Corticosteroid Induced, HHV-8 Positive Kaposi’s Sarcoma in a Non-HIV Elderly Patient
Identifieur interne : 005B47 ( Ncbi/Merge ); précédent : 005B46; suivant : 005B48Corticosteroid Induced, HHV-8 Positive Kaposi’s Sarcoma in a Non-HIV Elderly Patient
Auteurs : Gh Mohiuddin Wani ; Sheikh Manzoor Ahmad ; Seema Qayoom ; Bilquees Khursheed ; A. R. Khan [Inde]Source :
- The Journal of IMA [ 0899-8299 ] ; 2012.
Abstract
Kaposi’s sarcoma (KS) was first described in 1872 by Moritz Kaposi. In 1994, Chang
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DOI: 10.5915/44-1-9317
PubMed: 23864989
PubMed Central: 3708632
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Corticosteroid Induced, HHV-8 Positive Kaposi’s Sarcoma in a Non-HIV Elderly Patient</title><author><name sortKey="Wani, Gh Mohiuddin" sort="Wani, Gh Mohiuddin" uniqKey="Wani G" first="Gh Mohiuddin" last="Wani">Gh Mohiuddin Wani</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Ahmad, Sheikh Manzoor" sort="Ahmad, Sheikh Manzoor" uniqKey="Ahmad S" first="Sheikh Manzoor" last="Ahmad">Sheikh Manzoor Ahmad</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Qayoom, Seema" sort="Qayoom, Seema" uniqKey="Qayoom S" first="Seema" last="Qayoom">Seema Qayoom</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Khursheed, Bilquees" sort="Khursheed, Bilquees" uniqKey="Khursheed B" first="Bilquees" last="Khursheed">Bilquees Khursheed</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Khan, A R" sort="Khan, A R" uniqKey="Khan A" first="A. R." last="Khan">A. R. Khan</name><affiliation wicri:level="1"><nlm:aff id="af2-jima-44-1-09317">Department of Pathology Government Medical College Srinager, Kashmir, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pathology Government Medical College Srinager, Kashmir</wicri:regionArea><wicri:noRegion>Kashmir</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23864989</idno><idno type="pmc">3708632</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708632</idno><idno type="RBID">PMC:3708632</idno><idno type="doi">10.5915/44-1-9317</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002296</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002296</idno><idno type="wicri:Area/Pmc/Curation">002295</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002295</idno><idno type="wicri:Area/Pmc/Checkpoint">002A77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002A77</idno><idno type="wicri:Area/Ncbi/Merge">005B47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Corticosteroid Induced, HHV-8 Positive Kaposi’s Sarcoma in a Non-HIV Elderly Patient</title><author><name sortKey="Wani, Gh Mohiuddin" sort="Wani, Gh Mohiuddin" uniqKey="Wani G" first="Gh Mohiuddin" last="Wani">Gh Mohiuddin Wani</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Ahmad, Sheikh Manzoor" sort="Ahmad, Sheikh Manzoor" uniqKey="Ahmad S" first="Sheikh Manzoor" last="Ahmad">Sheikh Manzoor Ahmad</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Qayoom, Seema" sort="Qayoom, Seema" uniqKey="Qayoom S" first="Seema" last="Qayoom">Seema Qayoom</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Khursheed, Bilquees" sort="Khursheed, Bilquees" uniqKey="Khursheed B" first="Bilquees" last="Khursheed">Bilquees Khursheed</name><affiliation><nlm:aff id="af1-jima-44-1-09317">Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</nlm:aff><wicri:noCountry code="subfield">Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</wicri:noCountry></affiliation></author><author><name sortKey="Khan, A R" sort="Khan, A R" uniqKey="Khan A" first="A. R." last="Khan">A. R. Khan</name><affiliation wicri:level="1"><nlm:aff id="af2-jima-44-1-09317">Department of Pathology Government Medical College Srinager, Kashmir, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Pathology Government Medical College Srinager, Kashmir</wicri:regionArea><wicri:noRegion>Kashmir</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of IMA</title><idno type="ISSN">0899-8299</idno><idno type="eISSN">2160-9829</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Kaposi’s sarcoma (KS) was first described in 1872 by Moritz Kaposi. In 1994, Chang <italic>et al.</italic> first identified DNA sequences corresponding to human herpesvirus-8 (HHV-8) in AIDS-associated Kaposi sarcoma biopsies. It is now believed that presence of HHV-8 is necessary but not sufficient to cause KS. Other factors like immunosuppressive therapy also play a role. We describe an HIV-negative elderly patient who developed KS of skin and mucous membrane after prolonged use of corticosteroids for knee pain. The patient was positive for HHV-8.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bencini, Pl" uniqKey="Bencini P">PL Bencini</name></author><author><name sortKey="Montagnino, G" uniqKey="Montagnino G">G Montagnino</name></author><author><name sortKey="Tarantino, A" uniqKey="Tarantino A">A Tarantino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, F" uniqKey="Leung F">F Leung</name></author><author><name sortKey="Fam, Ag" uniqKey="Fam A">AG Fam</name></author><author><name sortKey="Osoba, D" uniqKey="Osoba D">D Osoba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Rw" uniqKey="Martin R">RW Martin</name></author><author><name sortKey="Hood, Af" uniqKey="Hood A">AF Hood</name></author><author><name sortKey="Farmer, Er" uniqKey="Farmer E">ER Farmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montagnino, G" uniqKey="Montagnino G">G Montagnino</name></author><author><name sortKey="Bencini, Pl" uniqKey="Bencini P">PL Bencini</name></author><author><name sortKey="Tarantino, A" uniqKey="Tarantino A">A Tarantino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abbasi, F" uniqKey="Abbasi F">F Abbasi</name></author><author><name sortKey="Fardkhani, Sk" uniqKey="Fardkhani S">SK Fardkhani</name></author><author><name sortKey="Sha Ani, M" uniqKey="Sha Ani M">M Sha’bani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frances, C" uniqKey="Frances C">C Francès</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trattner, A" uniqKey="Trattner A">A Trattner</name></author><author><name sortKey="Hodak, E" uniqKey="Hodak E">E Hodak</name></author><author><name sortKey="David, M" uniqKey="David M">M David</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Wx" uniqKey="Guo W">WX Guo</name></author><author><name sortKey="Antakly, T" uniqKey="Antakly T">T Antakly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name></author><author><name sortKey="Cesarman, E" uniqKey="Cesarman E">E Cesarman</name></author><author><name sortKey="Pessin, Ms" uniqKey="Pessin M">MS Pessin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kemeny, L" uniqKey="Kemeny L">L Kemény</name></author><author><name sortKey="Gyulai, R" uniqKey="Gyulai R">R Gyulai</name></author><author><name sortKey="Kiss, M" uniqKey="Kiss M">M Kiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bursics, A" uniqKey="Bursics A">A Bursics</name></author><author><name sortKey="Morvag, K" uniqKey="Morvag K">K Morvag</name></author><author><name sortKey="Abraham, K" uniqKey="Abraham K">K Ábrahám</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rady, Pl" uniqKey="Rady P">PL Rady</name></author><author><name sortKey="Hodak, E" uniqKey="Hodak E">E Hodak</name></author><author><name sortKey="Yen, A" uniqKey="Yen A">A Yen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toschi, E" uniqKey="Toschi E">E Toschi</name></author><author><name sortKey="Sgadari, C" uniqKey="Sgadari C">C Sgadari</name></author><author><name sortKey="Monini, P" uniqKey="Monini P">P Monini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Lorenzo, G" uniqKey="Di Lorenzo G">G Di Lorenzo</name></author><author><name sortKey="Kreuter, A" uniqKey="Kreuter A">A Kreuter</name></author><author><name sortKey="Di Trollo, R" uniqKey="Di Trollo R">R Di Trollo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J IMA</journal-id><journal-id journal-id-type="iso-abbrev">J IMA</journal-id><journal-id journal-id-type="publisher-id">JIMA</journal-id><journal-title-group><journal-title>The Journal of IMA</journal-title></journal-title-group><issn pub-type="ppub">0899-8299</issn><issn pub-type="epub">2160-9829</issn><publisher><publisher-name>Islamic Medical Association of North America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23864989</article-id><article-id pub-id-type="pmc">3708632</article-id><article-id pub-id-type="doi">10.5915/44-1-9317</article-id><article-id pub-id-type="publisher-id">jima-44-1-09317</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Corticosteroid Induced, HHV-8 Positive Kaposi’s Sarcoma in a Non-HIV Elderly Patient</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wani</surname><given-names>Gh Mohiuddin</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af1-jima-44-1-09317"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ahmad</surname><given-names>Sheikh Manzoor</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af1-jima-44-1-09317"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Qayoom</surname><given-names>Seema</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af1-jima-44-1-09317"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khursheed</surname><given-names>Bilquees</given-names></name><degrees>MBBS</degrees><xref ref-type="aff" rid="af1-jima-44-1-09317"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Khan</surname><given-names>A.R.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="af2-jima-44-1-09317"><sup>2</sup></xref></contrib></contrib-group><aff id="af1-jima-44-1-09317"><label>1</label>Department of Dermatology, Venereology and Leprosy Sheri-Kashmir Institute of Medical Sciences (SKIMS)</aff><aff id="af2-jima-44-1-09317"><label>2</label>Department of Pathology Government Medical College Srinager, Kashmir, India</aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>8</month><year>2012</year></pub-date><volume>44</volume><issue>1</issue><elocation-id>44-1-9317</elocation-id><permissions><copyright-statement>© 2012 by the authors.</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access"><license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/">http://creativecommons.org/licenses/by-nc-nd/3.0/</ext-link>).</license-p></license></permissions><abstract><p>Kaposi’s sarcoma (KS) was first described in 1872 by Moritz Kaposi. In 1994, Chang <italic>et al.</italic> first identified DNA sequences corresponding to human herpesvirus-8 (HHV-8) in AIDS-associated Kaposi sarcoma biopsies. It is now believed that presence of HHV-8 is necessary but not sufficient to cause KS. Other factors like immunosuppressive therapy also play a role. We describe an HIV-negative elderly patient who developed KS of skin and mucous membrane after prolonged use of corticosteroids for knee pain. The patient was positive for HHV-8.</p></abstract><kwd-group><kwd>Kaposi sarcoma</kwd><kwd>corticosteroids</kwd><kwd>HHV-8</kwd><kwd>HIV/AIDS</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Discrete, violaceous lesions of Kaposi’s sarcoma on the arm and thigh.</p></caption><graphic xlink:href="JIMA-44-1-09317-g001"></graphic></fig><fig id="f2-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Lesions of Kaposi’s sarcoma on the lower limb, showing confluence.</p></caption><graphic xlink:href="JIMA-44-1-09317-g002"></graphic></fig><fig id="f3-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Violaceous nodules and plaques of Kaposi’s sarcoma. Note also edema of the hand.</p></caption><graphic xlink:href="JIMA-44-1-09317-g003"></graphic></fig><fig id="f4-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Characteristic patches of Kaposi’s sarcoma on the hard and soft palate.</p></caption><graphic xlink:href="JIMA-44-1-09317-g004"></graphic></fig><fig id="f5-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 5</label><caption><p>Micro-section from plaque shows dilated, irregular new vessels and pre-existing vessels in the dermis. Also seen are few scattered spindle cells (H & E× 400).</p></caption><graphic xlink:href="JIMA-44-1-09317-g005"></graphic></fig><fig id="f6-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 6</label><caption><p>Micro-section from nodule shows fascicles of spindle cells in the dermis and superficial subcutis. Between the spindle cells are seen red blood cells in pseudo vascular channels. Spindle cells are seen encircling adipocytes and nerve fascicles (H & E×400).</p></caption><graphic xlink:href="JIMA-44-1-09317-g006"></graphic></fig><fig id="f7-jima-44-1-09317" orientation="portrait" position="float"><label>Figure 7</label><caption><p>Immunohistochemistry. The section which is immune-stained for CD31 highlights tumor cells in the vessels and in the stroma.</p></caption><graphic xlink:href="JIMA-44-1-09317-g007"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Ahmad, Sheikh Manzoor" sort="Ahmad, Sheikh Manzoor" uniqKey="Ahmad S" first="Sheikh Manzoor" last="Ahmad">Sheikh Manzoor Ahmad</name><name sortKey="Khursheed, Bilquees" sort="Khursheed, Bilquees" uniqKey="Khursheed B" first="Bilquees" last="Khursheed">Bilquees Khursheed</name><name sortKey="Qayoom, Seema" sort="Qayoom, Seema" uniqKey="Qayoom S" first="Seema" last="Qayoom">Seema Qayoom</name><name sortKey="Wani, Gh Mohiuddin" sort="Wani, Gh Mohiuddin" uniqKey="Wani G" first="Gh Mohiuddin" last="Wani">Gh Mohiuddin Wani</name></noCountry><country name="Inde"><noRegion><name sortKey="Khan, A R" sort="Khan, A R" uniqKey="Khan A" first="A. R." last="Khan">A. R. 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