Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.
Identifieur interne : 006A35 ( Ncbi/Merge ); précédent : 006A34; suivant : 006A36Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.
Auteurs : J Andrew Carlson [États-Unis]Source :
- Clinics in dermatology [ 1879-1131 ]
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Lymphoedème.
- immunologie : Dermatite, Infections de la peau, Lymphoedème, Tumeurs cutanées.
- physiopathologie : Lymphoedème.
- Humains, Lymphoedème, Sujet immunodéprimé.
English descriptors
- KwdEn :
- MESH :
- complications : Lymphedema.
- diagnosis : Lymphedema.
- immunology : Dermatitis, Lymphedema, Skin Diseases, Infectious, Skin Neoplasms.
- physiopathology : Lymphedema.
- Humans, Immunocompromised Host.
Abstract
Whether primary or secondary, lymphedema is caused by failure to drain protein-rich interstitial fluid. Typically affecting a whole limb, it has become apparent that lymphedema can also affect localized regions of the skin, or it can be clinically silent but histologically evident, denoted by dilated lymphangiectases (latent lymphedema). Chronic lymph stasis has numerous consequences, including lipogenesis, fibrosis, inflammation, lymphangiogenesis, and immunosuppression. For example, lymphedema's disruption of immune cell trafficking leads to localized immune suppression, predisposing the area affected to chronic inflammation, infection (cellulitis and verrucosis), and malignancy (angiosarcoma and nonmelanoma skin cancer). The pathogenesis of lymphedema is reviewed and exemplified by describing how a combination of lymph stasis-promoting factors such as trauma, obesity, infection, and inflammatory disorders produces localized elephantiasis; furthermore, the finding of lymphangiectases is found to be common in numerous dermatologic disorders and argued to play a role in their pathogenesis. Lastly, it is discussed how antigen burden, which is controlled by lymphatic clearance, affects the immune response, resulting in immune tolerance, immunopathology, or normal adaptive immunity.
DOI: 10.1016/j.clindermatol.2014.04.007
PubMed: 25160101
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001351
- to stream PubMed, to step Curation: 001351
- to stream PubMed, to step Checkpoint: 001351
Links to Exploration step
pubmed:25160101Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.</title><author><name sortKey="Carlson, J Andrew" sort="Carlson, J Andrew" uniqKey="Carlson J" first="J Andrew" last="Carlson">J Andrew Carlson</name><affiliation wicri:level="1"><nlm:affiliation>Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, MC-81, Albany, NY 12208. Electronic address: CarlsoA@mail.amc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2014 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:25160101</idno><idno type="pmid">25160101</idno><idno type="doi">10.1016/j.clindermatol.2014.04.007</idno><idno type="wicri:Area/PubMed/Corpus">001351</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001351</idno><idno type="wicri:Area/PubMed/Curation">001351</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001351</idno><idno type="wicri:Area/PubMed/Checkpoint">001351</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001351</idno><idno type="wicri:Area/Ncbi/Merge">006A35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.</title><author><name sortKey="Carlson, J Andrew" sort="Carlson, J Andrew" uniqKey="Carlson J" first="J Andrew" last="Carlson">J Andrew Carlson</name><affiliation wicri:level="2"><nlm:affiliation>Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, MC-81, Albany, NY 12208. Electronic address: CarlsoA@mail.amc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, MC-81, Albany</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinics in dermatology</title><idno type="eISSN">1879-1131</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dermatitis (immunology)</term><term>Humans</term><term>Immunocompromised Host</term><term>Lymphedema (complications)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (immunology)</term><term>Lymphedema (physiopathology)</term><term>Skin Diseases, Infectious (immunology)</term><term>Skin Neoplasms (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Dermatite (immunologie)</term><term>Humains</term><term>Infections de la peau (immunologie)</term><term>Lymphoedème ()</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (immunologie)</term><term>Lymphoedème (physiopathologie)</term><term>Sujet immunodéprimé</term><term>Tumeurs cutanées (immunologie)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Dermatite</term><term>Infections de la peau</term><term>Lymphoedème</term><term>Tumeurs cutanées</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dermatitis</term><term>Lymphedema</term><term>Skin Diseases, Infectious</term><term>Skin Neoplasms</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunocompromised Host</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Lymphoedème</term><term>Sujet immunodéprimé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Whether primary or secondary, lymphedema is caused by failure to drain protein-rich interstitial fluid. Typically affecting a whole limb, it has become apparent that lymphedema can also affect localized regions of the skin, or it can be clinically silent but histologically evident, denoted by dilated lymphangiectases (latent lymphedema). Chronic lymph stasis has numerous consequences, including lipogenesis, fibrosis, inflammation, lymphangiogenesis, and immunosuppression. For example, lymphedema's disruption of immune cell trafficking leads to localized immune suppression, predisposing the area affected to chronic inflammation, infection (cellulitis and verrucosis), and malignancy (angiosarcoma and nonmelanoma skin cancer). The pathogenesis of lymphedema is reviewed and exemplified by describing how a combination of lymph stasis-promoting factors such as trauma, obesity, infection, and inflammatory disorders produces localized elephantiasis; furthermore, the finding of lymphangiectases is found to be common in numerous dermatologic disorders and argued to play a role in their pathogenesis. Lastly, it is discussed how antigen burden, which is controlled by lymphatic clearance, affects the immune response, resulting in immune tolerance, immunopathology, or normal adaptive immunity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25160101</PMID><DateCreated><Year>2014</Year><Month>08</Month><Day>27</Day></DateCreated><DateCompleted><Year>2015</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2014</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1879-1131</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>5</Issue><PubDate><MedlineDate>2014 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Clinics in dermatology</Title><ISOAbbreviation>Clin. Dermatol.</ISOAbbreviation></Journal><ArticleTitle>Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.</ArticleTitle><Pagination><MedlinePgn>599-615</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.clindermatol.2014.04.007</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0738-081X(14)00098-4</ELocationID><Abstract><AbstractText>Whether primary or secondary, lymphedema is caused by failure to drain protein-rich interstitial fluid. Typically affecting a whole limb, it has become apparent that lymphedema can also affect localized regions of the skin, or it can be clinically silent but histologically evident, denoted by dilated lymphangiectases (latent lymphedema). Chronic lymph stasis has numerous consequences, including lipogenesis, fibrosis, inflammation, lymphangiogenesis, and immunosuppression. For example, lymphedema's disruption of immune cell trafficking leads to localized immune suppression, predisposing the area affected to chronic inflammation, infection (cellulitis and verrucosis), and malignancy (angiosarcoma and nonmelanoma skin cancer). The pathogenesis of lymphedema is reviewed and exemplified by describing how a combination of lymph stasis-promoting factors such as trauma, obesity, infection, and inflammatory disorders produces localized elephantiasis; furthermore, the finding of lymphangiectases is found to be common in numerous dermatologic disorders and argued to play a role in their pathogenesis. Lastly, it is discussed how antigen burden, which is controlled by lymphatic clearance, affects the immune response, resulting in immune tolerance, immunopathology, or normal adaptive immunity.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carlson</LastName><ForeName>J Andrew</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, MC-81, Albany, NY 12208. Electronic address: CarlsoA@mail.amc.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Dermatol</MedlineTA><NlmUniqueID>8406412</NlmUniqueID><ISSNLinking>0738-081X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003872" MajorTopicYN="N">Dermatitis</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016867" MajorTopicYN="Y">Immunocompromised Host</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008209" MajorTopicYN="N">Lymphedema</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012874" MajorTopicYN="N">Skin Diseases, Infectious</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012878" MajorTopicYN="N">Skin Neoplasms</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>8</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25160101</ArticleId><ArticleId IdType="pii">S0738-081X(14)00098-4</ArticleId><ArticleId IdType="doi">10.1016/j.clindermatol.2014.04.007</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Carlson, J Andrew" sort="Carlson, J Andrew" uniqKey="Carlson J" first="J Andrew" last="Carlson">J Andrew Carlson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006A35 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 006A35 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:25160101
|texte= Lymphedema and subclinical lymphostasis (microlymphedema) facilitate cutaneous infection, inflammatory dermatoses, and neoplasia: A locus minoris resistentiae.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:25160101" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |