[Febrile episodes of unknown origin, elevated level of plasma ferritin and rapidly developed multiorgan dysfunction].
Identifieur interne : 006465 ( Ncbi/Merge ); précédent : 006464; suivant : 006466[Febrile episodes of unknown origin, elevated level of plasma ferritin and rapidly developed multiorgan dysfunction].
Auteurs : Esa Jantunen ; Sanna Siitonen ; Marja-Liisa Karjalainen-LindsbergSource :
- Duodecim; laaketieteellinen aikakauskirja [ 0012-7183 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Ferritins, Receptors, Interleukin-2.
- diagnosis : Lymphohistiocytosis, Hemophagocytic, Lymphoma, T-Cell.
- Adult, Diagnosis, Differential, Fever of Unknown Origin, Humans, Liver Function Tests, Lymphedema, Male, Tomography, X-Ray Computed.
Abstract
A previously healthy 40-year-old man developed febrile episodes of unknown origin, articular symptoms, venous occlusion of the lower limb and transient elevation of hepatic enzymes, and cutaneous symptoms. Computed tomography scanning revealed enlarged lymph nodes, but no sample was collected. In addition to microcytic anemia, a high serum ferritin level and an increased IL-2 receptor value in serum were found. Drug therapy against tuberculosis and borreliosis was started, but febrile episodes continued and in a few days the patient developed multiorgan dysfunction. Hemophagocytic lymphohistiocytosis associated with T-cell lymphoma was revealed as the underlying condition.
PubMed: 24660387
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pubmed:24660387Le document en format XML
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<term>Fever of Unknown Origin</term>
<term>Humans</term>
<term>Liver Function Tests</term>
<term>Lymphedema</term>
<term>Lymphohistiocytosis, Hemophagocytic (diagnosis)</term>
<term>Lymphoma, T-Cell (diagnosis)</term>
<term>Male</term>
<term>Receptors, Interleukin-2 (blood)</term>
<term>Tomography, X-Ray Computed</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Diagnostic différentiel</term>
<term>Ferritines (sang)</term>
<term>Fièvre d'origine inconnue</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Lymphohistiocytose hémophagocytaire (diagnostic)</term>
<term>Lymphome T (diagnostic)</term>
<term>Mâle</term>
<term>Récepteurs à l'interleukine-2 (sang)</term>
<term>Tests de la fonction hépatique</term>
<term>Tomodensitométrie</term>
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<term>Receptors, Interleukin-2</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphohistiocytosis, Hemophagocytic</term>
<term>Lymphoma, T-Cell</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphohistiocytose hémophagocytaire</term>
<term>Lymphome T</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Ferritines</term>
<term>Récepteurs à l'interleukine-2</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Diagnosis, Differential</term>
<term>Fever of Unknown Origin</term>
<term>Humans</term>
<term>Liver Function Tests</term>
<term>Lymphedema</term>
<term>Male</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Diagnostic différentiel</term>
<term>Fièvre d'origine inconnue</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Mâle</term>
<term>Tests de la fonction hépatique</term>
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<front><div type="abstract" xml:lang="en">A previously healthy 40-year-old man developed febrile episodes of unknown origin, articular symptoms, venous occlusion of the lower limb and transient elevation of hepatic enzymes, and cutaneous symptoms. Computed tomography scanning revealed enlarged lymph nodes, but no sample was collected. In addition to microcytic anemia, a high serum ferritin level and an increased IL-2 receptor value in serum were found. Drug therapy against tuberculosis and borreliosis was started, but febrile episodes continued and in a few days the patient developed multiorgan dysfunction. Hemophagocytic lymphohistiocytosis associated with T-cell lymphoma was revealed as the underlying condition.</div>
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<Abstract><AbstractText>A previously healthy 40-year-old man developed febrile episodes of unknown origin, articular symptoms, venous occlusion of the lower limb and transient elevation of hepatic enzymes, and cutaneous symptoms. Computed tomography scanning revealed enlarged lymph nodes, but no sample was collected. In addition to microcytic anemia, a high serum ferritin level and an increased IL-2 receptor value in serum were found. Drug therapy against tuberculosis and borreliosis was started, but febrile episodes continued and in a few days the patient developed multiorgan dysfunction. Hemophagocytic lymphohistiocytosis associated with T-cell lymphoma was revealed as the underlying condition.</AbstractText>
</Abstract>
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<VernacularTitle>Epäselvä kuumeilu, suurentunut plasman ferritiinipitoisuus ja nopeasti kehittynyt monielinvaurio.</VernacularTitle>
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