her-2/neu over-expression (p = 0.016) were associated with higher LRR, whereas presence of LVI significantly predicted higher DRR (p = 0.026). Negative estrogen status (p = 0.033), Her-2/neu overexpression (p = 0.001) and LVI (p = 0.01) were significantly correlated with worse OS. PMRT didn’t prove to reduce 5-year LRR (p = 0.107), as well as 5-year OS (p = 0.918). In subgroup analysis, PMRT showed significant benefits of improvement LRR and OS in patients with positive LVI.</p>
</sec>
<sec><title>Conclusions</title>
<p>For patients with T1–2 and N1 stage breast cancer, PMRT can decrease locoregional recurrence and increase overall survival only in patients with lymphovascular invasion.</p>
</sec>
</abstract>
<kwd-group><kwd>breast cancer</kwd>
<kwd>postmastectomy radiotherapy</kwd>
<kwd>overall survival</kwd>
<kwd>locoregional recurrence</kwd>
<kwd>lymphovascular invasion</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><table-wrap id="t1-rado-48-03-314" position="float"><label>TABLE 1.</label>
<caption><p>Clinicopathologic characteristics of patient, tumor and treatment</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" rowspan="1" colspan="1"><bold>Characteristics</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>Radiotherapy</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>No Radiotherapy</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>p value</bold>
</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">No. of patients</td>
<td align="center" valign="top" rowspan="1" colspan="1">81</td>
<td align="center" valign="top" rowspan="1" colspan="1">126</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Age</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Median (years)</td>
<td align="center" valign="top" rowspan="1" colspan="1">50.75</td>
<td align="center" valign="top" rowspan="1" colspan="1">50.43</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.83</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  < 40</td>
<td align="center" valign="top" rowspan="1" colspan="1">9</td>
<td align="center" valign="top" rowspan="1" colspan="1">20</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  ≥ 40</td>
<td align="center" valign="top" rowspan="1" colspan="1">72</td>
<td align="center" valign="top" rowspan="1" colspan="1">106</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Histology</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Invasive ductal carcinoma</td>
<td align="center" valign="top" rowspan="1" colspan="1">71</td>
<td align="center" valign="top" rowspan="1" colspan="1">112</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.83</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Others</td>
<td align="center" valign="top" rowspan="1" colspan="1">10</td>
<td align="center" valign="top" rowspan="1" colspan="1">14</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Tumor size (T)</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  T1</td>
<td align="center" valign="top" rowspan="1" colspan="1">26</td>
<td align="center" valign="top" rowspan="1" colspan="1">48</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.46</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  T2</td>
<td align="center" valign="top" rowspan="1" colspan="1">55</td>
<td align="center" valign="top" rowspan="1" colspan="1">78</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">No. of positive lymph nodes</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  1</td>
<td align="center" valign="top" rowspan="1" colspan="1">41</td>
<td align="center" valign="top" rowspan="1" colspan="1">56</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.46</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  2</td>
<td align="center" valign="top" rowspan="1" colspan="1">21</td>
<td align="center" valign="top" rowspan="1" colspan="1">43</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  3</td>
<td align="center" valign="top" rowspan="1" colspan="1">19</td>
<td align="center" valign="top" rowspan="1" colspan="1">27</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Percentage of positive lymph nodes</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  < 25%</td>
<td align="center" valign="top" rowspan="1" colspan="1">65</td>
<td align="center" valign="top" rowspan="1" colspan="1">112</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.11</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  ≥ 25%</td>
<td align="center" valign="top" rowspan="1" colspan="1">16</td>
<td align="center" valign="top" rowspan="1" colspan="1">14</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Estrogen receptor status</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Positive</td>
<td align="center" valign="top" rowspan="1" colspan="1">55</td>
<td align="center" valign="top" rowspan="1" colspan="1">82</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.65</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Negative</td>
<td align="center" valign="top" rowspan="1" colspan="1">25</td>
<td align="center" valign="top" rowspan="1" colspan="1">43</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="center" valign="top" rowspan="1" colspan="1">1</td>
<td align="center" valign="top" rowspan="1" colspan="1">1</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Her-2/neu status</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Over-expressed</td>
<td align="center" valign="top" rowspan="1" colspan="1">19</td>
<td align="center" valign="top" rowspan="1" colspan="1">24</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.72</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Not over-expressed</td>
<td align="center" valign="top" rowspan="1" colspan="1">56</td>
<td align="center" valign="top" rowspan="1" colspan="1">84</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="center" valign="top" rowspan="1" colspan="1">6</td>
<td align="center" valign="top" rowspan="1" colspan="1">18</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Lymphovascular invasion</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Presence</td>
<td align="center" valign="top" rowspan="1" colspan="1">46</td>
<td align="center" valign="top" rowspan="1" colspan="1">59</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.41</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Absence</td>
<td align="center" valign="top" rowspan="1" colspan="1">21</td>
<td align="center" valign="top" rowspan="1" colspan="1">36</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="center" valign="top" rowspan="1" colspan="1">14</td>
<td align="center" valign="top" rowspan="1" colspan="1">31</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Adjuvant chemotherapy</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Yes</td>
<td align="center" valign="top" rowspan="1" colspan="1">76</td>
<td align="center" valign="top" rowspan="1" colspan="1">112</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.33</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  No</td>
<td align="center" valign="top" rowspan="1" colspan="1">5</td>
<td align="center" valign="top" rowspan="1" colspan="1">14</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Adjuvant hormone therapy</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Yes</td>
<td align="center" valign="top" rowspan="1" colspan="1">56</td>
<td align="center" valign="top" rowspan="1" colspan="1">90</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.91</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  No</td>
<td align="center" valign="top" rowspan="1" colspan="1">24</td>
<td align="center" valign="top" rowspan="1" colspan="1">35</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="center" valign="top" rowspan="1" colspan="1">1</td>
<td align="center" valign="top" rowspan="1" colspan="1">1</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn1-rado-48-03-314"><p>PMRT = postmastectomy radiotherapy</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t2-rado-48-03-314" position="float"><label>TABLE 2.</label>
<caption><p>Five-year Kaplan-Meier analysis of locoregional recurrence rate, distant recurrence rate and overall survival by basic characteristics of patients and tumors</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" rowspan="3" colspan="1"><bold>Characteristic</bold>
</th>
<th align="left" valign="middle" rowspan="3" colspan="1"><bold>No. of patients</bold>
</th>
<th colspan="2" align="left" valign="middle" rowspan="1"><bold>LRR</bold>
</th>
<th colspan="2" align="left" valign="middle" rowspan="1"><bold>DRR</bold>
</th>
<th colspan="2" align="left" valign="middle" rowspan="1"><bold>OS</bold>
</th>
</tr>
<tr><th colspan="6" align="left" valign="middle" rowspan="1"><hr></hr>
</th>
</tr>
<tr><th align="left" valign="middle" rowspan="1" colspan="1"><bold>%</bold>
</th>
<th align="left" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
<th align="left" valign="middle" rowspan="1" colspan="1"><bold>%</bold>
</th>
<th align="left" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
<th align="left" valign="middle" rowspan="1" colspan="1"><bold>%</bold>
</th>
<th align="left" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age (y)</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.003<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.18</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.69</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  < 40</td>
<td align="left" valign="top" rowspan="1" colspan="1">29</td>
<td align="left" valign="top" rowspan="1" colspan="1">22±9.0%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">30.3±9.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">79.6±8.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  ≥ 40</td>
<td align="left" valign="top" rowspan="1" colspan="1">178</td>
<td align="left" valign="top" rowspan="1" colspan="1">7±2.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">17.7±3.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">85.2±2.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Pathology</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.50</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.52</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.78</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Invasive ductal carcinoma</td>
<td align="left" valign="top" rowspan="1" colspan="1">183</td>
<td align="left" valign="top" rowspan="1" colspan="1">9.6±2.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">18.4±3.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">84.8±2.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Others</td>
<td align="left" valign="top" rowspan="1" colspan="1">24</td>
<td align="left" valign="top" rowspan="1" colspan="1">5.9±5.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">26.2±9.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">81.3±8.6%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">T stage</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.64</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.23</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.27</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  T1</td>
<td align="left" valign="top" rowspan="1" colspan="1">74</td>
<td align="left" valign="top" rowspan="1" colspan="1">7.7±3.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">14.0±4.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">92.4±3.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  T2</td>
<td align="left" valign="top" rowspan="1" colspan="1">133</td>
<td align="left" valign="top" rowspan="1" colspan="1">10.1±3.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">23.8±4.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">80.2±3.8%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Numbers of positive LN</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.34</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.22</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.87</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  1</td>
<td align="left" valign="top" rowspan="1" colspan="1">97</td>
<td align="left" valign="top" rowspan="1" colspan="1">4.7±2.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">14.3±3.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">84.8±3.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  2</td>
<td align="left" valign="top" rowspan="1" colspan="1">64</td>
<td align="left" valign="top" rowspan="1" colspan="1">15.4±5.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">22.4±5.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">85.7±4.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  3</td>
<td align="left" valign="top" rowspan="1" colspan="1">46</td>
<td align="left" valign="top" rowspan="1" colspan="1">10.3±4.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">31.4±8.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">81.5±6.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">% of Positive nodes</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.24</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.77</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.63</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  < 25%</td>
<td align="left" valign="top" rowspan="1" colspan="1">177</td>
<td align="left" valign="top" rowspan="1" colspan="1">7.7±2.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">21.1±3.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">83.1±3.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  ≥ 25%</td>
<td align="left" valign="top" rowspan="1" colspan="1">30</td>
<td align="left" valign="top" rowspan="1" colspan="1">18.5±8.8%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">15.3±7.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">91.7±5.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">ER status</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.25</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.08</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.033<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Negative</td>
<td align="left" valign="top" rowspan="1" colspan="1">68</td>
<td align="left" valign="top" rowspan="1" colspan="1">11.0±4.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">18.8±6.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">76.8±5.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Positive</td>
<td align="left" valign="top" rowspan="1" colspan="1">137</td>
<td align="left" valign="top" rowspan="1" colspan="1">8.2±2.6%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">15.2±3.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">87.9±3.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="left" valign="top" rowspan="1" colspan="1">2</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Her-2/neu</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.016<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.59</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.001<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Negative</td>
<td align="left" valign="top" rowspan="1" colspan="1">140</td>
<td align="left" valign="top" rowspan="1" colspan="1">6.2±2.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">18.8±3.6%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">89.2±2.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Positive</td>
<td align="left" valign="top" rowspan="1" colspan="1">43</td>
<td align="left" valign="top" rowspan="1" colspan="1">19.4±6.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">24.7±7.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">71.9±7.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="left" valign="top" rowspan="1" colspan="1">24</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">LVI</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.62</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.026<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.01<xref ref-type="table-fn" rid="tfn3-rado-48-03-314"><sup>*</sup>
</xref>
</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Negative</td>
<td align="left" valign="top" rowspan="1" colspan="1">57</td>
<td align="left" valign="top" rowspan="1" colspan="1">6.1±3.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">3.9±2.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">96.4±2.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Positive</td>
<td align="left" valign="top" rowspan="1" colspan="1">105</td>
<td align="left" valign="top" rowspan="1" colspan="1">9.7±3.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">21.1±4.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">82.7±4.0%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Unknown</td>
<td align="left" valign="top" rowspan="1" colspan="1">45</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Adjuvant Chemotherapy</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.94</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.16</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.29</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  No</td>
<td align="left" valign="top" rowspan="1" colspan="1">19</td>
<td align="left" valign="top" rowspan="1" colspan="1">6.2±6.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">38.1±14.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">68.9±13.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Yes</td>
<td align="left" valign="top" rowspan="1" colspan="1">188</td>
<td align="left" valign="top" rowspan="1" colspan="1">9.2±2.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">18.7±3.1%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">85.8±2.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">PMRT</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.11</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.94</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">0.92</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  No</td>
<td align="left" valign="top" rowspan="1" colspan="1">126</td>
<td align="left" valign="top" rowspan="1" colspan="1">11.8±3.2%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">20.3±3.9%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">83.8±3.5%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">  Yes</td>
<td align="left" valign="top" rowspan="1" colspan="1">81</td>
<td align="left" valign="top" rowspan="1" colspan="1">4.7±2.7%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">22.9±6.3%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
<td align="left" valign="top" rowspan="1" colspan="1">85.6±4.4%</td>
<td align="left" valign="top" rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn2-rado-48-03-314"><p>LRR = locoregional recurrence rate; DRR = distant recurrence rate; OS = overall survival; ER = estrogen receptor; LVI = lymphovascular invasion;</p>
</fn>
<fn id="tfn3-rado-48-03-314"><label>*</label>
<p>p < 0.05</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t3-rado-48-03-314" position="float"><label>TABLE 3.</label>
<caption><p>Multivariate analysis of locoregional recurrence, distant recurrence and overall survival</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" rowspan="3" colspan="1"><bold>Variable</bold>
</th>
<th colspan="2" align="center" valign="middle" rowspan="1"><bold>LRR</bold>
</th>
<th colspan="2" align="center" valign="middle" rowspan="1"><bold>DRR</bold>
</th>
<th colspan="2" align="center" valign="middle" rowspan="1"><bold>OS</bold>
</th>
</tr>
<tr><th colspan="6" align="center" valign="middle" rowspan="1"><hr></hr>
</th>
</tr>
<tr><th align="center" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>HR (95% CI)</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>HR (95% CI)</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>P</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>HR (95% CI)</bold>
</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age (≥ 40 vs. < 40)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.004<xref ref-type="table-fn" rid="tfn5-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.15 (0.04–0.55)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">% Positive nodes (>25% vs. ≤25%)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.064)</td>
<td align="center" valign="top" rowspan="1" colspan="1">3.87 (0.92–16.23)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">ER status (Positive vs. negative)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.061)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.45 (0.19–1.04)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Her-2/neu (Positive vs. negative)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.005<xref ref-type="table-fn" rid="tfn5-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">6.6 (1.8–24.28)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">0.002<xref ref-type="table-fn" rid="tfn5-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.01 (1.63–9.84)</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">LVI (Positive vs. negative)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.056)</td>
<td align="center" valign="top" rowspan="1" colspan="1">2.92 (0.97–8.76)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.031<xref ref-type="table-fn" rid="tfn5-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="top" rowspan="1" colspan="1">4.99 (1.16–21.55)</td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">Adjuvant chemotherapy (Yes vs. no)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.067)</td>
<td align="center" valign="top" rowspan="1" colspan="1">0.36 (0.12–1.08)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="top" rowspan="1" colspan="1">PMRT (Yes vs. no)</td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.30)</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.92)</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
<td align="center" valign="top" rowspan="1" colspan="1">NS (0.23)</td>
<td align="center" valign="top" rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn4-rado-48-03-314"><p>LRR = locoregional recurrence rate; DRR = distant recurrence rate; NS = Non-significant; OS = overall survival; ER = estrogen receptor; LVI = lymphovascular invasion; HR = hazard ratio; CI = confidence interval, PMRT=Postmastectomy radiotherapy;</p>
</fn>
<fn id="tfn5-rado-48-03-314"><label>*</label>
<p>p < 0.05</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="t4-rado-48-03-314" position="float"><label>TABLE 4.</label>
<caption><p>Analysis of clinical benefits on local regional recurrence and overall survival from PMRT</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" valign="middle" rowspan="3" colspan="1"><bold>Characteristic (case numbers)</bold>
</th>
<th align="center" valign="middle" rowspan="3" colspan="1"><bold>PMRT</bold>
</th>
<th colspan="2" align="center" valign="middle" rowspan="1"><bold>LRR</bold>
</th>
<th colspan="2" align="center" valign="middle" rowspan="1"><bold>OS</bold>
</th>
</tr>
<tr><th colspan="4" align="center" valign="middle" rowspan="1"><hr></hr>
</th>
</tr>
<tr><th align="center" valign="middle" rowspan="1" colspan="1"><bold>%</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>p</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>%</bold>
</th>
<th align="center" valign="middle" rowspan="1" colspan="1"><bold>p</bold>
</th>
</tr>
</thead>
<tbody><tr><td align="left" valign="middle" rowspan="1" colspan="1">Age (y)</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  < 40 (29)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">25</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">75</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.37</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">11.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">88.9</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  ≥ 40 (178)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">7.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.16</td>
<td align="center" valign="middle" rowspan="1" colspan="1">84</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.64</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2.8</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">84.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">Pathology</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Invasive ductal carcinoma (183)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">10.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.14</td>
<td align="center" valign="middle" rowspan="1" colspan="1">82.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.83</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">4.2</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.9</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Others (24)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">7.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.46</td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.4</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">80</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">T stage</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  T1 (74)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">10.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.088</td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.28</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">92.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  T2 (133)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">10.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.42</td>
<td align="center" valign="middle" rowspan="1" colspan="1">80.8</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.83</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">81.8</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">Numbers of positive LN</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  1 (97)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">7.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.42</td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.77</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  2 (63)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">11.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.82</td>
<td align="center" valign="middle" rowspan="1" colspan="1">81.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.8</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">9.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  3 (46)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">14.8</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.085</td>
<td align="center" valign="middle" rowspan="1" colspan="1">77.8</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.67</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">84.2</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">% of positive nodes</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  < 25% (177)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">8</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.46</td>
<td align="center" valign="middle" rowspan="1" colspan="1">82.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.8</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">4.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">86.2</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  ≥ 25% (30)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">28.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.033<xref ref-type="table-fn" rid="tfn7-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="middle" rowspan="1" colspan="1">85.7</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.37</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">81.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">ER status</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Negative (68)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">14</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.24</td>
<td align="center" valign="middle" rowspan="1" colspan="1">74.4</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.97</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">4</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">76</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Positive (137)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">8.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.27</td>
<td align="center" valign="middle" rowspan="1" colspan="1">86.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.96</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">3.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">89.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">Her-2/neu status</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Negative (140)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">7.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.43</td>
<td align="center" valign="middle" rowspan="1" colspan="1">89.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.48</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">3.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">87.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Positive (43)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">25</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1">58.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.45</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5.3</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">78.9</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="1" colspan="1">LVI status</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Negative (57)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">5.6</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.53</td>
<td align="center" valign="middle" rowspan="1" colspan="1">97.2</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.24</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">9.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">90.5</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" valign="middle" rowspan="2" colspan="1">  Positive (105)</td>
<td align="center" valign="middle" rowspan="1" colspan="1">No</td>
<td align="center" valign="middle" rowspan="1" colspan="1">11.9</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.049<xref ref-type="table-fn" rid="tfn7-rado-48-03-314"><sup>*</sup>
</xref>
</td>
<td align="center" valign="middle" rowspan="1" colspan="1">72.9</td>
<td align="center" valign="middle" rowspan="1" colspan="1">0.047<xref ref-type="table-fn" rid="tfn7-rado-48-03-314"><sup>*</sup>
</xref>
</td>
</tr>
<tr><td align="center" valign="middle" rowspan="1" colspan="1">Yes</td>
<td align="center" valign="middle" rowspan="1" colspan="1">2.2</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
<td align="center" valign="middle" rowspan="1" colspan="1">89.1</td>
<td align="center" valign="middle" rowspan="1" colspan="1"></td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="tfn6-rado-48-03-314"><p>LRR = locoregional recurrence rate; OS = overall survival; ER = estrogen receptor; LVI = lymphovascular invasion; PMRT=Postmastectomy radiotherapy;</p>
</fn>
<fn id="tfn7-rado-48-03-314"><label>*</label>
<p>p < 0.05</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Su, Yu Li" sort="Su, Yu Li" uniqKey="Su Y" first="Yu-Li" last="Su">Yu-Li Su</name>
</noRegion>
<name sortKey="Chen, Hui Chun" sort="Chen, Hui Chun" uniqKey="Chen H" first="Hui-Chun" last="Chen">Hui-Chun Chen</name>
<name sortKey="Chen, Yen Yang" sort="Chen, Yen Yang" uniqKey="Chen Y" first="Yen-Yang" last="Chen">Yen-Yang Chen</name>
<name sortKey="Chou, Fong Fu" sort="Chou, Fong Fu" uniqKey="Chou F" first="Fong-Fu" last="Chou">Fong-Fu Chou</name>
<name sortKey="Chou, Fong Fu" sort="Chou, Fong Fu" uniqKey="Chou F" first="Fong-Fu" last="Chou">Fong-Fu Chou</name>
<name sortKey="Huang, Cheng Hua" sort="Huang, Cheng Hua" uniqKey="Huang C" first="Cheng-Hua" last="Huang">Cheng-Hua Huang</name>
<name sortKey="Li, Shan Hsuan" sort="Li, Shan Hsuan" uniqKey="Li S" first="Shan-Hsuan" last="Li">Shan-Hsuan Li</name>
<name sortKey="Li, Shan Hsuan" sort="Li, Shan Hsuan" uniqKey="Li S" first="Shan-Hsuan" last="Li">Shan-Hsuan Li</name>
<name sortKey="Rau, Kun Ming" sort="Rau, Kun Ming" uniqKey="Rau K" first="Kun-Ming" last="Rau">Kun-Ming Rau</name>
<name sortKey="Rau, Kun Ming" sort="Rau, Kun Ming" uniqKey="Rau K" first="Kun-Ming" last="Rau">Kun-Ming Rau</name>
<name sortKey="Rau, Kun Ming" sort="Rau, Kun Ming" uniqKey="Rau K" first="Kun-Ming" last="Rau">Kun-Ming Rau</name>
<name sortKey="Tang, Yen" sort="Tang, Yen" uniqKey="Tang Y" first="Yen" last="Tang">Yen Tang</name>
<name sortKey="Wu, Shih Chung" sort="Wu, Shih Chung" uniqKey="Wu S" first="Shih-Chung" last="Wu">Shih-Chung Wu</name>
</country>
</tree>
</affiliations>
</record>

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Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1–2 tumor and 1–3 axillary lymph node(s) metastasis

Post-mastectomy radiotherapy benefits subgroups of breast cancer patients with T1–2 tumor and 1–3 axillary lymph node(s) metastasis

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