Primary Renal Angiosarcoma with Extensive Necrosis: A Difficult Diagnosis
Identifieur interne : 006992 ( Ncbi/Merge ); précédent : 006991; suivant : 006993Primary Renal Angiosarcoma with Extensive Necrosis: A Difficult Diagnosis
Auteurs : Sohail Qayyum [États-Unis] ; Jignesh G. Parikh [États-Unis] ; Nadeem Zafar [États-Unis]Source :
- Case Reports in Pathology [ 2090-6781 ] ; 2014.
Abstract
Angiosarcoma of the kidney is an exceedingly rare and aggressive neoplasm. Very few cases have been reported in the English literature to date. We report a case of primary renal angiosarcoma with extensive necrosis and discuss its diagnostic difficulties. An 86-year-old male presented with a 12 cm necrotic renal mass and multiple pulmonary and hepatic nodules. A CT guided renal biopsy revealed extensive necrosis and few vascular channels lined by malignant endothelial cells. Diagnosis was given on a morphologic base and proven by an immunohistochemical study. Primary renal angiosarcoma should be included among the differential diagnosis of necrotic renal lesions.
Url:
DOI: 10.1155/2014/416170
PubMed: 25133004
PubMed Central: 4123473
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Parikh</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163</wicri:regionArea><wicri:noRegion>TN 38163</wicri:noRegion></affiliation></author><author><name sortKey="Zafar, Nadeem" sort="Zafar, Nadeem" uniqKey="Zafar N" first="Nadeem" last="Zafar">Nadeem Zafar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163</wicri:regionArea><wicri:noRegion>TN 38163</wicri:noRegion></affiliation></author></analytic><series><title level="j">Case Reports in Pathology</title><idno type="ISSN">2090-6781</idno><idno type="eISSN">2090-679X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiosarcoma of the kidney is an exceedingly rare and aggressive neoplasm. Very few cases have been reported in the English literature to date. We report a case of primary renal angiosarcoma with extensive necrosis and discuss its diagnostic difficulties. An 86-year-old male presented with a 12 cm necrotic renal mass and multiple pulmonary and hepatic nodules. A CT guided renal biopsy revealed extensive necrosis and few vascular channels lined by malignant endothelial cells. Diagnosis was given on a morphologic base and proven by an immunohistochemical study. Primary renal angiosarcoma should be included among the differential diagnosis of necrotic renal lesions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lopez, B" uniqKey="Lopez B">B Lopez</name></author><author><name sortKey="Perez, F" uniqKey="Perez F">F Perez</name></author><author><name sortKey="Alvarez, Jac" uniqKey="Alvarez J">JAC Alvarez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ch" uniqKey="Lee C">CH Lee</name></author><author><name sortKey="Park, Ku" uniqKey="Park K">KU Park</name></author><author><name sortKey="Nah, Dy" uniqKey="Nah D">DY Nah</name></author><author><name sortKey="Won, Ks" uniqKey="Won K">KS Won</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, K" uniqKey="Yoshida K">K Yoshida</name></author><author><name sortKey="Ito, F" uniqKey="Ito F">F Ito</name></author><author><name sortKey="Nakazawa, H" uniqKey="Nakazawa H">H Nakazawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leggio, L" uniqKey="Leggio L">L Leggio</name></author><author><name sortKey="Addolorato, G" uniqKey="Addolorato G">G Addolorato</name></author><author><name sortKey="Abenavoli, L" uniqKey="Abenavoli L">L Abenavoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Vv" uniqKey="Johnson V">VV Johnson</name></author><author><name sortKey="Gaertner, Em" uniqKey="Gaertner E">EM Gaertner</name></author><author><name sortKey="Crothers, Ba" uniqKey="Crothers B">BA Crothers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leibovitch, I" uniqKey="Leibovitch I">I Leibovitch</name></author><author><name sortKey="Lev, R" uniqKey="Lev R">R Lev</name></author><author><name sortKey="Mor, Y" uniqKey="Mor Y">Y Mor</name></author><author><name sortKey="Golomb, J" uniqKey="Golomb J">J Golomb</name></author><author><name sortKey="Dotan, Za" uniqKey="Dotan Z">ZA Dotan</name></author><author><name sortKey="Ramon, J" uniqKey="Ramon J">J Ramon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Jg" uniqKey="Brown J">JG Brown</name></author><author><name sortKey="Folpe, Al" uniqKey="Folpe A">AL Folpe</name></author><author><name sortKey="Rao, P" uniqKey="Rao P">P Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiratsuka, Y" uniqKey="Hiratsuka Y">Y Hiratsuka</name></author><author><name sortKey="Nishimura, H" uniqKey="Nishimura H">H Nishimura</name></author><author><name sortKey="Kajiwara, I" uniqKey="Kajiwara I">I Kajiwara</name></author><author><name sortKey="Matsuoka, H" uniqKey="Matsuoka H">H Matsuoka</name></author><author><name sortKey="Kawamura, K" uniqKey="Kawamura K">K Kawamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ribeiro De Souza, Oe" uniqKey="Ribeiro De Souza O">OE Ribeiro de Souza</name></author><author><name sortKey="Etchebehere, Rm" uniqKey="Etchebehere R">RM Etchebehere</name></author><author><name sortKey="Lima, Ma" uniqKey="Lima M">MA Lima</name></author><author><name sortKey="Monti, Pr" uniqKey="Monti P">PR Monti</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Pathol</journal-id><journal-id journal-id-type="iso-abbrev">Case Rep Pathol</journal-id><journal-id journal-id-type="publisher-id">CRIPA</journal-id><journal-title-group><journal-title>Case Reports in Pathology</journal-title></journal-title-group><issn pub-type="ppub">2090-6781</issn><issn pub-type="epub">2090-679X</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25133004</article-id><article-id pub-id-type="pmc">4123473</article-id><article-id pub-id-type="doi">10.1155/2014/416170</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Primary Renal Angiosarcoma with Extensive Necrosis: A Difficult Diagnosis</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-9944-0679</contrib-id><name><surname>Qayyum</surname><given-names>Sohail</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Parikh</surname><given-names>Jignesh G.</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-2106-7063</contrib-id><name><surname>Zafar</surname><given-names>Nadeem</given-names></name><xref ref-type="aff" rid="I1"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="I1">Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA</aff><author-notes><corresp id="cor1">*Nadeem Zafar: <email>nzafar@uthsc.edu</email></corresp><fn fn-type="other"><p>Academic Editor: Katsuyuki Aozasa</p></fn></author-notes><pub-date pub-type="ppub"><year>2014</year></pub-date><pub-date pub-type="epub"><day>15</day><month>7</month><year>2014</year></pub-date><volume>2014</volume><elocation-id>416170</elocation-id><history><date date-type="received"><day>23</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>22</day><month>6</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2014 Sohail Qayyum et al.</copyright-statement><copyright-year>2014</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Angiosarcoma of the kidney is an exceedingly rare and aggressive neoplasm. Very few cases have been reported in the English literature to date. We report a case of primary renal angiosarcoma with extensive necrosis and discuss its diagnostic difficulties. An 86-year-old male presented with a 12 cm necrotic renal mass and multiple pulmonary and hepatic nodules. A CT guided renal biopsy revealed extensive necrosis and few vascular channels lined by malignant endothelial cells. Diagnosis was given on a morphologic base and proven by an immunohistochemical study. Primary renal angiosarcoma should be included among the differential diagnosis of necrotic renal lesions.</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><graphic xlink:href="CRIPA2014-416170.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Microphotographs of a renal biopsy. (a) Scant tissue fragments with extensive necrosis (HE, ×40). (b) Scant tissue fragments with extensive necrosis (HE, ×100). (c) Multiple vascular channels lined by pleomorphic endothelial cells and increased mitotic figures (arrows) (HE, ×400). (d) Strong immunoreactivity for an endothelial marker CD34 (IHC, ×400).</p></caption><graphic xlink:href="CRIPA2014-416170.002"></graphic></fig></floats-group></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Qayyum, Sohail" sort="Qayyum, Sohail" uniqKey="Qayyum S" first="Sohail" last="Qayyum">Sohail Qayyum</name></noRegion><name sortKey="Parikh, Jignesh G" sort="Parikh, Jignesh G" uniqKey="Parikh J" first="Jignesh G." last="Parikh">Jignesh G. Parikh</name><name sortKey="Zafar, Nadeem" sort="Zafar, Nadeem" uniqKey="Zafar N" first="Nadeem" last="Zafar">Nadeem Zafar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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