A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies
Identifieur interne : 006682 ( Ncbi/Merge ); précédent : 006681; suivant : 006683A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies
Auteurs : Jun-Dae Kim ; Suk-Won JinSource :
- Molecules and Cells [ 1016-8478 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (physiologie), Danio zébré, Facteur de croissance endothéliale vasculaire de type A (métabolisme), Humains, Lymphoedème (), Lymphoedème (physiopathologie), Modèles animaux, Métabolisme des lipides, Souris, Thérapie moléculaire ciblée, Transduction du signal, Vaisseaux lymphatiques (physiologie).
- MESH :
- métabolisme : Facteur de croissance endothéliale vasculaire de type A.
- physiologie : Cellules endothéliales, Vaisseaux lymphatiques.
- physiopathologie : Lymphoedème.
- Animaux, Danio zébré, Humains, Lymphoedème, Modèles animaux, Métabolisme des lipides, Souris, Thérapie moléculaire ciblée, Transduction du signal.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Vascular Endothelial Growth Factor A.
- physiology : Endothelial Cells, Lymphatic Vessels.
- physiopathology : Lymphedema.
- therapy : Lymphedema.
- Animals, Humans, Lipid Metabolism, Mice, Models, Animal, Molecular Targeted Therapy, Signal Transduction, Zebrafish.
Abstract
Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.
Url:
DOI: 10.14348/molcells.2014.0108
PubMed: 24854860
PubMed Central: 4132301
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PMC:4132301Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.</p>
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<front><div type="abstract" xml:lang="en">Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical importance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endothelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lymphedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in vertebrates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.</div>
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