Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence
Identifieur interne : 006758 ( Ncbi/Merge ); précédent : 006757; suivant : 006759Identification of novel craniofacial regulatory domains located far upstream of SOX9 and disrupted in Pierre Robin sequence
Auteurs : Christopher T. Gordon [France] ; Catia Attanasio [États-Unis, Suisse] ; Shipra Bhatia [Royaume-Uni] ; Sabina Benko [France, États-Unis] ; Morad Ansari [Royaume-Uni] ; Tiong Y. Tan [Australie] ; Arnold Munnich [France] ; Len A. Pennacchio [États-Unis] ; Véronique Abadie [France] ; I. Karen Temple [Royaume-Uni] ; Alice Goldenberg [France] ; Veronica Van Heyningen [Royaume-Uni] ; Jeanne Amiel [France] ; David Fitzpatrick [Royaume-Uni] ; Dirk A. Kleinjan [Royaume-Uni] ; Axel Visel [États-Unis] ; Stanislas Lyonnet [France]Source :
- Human mutation [ 1059-7794 ] ; 2014.
Abstract
Mutations in the coding sequence of
Url:
DOI: 10.1002/humu.22606
PubMed: 24934569
PubMed Central: 4389788
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PMC:4389788Le document en format XML
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<affiliation wicri:level="2"><nlm:aff id="A8">U.S. Department of Energy Joint Genome Institute, Walnut Creek, California, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abadie, Veronique" sort="Abadie, Veronique" uniqKey="Abadie V" first="Véronique" last="Abadie">Véronique Abadie</name>
<affiliation wicri:level="4"><nlm:aff id="A9">Service de Pédiatrie Générale, Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Service de Pédiatrie Générale, Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
</author>
<author><name sortKey="Temple, I Karen" sort="Temple, I Karen" uniqKey="Temple I" first="I. Karen" last="Temple">I. Karen Temple</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goldenberg, Alice" sort="Goldenberg, Alice" uniqKey="Goldenberg A" first="Alice" last="Goldenberg">Alice Goldenberg</name>
<affiliation wicri:level="3"><nlm:aff id="A11">Service de Génétique Médicale, CHU Charles Nicolle, Rouen, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Service de Génétique Médicale, CHU Charles Nicolle, Rouen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Heyningen, Veronica" sort="Van Heyningen, Veronica" uniqKey="Van Heyningen V" first="Veronica" last="Van Heyningen">Veronica Van Heyningen</name>
<affiliation wicri:level="4"><nlm:aff id="A4">MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Amiel, Jeanne" sort="Amiel, Jeanne" uniqKey="Amiel J" first="Jeanne" last="Amiel">Jeanne Amiel</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Université Paris Descartes–Sorbonne Paris Cité, Institut<italic>Imagine</italic>
, INSERM U1163, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>, INSERM U1163, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Hôpital Necker-Enfants Malades AP-HP, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Hôpital Necker-Enfants Malades AP-HP, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fitzpatrick, David" sort="Fitzpatrick, David" uniqKey="Fitzpatrick D" first="David" last="Fitzpatrick">David Fitzpatrick</name>
<affiliation wicri:level="4"><nlm:aff id="A4">MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Kleinjan, Dirk A" sort="Kleinjan, Dirk A" uniqKey="Kleinjan D" first="Dirk A." last="Kleinjan">Dirk A. Kleinjan</name>
<affiliation wicri:level="4"><nlm:aff id="A4">MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Visel, Axel" sort="Visel, Axel" uniqKey="Visel A" first="Axel" last="Visel">Axel Visel</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">U.S. Department of Energy Joint Genome Institute, Walnut Creek, California, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>U.S. Department of Energy Joint Genome Institute, Walnut Creek, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A12">School of Natural Sciences, University of California, Merced, California, USA.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>School of Natural Sciences, University of California, Merced, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lyonnet, Stanislas" sort="Lyonnet, Stanislas" uniqKey="Lyonnet S" first="Stanislas" last="Lyonnet">Stanislas Lyonnet</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Université Paris Descartes–Sorbonne Paris Cité, Institut<italic>Imagine</italic>
, INSERM U1163, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>, INSERM U1163, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Hôpital Necker-Enfants Malades AP-HP, Paris, France.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">France</country>
<wicri:regionArea>Hôpital Necker-Enfants Malades AP-HP, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Human mutation</title>
<idno type="ISSN">1059-7794</idno>
<idno type="eISSN">1098-1004</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p id="P1">Mutations in the coding sequence of <italic>SOX9</italic>
cause campomelic dysplasia (CD), a disorder of skeletal development associated with 46,XY disorders of sex development (DSDs). Translocations, deletions and duplications within a ~2 Mb region upstream of <italic>SOX9</italic>
can recapitulate the CD-DSD phenotype fully or partially, suggesting the existence of an unusually large cis-regulatory control region. Pierre Robin sequence (PRS) is a craniofacial disorder that is frequently an endophenotype of CD and a locus for isolated PRS at ~1.2-1.5 Mb upstream of <italic>SOX9</italic>
has been previously reported. The craniofacial regulatory potential within this locus, and within the greater genomic domain surrounding <italic>SOX9</italic>
, remains poorly defined. We report two novel deletions upstream of <italic>SOX9</italic>
in families with PRS, allowing refinement of the regions harbouring candidate craniofacial regulatory elements. In parallel, ChIP-Seq for p300 binding sites in mouse craniofacial tissue led to the identification of several novel craniofacial enhancers at the <italic>SOX9</italic>
locus, which were validated in transgenic reporter mice and zebrafish. Notably, some of the functionally validated elements fall within the PRS deletions. These studies suggest that multiple non-coding elements contribute to the craniofacial regulation of <italic>SOX9</italic>
expression, and that their disruption results in PRS.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9215429</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2408</journal-id>
<journal-id journal-id-type="nlm-ta">Hum Mutat</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum. Mutat.</journal-id>
<journal-title-group><journal-title>Human mutation</journal-title>
</journal-title-group>
<issn pub-type="ppub">1059-7794</issn>
<issn pub-type="epub">1098-1004</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24934569</article-id>
<article-id pub-id-type="pmc">4389788</article-id>
<article-id pub-id-type="doi">10.1002/humu.22606</article-id>
<article-id pub-id-type="manuscript">NIHMS675991</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Identification of novel craniofacial regulatory domains located far upstream of <italic>SOX9</italic>
and disrupted in Pierre Robin sequence</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gordon</surname>
<given-names>Christopher T.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="CR1">#</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Attanasio</surname>
<given-names>Catia</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bhatia</surname>
<given-names>Shipra</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Benko</surname>
<given-names>Sabina</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ansari</surname>
<given-names>Morad</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tan</surname>
<given-names>Tiong Y.</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Munnich</surname>
<given-names>Arnold</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pennacchio</surname>
<given-names>Len A.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abadie</surname>
<given-names>Véronique</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Temple</surname>
<given-names>I. Karen</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goldenberg</surname>
<given-names>Alice</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Heyningen</surname>
<given-names>Veronica</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Amiel</surname>
<given-names>Jeanne</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>FitzPatrick</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kleinjan</surname>
<given-names>Dirk A.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Visel</surname>
<given-names>Axel</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A8">8</xref>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lyonnet</surname>
<given-names>Stanislas</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A7">7</xref>
<xref ref-type="corresp" rid="CR1">#</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Université Paris Descartes–Sorbonne Paris Cité, Institut<italic>Imagine</italic>
, INSERM U1163, Paris, France.</aff>
<aff id="A2"><label>2</label>
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.</aff>
<aff id="A3"><label>3</label>
Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland.</aff>
<aff id="A4"><label>4</label>
MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</aff>
<aff id="A5"><label>5</label>
Department of Structural and Chemical Biology, Ichan School of Medicine at Mount Sinai, New York, USA.</aff>
<aff id="A6"><label>6</label>
Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.</aff>
<aff id="A7"><label>7</label>
Hôpital Necker-Enfants Malades AP-HP, Paris, France.</aff>
<aff id="A8"><label>8</label>
U.S. Department of Energy Joint Genome Institute, Walnut Creek, California, USA.</aff>
<aff id="A9"><label>9</label>
Service de Pédiatrie Générale, Université Paris Descartes, Hôpital Necker-Enfants Malades, Paris, France.</aff>
<aff id="A10"><label>10</label>
Human Genetics and Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.</aff>
<aff id="A11"><label>11</label>
Service de Génétique Médicale, CHU Charles Nicolle, Rouen, France.</aff>
<aff id="A12"><label>12</label>
School of Natural Sciences, University of California, Merced, California, USA.</aff>
<author-notes><corresp id="CR1"><label>#</label>
- <bold>Corresponding authors:</bold>
CTG and SL INSERM U1163 Institut Imagine, 24 Boulevard du Montparnasse, 75015, Paris France. <email>chris.gordon@inserm.fr</email>
, <email>stanislas.lyonnet@inserm.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>1</day>
<month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2015</year>
</pub-date>
<volume>35</volume>
<issue>8</issue>
<fpage>1011</fpage>
<lpage>1020</lpage>
<pmc-comment>elocation-id from pubmed: 10.1002/humu.22606</pmc-comment>
<abstract><p id="P1">Mutations in the coding sequence of <italic>SOX9</italic>
cause campomelic dysplasia (CD), a disorder of skeletal development associated with 46,XY disorders of sex development (DSDs). Translocations, deletions and duplications within a ~2 Mb region upstream of <italic>SOX9</italic>
can recapitulate the CD-DSD phenotype fully or partially, suggesting the existence of an unusually large cis-regulatory control region. Pierre Robin sequence (PRS) is a craniofacial disorder that is frequently an endophenotype of CD and a locus for isolated PRS at ~1.2-1.5 Mb upstream of <italic>SOX9</italic>
has been previously reported. The craniofacial regulatory potential within this locus, and within the greater genomic domain surrounding <italic>SOX9</italic>
, remains poorly defined. We report two novel deletions upstream of <italic>SOX9</italic>
in families with PRS, allowing refinement of the regions harbouring candidate craniofacial regulatory elements. In parallel, ChIP-Seq for p300 binding sites in mouse craniofacial tissue led to the identification of several novel craniofacial enhancers at the <italic>SOX9</italic>
locus, which were validated in transgenic reporter mice and zebrafish. Notably, some of the functionally validated elements fall within the PRS deletions. These studies suggest that multiple non-coding elements contribute to the craniofacial regulation of <italic>SOX9</italic>
expression, and that their disruption results in PRS.</p>
</abstract>
<kwd-group><kwd><italic>SOX9</italic>
</kwd>
<kwd>craniofacial</kwd>
<kwd>enhancer</kwd>
<kwd>Pierre Robin</kwd>
<kwd>long-range regulation</kwd>
<kwd>campomelic dysplasia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Haute-Normandie</li>
<li>Région Normandie</li>
<li>Écosse</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
<li>Rouen</li>
<li>Édimbourg</li>
</settlement>
<orgName><li>Université Paris-Descartes</li>
<li>Université d'Édimbourg</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Gordon, Christopher T" sort="Gordon, Christopher T" uniqKey="Gordon C" first="Christopher T." last="Gordon">Christopher T. Gordon</name>
</region>
<name sortKey="Abadie, Veronique" sort="Abadie, Veronique" uniqKey="Abadie V" first="Véronique" last="Abadie">Véronique Abadie</name>
<name sortKey="Amiel, Jeanne" sort="Amiel, Jeanne" uniqKey="Amiel J" first="Jeanne" last="Amiel">Jeanne Amiel</name>
<name sortKey="Amiel, Jeanne" sort="Amiel, Jeanne" uniqKey="Amiel J" first="Jeanne" last="Amiel">Jeanne Amiel</name>
<name sortKey="Benko, Sabina" sort="Benko, Sabina" uniqKey="Benko S" first="Sabina" last="Benko">Sabina Benko</name>
<name sortKey="Goldenberg, Alice" sort="Goldenberg, Alice" uniqKey="Goldenberg A" first="Alice" last="Goldenberg">Alice Goldenberg</name>
<name sortKey="Lyonnet, Stanislas" sort="Lyonnet, Stanislas" uniqKey="Lyonnet S" first="Stanislas" last="Lyonnet">Stanislas Lyonnet</name>
<name sortKey="Lyonnet, Stanislas" sort="Lyonnet, Stanislas" uniqKey="Lyonnet S" first="Stanislas" last="Lyonnet">Stanislas Lyonnet</name>
<name sortKey="Munnich, Arnold" sort="Munnich, Arnold" uniqKey="Munnich A" first="Arnold" last="Munnich">Arnold Munnich</name>
<name sortKey="Munnich, Arnold" sort="Munnich, Arnold" uniqKey="Munnich A" first="Arnold" last="Munnich">Arnold Munnich</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Attanasio, Catia" sort="Attanasio, Catia" uniqKey="Attanasio C" first="Catia" last="Attanasio">Catia Attanasio</name>
</region>
<name sortKey="Benko, Sabina" sort="Benko, Sabina" uniqKey="Benko S" first="Sabina" last="Benko">Sabina Benko</name>
<name sortKey="Pennacchio, Len A" sort="Pennacchio, Len A" uniqKey="Pennacchio L" first="Len A." last="Pennacchio">Len A. Pennacchio</name>
<name sortKey="Pennacchio, Len A" sort="Pennacchio, Len A" uniqKey="Pennacchio L" first="Len A." last="Pennacchio">Len A. Pennacchio</name>
<name sortKey="Visel, Axel" sort="Visel, Axel" uniqKey="Visel A" first="Axel" last="Visel">Axel Visel</name>
<name sortKey="Visel, Axel" sort="Visel, Axel" uniqKey="Visel A" first="Axel" last="Visel">Axel Visel</name>
<name sortKey="Visel, Axel" sort="Visel, Axel" uniqKey="Visel A" first="Axel" last="Visel">Axel Visel</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Attanasio, Catia" sort="Attanasio, Catia" uniqKey="Attanasio C" first="Catia" last="Attanasio">Catia Attanasio</name>
</noRegion>
</country>
<country name="Royaume-Uni"><region name="Écosse"><name sortKey="Bhatia, Shipra" sort="Bhatia, Shipra" uniqKey="Bhatia S" first="Shipra" last="Bhatia">Shipra Bhatia</name>
</region>
<name sortKey="Ansari, Morad" sort="Ansari, Morad" uniqKey="Ansari M" first="Morad" last="Ansari">Morad Ansari</name>
<name sortKey="Fitzpatrick, David" sort="Fitzpatrick, David" uniqKey="Fitzpatrick D" first="David" last="Fitzpatrick">David Fitzpatrick</name>
<name sortKey="Kleinjan, Dirk A" sort="Kleinjan, Dirk A" uniqKey="Kleinjan D" first="Dirk A." last="Kleinjan">Dirk A. Kleinjan</name>
<name sortKey="Temple, I Karen" sort="Temple, I Karen" uniqKey="Temple I" first="I. Karen" last="Temple">I. Karen Temple</name>
<name sortKey="Van Heyningen, Veronica" sort="Van Heyningen, Veronica" uniqKey="Van Heyningen V" first="Veronica" last="Van Heyningen">Veronica Van Heyningen</name>
</country>
<country name="Australie"><noRegion><name sortKey="Tan, Tiong Y" sort="Tan, Tiong Y" uniqKey="Tan T" first="Tiong Y." last="Tan">Tiong Y. Tan</name>
</noRegion>
</country>
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